An evidence-based guide to writing grant proposals for clinical research.

abstract：BACKGROUND:It is unclear whether patients understand that percutaneous coronary intervention (PCI) reduces only chronic stable angina and not myocardial infarction (MI) or associated mortality. OBJECTIVE:To compare cardiologists' and patients' beliefs about PCI. DESIGN:Survey. SETTING:Academic center. PARTICIPANTS:...

journal_title：Annals of internal medicine

authors： Rothberg MB,Sivalingam SK,Ashraf J,Visintainer P,Joelson J,Kleppel R,Vallurupalli N,Schweiger MJ

更新日期：2010-09-07 00:00:00

abstract：:After decades of silence, the German Society for Internal Medicine (DGIM) has made considerable efforts to come to terms with its role and actions during the Nazi era (1933 to 1945). This is particularly important because, with more than 27 000 members, the DGIM is the largest medical society in present-day Germany. S...

journal_title：Annals of internal medicine

authors： Hofer HG,Forsbach R,Fölsch UR

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:To evaluate the possibility that fibrinogen represents a cardiovascular risk factor. DATA IDENTIFICATION:A computerized literature search (1980 to 1992) identified all published epidemiologic studies on fibrinogen and cardiovascular disease. Clinical and basic research data were found by separate searches. Ref...

journal_title：Annals of internal medicine

authors： Ernst E,Resch KL

更新日期：1993-06-15 00:00:00

abstract：:Hyperamylasemia, which has been reported in patients with the eating disorders anorexia nervosa and bulimia, generally has been thought to result from pancreatitis. To evaluate the mechanisms of hyperamylasemia, we measured amylase, lipase, and isoamylase activity in 17 consecutive patients admitted to the eating diso...

journal_title：Annals of internal medicine

authors： Humphries LL,Adams LJ,Eckfeldt JH,Levitt MD,McClain CJ

更新日期：1987-01-01 00:00:00

abstract：:Twenty-three patients with hyperparathyroidism from six families with the multiple endocrine adenomatosis (MEA) I-syndrome were tested by secretin provocation. In nine cases this led to increases in serum gastrin ranging from 298 to 13 300 pg/ml, whereas the maximum rise in gastrin in the other 14 patients was 32 pg/m...

journal_title：Annals of internal medicine

authors： Lamers CB,Buis JT,van Tongeren J

更新日期：1977-06-01 00:00:00

abstract：OBJECTIVE:To identify and describe patients with hepatotoxicity possibly caused by flutamide, an antiandrogen drug. DESIGN:Case series of reports, submitted to the Adverse Drug Event Reporting System of the Food and Drug Administration. SETTING:Outpatient clinics and physicians' offices in the United States. PATIENT...

journal_title：Annals of internal medicine

authors： Wysowski DK,Freiman JP,Tourtelot JB,Horton ML 3rd

更新日期：1993-06-01 00:00:00

abstract：OBJECTIVE:To describe the course of rheumatoid arthritis over 5 years in adults and to evaluate the effect of parenterally administered gold salts on that course. DESIGN:A prospective observational study of adults with rheumatoid arthritis. Data derived from annual interviews with patients from 1983 to 1988 and from p...

journal_title：Annals of internal medicine

authors： Epstein WV,Henke CJ,Yelin EH,Katz PP

更新日期：1991-03-15 00:00:00

abstract：:Clinical features of 99 patients with staphylococcal infection were reviewed, and sera were tested by solid-phase radioimmunoassay and gel diffusion for staphylococcal antibodies to ascertain whether these variables predict the extent of infection and the need for prolonged therapy. Clinical features, including the pr...

journal_title：Annals of internal medicine

authors： Wheat LJ,Kohler RB,White A

更新日期：1978-10-01 00:00:00

abstract：:Sixty-nine out of a kindred of 100 members covering five generations were examined and studied, and 34 were hypercalcemic. Sixteen subjects were believed, on the basis of laboratory and clinical observations, to have primary hyperparathyroidism. Eight patients were subjected to exhaustive study to identify polyendocri...

journal_title：Annals of internal medicine

authors： Goldsmith RE,Sizemore GW,Chen IW,Zalme E,Altemeier WA

更新日期：1976-01-01 00:00:00

abstract：BACKGROUND:Alleviating the problems faced by dying persons and their families has drawn substantial public attention, but little is known about the experience of dying. OBJECTIVE:To characterize the experience of dying from the perspective of surrogate decision makers, usually close family members (89%). DESIGN:Prosp...

journal_title：Annals of internal medicine

authors： Lynn J,Teno JM,Phillips RS,Wu AW,Desbiens N,Harrold J,Claessens MT,Wenger N,Kreling B,Connors AF Jr

