Uncertain effects of rosiglitazone on the risk for myocardial infarction and cardiovascular death.

abstract：:More than 18 million Americans currently have diabetes mellitus. The economic and human cost of the disease is devastating. In the United States, diabetes is the most common cause of blindness among working-age adults, the most common cause of nontraumatic amputations and end-stage renal disease, and the sixth most co...

journal_title：Annals of internal medicine

authors： Williamson DF,Vinicor F,Bowman BA,Centers For Disease Control And Prevention Primary Prevention Working Group.

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVE:To assess the accuracy of Histoplasma capsulatum variety capsulatum polysaccharide antigen testing for the identification of histoplasmosis relapse in patients with the acquired immunodeficiency syndrome (AIDS). DESIGN:A retrospective study using stored specimens. SETTING:A referral center and several priva...

journal_title：Annals of internal medicine

authors： Wheat LJ,Connolly-Stringfield P,Blair R,Connolly K,Garringer T,Katz BP

更新日期：1991-12-15 00:00:00

abstract：:Type 2 diabetes mellitus is a chronic metabolic disorder that results from defects in both insulin secretion and insulin action. An elevated rate of basal hepatic glucose production in the presence of hyperinsulinemia is the primary cause of fasting hyperglycemia; after a meal, impaired suppression of hepatic glucose ...

journal_title：Annals of internal medicine

authors： DeFronzo RA

更新日期：1999-08-17 00:00:00

abstract：BACKGROUND:Many constituents of fruits and vegetables may reduce the risk for coronary heart disease, but data on the relationship between fruit and vegetable consumption and risk for coronary heart disease are sparse. OBJECTIVE:To evaluate the association of fruit and vegetable consumption with risk for coronary hear...

journal_title：Annals of internal medicine

authors： Joshipura KJ,Hu FB,Manson JE,Stampfer MJ,Rimm EB,Speizer FE,Colditz G,Ascherio A,Rosner B,Spiegelman D,Willett WC

更新日期：2001-06-19 00:00:00

abstract：STUDY OBJECTIVE:To determine whether obesity preceded knee osteoarthritis and was thus a possible cause. DESIGN:Cohort study with weight and other important variables measured in 1948 to 1951 (mean age of subjects, 37 years) and knee arthritis evaluated in 1983 to 1985 (mean age of subjects, 73 years). SETTING:Popula...

journal_title：Annals of internal medicine

authors： Felson DT,Anderson JJ,Naimark A,Walker AM,Meenan RF

更新日期：1988-07-01 00:00:00

abstract：:During the National Cooperative Gallstone Study, therapy with chenodiol, 750 or 375 mg/d, for 2 years resulted in confirmed, complete gallstone dissolution in 14% and 5% of patients, respectively, and partial dissolution (greater than 50%) in 27% and 18%. The present study was done to determine the frequency with whic...

journal_title：Annals of internal medicine

authors： Marks JW,Baum RA,Hanson RF,Hersh T,Hightower NC Jr,Mekhjian H,Schaefer RA,Soloway RD,Thistle JL,Thomas FB

更新日期：1984-03-01 00:00:00

abstract：BACKGROUND:The paucity of public health messages that directly address communities of color might contribute to racial and ethnic disparities in knowledge and behavior related to coronavirus disease 2019 (COVID-19). OBJECTIVE:To determine whether physician-delivered prevention messages affect knowledge and information...

journal_title：Annals of internal medicine

authors： Alsan M,Stanford FC,Banerjee A,Breza E,Chandrasekhar AG,Eichmeyer S,Goldsmith-Pinkham P,Ogbu-Nwobodo L,Olken BA,Torres C,Sankar A,Vautrey PL,Duflo E

更新日期：2020-12-21 00:00:00

abstract：Background:Difficulties with daily functioning are common in middle-aged adults. However, little is known about the epidemiology or clinical course of these problems, including the extent to which they share common features with functional impairment in older adults. Objective:To determine the epidemiology and clinica...

journal_title：Annals of internal medicine

authors： Brown RT,Diaz-Ramirez LG,Boscardin WJ,Lee SJ,Steinman MA

更新日期：2017-12-05 00:00:00

abstract：BACKGROUND:Several studies show an inverse association between self-reported physical activity and type 2 diabetes. It is not known whether physical activity or cardiorespiratory fitness is associated with the onset of objectively determined impaired fasting glucose and type 2 diabetes. OBJECTIVE:To determine whether ...

journal_title：Annals of internal medicine

authors： Wei M,Gibbons LW,Mitchell TL,Kampert JB,Lee CD,Blair SN

更新日期：1999-01-19 00:00:00

abstract：:Patients with serious psychiatric disorders are frequently treated by primary care physicians, who may have difficulty keeping up with recent advances in psychiatry. This paper presents an updated synopsis for three major psychiatric illnesses: major depression, bipolar disorder, and schizophrenia. Current definitions...

