A systematic review of newer pharmacotherapies for depression in adults: evidence report summary.

Abstract:

BACKGROUND:Depressive disorders are persistent, recurring illnesses that cause great suffering for patients and their families. PURPOSE:To evaluate the benefits and adverse effects of newer pharmacotherapies and herbal treatments for depressive disorders in adults and adolescents. DATA SOURCES:English-language and non-English-language literature from 1980 to January 1998 was identified from a specialized registry of controlled trials, meta-analyses, and experts. STUDY SELECTION:Randomized trials evaluating newer antidepressants (such as serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, and St. John's wort) that reported clinical outcomes were selected. DATA EXTRACTION:Two persons independently abstracted data that were then synthesized descriptively; some data were pooled by using a random-effects model. DATA SYNTHESIS:Of 315 eligible trials, most evaluated antidepressants in adults with major depression, were conducted among outpatients, and examined acute-phase treatment. Newer antidepressants were more effective than placebo for major depression (relative benefit, 1.6 [95% CI, 1.5 to 1.7]) and dysthymia (relative benefit, 1.7 [CI, 1.3 to 2.3]). They were effective among older adults and primary care patients. Efficacy did not differ among newer agents or between newer and older agents. Hypericum (St. John's wort) was more effective than placebo for mild to moderate depression (risk ratio, 1.9 [CI, 1.2 to 2.8]), but publication bias may have inflated the estimate of benefit. Newer and older antidepressants did not differ for overall discontinuation rates, but side effect profiles varied significantly. Data were insufficient for determining the efficacy of newer antidepressants for subsyndromal depression, depression with coexisting medical or psychiatric illness, or depression in adolescents. CONCLUSIONS:Newer antidepressants are clearly effective in treating depressive disorders in diverse settings. Because of similar efficacy, both newer and older antidepressants should be considered when making treatment decisions. Better information is urgently needed on the efficacy of newer antidepressants in patients with nonmajor depression and in special populations, including adolescents.

journal_name

Ann Intern Med

authors

Williams JW Jr,Mulrow CD,Chiquette E,Noël PH,Aguilar C,Cornell J

doi

10.7326/0003-4819-132-9-200005020-00011

subject

Has Abstract

pub_date

2000-05-02 00:00:00

pages

743-56

issue

9

eissn

0003-4819

issn

1539-3704

pii

200005020-00011

journal_volume

132

pub_type

杂志文章,评审
  • Management of influenza in adults older than 65 years of age: cost-effectiveness of rapid testing and antiviral therapy.

    abstract:BACKGROUND:Although antiviral therapy is cost-effective in adults, its cost-effectiveness in older adults has not been studied. OBJECTIVE:To determine the cost-effectiveness of influenza testing and treatment strategies for older adults. DESIGN:Cost-utility decision model. DATA SOURCES:Clinical trials of antiviral d...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-139-5_part_1-200309020-00007

    authors: Rothberg MB,Bellantonio S,Rose DN

    更新日期:2003-09-02 00:00:00

  • Screening for hereditary hemochromatosis in siblings and children of affected patients. A cost-effectiveness analysis.

    abstract:BACKGROUND:Screening for hereditary hemochromatosis is traditionally done by using serum iron studies. However, mutation analysis of the hemochromatosis-associated HFE gene has recently become available. OBJECTIVE:To compare the cost-effectiveness of no screening with four screening strategies that incorporate HFE gen...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-132-4-200002150-00003

    authors: El-Serag HB,Inadomi JM,Kowdley KV

    更新日期:2000-02-15 00:00:00

  • Screening for Urinary Incontinence in Women: A Recommendation From the Women's Preventive Services Initiative.

    abstract:Description:Recommendation on screening for urinary incontinence in women by the Women's Preventive Services Initiative (WPSI), a national coalition of women's health professional organizations and patient representatives. The WPSI's recommendations are intended to guide clinical practice and coverage of services for t...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,实务指引

    doi:10.7326/M18-0595

    authors: O'Reilly N,Nelson HD,Conry JM,Frost J,Gregory KD,Kendig SM,Phipps M,Salganicoff A,Ramos D,Zahn C,Qaseem A,Women's Preventive Services Initiative.

