Advanced seminoma: the role of chemotherapy and adjunctive surgery.

Abstract:

STUDY OBJECTIVE:To determine the effectiveness of chemotherapy and adjunctive surgery in managing patients with advanced seminoma. DESIGN:Nonrandomized prospective clinical trial of chemotherapy in a cohort of patients with advanced seminoma. SETTING:Referral cancer hospital. PATIENTS:Consecutive sample of 62 patients with primary extragonadal, stage IIC (greater than 5-cm retroperitoneal adenopathy) and stage III seminoma; 45 patients were previously untreated, 13 had received radiotherapy, and 4 had previously received radiotherapy and chemotherapy. INTERVENTION:Cisplatin-based chemotherapy (100 to 120 mg/m2 body surface area per cycle of treatment); 45 patients received vinblastine, bleomycin, cisplatin, dactinomycin, and cyclophosphamide; 15, etoposide and cisplatin; and 2, both regimens. MEASUREMENTS AND MAIN RESULTS:Fifty-three of the sixty (88%) evaluable patients achieved a complete remission, and only 6 patients had relapses. Fifty-three of the sixty-two patients (85%) remain alive and disease-free. The regimen of etoposide and cisplatin was equivalent to regimens using more drugs. An elevated level of human chorionic gonadotropin at the initiation of treatment was associated with a worse prognosis. CONCLUSIONS:Cisplatin-based chemotherapy is effective treatment for patients with extragonadal, stage IIC, and stage III seminoma and should be considered as initial therapy.

journal_name

Ann Intern Med

authors

Motzer RJ,Bosl GJ,Geller NL,Penenberg D,Yagoda A,Golbey R,Whitmore WF Jr,Fair WR,Sogani P,Herr H

doi

10.7326/0003-4819-108-4-513

subject

Has Abstract,Author List Incomplete

pub_date

1988-04-01 00:00:00

pages

513-8

issue

4

eissn

0003-4819

issn

1539-3704

journal_volume

108

pub_type

杂志文章
  • Drug evaluation after marketing.

    abstract::After marketing, drugs should be evaluated for safety and for efficacy. Present national systems are inadequate for both tasks. Safety can be evaluated by means of nonexperimental research, whereas evaluation of efficacy in a variety of settings representing normal medical practice generally requires experiments, rand...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-90-2-257

    authors: Slone D,Shapiro S,Miettinen OS,Finkle WD,Stolley PD

    更新日期:1979-02-01 00:00:00

  • General internal medicine and general internists: recognizing a national need. Federated Council for Internal Medicine.

    abstract::The Federated Council for Internal Medicine (FCIM) comprises the American Board of Internal Medicine, American College of Physicians, American Society of Internal Medicine, Association of Professors of Medicine, Association of Program Directors in Internal Medicine, and the Society of General Internal Medicine. The Co...

    journal_title:Annals of internal medicine

    pub_type: 指南,杂志文章

    doi:10.7326/0003-4819-117-9-778

    authors:

    更新日期:1992-11-01 00:00:00

  • Management of influenza in adults older than 65 years of age: cost-effectiveness of rapid testing and antiviral therapy.

    abstract:BACKGROUND:Although antiviral therapy is cost-effective in adults, its cost-effectiveness in older adults has not been studied. OBJECTIVE:To determine the cost-effectiveness of influenza testing and treatment strategies for older adults. DESIGN:Cost-utility decision model. DATA SOURCES:Clinical trials of antiviral d...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-139-5_part_1-200309020-00007

    authors: Rothberg MB,Bellantonio S,Rose DN

    更新日期:2003-09-02 00:00:00

  • The ethics of using quality improvement methods in health care.

    abstract::Quality improvement (QI) activities can improve health care but must be conducted ethically. The Hastings Center convened leaders and scholars to address ethical requirements for QI and their relationship to regulations protecting human subjects of research. The group defined QI as systematic, data-guided activities d...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-146-9-200705010-00155

    authors: Lynn J,Baily MA,Bottrell M,Jennings B,Levine RJ,Davidoff F,Casarett D,Corrigan J,Fox E,Wynia MK,Agich GJ,O'Kane M,Speroff T,Schyve P,Batalden P,Tunis S,Berlinger N,Cronenwett L,Fitzmaurice JM,Dubler NN,James B

    更新日期:2007-05-01 00:00:00

  • Primary care residency training: the first five years.

    abstract::The training of physicians for the delivery of primary care is becoming a national priority. The period of residency training is viewed by many as the focal point for educational change to meet this demand. The Residency Program in Social Medicine at Montefiore Hospital and Medical Center was begun in 1970 and offers ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-87-3-359

    authors: Boufford JI

    更新日期:1977-09-01 00:00:00

  • Emerging magnetic resonance imaging technologies for musculoskeletal imaging under loading stress: scope of the literature.