journal_title：Annals of internal medicine

authors： Glick ID,Suppes T,DeBattista C,Hu RJ,Marder S

更新日期：2001-01-02 00:00:00

abstract：Background:Iron chelation therapy (ICT) in patients with lower-risk myelodysplastic syndromes (MDS) has not been evaluated in randomized studies. Objective:To evaluate event-free survival (EFS) and safety of ICT in iron-overloaded patients with low- or intermediate-1-risk MDS. Design:Multicenter, randomized, double-b...

journal_title：Annals of internal medicine

authors： Angelucci E,Li J,Greenberg P,Wu D,Hou M,Montano Figueroa EH,Rodriguez MG,Dong X,Ghosh J,Izquierdo M,Garcia-Manero G,TELESTO Study Investigators.

更新日期：2020-04-21 00:00:00

abstract：:Medically unexplained functional or somatization symptoms are somatic disorders that are not adequately explained by physical disease processes. The way in which these disorders have been understood and managed has varied over the history of medicine. However, only in the past 100 years has the "mental" explanation pr...

journal_title：Annals of internal medicine

authors： Sharpe M,Carson A

更新日期：2001-05-01 00:00:00

abstract：STUDY OBJECTIVE:To determine whether patients with Parkinson disease are at an increased risk for postoperative confusion. DESIGN:Retrospective chart review of patients with Parkinson disease who remained in the hospital at least 48 hours after their surgery. Current data were compared with published historical contro...

journal_title：Annals of internal medicine

authors： Golden WE,Lavender RC,Metzer WS

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:Growing evidence indicates that peripheral neuropathy (PN) is common even in the absence of diabetes. However, the clinical sequelae of PN have not been quantified in the general population. OBJECTIVE:To assess the associations of PN with all-cause and cardiovascular mortality in the general adult populatio...

journal_title：Annals of internal medicine

authors： Hicks CW,Wang D,Matsushita K,Windham BG,Selvin E

更新日期：2020-12-08 00:00:00

abstract：:Twenty-nine men with stage III or unresectable stage II malignant germ cell tumors and no previous chemotherapy received treatments with the VAB-6 protocol. The VAB-6 regimen is a 1-year program beginning with three successive inductions at 3-to-4-week intervals: day 1--cyclophosphamide, 600 mg/m of body surface area ...

journal_title：Annals of internal medicine

authors： Vugrin D,Herr HW,Whitmore WF Jr,Sogani PC,Golbey RB

更新日期：1981-07-01 00:00:00

abstract：:Axial, dual spin-echo magnetic resonance (MR) images, taken at the level of the pulmonary arteries and gated to the cardiac cycle, were qualitatively and quantitatively evaluated in nine patients with primary pulmonary arterial hypertension and six controls. In controls and patients, intravascular signal intensity was...

journal_title：Annals of internal medicine

authors： von Schulthess GK,Fisher MR,Higgins CB

更新日期：1985-09-01 00:00:00

abstract：:Cataract disrupts the crystalline lens, a transparent, elastic, avascular, biconvex structure composed of a capsule, lens epithelium, and lens fiber cells. Many factors contribute to the progression of lens opacity, but aging is most frequently associated with cataract. As aging-related cataract develops, many biochem...

journal_title：Annals of internal medicine

authors： Straatsma BR,Foos RY,Horwitz J,Gardner KM,Pettit TH

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:To evaluate the possibility that fibrinogen represents a cardiovascular risk factor. DATA IDENTIFICATION:A computerized literature search (1980 to 1992) identified all published epidemiologic studies on fibrinogen and cardiovascular disease. Clinical and basic research data were found by separate searches. Ref...

journal_title：Annals of internal medicine

authors： Ernst E,Resch KL

更新日期：1993-06-15 00:00:00

abstract：BACKGROUND:Chronic myelogenous leukemia (CML) is an indolent but ultimately fatal disease. Because the natural history of CML varies and quality of life with CML may be excellent until shortly before death, deciding whether and when to pursue unrelated donor bone marrow transplantation is often difficult. OBJECTIVE:To...

journal_title：Annals of internal medicine

authors： Lee SJ,Kuntz KM,Horowitz MM,McGlave PB,Goldman JM,Sobocinski KA,Hegland J,Kollman C,Parsons SK,Weinstein MC,Weeks JC,Antin JH

更新日期：1997-12-15 00:00:00

abstract：:We surveyed the faculty, fellows, and residents of a department of medicine to determine the relative importance of each of eight personal characteristics evaluated during the interview of house staff candidates. A booklet containing all possible pairings of the eight characteristics was distributed to 219 participant...

