Drug evaluation after marketing.

abstract：STUDY OBJECTIVE:To evaluate the efficacy of cisplatin-based combination chemotherapy in patients with advanced ovarian germ-cell tumors. DESIGN:Nonrandom prospective trial with endpoints of tumor response, results of repeat surgical exploration, progression-free interval, and survival. SETTING:Cooperative university-...

journal_title：Annals of internal medicine

authors： Williams SD,Blessing JA,Moore DH,Homesley HD,Adcock L

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:Although weight loss improves risk factors for cardiovascular and metabolic disease, it is unclear whether intentional weight loss reduces mortality rates. OBJECTIVE:To examine the relationships among intention to lose weight, weight loss, and all-cause mortality. DESIGN:Prospective cohort study using a pr...

journal_title：Annals of internal medicine

authors： Gregg EW,Gerzoff RB,Thompson TJ,Williamson DF

更新日期：2003-03-04 00:00:00

abstract：BACKGROUND:Understanding the risk factors for ventilator-associated pneumonia can help to assess prognosis and devise and test preventive strategies. OBJECTIVE:To examine the baseline and time-dependent risk factors for ventilator-associated pneumonia and to determine the conditional probability and cumulative risk ov...

journal_title：Annals of internal medicine

authors： Cook DJ,Walter SD,Cook RJ,Griffith LE,Guyatt GH,Leasa D,Jaeschke RZ,Brun-Buisson C

更新日期：1998-09-15 00:00:00

abstract：OBJECTIVE:To determine whether self-assessment of purified protein derivative of tuberculin (PPD) skin test reactions, done using a simple two-choice approach, is an effective screening method for tuberculosis. DESIGN:Double-blind comparison between self-assessments and trained professional readings of PPD skin test r...

journal_title：Annals of internal medicine

authors： Prezant DJ,Kelly KJ,Karwa ML,Kavanagh K

更新日期：1996-08-15 00:00:00

abstract：BACKGROUND:The risk for and determinants of transmission of tuberculosis in hospitals caring for moderate numbers of patients with tuberculosis remain uncertain. OBJECTIVE:To study the association of tuberculin conversion among health care workers with ventilation of patient care areas. DESIGN:Cross-sectional observa...

journal_title：Annals of internal medicine

authors： Menzies D,Fanning A,Yuan L,FitzGerald JM

更新日期：2000-11-21 00:00:00

abstract：Background:A 2007 American College of Physicians guideline addressed pharmacologic options for low back pain. New evidence and medications have now become available. Purpose:To review the current evidence on systemic pharmacologic therapies for acute or chronic nonradicular or radicular low back pain. Data Sources:Ov...

journal_title：Annals of internal medicine

authors： Chou R,Deyo R,Friedly J,Skelly A,Weimer M,Fu R,Dana T,Kraegel P,Griffin J,Grusing S

更新日期：2017-04-04 00:00:00

abstract：OBJECTIVE:To determine whether a noninvasive method for evaluating contrast-enhancing brain lesions in patients with the acquired immunodeficiency syndrome (AIDS) can accurately differentiate between lymphoma and nonlymphoma diagnoses. This method is based on Toxoplasma serologic testing and positron emission tomograph...

journal_title：Annals of internal medicine

authors： Pierce MA,Johnson MD,Maciunas RJ,Murray MJ,Allen GS,Harbison MA,Creasy JL,Kessler RM

更新日期：1995-10-15 00:00:00

abstract：OBJECTIVE:To determine the relations among esophageal dysfunction, gastroesophageal reflux, and lung involvement in patients with systemic sclerosis. DESIGN:Retrospective review of esophageal motility, esophageal pH, and pulmonary function data. SETTING:University hospital outpatient clinic and community. PATIENTS:3...

journal_title：Annals of internal medicine

authors： Troshinsky MB,Kane GC,Varga J,Cater JR,Fish JE,Jimenez SA,Castell DO

更新日期：1994-07-01 00:00:00

abstract：:The cause of stroke in young patients frequently cannot be established. Eleven consecutive patients, age 50 and younger, had clinical evidence of cerebral embolization. Results of physical, radiographic, electrocardiographic, and two-dimensional echocardiographic examinations were normal in all patients. During normal...

