Pituitary enlargement, pituitary failure, and primary hypothyroidism.

abstract：:Advances through basic research have elucidated the disturbances of neurotransmitter function in Parkinson's Dopamine has replaced acetylcholine and norepinephrine as the most studied neurotransmitter, with both conceptual and practical developments, exemplified by the hypothesis of cyclic adenosine monophosphate as a...

journal_title：Annals of internal medicine

authors： Calne DB,Kebabian J,Silbergeld E,Evarts E

更新日期：1979-02-01 00:00:00

abstract：:Type 2 diabetes mellitus is a chronic metabolic disorder that results from defects in both insulin secretion and insulin action. An elevated rate of basal hepatic glucose production in the presence of hyperinsulinemia is the primary cause of fasting hyperglycemia; after a meal, impaired suppression of hepatic glucose ...

journal_title：Annals of internal medicine

authors： DeFronzo RA

更新日期：1999-08-17 00:00:00

abstract：:During a 6-month period in 1983, Escherichia coli O157:H7 was isolated from 19 (15%) of 125 patients with grossly bloody diarrhea and 1 sibling with non-bloody diarrhea in the Calgary area. There was no clustering of the cases geographically or in time. All but 1 had clinical manifestations typical of hemorrhagic coli...

journal_title：Annals of internal medicine

authors： Pai CH,Gordon R,Sims HV,Bryan LE

更新日期：1984-12-01 00:00:00

abstract：:Four hundred sixty patients and staff from 15 U.S. dialysis centers were surveyed by the immune adherence hemagglutination technique for antibody to hepatitis A antigen (anti-HA). The age-standardized anti-HA prevalence was 42.9% in patients and 42.1% in staff. These rates are almost identical to those of socioeconomi...

journal_title：Annals of internal medicine

authors： Szmuness W,Dienstag JL,Purcell RH,Prince AM,Stevens CE,Levine RW

更新日期：1977-07-01 00:00:00

abstract：BACKGROUND:Benign reductions in neutrophil counts may be more common at certain ages and in certain ethnic groups and may be affected by sex and smoking status. OBJECTIVE:To determine differences in neutrophil counts in the U.S. population according to ethnicity, age, sex, and smoking status. DESIGN:Population-based,...

journal_title：Annals of internal medicine

authors： Hsieh MM,Everhart JE,Byrd-Holt DD,Tisdale JF,Rodgers GP

更新日期：2007-04-03 00:00:00

abstract：STUDY OBJECTIVE:To determine the clinical variables affecting outcome after balloon aortic valvuloplasty. DESIGN:Longitudinal follow-up of consecutive case series. PATIENTS:Consecutive sample of 36 patients with severe calcific aortic stenosis, and without active infection or left ventricular mural thrombus. INTERVE...

journal_title：Annals of internal medicine

authors： Sherman W,Hershman R,Lazzam C,Cohen M,Ambrose J,Gorlin R

更新日期：1989-03-15 00:00:00

abstract：OBJECTIVE:To determine whether diabetic patients, when compared with nondiabetic patients, have a higher incidence of restenosis after coronary stenting, and, if so, whether restenosis is attributable to lesion or procedural differences or to a greater biologic tendency for late loss of minimum diameter in diabetic pat...

journal_title：Annals of internal medicine

authors： Carrozza JP Jr,Kuntz RE,Fishman RF,Baim DS

更新日期：1993-03-01 00:00:00

abstract：:During the early 1990s, the U.S. government addressed the issue of providing universal health care to all its citizens. Although this issue has not been completely resolved, centralization of electronic data and sharing of health care information among insurers and providers have been pursued. The emergence of electro...

journal_title：Annals of internal medicine

authors： Gostin L

更新日期：1997-10-15 00:00:00

abstract：:Because of difficulties in antemortem diagnosis of systemic aspergillosis, a radioimmunoassay to an Aspergillus fumigatus carbohydrate was developed and evaluated in patients with mycotic or bacterial infections. Antigenemia was detected in sera obtained antemortem from four of seven patients with systemic aspergillos...

journal_title：Annals of internal medicine

authors： Weiner MH

更新日期：1980-06-01 00:00:00

abstract：DESCRIPTION:Update of the 2009 U.S. Preventive Services Task Force (USPSTF) recommendation on screening for breast cancer. METHODS:The USPSTF reviewed the evidence on the following: effectiveness of breast cancer screening in reducing breast cancer-specific and all-cause mortality, as well as the incidence of advanced...

journal_title：Annals of internal medicine

authors： Siu AL,U.S. Preventive Services Task Force.

