Palliative treatments of last resort: choosing the least harmful alternative. University of Pennsylvania Center for Bioethics Assisted Suicide Consensus Panel.

Abstract:

:Comprehensive palliative care, as exemplified by many state-of-the-art hospice programs, is the standard of care for the dying. Although palliative care is very effective, physicians, nurses, patients, families, and loved ones regularly face clinically, ethically, legally, and morally challenging decisions throughout the dying process. This is especially true when terminally ill patients are ready to die in the face of complex, difficult-to-treat suffering and request assistance from their health care providers. Although physician-assisted suicide has received the most attention as a potential last-resort response, this practice remains illegal in the United States except in Oregon, and even there it is relatively infrequent. More commonly, decisions are made about accelerating opioid therapy for pain, foregoing life-sustaining therapy, voluntarily stopping eating and drinking, and administering terminal sedation in response to unacceptable suffering. The moral distinctions between these practices are critical to some but relatively inconsequential to others. This paper illustrates, through summaries of real clinical cases, how each of these practices might be used in response to patients in particular clinical circumstances, keeping in focus the patient's values as well as those of families, other loved ones, and health care providers. The challenge is to find the least harmful solution to the patient's problem without abandoning patients and their loved ones to unacceptable suffering or to acting in a more deleterious way on their own.

journal_name

Ann Intern Med

authors

Quill TE,Lee BC,Nunn S

doi

10.7326/0003-4819-132-6-200003210-00011

subject

Has Abstract

pub_date

2000-03-21 00:00:00

pages

488-93

issue

6

eissn

0003-4819

issn

1539-3704

pii

200003210-00011

journal_volume

132

pub_type

杂志文章
  • Digoxin for atrial fibrillation: a drug whose time has gone?

    abstract::For over 200 years digitalis compounds have been used to treat atrial fibrillation. The rapid ventricular response to atrial fibrillation is frequently treated with digoxin to produce a controlled heart rate. Digoxin has also been proposed as a treatment for terminating recent-onset atrial fibrillation, for maintainin...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-114-7-573

    authors: Falk RH,Leavitt JI

    更新日期:1991-04-01 00:00:00

  • Substituting walnuts for monounsaturated fat improves the serum lipid profile of hypercholesterolemic men and women. A randomized crossover trial.

    abstract:BACKGROUND:It has been reported that walnuts reduce serum cholesterol levels in normal young men. OBJECTIVE:To assess the acceptability of walnuts and their effects on serum lipid levels and low-density lipoprotein (LDL) oxidizability in free-living hypercholesterolemic persons. DESIGN:Randomized, crossover feeding t...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.7326/0003-4819-132-7-200004040-00005

    authors: Zambón D,Sabaté J,Muñoz S,Campero B,Casals E,Merlos M,Laguna JC,Ros E

    更新日期:2000-04-04 00:00:00

  • A diagnostic strategy involving a quantitative latex D-dimer assay reliably excludes deep venous thrombosis.

    abstract:BACKGROUND:Because clinical diagnosis is inaccurate, objective testing is usually considered necessary when patients present with suspected deep venous thrombosis (DVT). OBJECTIVE:To determine whether a negative result on a quantitative latex D dimer assay eliminates the need for further investigation in patients with...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,多中心研究

    doi:10.7326/0003-4819-138-10-200305200-00006

    authors: Bates SM,Kearon C,Crowther M,Linkins L,O'Donnell M,Douketis J,Lee AY,Weitz JI,Johnston M,Ginsberg JS

    更新日期:2003-05-20 00:00:00

  • Management of suspected deep venous thrombosis in outpatients by using clinical assessment and D-dimer testing.

    abstract:BACKGROUND:When deep venous thrombosis is suspected, objective testing is required to confirm or refute the diagnosis. OBJECTIVE:To determine whether the combination of a low clinical suspicion and a normal D -dimer result rules out deep venous thrombosis. DESIGN:Prospective cohort study. SETTING:Three tertiary care...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-135-2-200107170-00011

    authors: Kearon C,Ginsberg JS,Douketis J,Crowther M,Brill-Edwards P,Weitz JI,Hirsh J

    更新日期:2001-07-17 00:00:00

  • The effect of recombinant human granulocyte-macrophage colony-stimulating factor on neutropenia and related morbidity in chronic severe neutropenia.

