Aspirin hepatotoxicity and disseminated intravascular coagulation.

Abstract:

:A 17-year-old girl with a clinical diagnosis of adult-type juvenile rheumatoid arthritis developed a severe hepatotoxic reaction to 3.6 g of aspirin per day. This was associated with a microangiopathic anemia and transient congestive cardiac failure. She responded well to steroids, and when all laboratory test findings were back to normal, she was "challenged" with five divided doses of aspirin (total, 3.0 g). This produced a salicylate level of 9.1 g/dl and was associated with an immediate deterioration in liver function test findings and a return of microangiopathic blood features with elevation of fibrin split products and a prolonged prothrombin time. These changes were again reversed by promptly starting steroid therapy. This case suggests that disseminated intravascular coagulation, and its rare association with hepatotoxicity, is a potentially fatal side effect of aspirin therapy.

journal_name

Ann Intern Med

authors

Sbarbaro JA,Bennett RM

doi

10.7326/0003-4819-86-2-183

subject

Has Abstract

pub_date

1977-02-01 00:00:00

pages

183-5

issue

2

eissn

0003-4819

issn

1539-3704

journal_volume

86

pub_type

杂志文章
  • Formulating questions and locating primary studies for inclusion in systematic reviews.

    abstract::Much time and effort are spent on designing primary research studies. Similar care must be given to planning systematic reviews. The review should be based on an important, well-focused question that is relevant to patient care. By formulating the question properly, the criteria that primary studies must meet to be in...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-127-5-199709010-00008

    authors: Counsell C

    更新日期:1997-09-01 00:00:00

  • Systematic review: using magnetic resonance imaging to screen women at high risk for breast cancer.

    abstract:BACKGROUND:A sensitive and acceptable screening regimen for women at high risk for breast cancer is essential. Contrast-enhanced magnetic resonance imaging (MRI) of the breast is highly sensitive for diagnosis of breast cancer but has variable specificity. PURPOSE:To summarize the sensitivity, specificity, likelihood ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.7326/0003-4819-148-9-200805060-00007

    authors: Warner E,Messersmith H,Causer P,Eisen A,Shumak R,Plewes D

    更新日期:2008-05-06 00:00:00

  • Elevated levels of circulating platelet aggregates and beta-thromboglobulin in scleroderma.

    abstract::Levels of circulating platelet aggregates and plasma beta-thromboglobulin reflect the degree of platelet activation in vascular injury and repair. Both values were evaluated in 38 patients with scleroderma and 18 control subjects matched for age, sex, and race. Circulating platelet aggregates (expressed as percentage ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-96-5-610

    authors: Kahaleh MB,Osborn I,Leroy EC

    更新日期:1982-05-01 00:00:00

  • SGLT2 inhibitors increase risk for diabetic ketoacidosis in type 2 diabetes.

    abstract:SOURCE CITATION:Liu J, Li L, Li S, et al. Sodium-glucose co-transporter-2 inhibitors and the risk of diabetic ketoacidosis in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials. Diabetes Obes Metab. 2020;22:1619-27. 32364674. ...

    journal_title:Annals of internal medicine

    pub_type: 评论,杂志文章

    doi:10.7326/ACPJ202010200-040

    authors: Griffin TP,Dinneen SF

    更新日期:2020-10-20 00:00:00

  • Health implications of overweight and obesity in the United States.

    abstract::The second National Health and Nutrition Examination Survey found that 26% of U.S. adults, or about 34 million people aged 20 to 75 years, are overweight. The survey used a body mass index of 27.8 kg/m2 or greater for men and 27.3 or greater for women to define overweight. Prevalence of overweight increases with advan...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-103-6-983

    authors: Van Itallie TB

    更新日期:1985-12-01 00:00:00

  • The ethics of deactivating implanted cardioverter defibrillators.

    abstract::Implantable cardioverter defibrillators are life-saving devices for many patients with cardiac disease. Recipients of these devices, nevertheless, often suffer from progressive comorbid and cardiac conditions. Therefore, physicians should anticipate situations in which the defibrillator is no longer desired by the pat...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-142-8-200504190-00012

    authors: Berger JT

    更新日期:2005-04-19 00:00:00

  • Differences in generalists' and cardiologists' perceptions of cardiovascular risk and the outcomes of preventive therapy in cardiovascular disease.