journal_title：Annals of internal medicine

authors： Harvey JR,Teague SM,Anderson JL,Voyles WF,Thadani U

更新日期：1986-11-01 00:00:00

abstract：:Evidence on the safety and efficacy of methotrexate as a second- or third-line agent for treating patients with rheumatoid arthritis is reviewed. Four placebo-controlled clinical trials have documented short-term benefit from methotrexate; although true remission is rare, patients receiving methotrexate showed a 26% (...

journal_title：Annals of internal medicine

authors： Tugwell P,Bennett K,Gent M

更新日期：1987-09-01 00:00:00

abstract：:Diabetes mellitus is classified into two major categories: type I, which is insulin dependent, and type II, which is not. Insulin resistance in type II diabetes may be related to impaired receptor binding in some forms of the disorder. In the past, diabetes in pregnant women resulted in high rates of maternal and infa...

journal_title：Annals of internal medicine

authors： Kaplan SA,Lippe BM,Brinkman CR,Davidson MB,Geffner ME

更新日期：1982-05-01 00:00:00

abstract：:A variety of forces are converging to reduce the number of internal medicine residency positions offered in this country. This reduction, referred to as downsizing, has been proposed as the solution to several of the problems facing internal medicine. We examine the forces that underlie the current enthusiasm for down...

journal_title：Annals of internal medicine

authors： Asch DA,Ende J

更新日期：1992-11-15 00:00:00

abstract：:Early defibrillation is the most important determinant of survival for victims of cardiac arrest due to ventricular fibrillation. The automated external defibrillator (AED) was developed as the result of the American Heart Association's Public Access Defibrillation initiative. The goal of this initiative is to place A...

journal_title：Annals of internal medicine

authors： Takata TS,Page RL,Joglar JA

更新日期：2001-12-04 00:00:00

abstract：:Two patients with renal failure developed N-acetylprocainamide toxicity while receiving procainamide. Treatment consisted of continuous arteriovenous hemofiltration in one and hemodialysis followed by continuous arteriovenous hemodiafiltration in the other. The efficacy of these treatments was compared with the effica...

journal_title：Annals of internal medicine

authors： Domoto DT,Brown WW,Bruggensmith P

更新日期：1987-04-01 00:00:00

abstract：:Nine of 81 members of two families were found to have renal problems. Three patients in one family had renal-retinal dysplasia with probable recessive inheritance. Of the 6 patients in the second family, one received a kidney transplant from his brother who initially had no detectable renal abnormality but later devel...

journal_title：Annals of internal medicine

authors： Avasthi PS,Erickson DG,Gardner KD

更新日期：1976-02-01 00:00:00

abstract：:The presence of a low anion gap in patients with multiple myeloma has recently been emphasized. This has been related to the retention of chloride and bicarbonate anions to offset the cationic charge of the monoclonal immunoglobulins. We now report the presence of a low anion gap in 50 patients with asymptomatic plasm...

journal_title：Annals of internal medicine

authors： Schnur MJ,Appel GB,Karp G,Osserman EP

更新日期：1977-03-01 00:00:00

abstract：:A platelet transfusion from a blood group O donor, immunized 1 month before with Pneumovax, caused a hemolytic reaction in a blood group A recipient. Forty-five of 59 group O donors (76%) and all of nine group B donors immunized with Pneumovax had a fourfold or higher anti-A response. Half of the anti-A antibody in hi...

journal_title：Annals of internal medicine

authors： Siber GR,Ambrosino DM,Gorgone BC

更新日期：1982-05-01 00:00:00

abstract：:Forceful new demands for accountability in medicine are arising from many interested parties. To maintain professional standards, physicians need to establish which demands are desirable and which are not. We adopt a model of stratified accountability that includes three major components: the accountable parties, the ...

journal_title：Annals of internal medicine

authors： Emanuel LL

更新日期：1996-01-15 00:00:00

abstract：BACKGROUND:Pay-for-performance (P4P) is increasingly touted as a means to improve health care quality. PURPOSE:To evaluate the effect of P4P remuneration targeting individual health care providers. DATA SOURCES:MEDLINE, EMBASE, Cochrane Library, OpenSIGLE, Canadian Evaluation Society Unpublished Literature Bank, New ...

journal_title：Annals of internal medicine

authors： Houle SK,McAlister FA,Jackevicius CA,Chuck AW,Tsuyuki RT

更新日期：2012-12-18 00:00:00

abstract：:Cataract disrupts the crystalline lens, a transparent, elastic, avascular, biconvex structure composed of a capsule, lens epithelium, and lens fiber cells. Many factors contribute to the progression of lens opacity, but aging is most frequently associated with cataract. As aging-related cataract develops, many biochem...

