In the clinic. Hypothyroidism.

abstract：STUDY OBJECTIVE:To define the clinical and hematologic effects of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) on patients with chronic severe neutropenia. DESIGN:Open-label, phase II study of rhGM-CSF. SETTING:Inpatient hematology and surgery clinic at a university medical center. P...

journal_title：Annals of internal medicine

authors： Ganser A,Ottmann OG,Erdmann H,Schulz G,Hoelzer D

更新日期：1989-12-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the efficacy of continuous intravenous infusion of prostacyclin (epoprostenol) in primary pulmonary hypertension. DESIGN:Randomized trial with 8-week treatment periods and nonrandomized treatment for up to 18 months. SETTING:Four referral centers. PATIENTS:Sequential sample of 24 patient...

journal_title：Annals of internal medicine

authors： Rubin LJ,Mendoza J,Hood M,McGoon M,Barst R,Williams WB,Diehl JH,Crow J,Long W

更新日期：1990-04-01 00:00:00

abstract：:Deaths and injuries from firearms are significant public health problems, and clinicians are in a unique position to identify risk among their patients and discuss the importance of safe firearm practices. Although clinicians may be ill-prepared to engage in such discussions, an adequate body of evidence is available ...

journal_title：Annals of internal medicine

authors： Pallin R,Spitzer SA,Ranney ML,Betz ME,Wintemute GJ

更新日期：2019-06-04 00:00:00

abstract：BACKGROUND:A daily injection of low-molecular-weight heparin (LMWH) is often prescribed to women with unexplained recurrent pregnancy loss (RPL), although evidence suggesting a benefit is questionable. OBJECTIVE:To determine whether LMWH increases ongoing pregnancy and live-birth rates in women with unexplained RPL. ...

journal_title：Annals of internal medicine

authors： Schleussner E,Kamin G,Seliger G,Rogenhofer N,Ebner S,Toth B,Schenk M,Henes M,Bohlmann MK,Fischer T,Brosteanu O,Bauersachs R,Petroff D,ETHIG II group.

更新日期：2015-05-05 00:00:00

abstract：:Three patients with the acquired immunodeficiency syndrome had biliary obstruction resulting from benign strictures of the biliary tract. Stenosis of the distal common bile duct with differing degrees of irregularity of the smaller intrahepatic and extrahepatic ducts was seen in association with either cryptosporidial...

journal_title：Annals of internal medicine

authors： Margulis SJ,Honig CL,Soave R,Govoni AF,Mouradian JA,Jacobson IM

更新日期：1986-08-01 00:00:00

abstract：:Tissues from guinea pigs inoculated intraperitoneally with the Legionnaires' disease (LD) bacterium were studied with light, immunofluorescent, and electron microscopy. The principal gross lesion was diffuse peritonitis of varying severity. Microscopically, the peritonitis of covered by a mixed inflammatory infiltrate...

journal_title：Annals of internal medicine

authors： Chandler FW,McDade JE,Hicklin MD,Blackmon JA,Thomason BM,Ewing EP Jr

更新日期：1979-04-01 00:00:00

abstract：:The efficacy of corticosteroid treatment in the prophylaxis of the fat embolism syndrome was evaluated in a prospective, randomized, double-blind study of high-risk patients with long-bone fractures. Using a set of objective diagnostic criteria, we saw a significant difference in the incidence of the syndrome between ...

journal_title：Annals of internal medicine

authors： Schonfeld SA,Ploysongsang Y,DiLisio R,Crissman JD,Miller E,Hammerschmidt DE,Jacob HS

更新日期：1983-10-01 00:00:00

abstract：:Active-control noninferiority trials are being performed with increasing frequency when standard placebo-controlled trials are considered unethical. Three attributes are optimally required to establish noninferiority: 1) The treatment under consideration exhibits therapeutic noninferiority to the active control; 2) th...

journal_title：Annals of internal medicine

authors： Kaul S,Diamond GA

更新日期：2006-07-04 00:00:00

abstract：STUDY OBJECTIVE:To describe the clinical and epidemiologic features of Vibrio vulnificus infections. DESIGN:Case series based on notifiable disease report forms and patient medical records. SETTING:Cases reported to the Florida Department of Health and Rehabilitative Services from 1981 to 1987. PATIENTS:Sixty-two pa...

journal_title：Annals of internal medicine

authors： Klontz KC,Lieb S,Schreiber M,Janowski HT,Baldy LM,Gunn RA

更新日期：1988-08-15 00:00:00

abstract：:Medicine has long sought to match diagnostic and treatment approaches to the particular needs and risks of individual patients. The decreasing cost and increasing ease of genetic sequencing have propelled the rise of precision medicine. Precision medicine aims to use genetic and other information to provide care tailo...

journal_title：Annals of internal medicine

authors： Kiryluk K,Goldstein DB,Rowe JW,Gharavi AG,Wapner R,Chung WK

更新日期：2019-05-07 00:00:00

abstract：OBJECTIVE:To evaluate the 6-month change in cardiovascular (coronary heart disease) risk as a function of diet and drug therapy for mild hypertension. DESIGN:Collaborative randomized, controlled clinical trial to assess the efficacy of alternative regimens in treating mild hypertension. SETTING:Three university-based...