    abstract::Imaging under loading stress is hypothesized to improve the diagnostic value of magnetic resonancel imaging (MRI) for musculoskeletal conditions. This article reviews 57 studies about MRI under physiologic loading stress performed in an upright or sitting position or under axial loading by using a compression device. ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-155-9-201111010-00009

    authors: Dahabreh IJ,Hadar N,Chung M

    更新日期:2011-11-01 00:00:00

  • An evidence-based guide to writing grant proposals for clinical research.

    abstract::The competition for funds to conduct clinical research is intense, and only a minority of grant proposals receive funding. In particular, funding for patient-oriented research lags behind that allocated for basic science research. Grant writing is a skill of fundamental importance to the clinical researcher, and condu...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-142-4-200502150-00009

    authors: Inouye SK,Fiellin DA

    更新日期:2005-02-15 00:00:00

  • A randomized, double-blind, placebo-controlled trial of rifaximin to prevent travelers' diarrhea.

    abstract:BACKGROUND:Travelers' diarrhea causes substantial morbidity and postinfectious irritable bowel syndrome. OBJECTIVE:To evaluate nonabsorbable rifaximin for prevention of travelers' diarrhea. DESIGN:Randomized, double-blind, placebo-controlled clinical trial. SETTING:Guadalajara, Mexico. PARTICIPANTS:U.S. students. ...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.7326/0003-4819-142-10-200505170-00005

    authors: DuPont HL,Jiang ZD,Okhuysen PC,Ericsson CD,de la Cabada FJ,Ke S,DuPont MW,Martinez-Sandoval F

    更新日期:2005-05-17 00:00:00

  • Human babesiosis on Nantucket Island. Clinical features.

    abstract::Between 20 July and 15 Octoboer 1975, five cases of human infection with Babesia microti were diagnosed on Nantucket Island, Massachusetts. The illness was characterized by fever, drenching sweats, shaking chills, myalgia, arthralgia, extreme fatigue, and a mild-to-moderate hemolytic anemia. None of the patients had a...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-86-1-6

    authors: Reubush TK 2nd,Cassaday PB,Marsh HJ,Lisker SA,Voorhees DB,Mahoney EB,Healy GR

    更新日期:1977-01-01 00:00:00

  • A highly automated hospital medication system. Five years' experience and evaluation.

    abstract::Since 1969, medications have been provided to patients at the Johns Hopkins Hospital using a computer system that controls the entire medication process from entry of physician's order to hourly drug distribution. Special envelopes containing patient and dosage information are computer generated for each dose to be ad...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-83-3-342

    authors: Simborg DW,Derewicz HJ

    更新日期:1975-09-01 00:00:00

  • Prevalence of advanced colorectal neoplasia in white and black patients undergoing screening colonoscopy in a safety-net hospital.

    abstract:UNLABELLED:Chinese translation BACKGROUND:Black persons are more likely than white persons to be diagnosed with colorectal cancer and to die from it. The extent to which genetic or biological factors versus disparities in screening rates explain this variance remains controversial. OBJECTIVE:To define the prevalence ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-159-1-201307020-00004

    authors: Schroy PC 3rd,Coe A,Chen CA,O'Brien MJ,Heeren TC

    更新日期:2013-07-02 00:00:00

  • Trajectories of life-space mobility after hospitalization.

    abstract:BACKGROUND:Life space is a measure of where a person goes, the frequency of going there, and the dependency in getting there. It may be a more accurate measure of mobility in older adults because it reflects participation in society as well as physical ability. OBJECTIVE:To assess effects of hospitalization on life sp...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-150-6-200903170-00005

    authors: Brown CJ,Roth DL,Allman RM,Sawyer P,Ritchie CS,Roseman JM

    更新日期:2009-03-17 00:00:00

  • Extended-duration venous thromboembolism prophylaxis in acutely ill medical patients with recently reduced mobility: a randomized trial.

    abstract:BACKGROUND:Extended-duration low-molecular-weight heparin has been shown to prevent venous thromboembolism (VTE) in high-risk surgical patients. OBJECTIVE:To evaluate the efficacy and safety of extended-duration enoxaparin thromboprophylaxis in acutely ill medical patients. DESIGN:Randomized, parallel, placebo-contro...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.7326/0003-4819-153-1-201007060-00004

    authors: Hull RD,Schellong SM,Tapson VF,Monreal M,Samama MM,Nicol P,Vicaut E,Turpie AG,Yusen RD,EXCLAIM (Extended Prophylaxis for Venous ThromboEmbolism in Acutely Ill Medical Patients With Prolonged Immobilization) study.

