Genotyping for Human Papillomavirus Types 16 and 18 in Women With Minor Cervical Lesions: A Systematic Review and Meta-analysis.

Abstract:

Background:High-risk human papillomavirus (hrHPV) testing to triage women with minor cervical lesions generates many referrals. Purpose:To evaluate the accuracy of genotyping for HPV types 16 and 18 and its utility as a second triage step after hrHPV testing in women with minor cervical lesions. Data Sources:Searches of 4 bibliographic databases, without language restrictions, from 1 January 1999 to 1 February 2016. Study Selection:Studies involving women with atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesions (LSIL) who were triaged with tests for hrHPV and HPV 16/18 to find cervical intraepithelial neoplasia (grade ≥2 [CIN2+] or grade ≥3 [CIN3+]). Data Extraction:Independent study selection, extraction of data, and quality assessment by 2 reviewers. Data Synthesis:Twenty-four moderate- to good-quality studies involving 8587 women with ASC-US and 5284 with LSIL were found. The pooled sensitivity of HPV 16/18 genotyping for CIN3+ was about 70% for women with either ASC-US or LSIL. The pooled specificity (with a threshold of grade <2 CIN) was 83% (95% CI, 80% to 86%) for women with ASC-US and 76% (CI, 74% to 79%) for those with LSIL. The average risk for CIN3+ was 17% and 19% in HPV 16/18-positive women with ASC-US and LSIL, respectively, and was 5% in hrHPV-positive but HPV 16/18-negative women with either ASC-US or LSIL. Limitation:Methodological and technical heterogeneity among studies; insufficient data to assess accuracy of separate assays. Conclusion:Testing for HPV 16/18 to triage women with minor abnormal cytology is poorly sensitive but may be useful as a second triage test after hrHPV testing, with direct referral if the woman is positive for HPV 16/18. Whether colposcopy or repeated testing is recommended for hrHPV-positive but HPV 16/18-negative women depends on local decision thresholds that can be derived from pretest-posttest probability plots. Primary Funding Source:7th Framework Programme of the European Commission.

journal_name

Ann Intern Med

authors

Arbyn M,Xu L,Verdoodt F,Cuzick J,Szarewski A,Belinson JL,Wentzensen N,Gage JC,Khan MJ

doi

10.7326/M15-2735

subject

Has Abstract

pub_date

2017-01-17 00:00:00

pages

118-127

issue

2

eissn

0003-4819

issn

1539-3704

pii

2583380

journal_volume

166

pub_type

杂志文章,meta分析,评审
  • Reporting discrepancies between the ClinicalTrials.gov results database and peer-reviewed publications.

    abstract:BACKGROUND:ClinicalTrials.gov requires reporting of result summaries for many drug and device trials. PURPOSE:To evaluate the consistency of reporting of trials that are registered in the ClinicalTrials.gov results database and published in the literature. DATA SOURCES:ClinicalTrials.gov results database and matched ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/M13-0480

    authors: Hartung DM,Zarin DA,Guise JM,McDonagh M,Paynter R,Helfand M

    更新日期:2014-04-01 00:00:00

  • Short-course therapy of catheter-related Staphylococcus aureus bacteremia: a meta-analysis.

    abstract:OBJECTIVE:To determine, through structured methodologic review of published articles, the effectiveness of short-course (< or = 2 weeks) antibiotic therapy for catheter-related Staphylococcus aureus bacteremia. DATA SOURCES:English-language publications on catheter-related S. aureus bacteremia identified using MEDLINE...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,meta分析

    doi:10.7326/0003-4819-119-4-199308150-00010

    authors: Jernigan JA,Farr BM

    更新日期:1993-08-15 00:00:00

  • The risk for fatal pulmonary embolism after discontinuing anticoagulant therapy for venous thromboembolism.

