The demise of primary care: a diatribe from the trenches.

abstract：:Disorders determined wholly or in part by genetic factors constitute a substantial number of human diseases. This realization has grown during the past 2 decades with the recognition of many specific heritable conditions and the identification of familial risk factors for common disorders. New technologies, such as fe...

journal_title：Annals of internal medicine

authors： Shapiro LJ,Comings DE,Jones OW,Rimoin DL

更新日期：1986-04-01 00:00:00

abstract：:Chinese herbal medicine (CHM) formulas are the major components of traditional Chinese medicine (TCM) interventions. The general reporting quality of randomized controlled trials (RCTs) of CHM formulas is disappointing, although CONSORT (Consolidated Standards of Reporting Trials) Statement extensions for herbal medic...

journal_title：Annals of internal medicine

authors： Cheng CW,Wu TX,Shang HC,Li YP,Altman DG,Moher D,Bian ZX,CONSORT-CHM Formulas 2017 Group.

更新日期：2017-06-27 00:00:00

abstract：BACKGROUND:Although antiviral therapy is cost-effective in adults, its cost-effectiveness in older adults has not been studied. OBJECTIVE:To determine the cost-effectiveness of influenza testing and treatment strategies for older adults. DESIGN:Cost-utility decision model. DATA SOURCES:Clinical trials of antiviral d...

journal_title：Annals of internal medicine

authors： Rothberg MB,Bellantonio S,Rose DN

更新日期：2003-09-02 00:00:00

abstract：:We developed a model to project morbidity, mortality, and costs attributable to type A influenza virus infections in nursing homes and to evaluate the relative benefits and costs of programs for prevention and control. Influenza vaccination was the most cost-effective intervention under various simulations in the mode...

journal_title：Annals of internal medicine

authors： Patriarca PA,Arden NH,Koplan JP,Goodman RA

更新日期：1987-11-01 00:00:00

abstract：:A discrete evoking factor or presumed pathophysiologic mechanism is not recognized in the majority of patients with chronic urticaria or angioedema. Two cases are reported in which chronic urticaria was the main manifestation of an immune cutaneous vasculitis associated with hypocomplementemia attributable to classic ...

journal_title：Annals of internal medicine

authors： Mathison DA,Arroyave CM,Bhat KN,Hurewitz DS,Marnell DJ

更新日期：1977-05-01 00:00:00

abstract：BACKGROUND:Life space is a measure of where a person goes, the frequency of going there, and the dependency in getting there. It may be a more accurate measure of mobility in older adults because it reflects participation in society as well as physical ability. OBJECTIVE:To assess effects of hospitalization on life sp...

journal_title：Annals of internal medicine

authors： Brown CJ,Roth DL,Allman RM,Sawyer P,Ritchie CS,Roseman JM

更新日期：2009-03-17 00:00:00

abstract：BACKGROUND:Extracts of the medicinal plant Tripterygium wilfordii Hook F (TwHF) have been used in China for centuries to treat a spectrum of inflammatory diseases. OBJECTIVE:To compare the benefits and side effects of TwHF extract with those of sulfasalazine for the treatment of active rheumatoid arthritis. DESIGN:Ra...

journal_title：Annals of internal medicine

authors： Goldbach-Mansky R,Wilson M,Fleischmann R,Olsen N,Silverfield J,Kempf P,Kivitz A,Sherrer Y,Pucino F,Csako G,Costello R,Pham TH,Snyder C,van der Heijde D,Tao X,Wesley R,Lipsky PE

更新日期：2009-08-18 00:00:00

abstract：:The relationship between oral contraceptives and death from thromboembolism shown by studies of vital statistics, and the contribution of cigarette smoking to these deaths are reviewed. In 1968 a British study showed that a slight increase in deaths from thromboembolism had occurred in young women, proportional to th...

journal_title：Annals of internal medicine

authors： Masi AT

更新日期：1970-09-01 00:00:00

abstract：BACKGROUND:The comparative effectiveness of rheumatoid arthritis therapies is uncertain. PURPOSE:To compare the benefits and harms of disease-modifying antirheumatic drugs (DMARDs) for adults with rheumatoid arthritis. DATA SOURCES:Records limited to the English language and studies of adults were identified by using...

journal_title：Annals of internal medicine

authors： Donahue KE,Gartlehner G,Jonas DE,Lux LJ,Thieda P,Jonas BL,Hansen RA,Morgan LC,Lohr KN

更新日期：2008-01-15 00:00:00

abstract：:The new knowledge of the regulation of cell growth and the genetic and biochemical changes that lead to malignancy have created many new opportunities for cancer drug discovery. These new targets include oncogenes, growth factors and their receptors, signal transduction pathways, and cell differentiation signals. Atte...

