Systemic lupus erythematosus during penicillamine therapy for rheumatoid arthritis.

Abstract:

:Six patients with rheumatoid arthritis developed a syndrome resembling lupus erythematosus while being treated with penicillamine. All patients had previous mucocutaneous reactions to chrysotherapy. Manifestations included pleurisy in five of six patients, rashes in three, nephritis in two, and neurologic disturbances in two; lupus erythematosus cells were found in five patients, antinuclear antibodies in all six, antideoxyribonucleic acid in three, positive Coombs' test results for three patients, and low C4 complement in five of the six. Symptoms were slow to resolve after penicillamine treatment was discontinued, and four of the patients needed corticosteroid therapy. A higher frequency than expected of HLA A 11 in three patients and B 15 in five patients was seen.

journal_name

Ann Intern Med

authors

Chalmers A,Thompson D,Stein HE,Reid G,Patterson AC

doi

10.7326/0003-4819-97-5-659

subject

Has Abstract

pub_date

1982-11-01 00:00:00

pages

659-63

issue

5

eissn

0003-4819

issn

1539-3704

journal_volume

97

pub_type

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