Intravascular coagulation with use of human prothrombin complex concentrates.

Abstract:

:Prothrombin complex concentrates are used in the treatment of the congenital bleeding disorders associated with Factors II, VII, IX, and X deficiencies. They have also been extensively used to treat acquired coagulation abnormalities secondary to vitamin K deficiency, warfarin ingestion, and various types of liver disease. The reported complications of prothrombin complex concentrates administration include hepatitis, anaphylaxis, and thrombosis. This paper documents the development of disseminated intravascular coagulation in association with the administration of prothrombin complex concentrates to patients with liver disease.

journal_name

Ann Intern Med

authors

Cederbaum AI,Blatt PM,Roberts HR

doi

10.7326/0003-4819-84-6-683

subject

Has Abstract

pub_date

1976-06-01 00:00:00

pages

683-7

issue

6

eissn

0003-4819

issn

1539-3704

journal_volume

84

pub_type

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