    更新日期:2010-07-06 00:00:00

  • Prospective study of color duplex ultrasonography compared with contrast venography in patients suspected of having deep venous thrombosis of the upper extremities.

    abstract:BACKGROUND:The optimal strategy for diagnosis of deep venous thrombosis (DVT) is less well established for the upper extremities than for the lower extremities. Duplex color ultrasonography can be difficult to perform in the upper extremities because of their anatomy, and contrast venography is often indicated. Moreove...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-136-12-200206180-00007

    authors: Baarslag HJ,van Beek EJ,Koopman MM,Reekers JA

    更新日期:2002-06-18 00:00:00

  • Medical ethics and human rights violations: the Iraqi occupation of Kuwait and its aftermath.

    abstract::Immediately after the liberation of Kuwait by a coalition of allied forces in March 1991, representatives of Physicians for Human Rights traveled to Kuwait and conducted an inquiry into human rights violations allegedly perpetrated by Iraqi forces. The inquiry focused on the abuses that were said to have occurred in h...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-117-1-78

    authors: Brennan TA,Kirschner R

    更新日期:1992-07-01 00:00:00

  • Efficacy and safety of enoxaparin to prevent deep venous thrombosis after hip replacement surgery. Enoxaparin Clinical Trial Group.

    abstract:OBJECTIVE:To determine the most effective and safe dose of enoxaparin to prevent deep venous thrombosis in high-risk surgical patients. DESIGN:A double-blind, randomized, multicenter clinical trial. SETTING:Private, university, and government hospitals in the United States. PATIENTS:572 patients having elective hip ...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.7326/0003-4819-121-2-199407150-00001

    authors: Spiro TE,Johnson GJ,Christie MJ,Lyons RM,MacFarlane DE,Blasier RB,Tremaine MD

    更新日期:1994-07-15 00:00:00

  • Physiotherapist-directed exercise, advice, or both for subacute low back pain: a randomized trial.

    abstract:BACKGROUND:Advice and exercise are widely recommended for subacute low back pain, but the effectiveness of these interventions is unclear. OBJECTIVE:To investigate the effectiveness of physiotherapist-prescribed exercise, advice, or both for subacute low back pain. DESIGN:Factorial randomized, placebo-controlled tria...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.7326/0003-4819-146-11-200706050-00007

    authors: Pengel LH,Refshauge KM,Maher CG,Nicholas MK,Herbert RD,McNair P

    更新日期:2007-06-05 00:00:00

  • Discontinuation of chemoprophylaxis against Pneumocystis carinii pneumonia in patients with HIV infection. HIV Outpatient Study (HOPS) Investigators.

    abstract:BACKGROUND:HIV-infected patients with sustained immunologic improvement from antiretroviral therapy may be able to discontinue chemoprophylaxis against Pneumocystis carinii pneumonia (PCP). OBJECTIVE:To compare PCP incidence in HIV-infected patients who had sustained CD4+ lymphocyte counts greater than 200 cells/mm3 a...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-132-3-200002010-00005

    authors: Yangco BG,Von Bargen JC,Moorman AC,Holmberg SD

    更新日期:2000-02-01 00:00:00

  • Hypophosphatemic osteomalacia: association with prostatic carcinoma.

    abstract::Hypophosphatemic osteomalacia that remits after resection of a coexisting tumor has been described in 35 patients. Because the associated neoplasms have been of mesenchymal origin, it has been inferred that this tumor-induced osteomalacia syndrome is uniquely related to tumours of this derivation. However, in the pres...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-93-2-275

    authors: Lyles KW,Berry WR,Haussler M,Harrelson JM,Drezner MK

    更新日期:1980-08-01 00:00:00

  • Comparison of Knowledge and Information-Seeking Behavior After General COVID-19 Public Health Messages and Messages Tailored for Black and Latinx Communities : A Randomized Controlled Trial.

    abstract:BACKGROUND:The paucity of public health messages that directly address communities of color might contribute to racial and ethnic disparities in knowledge and behavior related to coronavirus disease 2019 (COVID-19). OBJECTIVE:To determine whether physician-delivered prevention messages affect knowledge and information...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/M20-6141

    authors: Alsan M,Stanford FC,Banerjee A,Breza E,Chandrasekhar AG,Eichmeyer S,Goldsmith-Pinkham P,Ogbu-Nwobodo L,Olken BA,Torres C,Sankar A,Vautrey PL,Duflo E

    更新日期:2020-12-21 00:00:00

  • Prevention of exacerbations of chronic obstructive pulmonary disease with tiotropium, a once-daily inhaled anticholinergic bronchodilator: a randomized trial.

