Mutations in mouse myeloma cells: implications for human multiple myeloma and the production of immunoglobulins.

abstract：:The exocrine pancreas secretes into the gut on demand more than 20 proteins that are indispensable for digestion. In-vivo autodigestion is prevented by an array of natural safeguards. In acute pancreatitis, inappropriate intrapancreatic activation and release of pancreatic hydrolases occur, but the pathogenetic mechan...

journal_title：Annals of internal medicine

authors： Geokas MC,Baltaxe HA,Banks PA,Silva J Jr,Frey CF

更新日期：1985-07-01 00:00:00

abstract：:Visual loss from the complications of advanced diabetic retinopathy now can be managed more effectively by surgical vitrectomy with a significant reduction in operative and postoperative ocular morbidity. Ocular structures are now maintained in a more normal physiologic state, leaving the patient's lens in place, help...

journal_title：Annals of internal medicine

authors： Aaberg TM

更新日期：1983-10-01 00:00:00

abstract：OBJECTIVE:To prospectively study the clinical features, pathophysiology, treatment and prognosis of Wegener granulomatosis. DESIGN:Of the 180 patients with Wegener granulomatosis referred to the National Institute of Allergy and Infectious Diseases during the past 24 years, 158 have been followed for 6 months to 24 ye...

journal_title：Annals of internal medicine

authors： Hoffman GS,Kerr GS,Leavitt RY,Hallahan CW,Lebovics RS,Travis WD,Rottem M,Fauci AS

更新日期：1992-03-15 00:00:00

abstract：:Palliative care prioritizes symptom management and quality of life throughout the course of serious illness. Regardless of whether care is inpatient or outpatient, primary or subspecialty, a solid understanding of the basics of effective communication, symptom management, and end-of-life care is crucial. This article ...

journal_title：Annals of internal medicine

authors： Swetz KM,Kamal AH

更新日期：2018-03-06 00:00:00

abstract：BACKGROUND:Pay-for-performance (P4P) is increasingly touted as a means to improve health care quality. PURPOSE:To evaluate the effect of P4P remuneration targeting individual health care providers. DATA SOURCES:MEDLINE, EMBASE, Cochrane Library, OpenSIGLE, Canadian Evaluation Society Unpublished Literature Bank, New ...

journal_title：Annals of internal medicine

authors： Houle SK,McAlister FA,Jackevicius CA,Chuck AW,Tsuyuki RT

更新日期：2012-12-18 00:00:00

abstract：BACKGROUND:Because clinical diagnosis is inaccurate, objective testing is usually considered necessary when patients present with suspected deep venous thrombosis (DVT). OBJECTIVE:To determine whether a negative result on a quantitative latex D dimer assay eliminates the need for further investigation in patients with...

journal_title：Annals of internal medicine

authors： Bates SM,Kearon C,Crowther M,Linkins L,O'Donnell M,Douketis J,Lee AY,Weitz JI,Johnston M,Ginsberg JS

更新日期：2003-05-20 00:00:00

abstract：:Severe hypocalcemia secondary to magnesium depletion has been described in numerous patients with gastrointestinal disorders. The development of profound hypomagnesemia in chronic renal disease is a rare finding. We studied three patients with advanced renal failure and magnesium depletion. Severe hypocalcemia also wa...

journal_title：Annals of internal medicine

authors： Mennes P,Rosenbaum R,Martin K,Slatopolsky E

更新日期：1978-02-01 00:00:00

abstract：:We treated 50 patients who ingested packets of cocaine and developed a protocol for conservative medical management. Of the 50 patients, only 3 required emergency surgery. Surgery was precipitated by signs and symptoms of bowel obstruction in all cases. Six patients chose elective surgery. The rest of the patients pas...

journal_title：Annals of internal medicine

authors： Caruana DS,Weinbach B,Goerg D,Gardner LB

更新日期：1984-01-01 00:00:00

abstract：:The prevalence of active tuberculosis and positive tuberculin skin tests was assessed in 132 corticosteroid-treated asthmatics for an evaluation period that represented 620 corticosteroid-years of therapy. There was no evidence of active tuberculosis in any of these patients. Positive intermediate-strength tuberculin ...

journal_title：Annals of internal medicine

authors： Schatz M,Patterson R,Kloner R,Falk J

更新日期：1976-03-01 00:00:00

abstract：:The relationship between oral contraceptives and death from thromboembolism shown by studies of vital statistics, and the contribution of cigarette smoking to these deaths are reviewed. In 1968 a British study showed that a slight increase in deaths from thromboembolism had occurred in young women, proportional to th...

journal_title：Annals of internal medicine

authors： Masi AT

更新日期：1970-09-01 00:00:00

abstract：DESCRIPTION:New recommendation from the U.S. Preventive Services Task Force (USPSTF) on the use of nontraditional, or novel, risk factors in assessing the coronary heart disease (CHD) risk of asymptomatic persons. METHODS:Systematic reviews were conducted of literature since 1996 on 9 proposed nontraditional markers o...

journal_title：Annals of internal medicine

authors： U.S. Preventive Services Task Force.