更新日期：2016-02-16 00:00:00

abstract：:The U.S. Preventive Services Task Force (USPSTF) makes recommendations on which preventive services to routinely incorporate into primary care for specific populations. Behavioral counseling interventions are preventive services designed to help persons engage in healthy behaviors and limit unhealthy ones. The USPSTF'...

journal_title：Annals of internal medicine

authors： Curry SJ,Grossman DC,Whitlock EP,Cantu A

更新日期：2014-03-18 00:00:00

abstract：BACKGROUND:The appropriate roles for several diagnostic tests for coronary disease are uncertain. OBJECTIVE:To evaluate the cost-effectiveness of alternative approaches to diagnosis of coronary disease. DESIGN:Meta-analysis of the accuracy of alternative diagnostic tests plus decision analysis to assess the health ou...

journal_title：Annals of internal medicine

authors： Garber AM,Solomon NA

更新日期：1999-05-04 00:00:00

abstract：BACKGROUND:Clinical trial registries are in widespread use to promote transparency around trials and their results. OBJECTIVE:To describe characteristics of drug trials listed in ClinicalTrials.gov and examine whether the funding source of these trials is associated with favorable published outcomes. DESIGN:An observ...

journal_title：Annals of internal medicine

authors： Bourgeois FT,Murthy S,Mandl KD

更新日期：2010-08-03 00:00:00

abstract：PURPOSE:It is currently unknown whether intensive insulin treatment of diabetes decreases the risk for cardiovascular complications by lowering glucose levels or increases the risk by postulated direct atherogenic effects. This article reviews published data from two long-term, randomized clinical trials that compared ...

journal_title：Annals of internal medicine

authors： Genuth S

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:To critically evaluate the evidence for recommending the screening of asymptomatic men for prostate cancer with a blood test to detect a prostate-specific antigen (PSA). DATA SOURCES:Relevant articles on screening for prostate cancer were identified from MEDLINE searches, from the authors' files, and from th...

journal_title：Annals of internal medicine

authors： Kramer BS,Brown ML,Prorok PC,Potosky AL,Gohagan JK

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:The optimal strategy to prevent recurrent presumed paradoxical emboli in patients with patent foramen ovale is unknown. PURPOSE:To synthesize the current knowledge about and qualitatively assess the relative benefits of transcatheter closure versus medical therapy for patent foramen ovale. DATA SOURCES:Eng...

journal_title：Annals of internal medicine

authors： Khairy P,O'Donnell CP,Landzberg MJ

更新日期：2003-11-04 00:00:00

abstract：Background:Biosimilars are of growing clinical, regulatory, and commercial importance. Purpose:To summarize evidence about the bioequivalence between biosimilar and reference tumor necrosis factor-α (TNF-α) inhibitors. Data Sources:PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and LILACS from incept...

journal_title：Annals of internal medicine

authors： Chingcuanco F,Segal JB,Kim SC,Alexander GC

更新日期：2016-10-18 00:00:00

abstract：:Many health care professionals have sustained an almost single-minded conviction that disparities in access to health care across socioeconomic groups are the key reason for the major discrepancies in health status between wealthy persons and poor persons. Others, however, have argued that a host of factors work to cr...

journal_title：Annals of internal medicine

authors： Andrulis DP

更新日期：1998-09-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the efficacy of the addition of ifosfamide to cisplatin plus etoposide (VIP), or vinblastine (VeIP), in patients with recurrent germ cell tumors. DESIGN:Nonrandomized, prospective phase II trial. SETTING:Tertiary referral university hospital. PATIENTS:Fifty-six of fifty-eight entered pat...

journal_title：Annals of internal medicine

authors： Loehrer PJ Sr,Lauer R,Roth BJ,Williams SD,Kalasinski LA,Einhorn LH

更新日期：1988-10-01 00:00:00

abstract：:Very low calorie diets used to treat moderate and severe obesity produce average weight losses of 20 kg in 12 weeks. This paper reviews the development of very low calorie diets from research on fasting in the late 1950s and examines data on the amount of dietary protein needed to achieve positive nitrogen balance. Th...

journal_title：Annals of internal medicine

authors： Wadden TA,Stunkard AJ,Brownell KD

更新日期：1983-11-01 00:00:00

abstract：:Although many manifestations of giant cell arteries are increasingly recognized, little attention has been paid to respiratory symptoms associated with this disorder. We report the cases of 16 patients with giant cell arteritis who had prominent symptoms related to the respiratory tract including cough, sore throat, a...

journal_title：Annals of internal medicine

authors： Larson TS,Hall S,Hepper NG,Hunder GG

更新日期：1984-11-01 00:00:00

abstract：BACKGROUND:The effect of physician diagnostic variability on accuracy at a population level depends on the prevalence of diagnoses. OBJECTIVE:To estimate how diagnostic variability affects accuracy from the perspective of a U.S. woman aged 50 to 59 years having a breast biopsy. DESIGN:Applied probability using Bayes'...

