Hyperamylasemia in patients with eating disorders.

Abstract:

:Hyperamylasemia, which has been reported in patients with the eating disorders anorexia nervosa and bulimia, generally has been thought to result from pancreatitis. To evaluate the mechanisms of hyperamylasemia, we measured amylase, lipase, and isoamylase activity in 17 consecutive patients admitted to the eating disorder unit. Six patients had elevated amylase activity, and 5 of these 6 had isolated increases in salivary isoamylase activity. Six other patients had normal serum total amylase activity but modest elevations in the salivary isoamylase fraction. No patient developed clinical evidence of pancreatitis during hospitalization. Thus, the hyperamylasemia in patients with anorexia and bulimia often is caused by increased salivary-type amylase activity. The appropriate diagnostic test for hyperamylasemia in patients with anorexia or bulimia is the simple measurement of serum lipase or pancreatic isoamylase activity. If these levels are found to be normal, further tests to exclude pancreatitis are unnecessary.

journal_name

Ann Intern Med

authors

Humphries LL,Adams LJ,Eckfeldt JH,Levitt MD,McClain CJ

doi

10.7326/0003-4819-106-1-50

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

50-2

issue

1

eissn

0003-4819

issn

1539-3704

journal_volume

106

pub_type

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