    更新日期:2018-09-04 00:00:00

  • The Effects of Pay-for-Performance Programs on Health, Health Care Use, and Processes of Care: A Systematic Review.

    abstract:Background:The benefits of pay-for-performance (P4P) programs are uncertain. Purpose:To update and expand a prior review examining the effects of P4P programs targeted at the physician, group, managerial, or institutional level on process-of-care and patient outcomes in ambulatory and inpatient settings. Data Sources...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/M16-1881

    authors: Mendelson A,Kondo K,Damberg C,Low A,Motúapuaka M,Freeman M,O'Neil M,Relevo R,Kansagara D

    更新日期:2017-03-07 00:00:00

  • Using nontraditional risk factors in coronary heart disease risk assessment: U.S. Preventive Services Task Force recommendation statement.

    abstract:DESCRIPTION:New recommendation from the U.S. Preventive Services Task Force (USPSTF) on the use of nontraditional, or novel, risk factors in assessing the coronary heart disease (CHD) risk of asymptomatic persons. METHODS:Systematic reviews were conducted of literature since 1996 on 9 proposed nontraditional markers o...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,实务指引

    doi:10.7326/0003-4819-151-7-200910060-00008

    authors: U.S. Preventive Services Task Force.

    更新日期:2009-10-06 00:00:00

  • Sideroblastic anemia as a preleukemic event in patients treated for Hodgkin's disease.

    abstract::Sideroblastic anemia after treatment for Hogdkin's disease was seen in two patients 3 years after completion of radiation therapy and chemotherapy. This was followed in both by the development of myelomonoblastic leukemia. No evidence of recurrent Hodgkin's disease was present in either patient. Our observation sugges...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-92-5-625

    authors: Kitahara M,Cosgriff TM,Eyre HJ

    更新日期:1980-05-01 00:00:00

  • Combined idiopathic neutropenia and thrombocytopenia: evidence for an immune basis for the syndrome.

    abstract::We report a case of combined idiopathic immune neutropenia and immune thrombocytopenia (thromboneutropenia). Therapy with prednisone was ineffective. Treatment with vincristine raised the patient's platelet count but did not increase the neutrophil count. Splenectomy led to a prompt complete remission. Using radioimmu...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-93-5-704

    authors: Linker CA,Newcom SR,Nilsson CM,Wolf JL,Shuman MA

    更新日期:1980-11-01 00:00:00

  • Reduction of doxorubicin cardiotoxicity by prolonged continuous intravenous infusion.

    abstract::Doxorubicin (Adriamycin) was administered by continuous infusion to reduce peak plasma levels and thus lessen cardiac toxicity. Cardiotoxicity was monitored by noninvasive methods, and endomyocardial biopsy specimens were studied by electronmicroscopy. Cardiotoxicity was compared in 21 patients receiving doxorubicin i...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-96-2-133

    authors: Legha SS,Benjamin RS,Mackay B,Ewer M,Wallace S,Valdivieso M,Rasmussen SL,Blumenschein GR,Freireich EJ

    更新日期:1982-02-01 00:00:00

  • Procurement of cadaveric kidneys for transplantation.

    abstract::Kidney transplantation is safe, cost-effective, and beneficial for patients with end-stage renal disease. The number of patients who can receive transplants is severely limited by the availability of donor organs. Because most patients do not have a suitable living, related donor, transplant programs now rely on the u...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-98-4-536

    authors: Waltzer WC

    更新日期:1983-04-01 00:00:00

  • A highly automated hospital medication system. Five years' experience and evaluation.