journal_title：Annals of internal medicine

authors： Elmore JG,Nelson HD,Pepe MS,Longton GM,Tosteson AN,Geller B,Onega T,Carney PA,Jackson SL,Allison KH,Weaver DL

更新日期：2016-05-17 00:00:00

abstract：BACKGROUND:Lack of confidence in postpolypectomy surveillance guidelines may be a factor in the observed low adherence rates among providers. OBJECTIVE:To assess the 2006 postpolypectomy colonoscopy surveillance guidelines, which recommend 3-year follow-up colonoscopy for individuals with high-risk adenomas (defined a...

journal_title：Annals of internal medicine

authors： Laiyemo AO,Murphy G,Albert PS,Sansbury LB,Wang Z,Cross AJ,Marcus PM,Caan B,Marshall JR,Lance P,Paskett ED,Weissfeld J,Slattery ML,Burt R,Iber F,Shike M,Kikendall JW,Lanza E,Schatzkin A

更新日期：2008-03-18 00:00:00

abstract：:During a 21/2-year period, studies were done on 14 patients with chronic renal failure to evaluate pleural effusions which we believe were secondary to the uremic process. The patients with uremic pleural effusions closely resembled those in the group with chronic renal failure as a whole with respect to diagnosis and...

journal_title：Annals of internal medicine

authors： Berger HW,Rammohan G,Neff MS,Buhain WJ

更新日期：1975-03-01 00:00:00

abstract：:To assess the course and prognosis of salicylate-induced pulmonary edema, we reviewed the records of 36 consecutive patients admitted with serum salicylate levels greater than 30 mg/dL. Pulmonary edema developed in eight patients, and pulmonary infiltrates were never seen in 28 patients. Several features distinguished...

journal_title：Annals of internal medicine

authors： Heffner JE,Sahn SA

更新日期：1981-10-01 00:00:00

abstract：BACKGROUND:Telaprevir (TVR) plus peginterferon-α2a (PEG-IFN-α2a) and ribavirin substantially increases treatment efficacy for genotype 1 chronic hepatitis C virus (HCV) infection versus PEG-IFN-α2a-ribavirin alone. Its safety and efficacy in patients with HCV and HIV-1 are unknown. OBJECTIVE:To assess the safety and e...

journal_title：Annals of internal medicine

authors： Sulkowski MS,Sherman KE,Dieterich DT,Bsharat M,Mahnke L,Rockstroh JK,Gharakhanian S,McCallister S,Henshaw J,Girard PM,Adiwijaya B,Garg V,Rubin RA,Adda N,Soriano V

更新日期：2013-07-16 00:00:00

abstract：:Discovery of the factor V Leiden and prothrombin G20210A mutations has greatly increased the percentage of patients in whom venous thrombosis can be attributed to hereditary thrombophilia. The first step in the diagnostic approach to all patients with venous thrombosis consists of a careful history and physical examin...

journal_title：Annals of internal medicine

authors： Bauer KA

更新日期：2001-09-04 00:00:00

abstract：:Of 5379 patients who had received radiation treatment at our institution for benign conditions of the head and neck, 318 developed thyroid cancer 3 to 42 years later. We report follow-up observations (median interval from diagnosis to recurrence or last contact, 10 years; longest interval, 31) for 296 of these patient...

journal_title：Annals of internal medicine

authors： Schneider AB,Recant W,Pinsky SM,Ryo UY,Bekerman C,Shore-Freedman E

更新日期：1986-09-01 00:00:00

abstract：BACKGROUND:Four months of rifampin treatment for latent tuberculosis infection is safer, has superior treatment completion rates, and is as effective as 9 months of isoniazid. However, daily medication costs are higher for a 4-month rifampin regimen than a 9-month isoniazid regimen. OBJECTIVE:To compare health care us...

journal_title：Annals of internal medicine

authors： Bastos ML,Campbell JR,Oxlade O,Adjobimey M,Trajman A,Ruslami R,Kim HJ,Baah JO,Toelle BG,Long R,Hoeppner V,Elwood K,Al-Jahdali H,Apriani L,Benedetti A,Schwartzman K,Menzies D

更新日期：2020-08-04 00:00:00

abstract：:The mechanisms of flushing reactions are pharmacologically and physiologically heterogeneous. Flushing may result from agents acting directly on the vascular smooth muscle or may be mediated by vasomotor nerves. Vasomotor nerves may lead to flushing as a result of events at both peripheral and central sites. In suscep...

journal_title：Annals of internal medicine

authors： Wilkin JK

更新日期：1981-10-01 00:00:00