journal_title：Annals of internal medicine

authors： Chabner BA

更新日期：1993-04-15 00:00:00

abstract：:When cytotoxic agents were introduced, their ability to disrupt nucleic acid and protein synthesis led to their effective use for the treatment of neoplastic disease. During the course of this use, however, it became apparent that these agents also suppress the immune system. This usually unwelcome effect was subseque...

journal_title：Annals of internal medicine

authors： Langford CA,Klippel JH,Balow JE,James SP,Sneller MC

更新日期：1998-07-01 00:00:00

abstract：:Although thyroid nodules are common, few are malignant and require surgical treatment. A systematic approach to their evaluation is important to avoid unnecessary surgery. Fine-needle aspiration biopsy has resulted in substantial improvements in diagnostic accuracy, cost reductions, and higher malignancy yield at time...

journal_title：Annals of internal medicine

authors： Castro MR,Gharib H

更新日期：2005-06-07 00:00:00

abstract：STUDY OBJECTIVE:To determine the sensitivity of herpes simplex virus isolates to acyclovir and the importance of resistant isolates in hospitalized patients. DESIGN:Retrospective incidence cohort study. SETTING:All herpes simplex virus isolates cultured over 1 year from patients followed at a tertiary care center. P...

journal_title：Annals of internal medicine

authors： Englund JA,Zimmerman ME,Swierkosz EM,Goodman JL,Scholl DR,Balfour HH Jr

更新日期：1990-03-15 00:00:00

abstract：PURPOSE:To integrate information from the various disciplines that contribute to the understanding of the cause and prevention of sudden cardiac death: identification of new approaches from applied clinical epidemiology; identification and control of transient risk factors; and evaluation of the results of intervention...

journal_title：Annals of internal medicine

authors： Myerburg RJ,Kessler KM,Castellanos A

更新日期：1993-12-15 00:00:00

abstract：:Three cases of carbamazepine-induced granulomatous hepatitis are reported. Each patient had ingested carbamazepine for less than 1 month before presenting with a febrile illness suggestive of biliary tract infection. After withdrawal of carbamazepine, symptoms disappeared rapidly. Histologically, all patients had gran...

journal_title：Annals of internal medicine

authors： Levy M,Goodman MW,Van Dyne BJ,Sumner HW

更新日期：1981-07-01 00:00:00

abstract：Background:Frailty assessment may inform surgical risk and prognosis not captured by conventional surgical risk scores. Purpose:To evaluate the evidence for various frailty instruments used to predict mortality, functional status, or major adverse cardiovascular and cerebrovascular events (MACCEs) in older adults unde...

journal_title：Annals of internal medicine

authors： Kim DH,Kim CA,Placide S,Lipsitz LA,Marcantonio ER

更新日期：2016-11-01 00:00:00

abstract：:Adverse effects to D-penicillamine were studied prospectively over 3 years in 259 patients with rheumatoid arthritis. Ninety-five percent had had gold therapy previously, yet 70% benefited from D-penicillamine therapy. Of the 275 courses given, 160 (58%) were complicated by at least one reaction, including rashes (44%...

journal_title：Annals of internal medicine

authors： Stein HB,Patterson AC,Offer RC,Atkins CJ,Teufel A,Robinson HS

更新日期：1980-01-01 00:00:00

abstract：Background:Medicare uses the Centers for Medicare & Medicaid Services Hierarchical Condition Category (CMS-HCC) model to predict patients' annualized Medicare costs in value-based payment programs. The CMS-HCC model does not include measures of frailty, and prior research shows that it systematically underpredicts cost...

journal_title：Annals of internal medicine

authors： Johnston KJ,Wen H,Joynt Maddox KE

更新日期：2020-04-21 00:00:00

abstract：OBJECTIVE:To determine the most effective and safe dose of enoxaparin to prevent deep venous thrombosis in high-risk surgical patients. DESIGN:A double-blind, randomized, multicenter clinical trial. SETTING:Private, university, and government hospitals in the United States. PATIENTS:572 patients having elective hip ...

journal_title：Annals of internal medicine

authors： Spiro TE,Johnson GJ,Christie MJ,Lyons RM,MacFarlane DE,Blasier RB,Tremaine MD

更新日期：1994-07-15 00:00:00

abstract：BACKGROUND:Many nonpharmacologic therapies are available for treatment of low back pain. PURPOSE:To assess benefits and harms of acupuncture, back schools, psychological therapies, exercise therapy, functional restoration, interdisciplinary therapy, massage, physical therapies (interferential therapy, low-level laser ...

journal_title：Annals of internal medicine

authors： Chou R,Huffman LH,American Pain Society.,American College of Physicians.