    abstract:STUDY OBJECTIVE:To define the clinical and hematologic effects of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) on patients with chronic severe neutropenia. DESIGN:Open-label, phase II study of rhGM-CSF. SETTING:Inpatient hematology and surgery clinic at a university medical center. P...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-111-11-887

    authors: Ganser A,Ottmann OG,Erdmann H,Schulz G,Hoelzer D

    更新日期:1989-12-01 00:00:00

  • Behavioral Programs for Type 1 Diabetes Mellitus: A Systematic Review and Meta-analysis.

    abstract:BACKGROUND:Whether behavioral approaches for self-management programs benefit individuals with type 1 diabetes mellitus is unclear. PURPOSE:To determine the effects of behavioral programs for patients with type 1 diabetes on behavioral, clinical, and health outcomes and to investigate factors that might moderate effec...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.7326/M15-1399

    authors: Pillay J,Armstrong MJ,Butalia S,Donovan LE,Sigal RJ,Chordiya P,Dhakal S,Vandermeer B,Hartling L,Nuspl M,Featherstone R,Dryden DM

    更新日期:2015-12-01 00:00:00

  • Health care information and the protection of personal privacy: ethical and legal considerations.

    abstract::During the early 1990s, the U.S. government addressed the issue of providing universal health care to all its citizens. Although this issue has not been completely resolved, centralization of electronic data and sharing of health care information among insurers and providers have been pursued. The emergence of electro...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-127-8_part_2-199710151-00050

    authors: Gostin L

    更新日期:1997-10-15 00:00:00

  • Solid tumors in multiple myeloma.

    abstract::The frequency of solid tumors was evaluated in 628 consecutive patients with multiple myeloma who had been treated with various melphalan-prednisone combinations. Among those patients who lived at least 2 months, the incidence and diversity of second tumors were similar to those in normal persons of the same age and d...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-90-5-780

    authors: Stegman R,Alexanian R

    更新日期:1979-05-01 00:00:00

  • Clinically silent atrial septal defects with evidence for cerebral embolization.

    abstract::The cause of stroke in young patients frequently cannot be established. Eleven consecutive patients, age 50 and younger, had clinical evidence of cerebral embolization. Results of physical, radiographic, electrocardiographic, and two-dimensional echocardiographic examinations were normal in all patients. During normal...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-105-5-695

    authors: Harvey JR,Teague SM,Anderson JL,Voyles WF,Thadani U

    更新日期:1986-11-01 00:00:00

  • Pharmacologic and nutritional treatment of mild hypertension: changes in cardiovascular risk status.

    abstract:OBJECTIVE:To evaluate the 6-month change in cardiovascular (coronary heart disease) risk as a function of diet and drug therapy for mild hypertension. DESIGN:Collaborative randomized, controlled clinical trial to assess the efficacy of alternative regimens in treating mild hypertension. SETTING:Three university-based...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.7326/0003-4819-112-2-89

    authors: Oberman A,Wassertheil-Smoller S,Langford HG,Blaufox MD,Davis BR,Blaszkowski T,Zimbaldi N,Hawkins CM

    更新日期:1990-01-15 00:00:00

  • The anion gap in asymptomatic plasma cell dyscrasias.

    abstract::The presence of a low anion gap in patients with multiple myeloma has recently been emphasized. This has been related to the retention of chloride and bicarbonate anions to offset the cationic charge of the monoclonal immunoglobulins. We now report the presence of a low anion gap in 50 patients with asymptomatic plasm...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-86-3-304

    authors: Schnur MJ,Appel GB,Karp G,Osserman EP

    更新日期:1977-03-01 00:00:00

  • Sample size nomograms for interpreting negative clinical studies.

    abstract::In recent years there has been increasing attention to the appropriate interpretation of a clinical study. One special concern has been the difficulty inherent in interpreting studies that were not statistically significant: Was the sample size sufficient to detect a clinically important effect if, in fact, it existed...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-99-2-248

    authors: Young MJ,Bresnitz EA,Strom BL

    更新日期:1983-08-01 00:00:00

  • A professional response to demands for accountability: practical recommendations regarding ethical aspects of patient care. Working Group on Accountability.

    abstract::Forceful new demands for accountability in medicine are arising from many interested parties. To maintain professional standards, physicians need to establish which demands are desirable and which are not. We adopt a model of stratified accountability that includes three major components: the accountable parties, the ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-124-2-199601150-00008

    authors: Emanuel LL

    更新日期:1996-01-15 00:00:00

  • The ethics of deactivating implanted cardioverter defibrillators.

    abstract::Implantable cardioverter defibrillators are life-saving devices for many patients with cardiac disease. Recipients of these devices, nevertheless, often suffer from progressive comorbid and cardiac conditions. Therefore, physicians should anticipate situations in which the defibrillator is no longer desired by the pat...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-142-8-200504190-00012

    authors: Berger JT

    更新日期:2005-04-19 00:00:00

  • Simulation exercises as a patient safety strategy: a systematic review.