    abstract:BACKGROUND:The long-term risk for fatal pulmonary embolism (PE) after treatment of venous thromboembolism (VTE) may be an important factor in the decision to discontinue this treatment. OBJECTIVE:To provide reliable and precise estimates of the annual risk for fatal PE and the case-fatality rate of disease recurrence ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-147-11-200712040-00007

    authors: Douketis JD,Gu CS,Schulman S,Ghirarduzzi A,Pengo V,Prandoni P

    更新日期:2007-12-04 00:00:00

  • Rapid Rule-out of Acute Myocardial Infarction With a Single High-Sensitivity Cardiac Troponin T Measurement Below the Limit of Detection: A Collaborative Meta-analysis.

    abstract:Background:High-sensitivity assays for cardiac troponin T (hs-cTnT) are sometimes used to rapidly rule out acute myocardial infarction (AMI). Purpose:To estimate the ability of a single hs-cTnT concentration below the limit of detection (<0.005 µg/L) and a nonischemic electrocardiogram (ECG) to rule out AMI in adults ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,meta分析

    doi:10.7326/M16-2562

    authors: Pickering JW,Than MP,Cullen L,Aldous S,Ter Avest E,Body R,Carlton EW,Collinson P,Dupuy AM,Ekelund U,Eggers KM,Florkowski CM,Freund Y,George P,Goodacre S,Greenslade JH,Jaffe AS,Lord SJ,Mokhtari A,Mueller C,Munro A

    更新日期:2017-05-16 00:00:00

  • NIH conference. Insulin-like growth factors in health and disease.

    abstract::The insulin-like growth factor (IGF) family of peptides, binding proteins, and receptors are ubiquitous and important for normal human growth and development. Modern techniques including specific radioimmunoassays, radioreceptor assays and recombinant DNA technology have improved our understanding of the role of IGFs ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-116-10-854

    authors: LeRoith D,Clemmons D,Nissley P,Rechler MM

    更新日期:1992-05-15 00:00:00

  • Narrative review: the new epidemic of Clostridium difficile-associated enteric disease.

    abstract::Antibiotic-associated diarrhea and colitis were well established soon after antibiotics became available. Early work implicated Staphylococcus aureus, but in 1978 Clostridium difficile became the established pathogen in the vast majority of cases. In the first 5 years (1978 through 1983), the most common cause was cli...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-145-10-200611210-00008

    authors: Bartlett JG

    更新日期:2006-11-21 00:00:00

  • No initial therapy for stage III and IV non-Hodgkin's lymphomas of favorable histologic types.

    abstract::The question of whether initial treatment is necessary in relatively asymptomatic patients with stage III and IV non-Hodgkin's lymphomas of favorable histologic types was studied by retrospective analysis. Two groups of patients were studied: [1] 44 nonprotocol patients, followed since 1963, in whom initial treatment ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-90-1-10

    authors: Portlock CS,Rosenberg SA

    更新日期:1979-01-01 00:00:00

  • Fat embolism prophylaxis with corticosteroids. A prospective study in high-risk patients.

    abstract::The efficacy of corticosteroid treatment in the prophylaxis of the fat embolism syndrome was evaluated in a prospective, randomized, double-blind study of high-risk patients with long-bone fractures. Using a set of objective diagnostic criteria, we saw a significant difference in the incidence of the syndrome between ...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.7326/0003-4819-99-4-438

    authors: Schonfeld SA,Ploysongsang Y,DiLisio R,Crissman JD,Miller E,Hammerschmidt DE,Jacob HS

    更新日期:1983-10-01 00:00:00

  • Studying symptoms: sampling and measurement issues.

    abstract::Physical symptoms account for more than half of all outpatient visits, but the specific causes and treatments of many common symptoms are frequently not well established. Because clinical research has primarily targeted specific diseases, symptoms-based research is still an emerging field of scientific inquiry, and op...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-134-9_part_2-200105011-00008

    authors: Kroenke K

    更新日期:2001-05-01 00:00:00

  • Community-acquired methicillin-resistant Staphylococcus aureus endocarditis in the Detroit Medical Center.