journal_title：Annals of internal medicine

authors： Oberman A,Wassertheil-Smoller S,Langford HG,Blaufox MD,Davis BR,Blaszkowski T,Zimbaldi N,Hawkins CM

更新日期：1990-01-15 00:00:00

abstract：BACKGROUND:Opioid detoxification in a primary care setting followed by ongoing substance abuse treatment may be appropriate for selected opioid-dependent patients. OBJECTIVE:To compare three pharmacologic protocols for opioid detoxification in a primary care setting. DESIGN:Randomized, double-blind clinical trial wit...

journal_title：Annals of internal medicine

authors： O'Connor PG,Carroll KM,Shi JM,Schottenfeld RS,Kosten TR,Rounsaville BJ

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND:Screening can detect prostate cancer at earlier, asymptomatic stages, when treatments might be more effective. PURPOSE:To update the 2002 and 2008 U.S. Preventive Services Task Force evidence reviews on screening and treatments for prostate cancer. DATA SOURCES:MEDLINE (2002 to July 2011) and the Cochrane ...

journal_title：Annals of internal medicine

authors： Chou R,Croswell JM,Dana T,Bougatsos C,Blazina I,Fu R,Gleitsmann K,Koenig HC,Lam C,Maltz A,Rugge JB,Lin K

更新日期：2011-12-06 00:00:00

abstract：:During a 21/2-year period, studies were done on 14 patients with chronic renal failure to evaluate pleural effusions which we believe were secondary to the uremic process. The patients with uremic pleural effusions closely resembled those in the group with chronic renal failure as a whole with respect to diagnosis and...

journal_title：Annals of internal medicine

authors： Berger HW,Rammohan G,Neff MS,Buhain WJ

更新日期：1975-03-01 00:00:00

abstract：:Conventional interpretation of clinical trials relies heavily on the classic p value. The p value, however, represents only a false-positive rate, and does not tell the probability that the investigator's hypothesis is correct, given his observations. This more relevant posterior probability can be quantified by an ex...

journal_title：Annals of internal medicine

authors： Diamond GA,Forrester JS

更新日期：1983-03-01 00:00:00

abstract：BACKGROUND:3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin) therapy has proven efficacy in reducing the rate of coronary and cerebrovascular events in patients 75 years of age or younger with a history of myocardial infarction. However, in patients older than 75 years of age, the efficacy and potentia...

journal_title：Annals of internal medicine

authors： Ganz DA,Kuntz KM,Jacobson GA,Avorn J

更新日期：2000-05-16 00:00:00

abstract：OBJECTIVE:To evaluate whether a brief course of treatment with gallium nitrate can reduce biochemical parameters of accelerated bone turnover in patients with advanced Paget disease. DESIGN:Unblinded trial, decreasing dose schedules of gallium nitrate. SETTING:University hospital with primary orthopedic and metabolic...

journal_title：Annals of internal medicine

authors： Warrell RP Jr,Bosco B,Weinerman S,Levine B,Lane J,Bockman RS

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:U.S. HIV treatment guidelines recommend branded once-daily, 1-pill efavirenz-emtricitabine-tenofovir as first-line antiretroviral therapy (ART). With the anticipated approval of generic efavirenz in the United States, a once-daily, 3-pill alternative (generic efavirenz, generic lamivudine, and tenofovir) wil...

journal_title：Annals of internal medicine

authors： Walensky RP,Sax PE,Nakamura YM,Weinstein MC,Pei PP,Freedberg KA,Paltiel AD,Schackman BR

更新日期：2013-01-15 00:00:00

abstract：OBJECTIVE:To evaluate the relation between skeletal muscle disease (myopathy) and degenerative changes in cardiac muscle (cardiomyopathy) in patients with chronic alcoholism. DESIGN:A cross-sectional study. SETTING:University medical center. PARTICIPANTS:Group A included 24 patients with chronic alcoholism who had d...

journal_title：Annals of internal medicine

authors： Fernandez-Sola J,Estruch R,Grau JM,Pare JC,Rubin E,Urbano-Marquez A

更新日期：1994-04-01 00:00:00

abstract：:Quality improvement (QI) activities can improve health care but must be conducted ethically. The Hastings Center convened leaders and scholars to address ethical requirements for QI and their relationship to regulations protecting human subjects of research. The group defined QI as systematic, data-guided activities d...

journal_title：Annals of internal medicine

authors： Lynn J,Baily MA,Bottrell M,Jennings B,Levine RJ,Davidoff F,Casarett D,Corrigan J,Fox E,Wynia MK,Agich GJ,O'Kane M,Speroff T,Schyve P,Batalden P,Tunis S,Berlinger N,Cronenwett L,Fitzmaurice JM,Dubler NN,James B

