Physicians, cost control, and ethics.

abstract：:The U.S. Food and Drug Administration (FDA) Amendments Act of 2007 mandated that the FDA develop a system for using automated health care data to identify risks of marketed drugs and other medical products. The Observational Medical Outcomes Partnership is a public-private partnership among the FDA, academia, data own...

journal_title：Annals of internal medicine

authors： Stang PE,Ryan PB,Racoosin JA,Overhage JM,Hartzema AG,Reich C,Welebob E,Scarnecchia T,Woodcock J

更新日期：2010-11-02 00:00:00

abstract：BACKGROUND:Vertebral fractures are a hallmark of postmenopausal osteoporosis and an important end point in trials of osteoporosis treatment, but the clinical significance of these fractures remains uncertain. OBJECTIVE:To determine the association of new vertebral fractures with back pain and back-related functional l...

journal_title：Annals of internal medicine

authors： Nevitt MC,Ettinger B,Black DM,Stone K,Jamal SA,Ensrud K,Segal M,Genant HK,Cummings SR

更新日期：1998-05-15 00:00:00

abstract：:Some important health policy topics, such as those related to the delivery, organization, and financing of health care, present substantial challenges to established methods for evidence synthesis. For example, such reviews may ask: What is the effect of for-profit versus not-for-profit delivery of care on patient out...

journal_title：Annals of internal medicine

authors： Bravata DM,McDonald KM,Shojania KG,Sundaram V,Owens DK

更新日期：2005-06-21 00:00:00

abstract：OBJECTIVE:To evaluate the 6-month change in cardiovascular (coronary heart disease) risk as a function of diet and drug therapy for mild hypertension. DESIGN:Collaborative randomized, controlled clinical trial to assess the efficacy of alternative regimens in treating mild hypertension. SETTING:Three university-based...

journal_title：Annals of internal medicine

authors： Oberman A,Wassertheil-Smoller S,Langford HG,Blaufox MD,Davis BR,Blaszkowski T,Zimbaldi N,Hawkins CM

更新日期：1990-01-15 00:00:00

abstract：BACKGROUND:In previous open-label noncomparative clinical trials, both fluconazole and itraconazole were effective therapy for progressive forms of coccidioidomycosis. OBJECTIVE:To determine whether fluconazole or itraconazole is superior for treatment of nonmeningeal progressive coccidioidal infections. DESIGN:Rando...

journal_title：Annals of internal medicine

authors： Galgiani JN,Catanzaro A,Cloud GA,Johnson RH,Williams PL,Mirels LF,Nassar F,Lutz JE,Stevens DA,Sharkey PK,Singh VR,Larsen RA,Delgado KL,Flanigan C,Rinaldi MG

更新日期：2000-11-07 00:00:00

abstract：:Recently acquired knowledge about vitamin D metabolism has improved our understanding in different varieties of osteomalacia. Many new causes of osteomalacia continue to be found. Radiologic and biochemical changes are not always characteristic and may occasionally be misleading. Bone biopsy after a double tetracyclin...

journal_title：Annals of internal medicine

authors： Frame B,Parfitt AM

更新日期：1978-12-01 00:00:00

abstract：:Asthma is characterized by inflammation, reversible airway obstruction, and increased airway responsiveness to various stimuli. It has received wide public attention in recent years because of increasing morbidity and deaths, particularly among black persons. The important role of inflammation in the immunopathogenesi...

journal_title：Annals of internal medicine

authors： Goldstein RA,Paul WE,Metcalfe DD,Busse WW,Reece ER

更新日期：1994-11-01 00:00:00

abstract：:Evidence on the safety and efficacy of methotrexate as a second- or third-line agent for treating patients with rheumatoid arthritis is reviewed. Four placebo-controlled clinical trials have documented short-term benefit from methotrexate; although true remission is rare, patients receiving methotrexate showed a 26% (...

journal_title：Annals of internal medicine

authors： Tugwell P,Bennett K,Gent M

更新日期：1987-09-01 00:00:00

abstract：:We have seen two patients whose hepatitis was due to the administration of aprindine, a new antiarrhythmic agent. In both patients evidence of hepatitis appeared within 3 weeks of initiating aprindine therapy and resolved rapidly when the drug was withdrawn. The reintroduction of aprindine in one patient was associate...

journal_title：Annals of internal medicine

authors： Herlong HF,Reid PR,Boitnott JK,Maddrey WC

更新日期：1978-09-01 00:00:00

abstract：BACKGROUND:Persons with abdominal aortic aneurysm are more likely to have a higher prevalence of risk factors for and clinical manifestations of cardiovascular disease. It is unknown whether these factors explain the high mortality rate associated with abdominal aortic aneurysm. OBJECTIVE:To describe the risk for mort...