    abstract::Simulation is a versatile technique used in a variety of health care settings for a variety of purposes, but the extent to which simulation may improve patient safety remains unknown. This systematic review examined evidence on the effects of simulation techniques on patient safety outcomes. PubMed and the Cochrane Li...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-158-5-201303051-00010

    authors: Schmidt E,Goldhaber-Fiebert SN,Ho LA,McDonald KM

    更新日期:2013-03-05 00:00:00

  • Pathologic blood flow in pulmonary vascular disease as shown by gated magnetic resonance imaging.

    abstract::Axial, dual spin-echo magnetic resonance (MR) images, taken at the level of the pulmonary arteries and gated to the cardiac cycle, were qualitatively and quantitatively evaluated in nine patients with primary pulmonary arterial hypertension and six controls. In controls and patients, intravascular signal intensity was...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-103-3-317

    authors: von Schulthess GK,Fisher MR,Higgins CB

    更新日期:1985-09-01 00:00:00

  • Palliative Care.

    abstract::Palliative care prioritizes symptom management and quality of life throughout the course of serious illness. Regardless of whether care is inpatient or outpatient, primary or subspecialty, a solid understanding of the basics of effective communication, symptom management, and end-of-life care is crucial. This article ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/AITC201803060

    authors: Swetz KM,Kamal AH

    更新日期:2018-03-06 00:00:00

  • Healing skills for medical practice.

    abstract::It is well recognized that physicians' relationships with their patients can have healing effects, but the skills in this area of medical practice are understudied. This article reports on research designed to identify a core set of healing skills. The authors interviewed 50 practitioners, who were identified by their...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-149-10-200811180-00006

    authors: Churchill LR,Schenck D

    更新日期:2008-11-18 00:00:00

  • Residual venous thrombosis as a predictive factor of recurrent venous thromboembolism.

    abstract:BACKGROUND:The optimum duration of anticoagulant therapy after an episode of deep venous thrombosis (DVT) is controversial. Contributing to the controversy is uncertainty about whether residual venous thrombosis, as assessed by repeated ultrasonography over time, increases the risk for recurrent thromboembolism. OBJEC...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-137-12-200212170-00008

    authors: Prandoni P,Lensing AW,Prins MH,Bernardi E,Marchiori A,Bagatella P,Frulla M,Mosena L,Tormene D,Piccioli A,Simioni P,Girolami A

    更新日期:2002-12-17 00:00:00

  • Hypocomplementemia in chronic idiopathic urticaria.

    abstract::A discrete evoking factor or presumed pathophysiologic mechanism is not recognized in the majority of patients with chronic urticaria or angioedema. Two cases are reported in which chronic urticaria was the main manifestation of an immune cutaneous vasculitis associated with hypocomplementemia attributable to classic ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-86-5-534

    authors: Mathison DA,Arroyave CM,Bhat KN,Hurewitz DS,Marnell DJ

    更新日期:1977-05-01 00:00:00

  • Firearm-related injury and death in the United States: a call to action from 8 health professional organizations and the American Bar Association.

    abstract::Deaths and injuries related to firearms constitute a major public health problem in the United States. In response to firearm violence and other firearm-related injuries and deaths, an interdisciplinary, interprofessional group of leaders of 8 national health professional organizations and the American Bar Association...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/M15-0337

    authors: Weinberger SE,Hoyt DB,Lawrence HC 3rd,Levin S,Henley DE,Alden ER,Wilkerson D,Benjamin GC,Hubbard WC

    更新日期:2015-04-07 00:00:00

  • Pleural effusions in hospitalized patients with AIDS.

    abstract:OBJECTIVE:To determine the incidence, cause, and characteristics of pleural effusions in hospitalized patients with the acquired immunodeficiency syndrome (AIDS). DESIGN:Retrospective. PARTICIPANTS:A total of 222 patients with AIDS hospitalized between January 1986 and January 1992 at the Medical University of South ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-118-11-199306010-00005

    authors: Joseph J,Strange C,Sahn SA

    更新日期:1993-06-01 00:00:00

  • Achieving Gender Equity in Physician Compensation and Career Advancement: A Position Paper of the American College of Physicians.

    abstract::Women comprise more than one third of the active physician workforce, an estimated 46% of all physicians-in-training, and more than half of all medical students in the United States. Although progress has been made toward gender diversity in the physician workforce, disparities in compensation exist and inequities hav...

    journal_title:Annals of internal medicine

    pub_type: 指南,杂志文章

    doi:10.7326/M17-3438

    authors: Butkus R,Serchen J,Moyer DV,Bornstein SS,Hingle ST,Health and Public Policy Committee of the American College of Physicians.