journal_title：Annals of internal medicine

authors： Greganti MA,McGaghie WC,Finn WF

更新日期：1982-07-01 00:00:00

abstract：BACKGROUND:Impressive decreases in cardiovascular mortality have been achieved through risk factor reduction and clinical intervention, yet cardiovascular disease remains a leading cause of death nationally. OBJECTIVE:To estimate up-to-date preventable fractions of cardiovascular mortality associated with elimination ...

journal_title：Annals of internal medicine

authors： Patel SA,Winkel M,Ali MK,Narayan KM,Mehta NK

更新日期：2015-08-18 00:00:00

abstract：:Ambulatory education has become an essential part of all internal medicine residencies. To develop excellent ambulatory education programs, we must thoroughly understand the opportunities available in such a setting, and the leaders in internal medicine must be willing to experiment with nontraditional locations and r...

journal_title：Annals of internal medicine

authors： Schuster BL

更新日期：1992-06-15 00:00:00

abstract：:Two patients referred for cancer chemotherapy were found to be chronic, asymptomatic hepatitis B surface antigen (HBsAg) carriers. They had normal serum aminotransferase levels, but their sera were positive for HGsAg and antibody to hepatitis B e antigen. Both patients developed acute, icteric hepatitis within 3 month...

journal_title：Annals of internal medicine

authors： Hoofnagle JH,Dusheiko GM,Schafer DF,Jones EA,Micetich KC,Young RC,Costa J

更新日期：1982-04-01 00:00:00

abstract：:Meningitis caused by enteric gram-negative bacilli is relatively uncommon but is very difficult to treat despite susceptibility in vitro to many antimicrobics. A major problem appears to be poor entry of many drugs into the central nervous system. Moxalactam is an investigational cephalosporin that attains concentrati...

journal_title：Annals of internal medicine

authors： Olson DA,Hoeprich PD,Nolan SM,Goldstein E

更新日期：1981-09-01 00:00:00

abstract：BACKGROUND:Data suggest that the effects of coronavirus disease 2019 (COVID-19) differ among U.S. racial/ethnic groups. PURPOSE:To evaluate racial/ethnic disparities in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection rates and COVID-19 outcomes, factors contributing to disparities, and intervent...

journal_title：Annals of internal medicine

authors： Mackey K,Ayers CK,Kondo KK,Saha S,Advani SM,Young S,Spencer H,Rusek M,Anderson J,Veazie S,Smith M,Kansagara D

更新日期：2020-12-01 00:00:00

abstract：Background:Triplex vaccine was developed to enhance cytomegalovirus (CMV)-specific T cells and prevent CMV reactivation early after hematopoietic stem cell transplant (HCT). Objective:To determine the safety and efficacy of Triplex. Design:First-in-patient, phase 2 trial. (ClinicalTrials.gov: NCT02506933). Setting:3...

journal_title：Annals of internal medicine

authors： Aldoss I,La Rosa C,Baden LR,Longmate J,Ariza-Heredia EJ,Rida WN,Lingaraju CR,Zhou Q,Martinez J,Kaltcheva T,Dagis A,Hardwick N,Issa NC,Farol L,Nademanee A,Al Malki MM,Forman S,Nakamura R,Diamond DJ,TRIPLEX VACCINE St

更新日期：2020-03-03 00:00:00

abstract：:Levels of circulating platelet aggregates and plasma beta-thromboglobulin reflect the degree of platelet activation in vascular injury and repair. Both values were evaluated in 38 patients with scleroderma and 18 control subjects matched for age, sex, and race. Circulating platelet aggregates (expressed as percentage ...

journal_title：Annals of internal medicine

authors： Kahaleh MB,Osborn I,Leroy EC

更新日期：1982-05-01 00:00:00

abstract：:The new knowledge of the regulation of cell growth and the genetic and biochemical changes that lead to malignancy have created many new opportunities for cancer drug discovery. These new targets include oncogenes, growth factors and their receptors, signal transduction pathways, and cell differentiation signals. Atte...

journal_title：Annals of internal medicine

authors： Chabner BA

更新日期：1993-04-15 00:00:00

abstract：:The diagnosis of gout depends on showing urate crystals in synovial effusions or, with less certainty, recognizing a characteristic clinical presentation. The management of gout has four phases: control of inflammation, diagnostic evaluation, education of the patient, and treatment for the hyperuricemia. Sound logical...

journal_title：Annals of internal medicine

authors： Simkin PA

更新日期：1979-05-01 00:00:00

abstract：:Wilson's disease is an inherited disorder of copper accumulation that is fatal if untreated. Because penicillamine, the established treatment, is toxic in a substantial number of patients, we studied the efficacy of zinc treatment. We induced a negative or neutral copper balance in five out of five patients with Wilso...

journal_title：Annals of internal medicine

authors： Brewer GJ,Hill GM,Prasad AS,Cossack ZT,Rabbani P

更新日期：1983-09-01 00:00:00