更新日期：2007-10-02 00:00:00

abstract：:Simulation is a versatile technique used in a variety of health care settings for a variety of purposes, but the extent to which simulation may improve patient safety remains unknown. This systematic review examined evidence on the effects of simulation techniques on patient safety outcomes. PubMed and the Cochrane Li...

journal_title：Annals of internal medicine

authors： Schmidt E,Goldhaber-Fiebert SN,Ho LA,McDonald KM

更新日期：2013-03-05 00:00:00

abstract：:Endomyocardial biopsy was done 119 times in 98 patients receiving doxorubicin therapy once every 3 weeks and 41 times in 27 patients receiving doxorubicin therapy weekly. Factors contributing to the degree of anthracycline-induced endomyocardial injury were evaluated. Neither age, sex, type of malignancy, concomitant ...

journal_title：Annals of internal medicine

authors： Torti FM,Bristow MR,Howes AE,Aston D,Stockdale FE,Carter SK,Kohler M,Brown BW Jr,Billingham ME

更新日期：1983-12-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the effect of a nurse-managed intervention for smoking cessation in patients who have had a myocardial infarction. DESIGN:Randomized, with a 6-month treatment period and a 6-month follow-up. SETTING:Kaiser Foundation hospitals in Redwood City, Santa Clara, Hayward, and San Jose, Californi...

journal_title：Annals of internal medicine

authors： Taylor CB,Houston-Miller N,Killen JD,DeBusk RF

更新日期：1990-07-15 00:00:00

abstract：SOURCE CITATION:Liu J, Li L, Li S, et al. Sodium-glucose co-transporter-2 inhibitors and the risk of diabetic ketoacidosis in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials. Diabetes Obes Metab. 2020;22:1619-27. 32364674. ...

journal_title：Annals of internal medicine

authors： Griffin TP,Dinneen SF

更新日期：2020-10-20 00:00:00

abstract：Background:A 2007 American College of Physicians guideline addressed pharmacologic options for low back pain. New evidence and medications have now become available. Purpose:To review the current evidence on systemic pharmacologic therapies for acute or chronic nonradicular or radicular low back pain. Data Sources:Ov...

journal_title：Annals of internal medicine

authors： Chou R,Deyo R,Friedly J,Skelly A,Weimer M,Fu R,Dana T,Kraegel P,Griffin J,Grusing S

更新日期：2017-04-04 00:00:00

abstract：:Eighty-six patients who required heparin therapy were randomly assigned to receive bovine or porcine heparin. Abnormal concentrations of alanine transaminase and aspartate transaminase developed during treatment in 59.3% and 26.7% of patients, respectively. Patient characteristics that significantly influenced the dev...

journal_title：Annals of internal medicine

authors： Dukes GE Jr,Sanders SW,Russo J Jr,Swenson E,Burnakis TG,Saffle JR,Warden GD

更新日期：1984-05-01 00:00:00

abstract：:Endocarditis is a relatively frequent infection in intravenous drug users. We compared features in the cases of 102 patients with those in intravenous drug users with other causes of fever to identify risk factors predictive of endocarditis. Logistic regression analysis showed cocaine use to be strongly associated wit...

journal_title：Annals of internal medicine

authors： Chambers HF,Morris DL,Täuber MG,Modin G

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND:Angiotensin-converting enzyme (ACE) inhibitors slow renal disease progression and reduce cardiac morbidity and mortality in patients with diabetes. Patients' out-of-pocket costs pose a barrier to using this effective therapy. OBJECTIVE:To estimate the cost-effectiveness to Medicare of first-dollar coverage ...

journal_title：Annals of internal medicine

authors： Rosen AB,Hamel MB,Weinstein MC,Cutler DM,Fendrick AM,Vijan S

更新日期：2005-07-19 00:00:00

abstract：:The Advisory Committee on Immunization Practices (ACIP) consists of 15 experts in immunization and related fields, selected by the Secretary of the U.S. Department of Health and Human Services, to provide advice and guidance on control of vaccine-preventable diseases. In its role as a federal advisory committee, the A...

journal_title：Annals of internal medicine

authors： Smith JC,Snider DE,Pickering LK,Advisory Committee on Immunization Practices.

更新日期：2009-01-06 00:00:00

abstract：OBJECTIVE:To determine the effectiveness of levothyroxine and potassium iodide in treating patients with benign solitary cold thyroid nodules. DESIGN:Randomized controlled study. SETTING:Outpatient clinic at a university hospital. PATIENTS:80 patients with solitary solid cold thyroid nodules found to be benign at cy...

journal_title：Annals of internal medicine

authors： La Rosa GL,Lupo L,Giuffrida D,Gullo D,Vigneri R,Belfiore A

更新日期：1995-01-01 00:00:00