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Reviews have compared the efficacy and tolerability of newer second-generation antidepressants with those of placebo or older treatments, but comparative evidence for use of second-generation antidepressants to treat major depressive disorder has not been evaluated. PURPOSE:To systematically evaluate compar...

journal_title：Annals of internal medicine

authors： Hansen RA,Gartlehner G,Lohr KN,Gaynes BN,Carey TS

更新日期：2005-09-20 00:00:00

abstract：BACKGROUND:The established International Prognostic Index for lymphomas has not included patients with systemic AIDS-related non-Hodgkin lymphoma. OBJECTIVE:To establish the most appropriate prognostic index for use in patients with systemic AIDS-related non-Hodgkin lymphoma. DESIGN:A prospective study involving univ...

journal_title：Annals of internal medicine

authors： Bower M,Gazzard B,Mandalia S,Newsom-Davis T,Thirlwell C,Dhillon T,Young AM,Powles T,Gaya A,Nelson M,Stebbing J

更新日期：2005-08-16 00:00:00

abstract：BACKGROUND:Adherence to short-term continuous positive airway pressure (CPAP) may predict long-term use. Unfortunately, initial CPAP intolerance may lead to poor adherence or abandonment of therapy. OBJECTIVE:To determine whether a short course of eszopiclone at the onset of therapy improves long-term CPAP adherence m...

journal_title：Annals of internal medicine

authors： Lettieri CJ,Shah AA,Holley AB,Kelly WF,Chang AS,Roop SA,CPAP Promotion and Prognosis-The Army Sleep Apnea Program Trial.

更新日期：2009-11-17 00:00:00

abstract：BACKGROUND:Warfarin reduces the risk for ischemic stroke in patients with atrial fibrillation (AF) but increases the risk for hemorrhage. Dabigatran is a fixed-dose, oral direct thrombin inhibitor with similar or reduced rates of ischemic stroke and intracranial hemorrhage in patients with AF compared with those of war...

journal_title：Annals of internal medicine

authors： Freeman JV,Zhu RP,Owens DK,Garber AM,Hutton DW,Go AS,Wang PJ,Turakhia MP

更新日期：2011-01-04 00:00:00

abstract：:Between 1 January 1980 and 18 October 1981, investigators from the Centers for Disease Control collected information on 1407 cases of toxic shock syndrome using a nationwide passive surveillance system. Ninety-two percent of the reported cases were associated with menstruation. Information available on the type of men...

journal_title：Annals of internal medicine

authors： Reingold AL,Hargrett NT,Shands KN,Dan BB,Schmid GP,Strickland BY,Broome CV

更新日期：1982-06-01 00:00:00

abstract：:Fifty-five consecutive patients with advanced recurrent Hodgkin's disease resistant to MOPP chemotherapy (mechlorethamine, vincristine, procarbazine, and prednisone) were given ABVD chemotherapy (doxorubicin, bleomycin, vinblastine, and dacarbazine). In 54 patients evaluable for response, complete remission after path...

journal_title：Annals of internal medicine

authors： Santoro A,Bonfante V,Bonadonna G

更新日期：1982-02-01 00:00:00

abstract：BACKGROUND:The appropriate duration of therapy for catheter-associated Staphylococcus aureus bacteremia is controversial. Conventional practice dictates that all patients receive prolonged courses of intravenous antibiotics. Some clinicians recommend abbreviated therapeutic courses, but an alternate approach involves p...

journal_title：Annals of internal medicine

authors： Rosen AB,Fowler VG Jr,Corey GR,Downs SM,Biddle AK,Li J,Jollis JG

更新日期：1999-05-18 00:00:00

abstract：BACKGROUND:Magnetic resonance imaging (MRI) is avoided in most patients with implanted cardiac devices because of safety concerns. OBJECTIVE:To define the safety of a protocol for MRI at the commonly used magnetic strength of 1.5 T in patients with implanted cardiac devices. DESIGN:Prospective nonrandomized trial. (C...

journal_title：Annals of internal medicine

authors： Nazarian S,Hansford R,Roguin A,Goldsher D,Zviman MM,Lardo AC,Caffo BS,Frick KD,Kraut MA,Kamel IR,Calkins H,Berger RD,Bluemke DA,Halperin HR

更新日期：2011-10-04 00:00:00

abstract：:Thirty-two studies (2889 subjects) that investigated the prevalence of the causes of dementia were critically reviewed. Particular attention was paid to potential and actual reversibility. Although dementia manifests itself primarily in old age (particularly age 75 and older), the mean age of patients for the studies ...

journal_title：Annals of internal medicine

authors： Clarfield AM

更新日期：1988-09-15 00:00:00

abstract：:Five of 70 patients with systemic lupus erythematosus seen over a 5-year period had peripheral blood films suggestive of hyposplenism. Technetium-99m-sulfur colloid scans showed no splenic activity in three patients. One of these three patients, who had a spontaneous remission of persistent thrombocytopenia concurrent...

journal_title：Annals of internal medicine

authors： Dillon AM,Stein HB,English RA

更新日期：1982-01-01 00:00:00