Current and future concepts of lung cancer.


:We discuss here some of the last decade's diagnostic and therapeutic advances in the treatment of lung cancer, as well as current and future research objectives. Roentgenographs from selected patients illustrate the natural history of lung cancer. We present perspectives concerning selection from the growing diagnostic armamentarium, with comments upon early detection and localization of "occult" cancers with the help of flexible bronchoscopy. Operative approaches have changed over the past 4 decades; we review how and why they evolved, including perspectives concerning mediastinoscopy. There is a presentation on a radiotherapeutic research approach to oat-cell cancers and the current status of immunotherapy. Such issues as animal models available for lung cancer research emerge in the general discussion, and it becomes clear that lung cancer merits a truly interdisciplinary approach in order to bring meaningful advances to the patient's bedside.


Ann Intern Med


Benfield JR,Julliard GJ,Pilch YH,Rigler LG,Selecky P




Has Abstract


1975-07-01 00:00:00












  • Implantable cardioverter-defibrillators: implications for the nonelectrophysiologist.

    abstract:PURPOSE:To review clinical scenarios in which nonelectrophysiologist physicians may interact with patients who have implantable defibrillators. DATA SOURCES:Peer-reviewed original articles and reviews addressing aspects of implantable defibrillator therapy that are relevant to the clinician. DATA SYNTHESIS:The capaci...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审


    authors: Pinski SL,Trohman RG

    更新日期:1995-05-15 00:00:00

  • Dual Versus Triple Therapy for Atrial Fibrillation After Percutaneous Coronary Intervention: A Systematic Review and Meta-analysis.

    abstract:Background:The safety and effectiveness of dual therapy (direct oral anticoagulant [DOAC] plus P2Y12 inhibitor) versus triple therapy (vitamin K antagonist plus aspirin and P2Y12 inhibitor) in patients with nonvalvular atrial fibrillation (AF) after percutaneous coronary intervention (PCI) is unclear. Purpose:To exami...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,meta分析


    authors: Khan SU,Osman M,Khan MU,Khan MS,Zhao D,Mamas MA,Savji N,Al-Abdouh A,Hasan RK,Michos ED

    更新日期:2020-04-07 00:00:00

  • Acupuncture for chronic shoulder pain. An experimental study with attention to the role of placebo and hypnotic susceptibility.

    abstract::One half of 42 subjects treated for painful shoulders received classic acupuncture, and one half received a placebo in which the needles did not penetrate the skin. Half of each of these groups was treated in a positive setting to encourage the subject, and half in a negative setting designed to keep encouragement at ...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Moore ME,Berk SN

    更新日期:1976-04-01 00:00:00

  • Red blood cell transfusion: a clinical practice guideline from the AABB*.

    abstract:DESCRIPTION:Although approximately 85 million units of red blood cells (RBCs) are transfused annually worldwide, transfusion practices vary widely. The AABB (formerly, the American Association of Blood Banks) developed this guideline to provide clinical recommendations about hemoglobin concentration thresholds and othe...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,实务指引,评审


    authors: Carson JL,Grossman BJ,Kleinman S,Tinmouth AT,Marques MB,Fung MK,Holcomb JB,Illoh O,Kaplan LJ,Katz LM,Rao SV,Roback JD,Shander A,Tobian AA,Weinstein R,Swinton McLaughlin LG,Djulbegovic B,Clinical Transfusion Medicine Com

    更新日期:2012-07-03 00:00:00

  • Acute renal infection in women: treatment with trimethoprim-sulfamethoxazole or ampicillin for two or six weeks. A randomized trial.

    abstract::We compared the efficacy of orally administered ampicillin, 2 g/d, with that of trimethoprim-sulfamethoxazole, 320 mg/d-1600 mg/d, given for 2 or 6 weeks for outpatient management of acute uncomplicated renal infection in women. Of 98 women participating in the trial, 60 had renal infections with susceptible strains, ...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Stamm WE,McKevitt M,Counts GW

    更新日期:1987-03-01 00:00:00

  • Effects of an intervention to increase bed alarm use to prevent falls in hospitalized patients: a cluster randomized trial.

