The case for treating tobacco dependence as a chronic disease.

abstract：:We treated 289 men with nongonococcal urethritis in a randomized, double-blind study with minocycline, 100 mg once or twice daily for 7 or 21 days. Ureaplasma urealyticum was isolated before treatment from 167 (58%). The pretherapy isolates from 82 men re-examined 6 to 8 days after initiation of treatment were viable....

journal_title：Annals of internal medicine

authors： Stimson JB,Hale J,Bowie WR,Holmes KK

更新日期：1981-02-01 00:00:00

abstract：:Two-dimensional echocardiograms were done during rest and after exercise in 95 patients who subsequently had coronary arteriography. Prior myocardial infarction was present in 36 patients, 35 of whom had wall motion abnormalities. There was no evidence of prior infarction in 59 patients, 44 of whom had coronary diseas...

journal_title：Annals of internal medicine

authors： Armstrong WF,O'Donnell J,Dillon JC,McHenry PL,Morris SN,Feigenbaum H

更新日期：1986-12-01 00:00:00

abstract：:Although thyroid nodules are common, few are malignant and require surgical treatment. A systematic approach to their evaluation is important to avoid unnecessary surgery. Fine-needle aspiration biopsy has resulted in substantial improvements in diagnostic accuracy, cost reductions, and higher malignancy yield at time...

journal_title：Annals of internal medicine

authors： Castro MR,Gharib H

更新日期：2005-06-07 00:00:00

abstract：:Folate deficiency is a frequent cause of anemia in alcoholics, but little attention has been paid to its prevention. Folic acid was readily soluble in wines of high ethanol content at concentrations of 10 microgram/ml. Lactobacillus casei folate activity of folic acid added to wines was well maintained during a month'...

journal_title：Annals of internal medicine

authors： Kaunitz JD,Lindenbaum J

更新日期：1977-11-01 00:00:00

abstract：:During the National Cooperative Gallstone Study, therapy with chenodiol, 750 or 375 mg/d, for 2 years resulted in confirmed, complete gallstone dissolution in 14% and 5% of patients, respectively, and partial dissolution (greater than 50%) in 27% and 18%. The present study was done to determine the frequency with whic...

journal_title：Annals of internal medicine

authors： Marks JW,Baum RA,Hanson RF,Hersh T,Hightower NC Jr,Mekhjian H,Schaefer RA,Soloway RD,Thistle JL,Thomas FB

更新日期：1984-03-01 00:00:00

abstract：BACKGROUND:Although several agents are available to treat osteoporosis, the relative efficacy and toxicity of these agents when used to prevent fractures has not been well described. PURPOSE:To compare the benefits in fracture reduction and the harms from adverse events of various therapies for osteoporosis. DATA SOU...

journal_title：Annals of internal medicine

authors： MacLean C,Newberry S,Maglione M,McMahon M,Ranganath V,Suttorp M,Mojica W,Timmer M,Alexander A,McNamara M,Desai SB,Zhou A,Chen S,Carter J,Tringale C,Valentine D,Johnsen B,Grossman J

更新日期：2008-02-05 00:00:00

abstract：:In September 1978, cases of hepatitis B in two patients treated by the same dentist led to investigation of a dental practice in Baltimore, Maryland. The dentist had had acute hepatitis B in June 1978 and had remained positive for hepatitis B surface antigen and hepatitis B e antigen over the ensuing 6 months. He had ...

journal_title：Annals of internal medicine

authors： Hadler SC,Sorley DL,Acree KH,Webster HM,Schable CA,Francis DP,Maynard JE

更新日期：1981-08-01 00:00:00

abstract：:Nine of 81 members of two families were found to have renal problems. Three patients in one family had renal-retinal dysplasia with probable recessive inheritance. Of the 6 patients in the second family, one received a kidney transplant from his brother who initially had no detectable renal abnormality but later devel...

journal_title：Annals of internal medicine

authors： Avasthi PS,Erickson DG,Gardner KD

更新日期：1976-02-01 00:00:00

abstract：:Glomerular-fixed antibody was eluted from the kidney of a 17-year-old patient who died 2 weeks after the onset of acute poststreptococcal glomerulonephritis. Elevated titers of antibodies to streptococcal enzymes were found in the serum but not in the glomerular eluate. Streptococcal M protein and anti-M protein react...

journal_title：Annals of internal medicine

authors： Rodríguez-Iturbe B,Rabideau D,García R,Rubio L,McIntosh RM

更新日期：1980-04-01 00:00:00

abstract：:Implantable cardioverter defibrillators are life-saving devices for many patients with cardiac disease. Recipients of these devices, nevertheless, often suffer from progressive comorbid and cardiac conditions. Therefore, physicians should anticipate situations in which the defibrillator is no longer desired by the pat...