    abstract::Between June 1980 and September 1981 we evaluated 24 cases of endocarditis from methicillin-resistant Staphylococcus aureus. All of the cases occurred in drug addicts and all were community-acquired. The patients ranged in age from 21 to 59 years and represented an older population than that generally reported for bac...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-97-3-330

    authors: Levine DP,Cushing RD,Jui J,Brown WJ

    更新日期:1982-09-01 00:00:00

  • Physicians, cost control, and ethics.

    abstract::Rising health care expenditures have led to numerous cost-control proposals. An examination of the ethical questions surrounding the role that physicians play in the control of health care costs suggests that unilateral rationing decisions by individual physicians at the bedside are morally unacceptable. Such decision...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-116-11-920

    authors: Sulmasy DP

    更新日期:1992-06-01 00:00:00

  • Cardioversion guided by transesophageal echocardiography: the ACUTE Pilot Study. A randomized, controlled trial. Assessment of Cardioversion Using Transesophageal Echocardiography.

    abstract:BACKGROUND:Electrical cardioversion in patients with atrial fibrillation is associated with an increased risk for embolic stroke. Screening for atrial thrombi with transesophageal echocardiography (TEE) before cardioversion should, in many patients, safely permit cardioversion to be done earlier than would be possible ...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.7326/0003-4819-126-3-199702010-00004

    authors: Klein AL,Grimm RA,Black IW,Leung DY,Chung MK,Vaughn SE,Murray RD,Miller DP,Arheart KL

    更新日期:1997-02-01 00:00:00

  • Indications for arterial blood gas analysis.

    abstract::Arterial blood gas analysis is used to evaluate oxygen and carbon dioxide gas exchange and acid-base status. Few studies identify indications for arterial blood gas analysis, especially with regard to optimizing the quality of patient care. General indications in severely ill adults usually include pathophysiologic ab...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-105-3-390

    authors: Raffin TA

    更新日期:1986-09-01 00:00:00

  • Coronary angiography after thrombolytic therapy for acute myocardial infarction.

    abstract:PURPOSE:To review the status of emergency, urgent, routine, and selective angiography after intravenous thrombolytic therapy. DATA SOURCES:Relevant English-language articles published from January 1985 to July 1990 were identified through MEDLINE. STUDY SELECTION:For emergency angiography, four major randomized studi...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-114-10-877

    authors: Topol EJ,Holmes DR,Rogers WJ

    更新日期:1991-05-15 00:00:00

  • Mandated choice for organ donation: time to give it a try.

    abstract::A severe shortage of organs greatly limits the ability to deliver the miracle of transplantation to people suffering from end-stage organ disease. Contributing to this shortage is a high rate of refusal among families who are asked for permission to remove organs from a recently deceased relative. Mandated choice offe...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-125-1-199607010-00010

    authors: Spital A

    更新日期:1996-07-01 00:00:00

  • Improvements in diabetes processes of care and intermediate outcomes: United States, 1988-2002.

    abstract:BACKGROUND:Progress of diabetes care is a subject of public health concern. OBJECTIVE:To assess changes in quality of diabetes care in the United States by using standardized measures. DESIGN:National population-based, serial cross-sectional surveys. SETTING:National Health and Nutrition Examination Survey (1988-199...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-144-7-200604040-00005

    authors: Saaddine JB,Cadwell B,Gregg EW,Engelgau MM,Vinicor F,Imperatore G,Narayan KM

    更新日期:2006-04-04 00:00:00

  • Causes of persistent dizziness. A prospective study of 100 patients in ambulatory care.

    abstract:OBJECTIVE:To determine the causes of persistent dizziness in outpatients. DESIGN:Consecutive adult outpatients presenting with a chief complaint of dizziness. SETTING:Four clinics (internal medicine, walk-in, emergency room, and neurology) in a teaching hospital. PATIENTS:Of 185 patients presenting during the 10-mon...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-117-11-898

    authors: Kroenke K,Lucas CA,Rosenberg ML,Scherokman B,Herbers JE Jr,Wehrle PA,Boggi JO