    更新日期:2018-05-15 00:00:00

  • Does performance-based remuneration for individual health care practitioners affect patient care?: a systematic review.

    abstract:BACKGROUND:Pay-for-performance (P4P) is increasingly touted as a means to improve health care quality. PURPOSE:To evaluate the effect of P4P remuneration targeting individual health care providers. DATA SOURCES:MEDLINE, EMBASE, Cochrane Library, OpenSIGLE, Canadian Evaluation Society Unpublished Literature Bank, New ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-157-12-201212180-00009

    authors: Houle SK,McAlister FA,Jackevicius CA,Chuck AW,Tsuyuki RT

    更新日期:2012-12-18 00:00:00

  • The prevalence of tuberculosis and positive tuberculin skin tests in a steroid-treated asthmatic population.

    abstract::The prevalence of active tuberculosis and positive tuberculin skin tests was assessed in 132 corticosteroid-treated asthmatics for an evaluation period that represented 620 corticosteroid-years of therapy. There was no evidence of active tuberculosis in any of these patients. Positive intermediate-strength tuberculin ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-84-3-261

    authors: Schatz M,Patterson R,Kloner R,Falk J

    更新日期:1976-03-01 00:00:00

  • Screening for peripheral artery disease and cardiovascular disease risk assessment with the ankle-brachial index in adults: U.S. Preventive Services Task Force recommendation statement.

    abstract:DESCRIPTION:Update of the 2005 U.S. Preventive Services Task Force (USPSTF) recommendation on screening for peripheral artery disease (PAD). METHODS:The USPSTF reviewed the evidence on the use of resting ankle-brachial index (ABI) as a screening test for PAD or as a risk predictor for cardiovascular disease (CVD). The...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,实务指引

    doi:10.7326/0003-4819-159-5-201309030-00008

    authors: Moyer VA,U.S. Preventive Services Task Force.

    更新日期:2013-09-03 00:00:00

  • Management of non-insulin-dependent diabetes mellitus. The United Kingdom experience.

    abstract::Care of persons with non-insulin-dependent diabetes mellitus (NIDDM) in the United Kingdom resembles that in the United States. However, health care practice in Europe is being influenced by the Saint Vincent Declaration, the joint European World Health Organization-International Diabetes Federation initiative, which ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-124-1_part_2-199601011-00015

    authors: Keen H

    更新日期:1996-01-01 00:00:00

  • General internal medicine and general internists: recognizing a national need. Federated Council for Internal Medicine.

    abstract::The Federated Council for Internal Medicine (FCIM) comprises the American Board of Internal Medicine, American College of Physicians, American Society of Internal Medicine, Association of Professors of Medicine, Association of Program Directors in Internal Medicine, and the Society of General Internal Medicine. The Co...

    journal_title:Annals of internal medicine

    pub_type: 指南,杂志文章

    doi:10.7326/0003-4819-117-9-778

    authors:

    更新日期:1992-11-01 00:00:00

  • Tipping the balance of benefits and harms to favor screening mammography starting at age 40 years: a comparative modeling study of risk.

    abstract:BACKGROUND:Timing of initiation of screening for breast cancer is controversial in the United States. OBJECTIVE:To determine the threshold relative risk (RR) at which the harm-benefit ratio of screening women aged 40 to 49 years equals that of biennial screening for women aged 50 to 74 years. DESIGN:Comparative model...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-156-9-201205010-00002

    authors: van Ravesteyn NT,Miglioretti DL,Stout NK,Lee SJ,Schechter CB,Buist DS,Huang H,Heijnsdijk EA,Trentham-Dietz A,Alagoz O,Near AM,Kerlikowske K,Nelson HD,Mandelblatt JS,de Koning HJ

    更新日期:2012-05-01 00:00:00

  • Thyroxine suppressive therapy in patients with nodular thyroid disease.

    abstract:PURPOSE:To review evidence about thyroxine suppressive therapy in patients with thyroid nodules, including the clinical importance and natural history of nodules and the effects and potential side effects of thyroxine therapy. DATA SOURCES:English-language articles published from 1986 to December 1996 were identified ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-128-5-199803010-00008

    authors: Gharib H,Mazzaferri EL

    更新日期:1998-03-01 00:00:00