Additional chenodiol therapy after partial dissolution of gallstones with two years of treatment.

Abstract:

:During the National Cooperative Gallstone Study, therapy with chenodiol, 750 or 375 mg/d, for 2 years resulted in confirmed, complete gallstone dissolution in 14% and 5% of patients, respectively, and partial dissolution (greater than 50%) in 27% and 18%. The present study was done to determine the frequency with which complete dissolution occurs in patients having partial dissolution of gallstones who receive additional therapy. Eighty-six of one hundred thirty-eight eligible patients continued to receive 750 mg/d (61 patients) or 375 mg/d (25 patients) of chenodiol for 1 year. Patients whose oral cholecystogram at the end of the year showed further (greater than 50%) dissolution continued to receive chenodiol, (28 patients at 750 mg/d and 11 patients at 375 mg/d) for a second year (total duration of therapy, 4 years). A final oral cholecystogram was taken at the end of the fourth year. Complete dissolution occurred in 23% and 16% of patients receiving chenodiol, 750 or 375 mg/d, respectively, for an additional 1 or 2 years.

journal_name

Ann Intern Med

authors

Marks JW,Baum RA,Hanson RF,Hersh T,Hightower NC Jr,Mekhjian H,Schaefer RA,Soloway RD,Thistle JL,Thomas FB

doi

10.7326/0003-4819-100-3-382

subject

Has Abstract,Author List Incomplete

pub_date

1984-03-01 00:00:00

pages

382-4

issue

3

eissn

0003-4819

issn

1539-3704

journal_volume

100

pub_type

临床试验,杂志文章
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    pub_type: 杂志文章

    doi:10.7326/0003-4819-93-5-704

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    更新日期:1980-11-01 00:00:00

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    pub_type: 杂志文章

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    pub_type: 杂志文章,多中心研究,随机对照试验

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    pub_type: 杂志文章

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