journal_title：Annals of internal medicine

authors： Berger JT

更新日期：2005-04-19 00:00:00

abstract：:To understand the factors that distinguish terminally ill, incompetent patients who are given do-not-resuscitate status by physicians against the wishes of the patient's family, I reviewed the charts of 20 such patients (cases) seen in consultation by the ethics committee at the Massachusetts General Hospital over 10 ...

journal_title：Annals of internal medicine

authors： Brennan TA

更新日期：1988-11-15 00:00:00

abstract：BACKGROUND:The National Kidney Foundation has advocated the use of the abbreviated Modification of Diet in Renal Disease (MDRD) equation to estimate glomerular filtration rate (GFR) from serum creatinine measurements in clinical laboratories. However, healthy persons were not included in the development of the MDRD equ...

journal_title：Annals of internal medicine

authors： Rule AD,Larson TS,Bergstralh EJ,Slezak JM,Jacobsen SJ,Cosio FG

更新日期：2004-12-21 00:00:00

abstract：BACKGROUND:Cardiovascular disease (CVD) is the leading cause of death in the United States. PURPOSE:To update a systematic review about the benefits of aspirin for the primary prevention of cardiovascular events in adults aged 40 years or older and to evaluate effect modification in subpopulations. DATA SOURCES:MEDLI...

journal_title：Annals of internal medicine

authors： Guirguis-Blake JM,Evans CV,Senger CA,O'Connor EA,Whitlock EP

更新日期：2016-06-21 00:00:00

abstract：:Four hemodialysis patients receiving deferoxamine for metal overload had fatal rhinocerebral rhizopus infections. Serious fungal infections are not commonly seen in patients on dialysis, and none of these patients had the usual risk factors for rhizopus infection. Deferoxamine is being used with increased frequency in...

journal_title：Annals of internal medicine

authors： Windus DW,Stokes TJ,Julian BA,Fenves AZ

更新日期：1987-11-01 00:00:00

abstract：:The 1950s witnessed prodigious growth in our knowledge of the chemical nature of the gene, the mechanisms by which the information inherent in its sequence of nucleotide units was conveyed to the cell's machinery for synthesizing proteins, and the mode of operation of that machinery. Watson and Crick raised the curtai...

journal_title：Annals of internal medicine

authors： Hoagland MB

更新日期：2003-04-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the efficacy of the addition of ifosfamide to cisplatin plus etoposide (VIP), or vinblastine (VeIP), in patients with recurrent germ cell tumors. DESIGN:Nonrandomized, prospective phase II trial. SETTING:Tertiary referral university hospital. PATIENTS:Fifty-six of fifty-eight entered pat...

journal_title：Annals of internal medicine

authors： Loehrer PJ Sr,Lauer R,Roth BJ,Williams SD,Kalasinski LA,Einhorn LH

更新日期：1988-10-01 00:00:00

abstract：DESCRIPTION:Updated U.S. Preventive Services Task Force (USPSTF) recommendation about screening for type 2 diabetes mellitus in adults. METHODS:To estimate the balance of benefits and harms of screening, the USPSTF updated its 2003 evidence review, adding evidence from new trials as well as updates on earlier studies....

journal_title：Annals of internal medicine

authors： U.S. Preventive Services Task Force.

更新日期：2008-06-03 00:00:00

abstract：STUDY OBJECTIVE:To define the clinical and hematologic effects of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) on patients with chronic severe neutropenia. DESIGN:Open-label, phase II study of rhGM-CSF. SETTING:Inpatient hematology and surgery clinic at a university medical center. P...

journal_title：Annals of internal medicine

authors： Ganser A,Ottmann OG,Erdmann H,Schulz G,Hoelzer D

更新日期：1989-12-01 00:00:00

abstract：Background:Frailty assessment may inform surgical risk and prognosis not captured by conventional surgical risk scores. Purpose:To evaluate the evidence for various frailty instruments used to predict mortality, functional status, or major adverse cardiovascular and cerebrovascular events (MACCEs) in older adults unde...

journal_title：Annals of internal medicine

authors： Kim DH,Kim CA,Placide S,Lipsitz LA,Marcantonio ER

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Although viral rebound follows cessation of suppressive antiretroviral therapy in chronic HIV infection, a viremic clinical syndrome has not been described. OBJECTIVE:To describe a retroviral syndrome associated with cessation of effective antiretroviral therapy in chronic HIV infection. DESIGN:Case report...

journal_title：Annals of internal medicine

authors： Colven R,Harrington RD,Spach DH,Cohen CJ,Hooton TM

更新日期：2000-09-19 00:00:00

abstract：:Infection with human immunodeficiency virus (HIV) may cause viral antigenemia, detected primarily as p24 viral core protein. Among 16 patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex studied serially, 12 had or developed antigenemia ranging from 16 to 3006 pg/mL in plasma. The level ...