journal_title：Annals of internal medicine

authors： Newman AB,Arnold AM,Burke GL,O'Leary DH,Manolio TA

更新日期：2001-02-06 00:00:00

abstract：PURPOSE:To review evidence about thyroxine suppressive therapy in patients with thyroid nodules, including the clinical importance and natural history of nodules and the effects and potential side effects of thyroxine therapy. DATA SOURCES:English-language articles published from 1986 to December 1996 were identified ...

journal_title：Annals of internal medicine

authors： Gharib H,Mazzaferri EL

更新日期：1998-03-01 00:00:00

abstract：:Sulfasalazine is metabolized by intestinal bacteria, resulting in the release of sulfapyridine and 5-aminosalicylate. The drug is useful in the treatment of active ulcerative colitis as well as in preventing relapses of the disease in remission. Although effective in active Crohn's disease as well, sulfasalazine appea...

journal_title：Annals of internal medicine

authors： Peppercorn MA

更新日期：1984-09-01 00:00:00

abstract：:One hundred ninety-eight patients with chronic myelogenous leukemia received marrow transplants after intensive chemotherapy and total body irradiation. Multivariate analysis showed disease status at time of transplantation to be the most powerful predictor of survival. The probability of long-term survival for alloge...

journal_title：Annals of internal medicine

authors： Thomas ED,Clift RA,Fefer A,Appelbaum FR,Beatty P,Bensinger WI,Buckner CD,Cheever MA,Deeg HJ,Doney K

更新日期：1986-02-01 00:00:00

abstract：:The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including PIER (Physicians' Information and Education Resource) and MKSAP (Medical Knowledge and Self Assessment Program). Annals of Internal Medicine editors develop In the Clinic f...

journal_title：Annals of internal medicine

authors： McDermott MT

更新日期：2009-12-01 00:00:00

abstract：:A severe shortage of organs greatly limits the ability to deliver the miracle of transplantation to people suffering from end-stage organ disease. Contributing to this shortage is a high rate of refusal among families who are asked for permission to remove organs from a recently deceased relative. Mandated choice offe...

journal_title：Annals of internal medicine

authors： Spital A

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:Ear involvement is not unusual in autoimmune diseases, but few data on this problem in the Sjögren syndrome are available. OBJECTIVES:To determine whether the incidence of hearing loss is increased in patients with the Sjögren syndrome and to determine what factors might be involved in the pathogenesis of S...

journal_title：Annals of internal medicine

authors： Tumiati B,Casoli P,Parmeggiani A

更新日期：1997-03-15 00:00:00

abstract：BACKGROUND:Life space is a measure of where a person goes, the frequency of going there, and the dependency in getting there. It may be a more accurate measure of mobility in older adults because it reflects participation in society as well as physical ability. OBJECTIVE:To assess effects of hospitalization on life sp...

journal_title：Annals of internal medicine

authors： Brown CJ,Roth DL,Allman RM,Sawyer P,Ritchie CS,Roseman JM

更新日期：2009-03-17 00:00:00

abstract：:This article applies major economic concepts, such as supply, demand, monopoly, monopsony, adverse selection, and moral hazard, to central features of U.S. health care. These illustrations help explain some of the principal problems of health policy-high cost and the uninsured-and why solutions are difficult to obtain...

journal_title：Annals of internal medicine

authors： Fuchs VR

更新日期：2015-03-03 00:00:00

abstract：BACKGROUND:Depressive disorders are persistent, recurring illnesses that cause great suffering for patients and their families. PURPOSE:To evaluate the benefits and adverse effects of newer pharmacotherapies and herbal treatments for depressive disorders in adults and adolescents. DATA SOURCES:English-language and no...

journal_title：Annals of internal medicine

authors： Williams JW Jr,Mulrow CD,Chiquette E,Noël PH,Aguilar C,Cornell J

更新日期：2000-05-02 00:00:00

abstract：STUDY OBJECTIVE:To determine the efficacy of continuous intravenous infusion of prostacyclin (epoprostenol) in primary pulmonary hypertension. DESIGN:Randomized trial with 8-week treatment periods and nonrandomized treatment for up to 18 months. SETTING:Four referral centers. PATIENTS:Sequential sample of 24 patient...

journal_title：Annals of internal medicine

authors： Rubin LJ,Mendoza J,Hood M,McGoon M,Barst R,Williams WB,Diehl JH,Crow J,Long W

更新日期：1990-04-01 00:00:00

abstract：BACKGROUND:The vast scientific literature on smoking and health contains few large studies with direct estimates of long-term mortality by smoking habits. Data have been lacking, particularly for women. OBJECTIVE:To study smoking and deaths and causes of death in women and men of middle age (40 to 70 years of age). D...

