Cyclophosphamide in the management of advanced Graves' ophthalmopathy. A preliminary report.

Abstract:

:Three patients with advanced Graves' ophthalmopathy were treated with cyclophosphamide. All had proptosis and diplopia. One patient had disabling iatrogenic Cushing's syndrome from steroid treatment of the ophthalmopathy and had undergone bilateral orbital decompression before cyclophosphamide therapy; steroids could not subsequently be withdrawn. When cyclophosphamide was administered to the cushingoid patient, withdrawal of glucocorticoid therapy was then possible. Diplopia completely resolved in two patients and improved in the third coincident with administration of cyclophosphamide. Deteriorating visual acuity resolved in one patient. Chemosis improved in the two affected patients. Proptosis was unchanged in all three patients. Cyclophosphamide deserves further study as a therapeutic agent in Graves' disease.

journal_name

Ann Intern Med

authors

Bigos ST,Nisula BC,Daniels GH,Eastman RC,Johnston HH,Kohler PO

doi

10.7326/0003-4819-90-6-921

subject

Has Abstract

pub_date

1979-06-01 00:00:00

pages

921-3

issue

6

eissn

0003-4819

issn

1539-3704

journal_volume

90

pub_type

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