    abstract::Since 1969, medications have been provided to patients at the Johns Hopkins Hospital using a computer system that controls the entire medication process from entry of physician's order to hourly drug distribution. Special envelopes containing patient and dosage information are computer generated for each dose to be ad...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-83-3-342

    authors: Simborg DW,Derewicz HJ

    更新日期:1975-09-01 00:00:00

  • Community-based urine screening for Chlamydia trachomatis with a ligase chain reaction assay.

    abstract:BACKGROUND:Urine tests for Chlamydia trachomatis permit expansion of screening beyond traditional clinic environments. Prevention of infection in teenagers is a high priority. OBJECTIVE:To define the prevalence of C. trachomatis among teenagers by using the ligase chain reaction assay on urine specimens and to evaluat...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-127-9-199711010-00004

    authors: Marrazzo JM,White CL,Krekeler B,Celum CL,Lafferty WE,Stamm WE,Handsfield HH

    更新日期:1997-11-01 00:00:00

  • Effects of sibutramine treatment in obese adolescents: a randomized trial.

    abstract:BACKGROUND:Increased prevalence of adolescent obesity requires effective treatment options beyond behavior therapy. OBJECTIVE:To see whether sibutramine reduced weight more than placebo in obese adolescents who were receiving a behavior therapy program. DESIGN:12-month, 3:1 randomized, double-blind trial conducted fr...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.7326/0003-4819-145-2-200607180-00005

    authors: Berkowitz RI,Fujioka K,Daniels SR,Hoppin AG,Owen S,Perry AC,Sothern MS,Renz CL,Pirner MA,Walch JK,Jasinsky O,Hewkin AC,Blakesley VA,Sibutramine Adolescent Study Group.

    更新日期:2006-07-18 00:00:00

  • Very low calorie diets: their efficacy, safety, and future.

    abstract::Very low calorie diets used to treat moderate and severe obesity produce average weight losses of 20 kg in 12 weeks. This paper reviews the development of very low calorie diets from research on fasting in the late 1950s and examines data on the amount of dietary protein needed to achieve positive nitrogen balance. Th...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-99-5-675

    authors: Wadden TA,Stunkard AJ,Brownell KD

    更新日期:1983-11-01 00:00:00

  • Bundle-branch block and in-hospital mortality in acute myocardial infarction. National Registry of Myocardial Infarction 2 Investigators.

    abstract:BACKGROUND:Left bundle-branch block (BBB) is considered an important predictor of poor outcome in patients with acute myocardial infarction, but the consequences of right BBB are not well understood. OBJECTIVES:To 1) estimate the prevalence of left and right BBB in patients with myocardial infarction; 2) compare the c...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-129-9-199811010-00003

    authors: Go AS,Barron HV,Rundle AC,Ornato JP,Avins AL

    更新日期:1998-11-01 00:00:00

  • Economic savings versus health losses: the cost-effectiveness of generic antiretroviral therapy in the United States.

    abstract:BACKGROUND:U.S. HIV treatment guidelines recommend branded once-daily, 1-pill efavirenz-emtricitabine-tenofovir as first-line antiretroviral therapy (ART). With the anticipated approval of generic efavirenz in the United States, a once-daily, 3-pill alternative (generic efavirenz, generic lamivudine, and tenofovir) wil...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-158-2-201301150-00002

    authors: Walensky RP,Sax PE,Nakamura YM,Weinstein MC,Pei PP,Freedberg KA,Paltiel AD,Schackman BR

    更新日期:2013-01-15 00:00:00

  • Breast cancer in black women.

    abstract:PURPOSE:To review the current knowledge about breast cancer in black women--including epidemiology, risk factors, screening practices, pathology, clinical manifestations, treatment, and outcome--with emphasis on issues that might explain why the survival rate in this population of women is lower than that in white wome...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-124-10-199605150-00007

    authors: Moormeier J

    更新日期:1996-05-15 00:00:00

  • Smoking cessation after acute myocardial infarction: effects of a nurse-managed intervention.

