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The association between cardiorespiratory fitness and impaired fasting glucose and type 2 diabetes mellitus in men.

Abstract：

BACKGROUND:Several studies show an inverse association between self-reported physical activity and type 2 diabetes. It is not known whether physical activity or cardiorespiratory fitness is associated with the onset of objectively determined impaired fasting glucose and type 2 diabetes. OBJECTIVE:To determine whether cardiorespiratory fitness, an objective marker of physical activity, is associated with risk for impaired fasting glucose and type 2 diabetes. DESIGN:Population-based prospective study. SETTING:Preventive medicine clinic. PATIENTS:8633 nondiabetic men (of whom 7511 did not have impaired fasting glucose) who were examined at least twice. MEASUREMENTS:Cardiorespiratory fitness (determined by a maximal exercise test on a treadmill), fasting plasma glucose level, and other clinical and personal characteristics and incidence of impaired fasting glucose and type 2 diabetes. RESULTS:During an average follow-up of 6 years, 149 patients developed type 2 diabetes and 593 patients developed impaired fasting glucose. After age, cigarette smoking, alcohol consumption, and parental diabetes were considered, men in the low-fitness group (the least fit 20% of the cohort) at baseline had a 1.9-fold risk (95% CI, 1.5- to 2.4-fold) for impaired fasting glucose and a 3.7-fold risk (CI, 2.4- to 5.8-fold) for diabetes compared with those in the high-fitness group (the most fit 40% of the cohort). The risk for impaired fasting glucose was elevated in older men and those with a higher body mass index. Age, body mass index, blood pressure, triglyceride level, and a history of parental diabetes were also directly related to risk for type 2 diabetes. CONCLUSIONS:Low cardiorespiratory fitness was associated with increased risk for impaired fasting glucose and type 2 diabetes. A sedentary lifestyle may contribute to the progression from normal fasting glucose to impaired fasting glucose and diabetes. Risk for type 2 diabetes was elevated in older persons and those with higher body mass index, blood pressure, and triglyceride levels and a parental history of diabetes.

journal_name

Ann Intern Med

journal_title

Annals of internal medicine

authors

Wei M,Gibbons LW,Mitchell TL,Kampert JB,Lee CD,Blair SN

doi

10.7326/0003-4819-130-2-199901190-00002

subject

Has Abstract

pub_date

1999-01-19 00:00:00

pages

89-96

issue

eissn

0003-4819

issn

1539-3704

pii

199901190-00002

journal_volume

130

pub_type

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The association between cardiorespiratory fitness and impaired fasting glucose and type 2 diabetes mellitus in men.