    更新日期:1992-12-01 00:00:00

  • Secretin-stimulated serum gastrin levels in hyperparathyroid patients from families with multiple endocrine adenomatosis type I.

    abstract::Twenty-three patients with hyperparathyroidism from six families with the multiple endocrine adenomatosis (MEA) I-syndrome were tested by secretin provocation. In nine cases this led to increases in serum gastrin ranging from 298 to 13 300 pg/ml, whereas the maximum rise in gastrin in the other 14 patients was 32 pg/m...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-86-6-719

    authors: Lamers CB,Buis JT,van Tongeren J

    更新日期:1977-06-01 00:00:00

  • Radiation-Induced Breast Cancer Incidence and Mortality From Digital Mammography Screening: A Modeling Study.

    abstract:BACKGROUND:Estimates of risk for radiation-induced breast cancer from mammography screening have not considered variation in dose exposure or diagnostic work-up after abnormal screening results. OBJECTIVE:To estimate distributions of radiation-induced breast cancer incidence and mortality from digital mammography scre...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/M15-1241

    authors: Miglioretti DL,Lange J,van den Broek JJ,Lee CI,van Ravesteyn NT,Ritley D,Kerlikowske K,Fenton JJ,Melnikow J,de Koning HJ,Hubbard RA

    更新日期:2016-02-16 00:00:00

  • Screening for abdominal aortic aneurysm: U.S. Preventive Services Task Force recommendation statement.

    abstract:DESCRIPTION:Update of the 2005 U.S. Preventive Services Task Force (USPSTF) recommendation on screening for abdominal aortic aneurysm (AAA). METHODS:The USPSTF commissioned a systematic review that assessed the evidence on the benefits and harms of screening for AAA and strategies for managing small (3.0 to 5.4 cm) sc...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,实务指引

    doi:10.7326/M14-1204

    authors: LeFevre ML,U.S. Preventive Services Task Force.

    更新日期:2014-08-19 00:00:00

  • Meta-analysis: risk for hypertension in living kidney donors.

    abstract:BACKGROUND:The risk for hypertension after kidney donation remains uncertain. PURPOSE:To see whether normotensive adults who donate a kidney develop higher blood pressure and risk for hypertension compared with nondonor adults acting as control participants. DATA SOURCES:MEDLINE, EMBASE, and Science Citation Index we...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.7326/0003-4819-145-3-200608010-00006

    authors: Boudville N,Prasad GV,Knoll G,Muirhead N,Thiessen-Philbrook H,Yang RC,Rosas-Arellano MP,Housawi A,Garg AX,Donor Nephrectomy Outcomes Research (DONOR) Network.

    更新日期:2006-08-01 00:00:00

  • NIH Conference. Alzheimer's disease and Down's syndrome: new insights.

    abstract::Neuropathologic and neurochemical studies of older adults with Down's syndrome and those with Alzheimer's disease reveal striking similarities. Genetic studies indicate that near relatives of patients with Alzheimer's disease are at increased risk of developing Alzheimer's disease, and the risk appears to be age speci...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-103-4-566

    authors: Cutler NR,Heston LL,Davies P,Haxby JV,Schapiro MB

    更新日期:1985-10-01 00:00:00

  • Nasal carriage of and infection with Staphylococcus aureus in HIV-infected patients.

    abstract:BACKGROUND:Staphylococcus aureus is a common cause of serious infection in patients infected with HIV. OBJECTIVES:To evaluate risk factors for and quantitative effect of S. aureus infection in HIV-infected patients, with special attention to nasal carriage. DESIGN:Prospective, multihospital cohort study. SETTING:Thr...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-130-3-199902020-00026

    authors: Nguyen MH,Kauffman CA,Goodman RP,Squier C,Arbeit RD,Singh N,Wagener MM,Yu VL

    更新日期:1999-02-02 00:00:00

  • A prospective evaluation of a protocol for magnetic resonance imaging of patients with implanted cardiac devices.

