Hepatitis type A and hemodialysis: a seroepidemiologic study in 15 U.S. centers.

Abstract:

:Four hundred sixty patients and staff from 15 U.S. dialysis centers were surveyed by the immune adherence hemagglutination technique for antibody to hepatitis A antigen (anti-HA). The age-standardized anti-HA prevalence was 42.9% in patients and 42.1% in staff. These rates are almost identical to those of socioeconomically comparable urban volunteer blood donors never exposed to dialysis settings. There was no correlation between anti-HA prevalences and duration of dialysis treatment or employment. Among 100 patients and staff followed for 1 year 92% to 94% did not change their anti-HA status. The prevalence of anti-HA was identical in subjects with past histories of multiple blood transfusions or accidental inoculations with blood-contaminated instruments and in those without such histories. We conclude that hepatitis A virus rarely if every spreads by parenteral mechanisms, that there is no epidemiologic evidence confirming the existence of chronic hepatitis A viremic carrier states, and that hemodialysis does not play a significant role in the spread of type A hepatitis.

journal_name

Ann Intern Med

authors

Szmuness W,Dienstag JL,Purcell RH,Prince AM,Stevens CE,Levine RW

doi

10.7326/0003-4819-87-1-8

subject

Has Abstract

pub_date

1977-07-01 00:00:00

pages

8-12

issue

1

eissn

0003-4819

issn

1539-3704

journal_volume

87

pub_type

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