Abstract:
:Adult T-cell leukemia associated with human T-cell leukemia virus type I (HTLV-I) is characterized by a clonal expansion of a CD4-positive subset of T lymphocytes that constitutively express high numbers of interleukin-2 receptors and that frequently infiltrate the skin; osteolytic bone lesions, and hypercalcemia. Using an enzyme-linked immunosorbent assay (ELISA) test, we measured the level of soluble Tac peptide, one chain of the human interleukin-2 receptor, in the serum of 50 patients with adult T-cell leukemia (38 Japanese and 12 American patients), 8 patients with other hematologic malignancies, 8 asymptomatic HTLV-I-antibody-positive carriers, and 17 normal controls. The serum level of soluble Tac peptide (geometric mean U/mL, 95% CI) was elevated at presentation in all patients with adult T-cell leukemia (16,461; 819 to 330,896) when compared with normal controls (238; 112 to 502), patients with other hematologic malignancies (1302; 475 to 3569), and healthy HTLV-I antibody-positive carriers (490; 115 to 2086). The highest levels were seen in patients (n = 33) with acute (32,154; 2587 to 399,598) compared with chronic (5464; 661 to 45,156) disease (n = 14). Serum levels of Tac peptide also tended to be more elevated in patients with adult T-cell leukemia with hypercalcemia (32,072; 2461 to 417,908) compared with normocalcemic patients (13,885; 496 to 388,436). Serial measurements of soluble Tac peptide levels in serum were done in four patients with adult T-cell leukemia during chemotherapy and the levels reflected disease activity. These observations suggest that the measurement of soluble Tac peptide levels in patients with adult T-cell leukemia is useful as a noninvasive measure of tumor burden and will help in the diagnosis of the disease and management of these patients.
journal_name
Ann Intern Medjournal_title
Annals of internal medicineauthors
Marcon L,Rubin LA,Kurman CC,Fritz ME,Longo DL,Uchiyama T,Edwards BK,Nelson DLdoi
10.7326/0003-4819-109-4-274subject
Has Abstractpub_date
1988-08-15 00:00:00pages
274-9issue
4eissn
0003-4819issn
1539-3704journal_volume
109pub_type
杂志文章abstract::Subacute encephalitis caused by infection of the central nervous system by the human immunodeficiency virus (HIV) is the most frequent cause of neurologic dysfunction in patients with the acquired immunodeficiency syndrome (AIDS). This disorder results in progressive cognitive, motor, and behavioral abnormalities in a...
journal_title:Annals of internal medicine
pub_type: 杂志文章,评审
doi:10.7326/0003-4819-107-2-383
更新日期:1987-09-01 00:00:00
abstract:BACKGROUND:Recent evidence shows that arthroscopic partial meniscectomy (APM) offers no benefit over conservative treatment of patients with a degenerative meniscus tear. However, patients who report mechanical symptoms (sensations of knee catching or locking) may benefit from APM. OBJECTIVE:To assess whether APM impr...
journal_title:Annals of internal medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.7326/M15-0899
更新日期:2016-04-05 00:00:00
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doi:10.7326/0003-4819-132-6-200003210-00011
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abstract::To re-evaluate the relationship between Crohn's disease and sarcoidosis, we compared the numbers and types of cells recovered by bronchoalveolar lavage from normal volunteers and patients with Crohn's disease, with other forms of inflammatory bowel disease, and with sarcoidosis. Patients with Crohn's disease, but not ...
journal_title:Annals of internal medicine
pub_type: 杂志文章
doi:10.7326/0003-4819-104-1-17
更新日期:1986-01-01 00:00:00
abstract::The presence of a low anion gap in patients with multiple myeloma has recently been emphasized. This has been related to the retention of chloride and bicarbonate anions to offset the cationic charge of the monoclonal immunoglobulins. We now report the presence of a low anion gap in 50 patients with asymptomatic plasm...
journal_title:Annals of internal medicine
pub_type: 杂志文章
doi:10.7326/0003-4819-86-3-304
更新日期:1977-03-01 00:00:00
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journal_title:Annals of internal medicine
pub_type: 杂志文章
doi:10.7326/0003-4819-86-4-394
更新日期:1977-04-01 00:00:00
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journal_title:Annals of internal medicine
pub_type: 杂志文章,meta分析,评审
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更新日期:2007-10-02 00:00:00
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journal_title:Annals of internal medicine
pub_type: 杂志文章
doi:10.7326/0003-4819-111-8-650
更新日期:1989-10-15 00:00:00
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journal_title:Annals of internal medicine
pub_type: 杂志文章
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更新日期:1982-01-01 00:00:00
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journal_title:Annals of internal medicine
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1999-09-21 00:00:00
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journal_title:Annals of internal medicine
pub_type: 杂志文章
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journal_title:Annals of internal medicine
pub_type: 杂志文章
doi:10.7326/0003-4819-107-2-133
更新日期:1987-08-01 00:00:00
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journal_title:Annals of internal medicine
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更新日期:1997-04-01 00:00:00
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journal_title:Annals of internal medicine
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更新日期:2007-05-01 00:00:00
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journal_title:Annals of internal medicine
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更新日期:2007-12-04 00:00:00
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journal_title:Annals of internal medicine
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doi:10.7326/0003-4819-88-4-502
更新日期:1978-04-01 00:00:00
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journal_title:Annals of internal medicine
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journal_title:Annals of internal medicine
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title:Annals of internal medicine
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doi:10.7326/0003-4819-100-4-483
更新日期:1984-04-01 00:00:00
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journal_title:Annals of internal medicine
pub_type: 杂志文章
doi:10.7326/0003-4819-90-2-257
更新日期:1979-02-01 00:00:00
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journal_title:Annals of internal medicine
pub_type: 杂志文章,评审
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更新日期:1993-09-15 00:00:00
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journal_title:Annals of internal medicine
pub_type: 共识发展会议,杂志文章,评审
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更新日期:1994-11-01 00:00:00
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journal_title:Annals of internal medicine
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更新日期:2021-01-01 00:00:00
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journal_title:Annals of internal medicine
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Annals of internal medicine
pub_type: 杂志文章
doi:10.7326/0003-4819-93-1-32
更新日期:1980-07-01 00:00:00
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journal_title:Annals of internal medicine
pub_type: 杂志文章
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更新日期:1976-11-01 00:00:00
abstract:BACKGROUND:Corticosteroid injections (CSIs) and physical therapy are used to treat patients with the shoulder impingement syndrome (SIS) but have never been directly compared. OBJECTIVE:To compare the effectiveness of 2 common nonsurgical treatments for SIS. DESIGN:Randomized, single-blind, comparative-effectiveness,...
journal_title:Annals of internal medicine
pub_type: 杂志文章,随机对照试验
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更新日期:2014-08-05 00:00:00
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更新日期:2011-03-01 00:00:00