    abstract:OBJECTIVE:To compare generalists' and cardiologists' estimates of baseline cardiovascular risk and the outcomes of preventive therapy. DESIGN:Cross-sectional mail survey using written case simulations of typical patients from primary prevention trials for hypercholesterolemia and isolated systolic hypertension, and te...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-124-4-199602150-00005

    authors: Friedmann PD,Brett AS,Mayo-Smith MF

    更新日期:1996-02-15 00:00:00

  • Trace elements and blood pressure.

    abstract::Essential trace elements such as zinc, iron, and copper participate in various enzyme reactions directly related to the regulation of blood pressure and indirectly related to generation of oxidative metabolic energy, alterations in blood lipid levels, and alterations in taste acuity. The toxicological action of severa...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-98-5-823

    authors: Saltman P

    更新日期:1983-05-01 00:00:00

  • Intravascular coagulation with use of human prothrombin complex concentrates.

    abstract::Prothrombin complex concentrates are used in the treatment of the congenital bleeding disorders associated with Factors II, VII, IX, and X deficiencies. They have also been extensively used to treat acquired coagulation abnormalities secondary to vitamin K deficiency, warfarin ingestion, and various types of liver dis...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-84-6-683

    authors: Cederbaum AI,Blatt PM,Roberts HR

    更新日期:1976-06-01 00:00:00

  • Reduced cardiotoxicity of doxorubicin delivered on a weekly schedule. Assessment by endomyocardial biopsy.

    abstract::Endomyocardial biopsy was done 119 times in 98 patients receiving doxorubicin therapy once every 3 weeks and 41 times in 27 patients receiving doxorubicin therapy weekly. Factors contributing to the degree of anthracycline-induced endomyocardial injury were evaluated. Neither age, sex, type of malignancy, concomitant ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-99-6-745

    authors: Torti FM,Bristow MR,Howes AE,Aston D,Stockdale FE,Carter SK,Kohler M,Brown BW Jr,Billingham ME

    更新日期:1983-12-01 00:00:00

  • Acetaminophen does not impair clearance of zidovudine.

    abstract:OBJECTIVE:To determine whether concurrent treatment with acetaminophen and zidovudine impairs clearance of zidovudine, thereby increasing the risk for zidovudine-induced hematologic toxicity. DESIGN:Dose escalation, drug interaction study. SETTING:University clinical research center. PATIENTS:Patients with the acqui...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-114-11-937

    authors: Sattler FR,Ko R,Antoniskis D,Shields M,Cohen J,Nicoloff J,Leedom J,Koda R

    更新日期:1991-06-01 00:00:00

  • Pituitary enlargement, pituitary failure, and primary hypothyroidism.

    abstract::Enlargement of the pituitary gland associated with primary hypothyroidism was observed in two patients. Serum thyroid-stimulating hormone (TSH) concentration and the TSH response to thyrotropin-releasing hormone were increased in both. Other pituitary function tests were subnormal in both patients, suggesting that a t...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-85-2-195

    authors: Vagenakis AG,Dole K,Braverman LE

    更新日期:1976-08-01 00:00:00

  • Meta-analysis: the effect of dietary counseling for weight loss.

    abstract:BACKGROUND:Dietary and lifestyle modification efforts are the primary treatments for people who are obese or overweight. The effect of dietary counseling on long-term weight change is unclear. PURPOSE:To perform a meta-analysis of the effect of dietary counseling compared with usual care on body mass index (BMI) over ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.7326/0003-4819-147-1-200707030-00007

    authors: Dansinger ML,Tatsioni A,Wong JB,Chung M,Balk EM

    更新日期:2007-07-03 00:00:00

  • Is antimicrobial prophylaxis of urinary tract infections cost effective?

    abstract::Antimicrobial prophylaxis prevents recurrent urinary tract infections in susceptible women, but its cost effectiveness has not been studied. In a recent placebo-controlled trial of urinary prophylaxis, we also assessed cost effectiveness using a decision analysis model. In our hospital the direct cost of 1 patient yea...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.7326/0003-4819-94-2-251

    authors: Stamm WE,McKevitt M,Counts GW,Wagner KF,Turck M,Holmes KK

    更新日期:1981-02-01 00:00:00

  • Healing skills for medical practice.