journal_title：Annals of internal medicine

authors： Jackson GG,Paul DA,Falk LA,Rubenis M,Despotes JC,Mack D,Knigge M,Emeson EE

更新日期：1988-02-01 00:00:00

abstract：PURPOSE:It is currently unknown whether intensive insulin treatment of diabetes decreases the risk for cardiovascular complications by lowering glucose levels or increases the risk by postulated direct atherogenic effects. This article reviews published data from two long-term, randomized clinical trials that compared ...

journal_title：Annals of internal medicine

authors： Genuth S

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:To determine whether oral acyclovir reduces the incidence of recurrent herpes labialis in otherwise healthy patients with proven frequently recurrent disease. DESIGN:Randomized, double-blind, placebo-controlled, crossover trial. SETTING:Outpatient facility of the Clinical Center, National Institutes of Heal...

journal_title：Annals of internal medicine

authors： Rooney JF,Straus SE,Mannix ML,Wohlenberg CR,Alling DW,Dumois JA,Notkins AL

更新日期：1993-02-15 00:00:00

abstract：OBJECTIVE:To determine whether growth hormone replacement in older men improves functional ability. DESIGN:Randomized, controlled, double-blind trial. SETTING:General community. PATIENTS:52 healthy men older than 69 years of age with well-preserved functional ability but low baseline insulin-like growth factor 1 lev...

journal_title：Annals of internal medicine

authors： Papadakis MA,Grady D,Black D,Tierney MJ,Gooding GA,Schambelan M,Grunfeld C

更新日期：1996-04-15 00:00:00

abstract：:Two patients referred for cancer chemotherapy were found to be chronic, asymptomatic hepatitis B surface antigen (HBsAg) carriers. They had normal serum aminotransferase levels, but their sera were positive for HGsAg and antibody to hepatitis B e antigen. Both patients developed acute, icteric hepatitis within 3 month...

journal_title：Annals of internal medicine

authors： Hoofnagle JH,Dusheiko GM,Schafer DF,Jones EA,Micetich KC,Young RC,Costa J

更新日期：1982-04-01 00:00:00

abstract：BACKGROUND:Introduction of a universal varicella vaccine program for U.S. children in 1996 sparked concern that less-frequent exposure to varicella would decrease external boosting of immunity to varicella zoster virus and thereby increase incidence of herpes zoster (HZ). OBJECTIVE:To determine whether the varicella v...

journal_title：Annals of internal medicine

authors： Hales CM,Harpaz R,Joesoef MR,Bialek SR

更新日期：2013-12-03 00:00:00

abstract：STUDY OBJECTIVE:To determine the effectiveness of chemotherapy and adjunctive surgery in managing patients with advanced seminoma. DESIGN:Nonrandomized prospective clinical trial of chemotherapy in a cohort of patients with advanced seminoma. SETTING:Referral cancer hospital. PATIENTS:Consecutive sample of 62 patien...

journal_title：Annals of internal medicine

authors： Motzer RJ,Bosl GJ,Geller NL,Penenberg D,Yagoda A,Golbey R,Whitmore WF Jr,Fair WR,Sogani P,Herr H

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND:It is unclear whether patients understand that percutaneous coronary intervention (PCI) reduces only chronic stable angina and not myocardial infarction (MI) or associated mortality. OBJECTIVE:To compare cardiologists' and patients' beliefs about PCI. DESIGN:Survey. SETTING:Academic center. PARTICIPANTS:...

journal_title：Annals of internal medicine

authors： Rothberg MB,Sivalingam SK,Ashraf J,Visintainer P,Joelson J,Kleppel R,Vallurupalli N,Schweiger MJ

更新日期：2010-09-07 00:00:00

abstract：:The systemic capillary leak syndrome (SCLS) is a rare disease of reversible plasma extravasation and vascular collapse accompanied by hemoconcentration and hypoalbuminemia. Its cause is unknown, although it is believed to be a manifestation of transient endothelial dysfunction due to endothelial contraction, apoptosis...

journal_title：Annals of internal medicine

authors： Druey KM,Greipp PR

更新日期：2010-07-20 00:00:00

abstract：:Meningitis caused by enteric gram-negative bacilli is relatively uncommon but is very difficult to treat despite susceptibility in vitro to many antimicrobics. A major problem appears to be poor entry of many drugs into the central nervous system. Moxalactam is an investigational cephalosporin that attains concentrati...

journal_title：Annals of internal medicine

authors： Olson DA,Hoeprich PD,Nolan SM,Goldstein E

更新日期：1981-09-01 00:00:00