Measuring the performance of markers for guiding treatment decisions.

abstract：:Approximately 3000 people in Bennington, Vermont, 19% of the population, had a diarrheal illness during the first and second weeks of June 1978. Persons affected reported abdominal cramps (86%), diarrhea (82%), malaise (73%), and headache (47%). The mean duration of illness was 4.6 days. The illness was associated wit...

journal_title：Annals of internal medicine

authors： Vogt RL,Sours HE,Barrett T,Feldman RA,Dickinson RJ,Witherell L

更新日期：1982-03-01 00:00:00

abstract：:For years patients hospitalized with viral hepatitis have been placed in two categories of isolation--enteric precautions and blood precautions. This strategy was based on the inability to differentiate between hepatitis A and B and on the assumption that feces and blood from patients with either type might be infecti...

journal_title：Annals of internal medicine

authors： Favero MS,Maynard JE,Leger RT,Graham DR,Dixon RE

更新日期：1979-12-01 00:00:00

abstract：BACKGROUND:Sleep-related accidents often involve healthy young persons who are driving at night. Coffee and napping restore alertness, but no study has compared their effects on real nighttime driving performances. OBJECTIVE:To test the effects of 125 mL of coffee (half a cup) containing 200 mg of caffeine, placebo (d...

journal_title：Annals of internal medicine

authors： Philip P,Taillard J,Moore N,Delord S,Valtat C,Sagaspe P,Bioulac B

更新日期：2006-06-06 00:00:00

abstract：BACKGROUND:Tumor necrosis factor-alpha is present in arteries in giant cell arteritis. OBJECTIVE:To evaluate the efficacy of infliximab, an anti-tumor necrosis factor-alpha agent, in giant cell arteritis. DESIGN:Randomized, controlled trial. SETTING:22 sites in the United States, the United Kingdom, Belgium, Italy, ...

journal_title：Annals of internal medicine

authors： Hoffman GS,Cid MC,Rendt-Zagar KE,Merkel PA,Weyand CM,Stone JH,Salvarani C,Xu W,Visvanathan S,Rahman MU,Infliximab-GCA Study Group.

更新日期：2007-05-01 00:00:00

abstract：:Care of persons with non-insulin-dependent diabetes mellitus (NIDDM) in the United Kingdom resembles that in the United States. However, health care practice in Europe is being influenced by the Saint Vincent Declaration, the joint European World Health Organization-International Diabetes Federation initiative, which ...

journal_title：Annals of internal medicine

authors： Keen H

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Little evidence exists to support the theory that small-bore nasogastric tubes prevent gastroesophageal reflux and microaspiration in intubated patients. OBJECTIVE:To determine whether gastroesophageal reflux and microaspiration in intubated patients can be reduced by the use of a small-bore nasogastric tub...

journal_title：Annals of internal medicine

authors： Ferrer M,Bauer TT,Torres A,Hernández C,Piera C

更新日期：1999-06-15 00:00:00

abstract：STUDY OBJECTIVE:To define the clinical and hematologic effects of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) on patients with chronic severe neutropenia. DESIGN:Open-label, phase II study of rhGM-CSF. SETTING:Inpatient hematology and surgery clinic at a university medical center. P...

journal_title：Annals of internal medicine

authors： Ganser A,Ottmann OG,Erdmann H,Schulz G,Hoelzer D

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND:Extended-duration low-molecular-weight heparin has been shown to prevent venous thromboembolism (VTE) in high-risk surgical patients. OBJECTIVE:To evaluate the efficacy and safety of extended-duration enoxaparin thromboprophylaxis in acutely ill medical patients. DESIGN:Randomized, parallel, placebo-contro...

journal_title：Annals of internal medicine

authors： Hull RD,Schellong SM,Tapson VF,Monreal M,Samama MM,Nicol P,Vicaut E,Turpie AG,Yusen RD,EXCLAIM (Extended Prophylaxis for Venous ThromboEmbolism in Acutely Ill Medical Patients With Prolonged Immobilization) study.

更新日期：2010-07-06 00:00:00

abstract：OBJECTIVE:To determine whether low bone density and other risk factors for osteoporosis are associated with stress fractures in athletes. DESIGN:Case-control study. SETTING:Institutional sports injury clinic with primary and secondary care. PARTICIPANTS:Twenty-five athletes (nineteen women) with scintigraphically co...

journal_title：Annals of internal medicine

authors： Myburgh KH,Hutchins J,Fataar AB,Hough SF,Noakes TD

更新日期：1990-11-15 00:00:00

abstract：PURPOSE:To examine studies of normal colon and colorectal cancer for evidence that the location of the primary tumor proximal or distal to the splenic flexure of the colon may determine distinct genetic categories of this disease. DATA IDENTIFICATION:Studies were identified through a manual search of journals, through...