    abstract:STUDY OBJECTIVE:To determine the effect of a nurse-managed intervention for smoking cessation in patients who have had a myocardial infarction. DESIGN:Randomized, with a 6-month treatment period and a 6-month follow-up. SETTING:Kaiser Foundation hospitals in Redwood City, Santa Clara, Hayward, and San Jose, Californi...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.7326/0003-4819-113-2-118

    authors: Taylor CB,Houston-Miller N,Killen JD,DeBusk RF

    更新日期:1990-07-15 00:00:00

  • One-year outcome of subacromial corticosteroid injection compared with manual physical therapy for the management of the unilateral shoulder impingement syndrome: a pragmatic randomized trial.

    abstract:BACKGROUND:Corticosteroid injections (CSIs) and physical therapy are used to treat patients with the shoulder impingement syndrome (SIS) but have never been directly compared. OBJECTIVE:To compare the effectiveness of 2 common nonsurgical treatments for SIS. DESIGN:Randomized, single-blind, comparative-effectiveness,...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.7326/M13-2199

    authors: Rhon DI,Boyles RB,Cleland JA

    更新日期:2014-08-05 00:00:00

  • Reactivation of chronic hepatitis B virus infection by cancer chemotherapy.

    abstract::Two patients referred for cancer chemotherapy were found to be chronic, asymptomatic hepatitis B surface antigen (HBsAg) carriers. They had normal serum aminotransferase levels, but their sera were positive for HGsAg and antibody to hepatitis B e antigen. Both patients developed acute, icteric hepatitis within 3 month...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-96-4-447

    authors: Hoofnagle JH,Dusheiko GM,Schafer DF,Jones EA,Micetich KC,Young RC,Costa J

    更新日期:1982-04-01 00:00:00

  • Measuring the performance of markers for guiding treatment decisions.

    abstract::Treatment selection markers, sometimes called predictive markers, are factors that help clinicians select therapies that maximize good outcomes and minimize adverse outcomes for patients. Existing statistical methods for evaluating a treatment selection marker include assessing its prognostic value, evaluating treatme...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-154-4-201102150-00006

    authors: Janes H,Pepe MS,Bossuyt PM,Barlow WE

    更新日期:2011-02-15 00:00:00

  • Complementary value of two-dimensional exercise echocardiography to routine treadmill exercise testing.

    abstract::Two-dimensional echocardiograms were done during rest and after exercise in 95 patients who subsequently had coronary arteriography. Prior myocardial infarction was present in 36 patients, 35 of whom had wall motion abnormalities. There was no evidence of prior infarction in 59 patients, 44 of whom had coronary diseas...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-105-6-829

    authors: Armstrong WF,O'Donnell J,Dillon JC,McHenry PL,Morris SN,Feigenbaum H

    更新日期:1986-12-01 00:00:00

  • Fondaparinux or enoxaparin for the initial treatment of symptomatic deep venous thrombosis: a randomized trial.

    abstract:BACKGROUND:The current standard initial therapies for deep venous thrombosis are low-molecular-weight heparin and unfractionated heparin. In a dose-ranging study of patients with symptomatic deep venous thrombosis, fondaparinux had efficacy and a safety profile similar to those of low-molecular-weight heparin (daltepar...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.7326/0003-4819-140-11-200406010-00007

    authors: Büller HR,Davidson BL,Decousus H,Gallus A,Gent M,Piovella F,Prins MH,Raskob G,Segers AE,Cariou R,Leeuwenkamp O,Lensing AW,Matisse Investigators.

    更新日期:2004-06-01 00:00:00

  • Reporting the recruitment process in clinical trials: who are these patients and how did they get there?

    abstract:BACKGROUND:A common criticism of randomized, controlled trials (RCTs) is that the enrollment process may be highly selective and those who enroll may not represent persons in the general population. The recruitment process reported in published RCTs has not been systematically evaluated. OBJECTIVE:To determine whether...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-137-1-200207020-00007

    authors: Gross CP,Mallory R,Heiat A,Krumholz HM

    更新日期:2002-07-02 00:00:00

  • Health disparities among travelers visiting friends and relatives abroad.