    abstract::It is well recognized that physicians' relationships with their patients can have healing effects, but the skills in this area of medical practice are understudied. This article reports on research designed to identify a core set of healing skills. The authors interviewed 50 practitioners, who were identified by their...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-149-10-200811180-00006

    authors: Churchill LR,Schenck D

    更新日期:2008-11-18 00:00:00

  • Prediction of pulmonary embolism in the emergency department: the revised Geneva score.

    abstract:BACKGROUND:Diagnosis of pulmonary embolism requires clinical probability assessment. Implicit assessment is accurate but is not standardized, and current prediction rules have shortcomings. OBJECTIVE:To construct a simple score based entirely on clinical variables and independent from physicians' implicit judgment. D...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-144-3-200602070-00004

    authors: Le Gal G,Righini M,Roy PM,Sanchez O,Aujesky D,Bounameaux H,Perrier A

    更新日期:2006-02-07 00:00:00

  • Lymphadenopathy-associated virus: from molecular biology to pathogenicity.

    abstract::Recent data indicate that the lymphadenopathy-associated virus (LAV) is morphologically similar to animal lentiviruses, such as equine infectious anemia and visna viruses. This finding, together with the cross-reactivity of the core proteins of LAV with those of the equine infectious anemia virus and a similarity in g...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-103-5-689

    authors: Montagnier L

    更新日期:1985-11-01 00:00:00

  • Sex differences in access to coronary revascularization after cardiac catheterization: importance of detailed clinical data.

    abstract:BACKGROUND:Although some studies suggest that access to cardiac procedures may differ by sex, others have found no evidence of gender bias in cardiac care. OBJECTIVE:To study rates of percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) surgery in men and women after cardiac catheterization....

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-136-10-200205210-00007

    authors: Ghali WA,Faris PD,Galbraith PD,Norris CM,Curtis MJ,Saunders LD,Dzavik V,Mitchell LB,Knudtson ML,Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease (APPROACH) Investigators.

    更新日期:2002-05-21 00:00:00

  • Hyperamylasemia in patients with eating disorders.

    abstract::Hyperamylasemia, which has been reported in patients with the eating disorders anorexia nervosa and bulimia, generally has been thought to result from pancreatitis. To evaluate the mechanisms of hyperamylasemia, we measured amylase, lipase, and isoamylase activity in 17 consecutive patients admitted to the eating diso...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-106-1-50

    authors: Humphries LL,Adams LJ,Eckfeldt JH,Levitt MD,McClain CJ

    更新日期:1987-01-01 00:00:00

  • Comparative effectiveness of new oral anticoagulants and standard thromboprophylaxis in patients having total hip or knee replacement: a systematic review.

    abstract:BACKGROUND:Pharmacologic thromboprophylaxis reduces the risk for venous thromboembolism after total hip replacement (THR) or total knee replacement (TKR). New oral anticoagulants (NOACs), including direct thrombin inhibitors and factor Xa inhibitors, are emerging options for thromboprophylaxis after these procedures. ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-159-4-201308200-00008

    authors: Adam SS,McDuffie JR,Lachiewicz PF,Ortel TL,Williams JW Jr

    更新日期:2013-08-20 00:00:00

  • Test performance of positron emission tomography and computed tomography for mediastinal staging in patients with non-small-cell lung cancer: a meta-analysis.

    abstract:PURPOSE:To compare the diagnostic accuracy of computed tomography (CT) and positron emission tomography (PET) with 18-fluorodeoxyglucose (FDG) for mediastinal staging in patients with non-small-cell lung cancer and to determine whether test results are conditionally dependent (the sensitivity and specificity of FDG-PET...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.7326/0003-4819-139-11-200311180-00013

    authors: Gould MK,Kuschner WG,Rydzak CE,Maclean CC,Demas AN,Shigemitsu H,Chan JK,Owens DK

    更新日期:2003-12-02 00:00:00

  • Possible mechanisms for vaginal infection with Staphylococcus aureus: inferences drawn from studies of nosocomial infection of newborn infants and surgical patients.

    abstract::Previous epidemiologic studies of staphylococcal infections in newborn infants and surgical patients provide clues to the method of infection in toxic shock syndrome. In newborn infants, staphylococci were shown to be transmitted most often by the hands of nursery personnel to the umbilical stump, which afforded a war...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-96-6-934

    authors: Mortimer EA

    更新日期:1982-06-01 00:00:00

  • Physician-assisted suicide.

    abstract::Medical professional codes have long prohibited physician involvement in assisting a patient's suicide. However, despite ethical and legal prohibitions, calls for the liberalization of this ban have grown in recent years. The medical profession should articulate its views on the arguments for and against changes in pu...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-135-3-200108070-00015

    authors: Snyder L,Sulmasy DP,Ethics and Human Rights Committee, American College of Physicians-American Society of Internal Medicine.