    abstract:BACKGROUND:Bed alarm systems intended to prevent hospital falls have not been formally evaluated. OBJECTIVE:To investigate whether an intervention aimed at increasing bed alarm use decreases hospital falls and related events. DESIGN:Pair-matched, cluster randomized trial over 18 months. Nursing units were allocated b...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,随机对照试验


    authors: Shorr RI,Chandler AM,Mion LC,Waters TM,Liu M,Daniels MJ,Kessler LA,Miller ST

    更新日期:2012-11-20 00:00:00

  • Chemotherapy of advanced small-cell anaplastic carcinoma. Superiority of a four-drug combination to a three-drug combination.

    abstract::A controlled clinical trial compared three-drug and four-drug combination chemotherapy in 109 patients with advanced small-cell anaplastic carcinoma of the lung. The combination of vincristine, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), cyclophosphamide, and methotrexate was significantly superior to the com...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hansen HH,Dombernowsky P,Hansen M,Hirsch F

    更新日期:1978-08-01 00:00:00

  • Risk reduction for the acquired immunodeficiency syndrome among intravenous drug users.

    abstract::Intravenous drug users are the second largest risk group for the acquired immunodeficiency syndrome (AIDS) and a bridge to two other groups: children and heterosexual partners. In the absence of effective treatment or vaccines, control of the epidemic among drug users will rely on efforts to reduce needle sharing. How...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Des Jarlais DC,Friedman SR,Hopkins W

    更新日期:1985-11-01 00:00:00

  • Procedural skills of practicing nephrologists. A national survey of 700 members of the American College of Physicians.

    abstract:OBJECTIVE:To determine which procedures nephrologists do in practice, where they learned the procedures, and how much training they recommend to achieve and maintain clinical competence in each. DESIGN:Mailed survey. PARTICIPANTS:A random sample of 700 members of the American College of Physicians who were identified...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Tape TG,Wigton RS,Blank LL,Nicolas JA

    更新日期:1990-09-01 00:00:00

  • Death and taxes.

    abstract::Tax incentives can provide a large financial impetus to change behavior. Current U.S. law establishes a substantial discontinuity in the amount of estate tax that many patients will have to pay in 2010: During this year only, the tax rate drops to zero. This article discusses concerns regarding the sharp change in tax...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Mendenhall GS

    更新日期:2008-12-02 00:00:00

  • In the clinic. Hypothyroidism.

    abstract::The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including PIER (Physicians' Information and Education Resource) and MKSAP (Medical Knowledge and Self Assessment Program). Annals of Internal Medicine editors develop In the Clinic f...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审


    authors: McDermott MT

    更新日期:2009-12-01 00:00:00

  • Preoperative screening: value of previous tests.

    abstract:OBJECTIVE:To determine the frequency of tests done in the year before elective surgery that might substitute for preoperative screening tests and to determine the frequency of test results that change from a normal value to a value likely to alter perioperative management. DESIGN:Retrospective cohort analysis of compu...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Macpherson DS,Snow R,Lofgren RP

    更新日期:1990-12-15 00:00:00

  • Medication dispensing errors and potential adverse drug events before and after implementing bar code technology in the pharmacy.

    abstract:BACKGROUND:Many dispensing errors made in hospital pharmacies can harm patients. Some hospitals are investing in bar code technology to reduce these errors, but data about its efficacy are limited. OBJECTIVE:To evaluate whether implementation of bar code technology reduced dispensing errors and potential adverse drug ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Poon EG,Cina JL,Churchill W,Patel N,Featherstone E,Rothschild JM,Keohane CA,Whittemore AD,Bates DW,Gandhi TK

    更新日期:2006-09-19 00:00:00

  • The effect of physician behavior on the collection of data.

    abstract::Determining the patient's major reasons for seeking care is of critical importance in a successful medical encounter. To study the physician's role in soliciting and developing the patient's concerns at the outset of a clinical encounter, 74 office visits were recorded. In only 17 (23%) of the visits was the patient p...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Beckman HB,Frankel RM