    abstract::For an estimated 10 million trips abroad by U.S. residents in 2002, "visiting friends and relatives" (VFR) was a purpose for travel. Made up largely of foreign-born U.S. residents and their children, this population shows disparities in the number of reported cases of many preventable travel-related illnesses compared...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-142-1-200501040-00013

    authors: Angell SY,Cetron MS

    更新日期:2005-01-04 00:00:00

  • Predicting Bleeding Risk to Guide Aspirin Use for the Primary Prevention of Cardiovascular Disease: A Cohort Study.

    abstract:Background:Many prognostic models for cardiovascular risk can be used to estimate aspirin's absolute benefits, but few bleeding risk models are available to estimate its likely harms. Objective:To develop prognostic bleeding risk models among persons in whom aspirin might be considered for the primary prevention of ca...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/M18-2808

    authors: Selak V,Jackson R,Poppe K,Wu B,Harwood M,Grey C,Pylypchuk R,Mehta S,Kerr A,Wells S

    更新日期:2019-03-19 00:00:00

  • Infliximab for maintenance of glucocorticosteroid-induced remission of giant cell arteritis: a randomized trial.

    abstract:BACKGROUND:Tumor necrosis factor-alpha is present in arteries in giant cell arteritis. OBJECTIVE:To evaluate the efficacy of infliximab, an anti-tumor necrosis factor-alpha agent, in giant cell arteritis. DESIGN:Randomized, controlled trial. SETTING:22 sites in the United States, the United Kingdom, Belgium, Italy, ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.7326/0003-4819-146-9-200705010-00004

    authors: Hoffman GS,Cid MC,Rendt-Zagar KE,Merkel PA,Weyand CM,Stone JH,Salvarani C,Xu W,Visvanathan S,Rahman MU,Infliximab-GCA Study Group.

    更新日期:2007-05-01 00:00:00

  • NIH conference. New insights into common variable immunodeficiency.

    abstract::Common variable immunodeficiency (CVI) is a heterogenous immunodeficiency syndrome characterized by hypogammaglobulinemia, recurrent bacterial infections, and various immunologic abnormalities. In addition to recurrent infections, patients with this syndrome also have an increased incidence of autoimmune disease and m...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-118-9-199305010-00011

    authors: Sneller MC,Strober W,Eisenstein E,Jaffe JS,Cunningham-Rundles C

    更新日期:1993-05-01 00:00:00

  • Procedural skills of practicing nephrologists. A national survey of 700 members of the American College of Physicians.

    abstract:OBJECTIVE:To determine which procedures nephrologists do in practice, where they learned the procedures, and how much training they recommend to achieve and maintain clinical competence in each. DESIGN:Mailed survey. PARTICIPANTS:A random sample of 700 members of the American College of Physicians who were identified...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-113-5-392

    authors: Tape TG,Wigton RS,Blank LL,Nicolas JA

    更新日期:1990-09-01 00:00:00

  • Occupationally acquired infections in health care workers. Part I.

    abstract:BACKGROUND:Health care workers are at occupational risk for a vast array of infections that cause substantial illness and occasional deaths. Despite this, few studies have examined the incidence, prevalence, or exposure-associated rates of infection or have considered infection-specific interventions recommended to mai...

    journal_title:Annals of internal medicine

    pub_type: 历史文章,杂志文章,评审

    doi:10.7326/0003-4819-125-10-199611150-00007

    authors: Sepkowitz KA

    更新日期:1996-11-15 00:00:00

  • Functional Impairment and Decline in Middle Age: A Cohort Study.

    abstract:Background:Difficulties with daily functioning are common in middle-aged adults. However, little is known about the epidemiology or clinical course of these problems, including the extent to which they share common features with functional impairment in older adults. Objective:To determine the epidemiology and clinica...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/M17-0496

    authors: Brown RT,Diaz-Ramirez LG,Boscardin WJ,Lee SJ,Steinman MA

    更新日期:2017-12-05 00:00:00