更新日期：1997-01-15 00:00:00

abstract：:Tax incentives can provide a large financial impetus to change behavior. Current U.S. law establishes a substantial discontinuity in the amount of estate tax that many patients will have to pay in 2010: During this year only, the tax rate drops to zero. This article discusses concerns regarding the sharp change in tax...

journal_title：Annals of internal medicine

authors： Mendenhall GS

更新日期：2008-12-02 00:00:00

abstract：:To describe more explicitly the components of competence required of the internist, The American Board of Internal Medicine has analyzed the medical encounter and defined the major variables involved: the abilities required of the internist, the tasks that must be performed to solve a medical problem, the medical illn...

journal_title：Annals of internal medicine

authors：

更新日期：1979-03-01 00:00:00

abstract：BACKGROUND:Data suggest that the effects of coronavirus disease 2019 (COVID-19) differ among U.S. racial/ethnic groups. PURPOSE:To evaluate racial/ethnic disparities in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection rates and COVID-19 outcomes, factors contributing to disparities, and intervent...

journal_title：Annals of internal medicine

authors： Mackey K,Ayers CK,Kondo KK,Saha S,Advani SM,Young S,Spencer H,Rusek M,Anderson J,Veazie S,Smith M,Kansagara D

更新日期：2020-12-01 00:00:00

abstract：:Ambulatory education has become an essential part of all internal medicine residencies. To develop excellent ambulatory education programs, we must thoroughly understand the opportunities available in such a setting, and the leaders in internal medicine must be willing to experiment with nontraditional locations and r...

journal_title：Annals of internal medicine

authors： Schuster BL

更新日期：1992-06-15 00:00:00

abstract：:Hypophosphatemic osteomalacia that remits after resection of a coexisting tumor has been described in 35 patients. Because the associated neoplasms have been of mesenchymal origin, it has been inferred that this tumor-induced osteomalacia syndrome is uniquely related to tumours of this derivation. However, in the pres...

journal_title：Annals of internal medicine

authors： Lyles KW,Berry WR,Haussler M,Harrelson JM,Drezner MK

更新日期：1980-08-01 00:00:00

abstract：OBJECTIVE:To explore how frequently physicians lose medical malpractice cases despite providing standard care and to assess whether severity of patient injury influences the frequency of plaintiff payment. DESIGN:Retrospective cohort study. SETTING:Physicians from the state of New Jersey insured by one insurance comp...

journal_title：Annals of internal medicine

authors： Taragin MI,Willett LR,Wilczek AP,Trout R,Carson JL

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Home-based primary care for homebound seniors is complex, and practice constraints are unique. No quality-of-care standards exist. OBJECTIVE:To identify process quality indicators that are essential to high-quality, home-based primary care. DESIGN:An expert development panel reviewed established and new qu...

journal_title：Annals of internal medicine

authors： Smith KL,Soriano TA,Boal J

更新日期：2007-02-06 00:00:00

abstract：:In addition to gonorrhea and syphilis, both of which may develop primarily at anorectal or pharyngeal sites, a number of conditions, including Neisseria meningitidis urethritis, nonspecific urethritis, anorectal herpes, condyloma acuminatum, amebiasis, giardiasis, shigellosis, typhoid fever, enterobiasis, and hepatiti...

journal_title：Annals of internal medicine

authors： Owen WF Jr

更新日期：1980-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the relation between skeletal muscle disease (myopathy) and degenerative changes in cardiac muscle (cardiomyopathy) in patients with chronic alcoholism. DESIGN:A cross-sectional study. SETTING:University medical center. PARTICIPANTS:Group A included 24 patients with chronic alcoholism who had d...

journal_title：Annals of internal medicine

authors： Fernandez-Sola J,Estruch R,Grau JM,Pare JC,Rubin E,Urbano-Marquez A

更新日期：1994-04-01 00:00:00

abstract：:The microorganisms that regularly infect patients with the acquired immunodeficiency syndrome (AIDS) have become well recognized. Most take advantage of defects in T-lymphocyte function, but others, such as Streptococcus pneumoniae and Haemophilus influenzae, take advantage of B-cell defects. Still others, such as Sta...

journal_title：Annals of internal medicine

authors： Armstrong D,Gold JW,Dryjanski J,Whimbey E,Polsky B,Hawkins C,Brown AE,Bernard E,Kiehn TE

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND:Successful outcomes after cardiopulmonary resuscitation remain disappointingly infrequent, in animal studies, administration of exogenous vasopressin during closed- and open-chest cardiopulmonary resuscitation has recently been shown to be more effective than optimal doses of epinephrine in improving vital o...