journal_title：Annals of internal medicine

authors： Bufill JA

更新日期：1990-11-15 00:00:00

abstract：:Infection with human immunodeficiency virus (HIV) may cause viral antigenemia, detected primarily as p24 viral core protein. Among 16 patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex studied serially, 12 had or developed antigenemia ranging from 16 to 3006 pg/mL in plasma. The level ...

journal_title：Annals of internal medicine

authors： Jackson GG,Paul DA,Falk LA,Rubenis M,Despotes JC,Mack D,Knigge M,Emeson EE

更新日期：1988-02-01 00:00:00

abstract：Background:Delirium is common in hospitalized patients and is associated with worse outcomes. Antipsychotics are commonly used; however, the associated benefits and harms are unclear. Purpose:To conduct a systematic review evaluating the benefits and harms of antipsychotics to treat delirium in adults. Data Sources:P...

journal_title：Annals of internal medicine

authors： Nikooie R,Neufeld KJ,Oh ES,Wilson LM,Zhang A,Robinson KA,Needham DM

更新日期：2019-10-01 00:00:00

abstract：STUDY OBJECTIVE:To assess the efficacy and toxicity of cyclosporin A in patients with severe, treatment-refractory rheumatoid arthritis. DESIGN:Prospective randomized, double-blind 6-month trial. PATIENTS:Thirty-one patients who had classic seropositive rheumatoid arthritis with active synovitis unresponsive to conve...

journal_title：Annals of internal medicine

authors： Yocum DE,Klippel JH,Wilder RL,Gerber NL,Austin HA 3rd,Wahl SM,Lesko L,Minor JR,Preuss HG,Yarboro C

更新日期：1988-12-01 00:00:00

abstract：:Differences in blood levels of thyroid hormones have been reported when patients taking synthetic L-thyroxine were shifted from one manufactured form of the hormone to another. Because recent formulation changes have rendered these earlier data obsolete, we did a crossover study to determine differences in bioavailabi...

journal_title：Annals of internal medicine

authors： Hennessey JV,Burman KD,Wartofsky L

更新日期：1985-06-01 00:00:00

abstract：:Rapid growth in the use and complexity of Holter monitoring technologies has resulted in the diverse recorders and analysis devices that are compared in this review. Holter recording modes include continuous recording, which makes all electrocardiographic (ECG) data available for analysis; patient-activated recording,...

journal_title：Annals of internal medicine

authors： Morganroth J

更新日期：1985-01-01 00:00:00

abstract：:A discrete evoking factor or presumed pathophysiologic mechanism is not recognized in the majority of patients with chronic urticaria or angioedema. Two cases are reported in which chronic urticaria was the main manifestation of an immune cutaneous vasculitis associated with hypocomplementemia attributable to classic ...

journal_title：Annals of internal medicine

authors： Mathison DA,Arroyave CM,Bhat KN,Hurewitz DS,Marnell DJ

更新日期：1977-05-01 00:00:00

abstract：:Population screening for hemochromatosis done by using the transferrin saturation test has been advocated by experts to permit the initiation of therapeutic phlebotomy before the onset of clinical disease. The discovery of a gene associated with hemochromatosis has made DNA testing another option for screening and dia...

journal_title：Annals of internal medicine

authors： Cogswell ME,McDonnell SM,Khoury MJ,Franks AL,Burke W,Brittenham G

更新日期：1998-12-01 00:00:00

abstract：:A controlled clinical trial compared three-drug and four-drug combination chemotherapy in 109 patients with advanced small-cell anaplastic carcinoma of the lung. The combination of vincristine, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), cyclophosphamide, and methotrexate was significantly superior to the com...

journal_title：Annals of internal medicine

authors： Hansen HH,Dombernowsky P,Hansen M,Hirsch F

更新日期：1978-08-01 00:00:00

abstract：BACKGROUND:Indinavir, a protease inhibitor widely used to treat patients with HIV infection, has been associated with nephrolithiasis. Distinctive urinary crystals and a spectrum of urologic disorders were noted in patients receiving indinavir. OBJECTIVE:To determine the composition of urinary crystals and the frequen...

journal_title：Annals of internal medicine

authors： Kopp JB,Miller KD,Mican JA,Feuerstein IM,Vaughan E,Baker C,Pannell LK,Falloon J

更新日期：1997-07-15 00:00:00

abstract：:We studied D-penicillamine toxicity in 259 patients with systemic sclerosis treated since 1972. The average daily dose of 635 mg was given for a mean of 1.8 years. Of patients with systemic sclerosis, 47% has side effects from D-penicillamine treatment, similar to the 56% of 807 patients with rheumatoid arthritis in s...

journal_title：Annals of internal medicine

authors： Steen VD,Blair S,Medsger TA Jr

更新日期：1986-05-01 00:00:00

abstract：BACKGROUND:Magnetic resonance imaging (MRI) is avoided in most patients with implanted cardiac devices because of safety concerns. OBJECTIVE:To define the safety of a protocol for MRI at the commonly used magnetic strength of 1.5 T in patients with implanted cardiac devices. DESIGN:Prospective nonrandomized trial. (C...