    abstract:BACKGROUND:Patients with chronic obstructive pulmonary disease (COPD) frequently develop exacerbations, leading to major clinical and health resource use ramifications. OBJECTIVE:To prospectively evaluate the effectiveness of a long-acting inhaled anticholinergic bronchodilator, tiotropium, in reducing COPD exacerbati...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.7326/0003-4819-143-5-200509060-00007

    authors: Niewoehner DE,Rice K,Cote C,Paulson D,Cooper JA Jr,Korducki L,Cassino C,Kesten S

    更新日期:2005-09-06 00:00:00

  • Radiation-induced thyroid carcinoma. Clinical course and results of therapy in 296 patients.

    abstract::Of 5379 patients who had received radiation treatment at our institution for benign conditions of the head and neck, 318 developed thyroid cancer 3 to 42 years later. We report follow-up observations (median interval from diagnosis to recurrence or last contact, 10 years; longest interval, 31) for 296 of these patient...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-105-3-405

    authors: Schneider AB,Recant W,Pinsky SM,Ryo UY,Bekerman C,Shore-Freedman E

    更新日期:1986-09-01 00:00:00

  • Infections related to medical devices.

    abstract::Medical devices have become an integral part of hospital-based care but also predispose patients to more than 850 000 device-related infections annually. Devices predispose to infection by damaging or invading epithelial and mucosal barriers to infection, by supporting growth of microorganisms and thus serving as rese...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-89-5-764

    authors: Stamm WE

    更新日期:1978-11-01 00:00:00

  • Cortisol suppression test in patients with elevated adrenocorticotropic hormone levels.

    abstract::Increased adrenocorticotropic hormone (ACTH) levels after bilateral adrenalectomy could be secondary to a pituitary tumor, under replacement with cortisol, or an abnormality in the hypothalamic-pituitary-adrenal feedback loop. To distinguish between these possibilities, ACTH levels were measured before and after corti...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-96-3-277

    authors: Koletsky RJ,Dluhy RG,Crantz FR,Williams GH

    更新日期:1982-03-01 00:00:00

  • Guidelines for the care of patients hospitalized with viral hepatitis.

    abstract::For years patients hospitalized with viral hepatitis have been placed in two categories of isolation--enteric precautions and blood precautions. This strategy was based on the inability to differentiate between hepatitis A and B and on the assumption that feces and blood from patients with either type might be infecti...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-91-6-872

    authors: Favero MS,Maynard JE,Leger RT,Graham DR,Dixon RE

    更新日期:1979-12-01 00:00:00

  • Drug regulation in the United States and the United Kingdom: the Depo-Provera story.

    abstract::In 1984, both the United Kingdom and the United States received recommendations from panels of experts specifically convened to consider the merits of Depo-Provera (depot medroxyprogesterone acetate [DMPA]) as a long-term contraceptive agent. This study compares the final reports written by these panels. We explore wh...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-106-6-886

    authors: Richard BW,Lasagna L

    更新日期:1987-06-01 00:00:00

  • National Study of Internal Medicine Manpower. XVIII: Subspecialty fellowships with a special look at hematology and oncology, 1988-1989.

    abstract:OBJECTIVE:To determine the number and distribution of internists in subspecialty training and compare with data collected since 1976; to determine the distribution of activity of subspecialty fellows; and to focus on hematology and oncology. DESIGN:Repeated mail survey with telephone follow-up. PARTICIPANTS:All direc...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-114-1-36

    authors: Lyttle CS,Andersen RM,Neymarc K,Schmidt C,Kohrman CH,Levey GS

    更新日期:1991-01-01 00:00:00

  • Disease from infection with Vibrio mimicus, a newly recognized Vibrio species. Clinical characteristics and edipemiology.

    abstract::Clinical and epidemiologic characteristics of disease associated with a newly described nonhalophilic Vibrio species, Vibrio mimicus, were identified by studying isolates from 21 patients referred to the Centers for Disease Control between 1977 and 1981. Two isolates were from the ears of patients with otitis who had ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:

    authors: Shandera WX,Johnston JM,Davis BR,Blake PA

    更新日期:1983-08-01 00:00:00

  • Pemphigus: current concepts.

    abstract::Pemphigus is an autoimmune intraepidermal bullous disease involving the skin and mucous membranes. There are four clinically recognized variants of this disease. The histopathologic hallmark is acantholysis, which is disruption of normal cell-to-cell adhesion. Patients produce an IgG antibody directed against an antig...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-92-3-396

    authors:

    更新日期:1980-03-01 00:00:00

  • Mandated choice for organ donation: time to give it a try.

    abstract::A severe shortage of organs greatly limits the ability to deliver the miracle of transplantation to people suffering from end-stage organ disease. Contributing to this shortage is a high rate of refusal among families who are asked for permission to remove organs from a recently deceased relative. Mandated choice offe...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-125-1-199607010-00010

    authors: Spital A

    更新日期:1996-07-01 00:00:00