    更新日期:1984-11-01 00:00:00

  • Tracheal occlusion pressure: a simple index to monitor respiratory muscle fatigue during acute respiratory failure in patients with chronic obstructive pulmonary disease.

    abstract:STUDY OBJECTIVE:To assess respiratory muscle fatigue in acute respiratory failure in patients with chronic obstructive pulmonary disease and evaluate its influence on weaning patients from mechanical ventilation. DESIGN AND PATIENTS:We studied the time course of tracheal occlusion pressure (P0.1) and high-to-low ratio...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Murciano D,Boczkowski J,Lecocguic Y,Emili JM,Pariente R,Aubier M

    更新日期:1988-06-01 00:00:00

  • Critical pathways as a strategy for improving care: problems and potential.

    abstract::In an era of increasing competition in medical care, critical pathway guidelines have emerged as one of the most popular new initiatives intended to reduce costs while maintaining or even improving the quality of care. Developed primarily for high-volume hospital diagnoses, critical pathways display goals for patients...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Pearson SD,Goulart-Fisher D,Lee TH

    更新日期:1995-12-15 00:00:00

  • Critical perfusion pressure for renal function in patients with bilateral atherosclerotic renal vascular disease.

    abstract::We studied renal plasma flow and glomerular filtration rate during graded blood pressure reduction induced with sodium nitroprusside infusion in 16 hypertensive patients with atherosclerotic renovascular disease. Eight patients with unilateral disease tolerated pressure reduction from 205 +/- 9 (SE)/103 +/- 2 mm Hg to...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Textor SC,Novick AC,Tarazi RC,Klimas V,Vidt DG,Pohl M

    更新日期:1985-03-01 00:00:00

  • New federal initiatives to enhance the medical treatment of opioid dependence.

    abstract::Opioid dependence is a chronic relapsing medical condition with substantial health and societal complications. Recent federal initiatives are designed to enhance the medical treatment of patients with opioid dependence and will expand the role of internists in the care of these patients. These initiatives include a pr...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Fiellin DA,O'Connor PG

    更新日期:2002-10-15 00:00:00

  • The Institute of Medicine report, "A Manpower Policy for Primary Health Care": a commentary from the American College of Physicians.

    abstract::In 1978 the Institute of Medicine issued "A Manpower Policy for Health Care," the report of a study of major issues bearing on the availability of an adequate number of physicians for provision of primary care and on potential strategies for an appropriate manpower policy. The report was analyzed by committees of the ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Peterson ML

    更新日期:1980-06-01 00:00:00

  • Thirty years of HIV and AIDS: future challenges and opportunities.

    abstract::As the third decade since AIDS was first recognized comes to an end, extraordinary advances have occurred in the understanding, treatment, and prevention of HIV infection and AIDS. As a result of these successes, it is now time to focus on future challenges. Paramount among these is reaching the goal of truly controll...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Dieffenbach CW,Fauci AS

    更新日期:2011-06-07 00:00:00

  • Screening for Breast Cancer: U.S. Preventive Services Task Force Recommendation Statement.

    abstract:DESCRIPTION:Update of the 2009 U.S. Preventive Services Task Force (USPSTF) recommendation on screening for breast cancer. METHODS:The USPSTF reviewed the evidence on the following: effectiveness of breast cancer screening in reducing breast cancer-specific and all-cause mortality, as well as the incidence of advanced...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,实务指引


    authors: Siu AL,U.S. Preventive Services Task Force.

    更新日期:2016-02-16 00:00:00

  • Recovery from rabies in man.

    abstract::A 45-year-old woman from Mendoza, Argentina, was severely bitten by a dog that died 4 days later. Before death, the dog was nervous, aggressive, and had occasional seizures. Ten days after the woman had been bitten, rabies vaccine treatment was begun: 14 daily doses of suckling mouse brain vaccine followed by 2 booste...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Porras C,Barboza JJ,Fuenzalida E,Adaros HL,Oviedo AM,Furst J

    更新日期:1976-07-01 00:00:00

  • Trimethoprim-sulfamethoxazole compared with vancomycin for the treatment of Staphylococcus aureus infection.