journal_title：Annals of internal medicine

authors： Vollset SE,Tverdal A,Gjessing HK

更新日期：2006-03-21 00:00:00

abstract：BACKGROUND:The renin-angiotensin system is involved in adipocyte growth and differentiation and possibly in adipose tissue metabolism. OBJECTIVE:To investigate the association of polymorphism in the angiotensin-converting enzyme (ACE) I/D gene, angiotensinogen M235T gene, and angiotensin II type 1 receptor A1166C gene...

journal_title：Annals of internal medicine

authors： Strazzullo P,Iacone R,Iacoviello L,Russo O,Barba G,Russo P,D'Orazio A,Barbato A,Cappuccio FP,Farinaro E,Siani A,Olivetti Prospective Heart Study.

更新日期：2003-01-07 00:00:00

abstract：:Bulimarexia, an eating disorder that is characterized by binge eating followed by self-induced vomiting or abuse of cathartic or diuretic drugs, has been defined as both a sequela of anorexia nervosa and a distinct eating disorder. In this review the presentation, prevalence, and complications of the various eating di...

journal_title：Annals of internal medicine

authors： Harris RT

更新日期：1983-12-01 00:00:00

abstract：Background:In 1994, 40% of U.S. gun owners who had recently acquired a firearm did so without a background check. No contemporary estimates exist. Objective:To estimate the proportion of current U.S. gun owners who acquired their most recent firearm without a background check, by time since and manner of acquisition, ...

journal_title：Annals of internal medicine

authors： Miller M,Hepburn L,Azrael D

更新日期：2017-02-21 00:00:00

abstract：:Two patients had recurrent facial edema and peripheral blood eosinophilia. One patient showed a marked increase in the serum level of the eosinophil granule major basic protein. In both patients, skin biopsy samples showed nonspecific mononuclear cell inflammation with few eosinophils. However, immunofluorescence stai...

journal_title：Annals of internal medicine

authors： Songsiridej V,Peters MS,Dor PJ,Ackerman SJ,Gleich GJ,Busse WW

更新日期：1985-10-01 00:00:00

abstract：:Intravenous drug users are the second largest risk group for the acquired immunodeficiency syndrome (AIDS) and a bridge to two other groups: children and heterosexual partners. In the absence of effective treatment or vaccines, control of the epidemic among drug users will rely on efforts to reduce needle sharing. How...

journal_title：Annals of internal medicine

authors： Des Jarlais DC,Friedman SR,Hopkins W

更新日期：1985-11-01 00:00:00

abstract：:Prospective data at Framingham and elsewhere have shown conclusively that risk of coronary heart disease in persons younger than age 50 is strikingly related to the serum total cholesterol level. Within so-called normal limits risk has been found to mount over a five-fold range. The impact has been found to be augment...

journal_title：Annals of internal medicine

authors： Kannel WB,Castelli WP,Gordon T

更新日期：1979-01-01 00:00:00

abstract：:Hepatocellular carcinoma is the most frequent cancer worldwide, responsible for approximately 1,000,000 deaths annually, most of them in the Far East and in sub-Saharan Africa. It usually presents at an advanced stage and has a poor prognosis. There is evidence of an etiologic role for hepatitis B virus infection in t...

journal_title：Annals of internal medicine

authors： Di Bisceglie AM,Rustgi VK,Hoofnagle JH,Dusheiko GM,Lotze MT

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND:A daily injection of low-molecular-weight heparin (LMWH) is often prescribed to women with unexplained recurrent pregnancy loss (RPL), although evidence suggesting a benefit is questionable. OBJECTIVE:To determine whether LMWH increases ongoing pregnancy and live-birth rates in women with unexplained RPL. ...

journal_title：Annals of internal medicine

authors： Schleussner E,Kamin G,Seliger G,Rogenhofer N,Ebner S,Toth B,Schenk M,Henes M,Bohlmann MK,Fischer T,Brosteanu O,Bauersachs R,Petroff D,ETHIG II group.

更新日期：2015-05-05 00:00:00

abstract：BACKGROUND:Testing has been advocated for all persons with newly diagnosed colorectal cancer to identify families with the Lynch syndrome, an autosomal dominant cancer-predisposition syndrome that is a paradigm for personalized medicine. OBJECTIVE:To estimate the effectiveness and cost-effectiveness of strategies to i...

journal_title：Annals of internal medicine

authors： Ladabaum U,Wang G,Terdiman J,Blanco A,Kuppermann M,Boland CR,Ford J,Elkin E,Phillips KA

更新日期：2011-07-19 00:00:00