更新日期：2009-10-06 00:00:00

abstract：:The U.S. Preventive Services Task Force (USPSTF) makes recommendations on which preventive services to routinely incorporate into primary care for specific populations. Behavioral counseling interventions are preventive services designed to help persons engage in healthy behaviors and limit unhealthy ones. The USPSTF'...

journal_title：Annals of internal medicine

authors： Curry SJ,Grossman DC,Whitlock EP,Cantu A

更新日期：2014-03-18 00:00:00

abstract：BACKGROUND:Exercise stress testing in patients with abdominal aortic aneurysms may cause enlargement or rupture of aneurysms. OBJECTIVE:To evaluate the safety of treadmill exercise stress testing in patients with abdominal aortic aneurysms. DESIGN:Retrospective descriptive study. SETTING:Tertiary care center. PATIE...

journal_title：Annals of internal medicine

authors： Best PJ,Tajik AJ,Gibbons RJ,Pellikka PA

更新日期：1998-10-15 00:00:00

abstract：:To assess the course and prognosis of salicylate-induced pulmonary edema, we reviewed the records of 36 consecutive patients admitted with serum salicylate levels greater than 30 mg/dL. Pulmonary edema developed in eight patients, and pulmonary infiltrates were never seen in 28 patients. Several features distinguished...

journal_title：Annals of internal medicine

authors： Heffner JE,Sahn SA

更新日期：1981-10-01 00:00:00

abstract：:A 17-year-old girl with a clinical diagnosis of adult-type juvenile rheumatoid arthritis developed a severe hepatotoxic reaction to 3.6 g of aspirin per day. This was associated with a microangiopathic anemia and transient congestive cardiac failure. She responded well to steroids, and when all laboratory test finding...

journal_title：Annals of internal medicine

authors： Sbarbaro JA,Bennett RM

更新日期：1977-02-01 00:00:00

abstract：:For the diagnosis of M7, the bone marrow aspirate shows a leukemic cell infiltrate that comprises 30% or more of all cells. These cells are identified as being of megakaryocyte lineage by the platelet peroxidase reaction on electron microscopy or by tests with monoclonal or polyclonal platelet-specific antibodies. Mye...

journal_title：Annals of internal medicine

authors： Bennett JM,Catovsky D,Daniel MT,Flandrin G,Galton DA,Gralnick HR,Sultan C

更新日期：1985-09-01 00:00:00

abstract：:The syndrome of bulimia is a common disorder and can be associated with serious psychological and physical morbidity. Unfortunately, many patients are reluctant to discuss their symptoms with their physicians and few clues can be found on physical examination to aid in the diagnosis. Possible physical signs include ul...

journal_title：Annals of internal medicine

authors： Mitchell JE,Seim HC,Colon E,Pomeroy C

更新日期：1987-07-01 00:00:00

abstract：:Thyroid antibodies were found significantly more often in insulin-dependent diabetics than in their spouses or in non-insulin-dependent diabetics. The poor correlation between presence of thyroid autoimmunity and duration of disease and the significantly increased prevalence of thyroid antibodies in first-degree relat...

journal_title：Annals of internal medicine

authors： Fialkow PJ,Zavala C,Nielsen R

更新日期：1975-08-01 00:00:00

abstract：:Simulation is a versatile technique used in a variety of health care settings for a variety of purposes, but the extent to which simulation may improve patient safety remains unknown. This systematic review examined evidence on the effects of simulation techniques on patient safety outcomes. PubMed and the Cochrane Li...

journal_title：Annals of internal medicine

authors： Schmidt E,Goldhaber-Fiebert SN,Ho LA,McDonald KM

更新日期：2013-03-05 00:00:00

abstract：:Women comprise more than one third of the active physician workforce, an estimated 46% of all physicians-in-training, and more than half of all medical students in the United States. Although progress has been made toward gender diversity in the physician workforce, disparities in compensation exist and inequities hav...

journal_title：Annals of internal medicine

authors： Butkus R,Serchen J,Moyer DV,Bornstein SS,Hingle ST,Health and Public Policy Committee of the American College of Physicians.