journal_title：Annals of internal medicine

authors： Nazarian S,Hansford R,Roguin A,Goldsher D,Zviman MM,Lardo AC,Caffo BS,Frick KD,Kraut MA,Kamel IR,Calkins H,Berger RD,Bluemke DA,Halperin HR

更新日期：2011-10-04 00:00:00

abstract：BACKGROUND:Cardiovascular disease (CVD) is the leading cause of death in the United States. PURPOSE:To update a systematic review about the benefits of aspirin for the primary prevention of cardiovascular events in adults aged 40 years or older and to evaluate effect modification in subpopulations. DATA SOURCES:MEDLI...

journal_title：Annals of internal medicine

authors： Guirguis-Blake JM,Evans CV,Senger CA,O'Connor EA,Whitlock EP

更新日期：2016-06-21 00:00:00

abstract：BACKGROUND:Many constituents of fruits and vegetables may reduce the risk for coronary heart disease, but data on the relationship between fruit and vegetable consumption and risk for coronary heart disease are sparse. OBJECTIVE:To evaluate the association of fruit and vegetable consumption with risk for coronary hear...

journal_title：Annals of internal medicine

authors： Joshipura KJ,Hu FB,Manson JE,Stampfer MJ,Rimm EB,Speizer FE,Colditz G,Ascherio A,Rosner B,Spiegelman D,Willett WC

更新日期：2001-06-19 00:00:00

abstract：:A severe shortage of organs greatly limits the ability to deliver the miracle of transplantation to people suffering from end-stage organ disease. Contributing to this shortage is a high rate of refusal among families who are asked for permission to remove organs from a recently deceased relative. Mandated choice offe...

journal_title：Annals of internal medicine

authors： Spital A

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:Persons with abdominal aortic aneurysm are more likely to have a higher prevalence of risk factors for and clinical manifestations of cardiovascular disease. It is unknown whether these factors explain the high mortality rate associated with abdominal aortic aneurysm. OBJECTIVE:To describe the risk for mort...

journal_title：Annals of internal medicine

authors： Newman AB,Arnold AM,Burke GL,O'Leary DH,Manolio TA

更新日期：2001-02-06 00:00:00

abstract：:Hyperamylasemia, which has been reported in patients with the eating disorders anorexia nervosa and bulimia, generally has been thought to result from pancreatitis. To evaluate the mechanisms of hyperamylasemia, we measured amylase, lipase, and isoamylase activity in 17 consecutive patients admitted to the eating diso...

journal_title：Annals of internal medicine

authors： Humphries LL,Adams LJ,Eckfeldt JH,Levitt MD,McClain CJ

更新日期：1987-01-01 00:00:00

abstract：:We isolated a high molecular weight antigen of the Legionnaires' disease (LD) bacterium by column chromatography. The antigen was composed of 35% carbohydrate, 2.6% protein, 1.8% phospholipid, and 1% 2-keto-3-deoxyoctonate and was important in the host's antibody response because it inhibited the indirect immunofluore...

journal_title：Annals of internal medicine

authors： Johnson W,Elliott JA,Helms CM,Renner ED

更新日期：1979-04-01 00:00:00

abstract：BACKGROUND:Advice and exercise are widely recommended for subacute low back pain, but the effectiveness of these interventions is unclear. OBJECTIVE:To investigate the effectiveness of physiotherapist-prescribed exercise, advice, or both for subacute low back pain. DESIGN:Factorial randomized, placebo-controlled tria...

journal_title：Annals of internal medicine

authors： Pengel LH,Refshauge KM,Maher CG,Nicholas MK,Herbert RD,McNair P

更新日期：2007-06-05 00:00:00

abstract：:The earthquake that struck Haiti in January 2010 caused an estimated 230,000 deaths and injured approximately 250,000 people. The Israel Defense Forces Medical Corps Field Hospital was fully operational on site only 89 hours after the earthquake struck and was capable of providing sophisticated medical care. During th...

journal_title：Annals of internal medicine

authors： Kreiss Y,Merin O,Peleg K,Levy G,Vinker S,Sagi R,Abargel A,Bartal C,Lin G,Bar A,Bar-On E,Schwaber MJ,Ash N

更新日期：2010-07-06 00:00:00

abstract：:Recent data indicate that the lymphadenopathy-associated virus (LAV) is morphologically similar to animal lentiviruses, such as equine infectious anemia and visna viruses. This finding, together with the cross-reactivity of the core proteins of LAV with those of the equine infectious anemia virus and a similarity in g...

journal_title：Annals of internal medicine

authors： Montagnier L

更新日期：1985-11-01 00:00:00