    abstract:BACKGROUND:Magnetic resonance imaging (MRI) is avoided in most patients with implanted cardiac devices because of safety concerns. OBJECTIVE:To define the safety of a protocol for MRI at the commonly used magnetic strength of 1.5 T in patients with implanted cardiac devices. DESIGN:Prospective nonrandomized trial. (C...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.7326/0003-4819-155-7-201110040-00004

    authors: Nazarian S,Hansford R,Roguin A,Goldsher D,Zviman MM,Lardo AC,Caffo BS,Frick KD,Kraut MA,Kamel IR,Calkins H,Berger RD,Bluemke DA,Halperin HR

    更新日期:2011-10-04 00:00:00

  • Below-knee elastic compression stockings to prevent the post-thrombotic syndrome: a randomized, controlled trial.

    abstract:BACKGROUND:Because only limited evidence suggests that elastic stockings prevent the post-thrombotic syndrome in patients with symptomatic deep venous thrombosis (DVT), these stockings are not widely used. OBJECTIVE:To evaluate the efficacy of compression elastic stockings for prevention of the post-thrombotic syndrom...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.7326/0003-4819-141-4-200408170-00004

    authors: Prandoni P,Lensing AW,Prins MH,Frulla M,Marchiori A,Bernardi E,Tormene D,Mosena L,Pagnan A,Girolami A

    更新日期:2004-08-17 00:00:00

  • Effects of alcohol and fluvastatin on lipid metabolism and hepatic function.

    abstract:OBJECTIVE:To determine the effects of fluvastatin, a synthetic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, combined with moderate alcohol consumption on lipid profiles and hepatic function in patients with primary hypercholesterolemia. DESIGN:Randomized, placebo-controlled, crossover study. S...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.7326/0003-4819-122-9-199505010-00006

    authors: Smit JW,Wijnne HJ,Schobben F,Sitsen A,De Bruin TW,Erkelens DW

    更新日期:1995-05-01 00:00:00

  • Non-drug treatment of hypertension.

    abstract::As more people with mild hypertension are treated, non-drug therapies should be used more frequently and effectively. These therapies include weight reduction; sodium restriction; potassium, calcium, and magnesium supplementation; other dietary changes; exercise; relaxation; and moderation of alcohol use. Such therapi...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,评审

    doi:10.7326/0003-4819-102-3-359

    authors: Kaplan NM

    更新日期:1985-03-01 00:00:00

  • Recombinant leukocyte A interferon in advanced breast cancer. Results of a phase II efficacy trial.

    abstract::Nineteen patients with advanced refractory metastatic breast cancer no longer responsive to chemotherapy were treated in the first phase II efficacy trial of recombinant leukocyte A interferon (IFL-rA), a highly purified single molecular species of alpha interferon prepared by recombinant DNA methods. Patients receive...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章

    doi:10.7326/0003-4819-98-5-598

    authors: Sherwin SA,Mayer D,Ochs JJ,Abrams PG,Knost JA,Foon KA,Fein S,Oldham RK

    更新日期:1983-05-01 00:00:00

  • Aging-related cataract: laboratory investigation and clinical management.

    abstract::Cataract disrupts the crystalline lens, a transparent, elastic, avascular, biconvex structure composed of a capsule, lens epithelium, and lens fiber cells. Many factors contribute to the progression of lens opacity, but aging is most frequently associated with cataract. As aging-related cataract develops, many biochem...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-102-1-82

    authors: Straatsma BR,Foos RY,Horwitz J,Gardner KM,Pettit TH

    更新日期:1985-01-01 00:00:00

  • Discrepancy between consensus recommendations and actual community use of adjuvant chemotherapy in women with breast cancer.

    abstract:BACKGROUND:Although the efficacy of adjuvant chemotherapy in prolonging survival for women with breast cancer has been well documented, limited population-based information is available on the actual use of chemotherapy. OBJECTIVE:To examine the relationship between age and chemotherapy use. DESIGN:Cohort study. SET...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-138-2-200301210-00009

    authors: Du XL,Key CR,Osborne C,Mahnken JD,Goodwin JS

    更新日期:2003-01-21 00:00:00