    更新日期:2001-08-07 00:00:00

  • Venous limb gangrene during warfarin treatment of cancer-associated deep venous thrombosis.

    abstract:BACKGROUND:The cause of cancer-associated venous limb gangrene is unknown but could paradoxically be due to warfarin. OBJECTIVE:To determine the pathogenesis of venous gangrene in a patient with cancer. DESIGN:Case report. SETTING:University hospital in Ontario, Canada. PATIENT:66-year-old woman with metastatic lun...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-135-8_part_1-200110160-00009

    authors: Warkentin TE

    更新日期:2001-10-16 00:00:00

  • Screening for peripheral artery disease and cardiovascular disease risk assessment with the ankle-brachial index in adults: U.S. Preventive Services Task Force recommendation statement.

    abstract:DESCRIPTION:Update of the 2005 U.S. Preventive Services Task Force (USPSTF) recommendation on screening for peripheral artery disease (PAD). METHODS:The USPSTF reviewed the evidence on the use of resting ankle-brachial index (ABI) as a screening test for PAD or as a risk predictor for cardiovascular disease (CVD). The...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,实务指引

    doi:10.7326/0003-4819-159-5-201309030-00008

    authors: Moyer VA,U.S. Preventive Services Task Force.

    更新日期:2013-09-03 00:00:00

  • Guidelines for the care of patients hospitalized with viral hepatitis.

    abstract::For years patients hospitalized with viral hepatitis have been placed in two categories of isolation--enteric precautions and blood precautions. This strategy was based on the inability to differentiate between hepatitis A and B and on the assumption that feces and blood from patients with either type might be infecti...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-91-6-872

    authors: Favero MS,Maynard JE,Leger RT,Graham DR,Dixon RE

    更新日期:1979-12-01 00:00:00

  • Monovalent influenza A(H1N1) vaccine, 1986-1987. Recommendations of the Immunization Practices Advisory Committee. Centers for Disease Control, Department of Health and Human Services.

    abstract::These supplemental recommendations provide guidelines for a monovalent influenza A(H1N1) vaccine for protection against a newly emerged variant of influenza that has recently caused outbreaks among children and young adults in Asia. Guidance is provided for the use of this monovalent vaccine, which contains 15 microgr...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:

    authors:

    更新日期:1986-11-01 00:00:00

  • Sexually transmitted diseases and traumatic problems in homosexual men.

    abstract::In addition to gonorrhea and syphilis, both of which may develop primarily at anorectal or pharyngeal sites, a number of conditions, including Neisseria meningitidis urethritis, nonspecific urethritis, anorectal herpes, condyloma acuminatum, amebiasis, giardiasis, shigellosis, typhoid fever, enterobiasis, and hepatiti...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-92-6-805

    authors: Owen WF Jr

    更新日期:1980-06-01 00:00:00

  • Exogenous insulin administration and cardiovascular risk in non-insulin-dependent and insulin-dependent diabetes mellitus.

    abstract:PURPOSE:It is currently unknown whether intensive insulin treatment of diabetes decreases the risk for cardiovascular complications by lowering glucose levels or increases the risk by postulated direct atherogenic effects. This article reviews published data from two long-term, randomized clinical trials that compared ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,meta分析

    doi:10.7326/0003-4819-124-1_part_2-199601011-00005

    authors: Genuth S

    更新日期:1996-01-01 00:00:00

  • Procedural skills of practicing nephrologists. A national survey of 700 members of the American College of Physicians.

    abstract:OBJECTIVE:To determine which procedures nephrologists do in practice, where they learned the procedures, and how much training they recommend to achieve and maintain clinical competence in each. DESIGN:Mailed survey. PARTICIPANTS:A random sample of 700 members of the American College of Physicians who were identified...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-113-5-392

    authors: Tape TG,Wigton RS,Blank LL,Nicolas JA

    更新日期:1990-09-01 00:00:00