journal_title：Annals of internal medicine

authors： Lindner KH,Prengel AW,Brinkmann A,Strohmenger HU,Lindner IM,Lurie KG

更新日期：1996-06-15 00:00:00

abstract：Background:Medicare uses the Centers for Medicare & Medicaid Services Hierarchical Condition Category (CMS-HCC) model to predict patients' annualized Medicare costs in value-based payment programs. The CMS-HCC model does not include measures of frailty, and prior research shows that it systematically underpredicts cost...

journal_title：Annals of internal medicine

authors： Johnston KJ,Wen H,Joynt Maddox KE

更新日期：2020-04-21 00:00:00

abstract：BACKGROUND:A daily injection of low-molecular-weight heparin (LMWH) is often prescribed to women with unexplained recurrent pregnancy loss (RPL), although evidence suggesting a benefit is questionable. OBJECTIVE:To determine whether LMWH increases ongoing pregnancy and live-birth rates in women with unexplained RPL. ...

journal_title：Annals of internal medicine

authors： Schleussner E,Kamin G,Seliger G,Rogenhofer N,Ebner S,Toth B,Schenk M,Henes M,Bohlmann MK,Fischer T,Brosteanu O,Bauersachs R,Petroff D,ETHIG II group.

更新日期：2015-05-05 00:00:00

abstract：OBJECTIVE:To determine the effectiveness of levothyroxine and potassium iodide in treating patients with benign solitary cold thyroid nodules. DESIGN:Randomized controlled study. SETTING:Outpatient clinic at a university hospital. PATIENTS:80 patients with solitary solid cold thyroid nodules found to be benign at cy...

journal_title：Annals of internal medicine

authors： La Rosa GL,Lupo L,Giuffrida D,Gullo D,Vigneri R,Belfiore A

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:To review methods of preventing or minimizing the adverse effects associated with the transfusion of passenger leukocytes present in cellular blood components and to define groups of patients who are at risk for adverse effects. DATA SOURCES:English-language articles on transfusion medicine. STUDY SELECTION:O...

journal_title：Annals of internal medicine

authors： Lane TA,Anderson KC,Goodnough LT,Kurtz S,Moroff G,Pisciotto PT,Sayers M,Silberstein LE

更新日期：1992-07-15 00:00:00

abstract：:When cytotoxic agents were introduced, their ability to disrupt nucleic acid and protein synthesis led to their effective use for the treatment of neoplastic disease. During the course of this use, however, it became apparent that these agents also suppress the immune system. This usually unwelcome effect was subseque...

journal_title：Annals of internal medicine

authors： Langford CA,Klippel JH,Balow JE,James SP,Sneller MC

更新日期：1998-07-01 00:00:00

abstract：:The new knowledge of the regulation of cell growth and the genetic and biochemical changes that lead to malignancy have created many new opportunities for cancer drug discovery. These new targets include oncogenes, growth factors and their receptors, signal transduction pathways, and cell differentiation signals. Atte...

journal_title：Annals of internal medicine

authors： Chabner BA

更新日期：1993-04-15 00:00:00

abstract：OBJECTIVE:To assess the effectiveness of housestaff physician reporting as a method for identifying adverse events on a medical service and to compare the physician reporting mechanism with a retrospective record review mechanism. SETTING:Medical service of an urban, university-affiliated teaching hospital. DESIGN:Co...

journal_title：Annals of internal medicine

authors： O'Neil AC,Petersen LA,Cook EF,Bates DW,Lee TH,Brennan TA

更新日期：1993-09-01 00:00:00

abstract：:Deficiency of fat-soluble vitamins (A,D,E, and K) was evaluated in 15 patients with exocrine pancreatic insufficiency secondary to chronic alcoholic pancreatitis. Mild to moderate steatorrhea was present in all patients despite oral pancreatic enzyme therapy for 27 +/- 4 months (mean +/- SE). Deficiency of a single fa...

journal_title：Annals of internal medicine

authors： Dutta SK,Bustin MP,Russell RM,Costa BS

更新日期：1982-10-01 00:00:00

abstract：:We describe a sporadic, vitamin-D-resistant osteomalacic syndrome in 19 patients undergoing hemodialysis. The syndrome was found in less than 1.5% of patients from referring dialysis centers. All 19 patients had multiple fractures, severe myopathy, and many developed spontaneous hypercalcemia. Severe osteomalacia with...

journal_title：Annals of internal medicine

authors： Hodsman AB,Sherrard DJ,Wong EG,Brickman AS,Lee DB,Alfrey AC,Singer FR,Norman AW,Coburn JW

更新日期：1981-05-01 00:00:00