更新日期：2018-05-15 00:00:00

abstract：Description:The purpose of this guidance statement is to guide clinicians on colorectal cancer screening in average-risk adults. Methods:This guidance statement is derived from a critical appraisal of guidelines on screening for colorectal cancer in average-risk adults and the evidence presented in these guidelines. N...

journal_title：Annals of internal medicine

authors： Qaseem A,Crandall CJ,Mustafa RA,Hicks LA,Wilt TJ,Clinical Guidelines Committee of the American College of Physicians.

更新日期：2019-11-05 00:00:00

abstract：:For years patients hospitalized with viral hepatitis have been placed in two categories of isolation--enteric precautions and blood precautions. This strategy was based on the inability to differentiate between hepatitis A and B and on the assumption that feces and blood from patients with either type might be infecti...

journal_title：Annals of internal medicine

authors： Favero MS,Maynard JE,Leger RT,Graham DR,Dixon RE

更新日期：1979-12-01 00:00:00

abstract：BACKGROUND:Visits to physicians for genital herpes simplex virus (HSV) infection continue to increase. Most patients with symptomatic infections have recurrences, but no studies of the long-term clinical course of genital herpes are available. OBJECTIVE:To determine whether the frequency of HSV recurrences decreases o...

journal_title：Annals of internal medicine

authors： Benedetti JK,Zeh J,Corey L

更新日期：1999-07-06 00:00:00

abstract：:In 1978 the Institute of Medicine issued "A Manpower Policy for Health Care," the report of a study of major issues bearing on the availability of an adequate number of physicians for provision of primary care and on potential strategies for an appropriate manpower policy. The report was analyzed by committees of the ...

journal_title：Annals of internal medicine

authors： Peterson ML

更新日期：1980-06-01 00:00:00

abstract：BACKGROUND:New tests, such as magnetic resonance imaging (MRI) and electron-beam computed tomography (CT), are being developed for the diagnosis of coronary artery disease. OBJECTIVE:To determine the conditions that a new test must meet to be a cost-effective alternative to established imaging tests. DESIGN:Decision ...

journal_title：Annals of internal medicine

authors： Hunink MG,Kuntz KM,Fleischmann KE,Brady TJ

更新日期：1999-11-02 00:00:00

abstract：BACKGROUND:Motor vehicle crashes (MVCs) remain a leading cause of injury-related deaths in the United States. Primary seat belt laws allow vehicle occupants to be ticketed solely for not wearing seat belts, and secondary laws allow ticketing only for failure to wear seat belts in the setting of other violations. OBJEC...

journal_title：Annals of internal medicine

authors： Lee LK,Monuteaux MC,Burghardt LC,Fleegler EW,Nigrovic LE,Meehan WP,Schutzman SA,Mannix R

更新日期：2015-08-04 00:00:00

abstract：:[Figure: see text]. ...

journal_title：Annals of internal medicine

authors： Morganstein JC

更新日期：2020-05-19 00:00:00

abstract：BACKGROUND:Current magnetic resonance techniques generate high signal from venous blood and show thrombi as filling defects. Magnetic resonance direct thrombus imaging (MRDTI) directly visualizes acute thrombus. OBJECTIVE:To determine the accuracy of MRDTI for diagnosis of acute symptomatic deep venous thrombosis (DVT...

journal_title：Annals of internal medicine

authors： Fraser DG,Moody AR,Morgan PS,Martel AL,Davidson I

更新日期：2002-01-15 00:00:00

abstract：OBJECTIVE:To determine the incidence, cause, and characteristics of pleural effusions in hospitalized patients with the acquired immunodeficiency syndrome (AIDS). DESIGN:Retrospective. PARTICIPANTS:A total of 222 patients with AIDS hospitalized between January 1986 and January 1992 at the Medical University of South ...

journal_title：Annals of internal medicine

authors： Joseph J,Strange C,Sahn SA

更新日期：1993-06-01 00:00:00

abstract：:Impairment of penicillin G excretion in renal failure may result in life-threatening, dose-related toxicity. We report a method for achieving a desired mean serum penicillin G concentration in patients with renal failure, with minimal risk of both undertreatment and drug toxicity. The method is based on the linear rel...

journal_title：Annals of internal medicine

authors： Bryan CS,Stone WJ

更新日期：1975-02-01 00:00:00