    abstract:OBJECTIVE:To compare trimethoprim-sulfamethoxazole (TMP-SMZ) and vancomycin regarding efficacy and safety in the therapy of serious Staphylococcus aureus infections. DESIGN:Randomized, double-blind comparative trial. SETTING:A tertiary-care hospital. PATIENTS:One hundred and one intravenous drug users hospitalized w...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Markowitz N,Quinn EL,Saravolatz LD

    更新日期:1992-09-01 00:00:00

  • Persistent B19 parvovirus infection in patients infected with human immunodeficiency virus type 1 (HIV-1): a treatable cause of anemia in AIDS.

    abstract:OBJECTIVE:To determine the role of B19 parvovirus in red cell aplasia of patients infected with human immunodeficiency virus type 1 (HIV-1). DESIGN:Uncontrolled clinical trial, with assay of serum, peripheral blood cells, and bone marrow for virus using DNA hybridization and immunocytochemistry techniques; these assay...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Frickhofen N,Abkowitz JL,Safford M,Berry JM,Antunez-de-Mayolo J,Astrow A,Cohen R,Halperin I,King L,Mintzer D

    更新日期:1990-12-15 00:00:00

  • Aprindine hepatitis.

    abstract::We have seen two patients whose hepatitis was due to the administration of aprindine, a new antiarrhythmic agent. In both patients evidence of hepatitis appeared within 3 weeks of initiating aprindine therapy and resolved rapidly when the drug was withdrawn. The reintroduction of aprindine in one patient was associate...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Herlong HF,Reid PR,Boitnott JK,Maddrey WC

    更新日期:1978-09-01 00:00:00

  • Hepatitis-associated lipid storage myopathy.

    abstract::We report the case of a 23-year-old woman who developed severe myalgias in association with mild hepatitis B surface antigen-positive hepatitis. Muscle biopsy showed myriads of microvacuoles filled with neutral lipid. Prednisone therapy was associated with complete clearing of all clinical and laboratory abnormalities...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Patten BM,Shabot JM,Alperin J,Dodson RF

    更新日期:1977-10-01 00:00:00

  • Biliary excretion of aluminum in aluminum osteodystrophy with liver disease.

    abstract::Two patients with chronic liver disease developed elevated serum aluminum concentrations and biopsy-proven osteodystrophy. Neither patient had chronic renal failure but both had received aluminum-containing antacids for long periods. We measured biliary and urinary aluminum excretion during antacid loading in patients...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Williams JW,Vera SR,Peters TG,Luther RW,Bhattacharya S,Spears H,Graham A,Pitcock JA,Crawford AJ,Palmieri GM

    更新日期:1986-06-01 00:00:00

  • Processes for effective communication in primary care.

    abstract::Communication in the delivery of health care services occurs along 2 axes: between providers and patients and among several providers. In primary care, a principle objective in the provider-patient relationship is facilitating whole-person care, which is care provided in the context of family and community. In additio...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: Weiner SJ,Barnet B,Cheng TL,Daaleman TP

    更新日期:2005-04-19 00:00:00

  • Better access to information about clinical trials.

    abstract::Access to information about clinical trials is important to researchers, health care professionals, and patients. Many have argued for the establishment of clinical trials registries, citing their substantial benefits. Although some registries do exist, it has been difficult to create comprehensive, easily accessible ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章


    authors: McCray AT

    更新日期:2000-10-17 00:00:00

  • Effect of low-dose aspirin on the occurrence of venous thromboembolism: a randomized trial.

    abstract:BACKGROUND:Short-term aspirin therapy can lower the risk for venous thromboembolism (VTE) in high-risk patients, but whether the long-term use of low-dose aspirin reduces risk in healthy adults is uncertain. OBJECTIVE:To test the efficacy of long-term aspirin therapy for preventing VTE. DESIGN:Secondary analysis of a...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,随机对照试验


    authors: Glynn RJ,Ridker PM,Goldhaber SZ,Buring JE

    更新日期:2007-10-16 00:00:00