journal_title：Annals of internal medicine

authors： Straatsma BR,Foos RY,Horwitz J,Gardner KM,Pettit TH

更新日期：1985-01-01 00:00:00

abstract：:Adult salicylate intoxication has been considered to be easily recognized and assciated with low morbidity and mortality. In the present study of 73 consecutive adults hospitalized with salicylate intoxication, 27% of patients were undiagnosed for as long as 72 h after admission. The initial physical findings and labo...

journal_title：Annals of internal medicine

authors： Anderson RJ,Potts DE,Gabow PA,Rumack BH,Schrier RW

更新日期：1976-12-01 00:00:00

abstract：OBJECTIVE:To determine whether antimicrobial therapy for Helicobacter pylori infection accelerates the healing of duodenal ulcers. DESIGN:Single-blind, randomized, controlled trial. SETTING:Veterans Affairs hospital. PARTICIPANTS:One hundred and five patients with endoscopically verified duodenal ulcers. INTERVENTI...

journal_title：Annals of internal medicine

authors： Graham DY,Lew GM,Evans DG,Evans DJ Jr,Klein PD

更新日期：1991-08-15 00:00:00

abstract：:We provide a new perspective with which to understand what for a half century has been known as the "placebo effect." We argue that, as currently used, the concept includes much that has nothing to do with placebos, confusing the most interesting and important aspects of the phenomenon. We propose a new way to underst...

journal_title：Annals of internal medicine

authors： Moerman DE,Jonas WB

更新日期：2002-03-19 00:00:00

abstract：:The term "medical necessity" is used ubiquitously in health care, but its meaning and implementation vary substantially among providers, payers, and patients. This ambiguity has led some to suggest that cost-effectiveness be used as a basis for decision rules. This paper presents an analytical framework that is famili...

journal_title：Annals of internal medicine

authors： Glassman PA,Model KE,Kahan JP,Jacobson PD,Peabody JW

更新日期：1997-01-15 00:00:00

abstract：BACKGROUND:Resistance to activated protein C due to the factor V R506Q (Leiden) mutation is the most common clotting abnormality in patients with venous thromboembolism. OBJECTIVE:To evaluate the risk for venous thromboembolism associated with the factor V Leiden mutation or with resistance to activated protein C in t...

journal_title：Annals of internal medicine

authors： Rodeghiero F,Tosetto A

更新日期：1999-04-20 00:00:00

abstract：:We compared the efficacy of orally administered ampicillin, 2 g/d, with that of trimethoprim-sulfamethoxazole, 320 mg/d-1600 mg/d, given for 2 or 6 weeks for outpatient management of acute uncomplicated renal infection in women. Of 98 women participating in the trial, 60 had renal infections with susceptible strains, ...

journal_title：Annals of internal medicine

authors： Stamm WE,McKevitt M,Counts GW

更新日期：1987-03-01 00:00:00

abstract：OBJECTIVE:To determine which procedures nephrologists do in practice, where they learned the procedures, and how much training they recommend to achieve and maintain clinical competence in each. DESIGN:Mailed survey. PARTICIPANTS:A random sample of 700 members of the American College of Physicians who were identified...

journal_title：Annals of internal medicine

authors： Tape TG,Wigton RS,Blank LL,Nicolas JA

更新日期：1990-09-01 00:00:00

abstract：:Deaths and injuries related to firearms constitute a major public health problem in the United States. In response to firearm violence and other firearm-related injuries and deaths, an interdisciplinary, interprofessional group of leaders of 8 national health professional organizations and the American Bar Association...

journal_title：Annals of internal medicine

authors： Weinberger SE,Hoyt DB,Lawrence HC 3rd,Levin S,Henley DE,Alden ER,Wilkerson D,Benjamin GC,Hubbard WC

更新日期：2015-04-07 00:00:00

abstract：SOURCE CITATION:Ye Z, Rochwerg B, Wang Y, et al. Treatment of patients with nonsevere and severe coronavirus disease 2019: an evidence-based guideline. CMAJ. 2020;192:E536-45. 32350002. ...

journal_title：Annals of internal medicine

authors： Paladugu S,Donato AA

更新日期：2020-07-21 00:00:00

abstract：OBJECTIVE:To develop an early diagnostic test for pancreatic cancer based on the identification of K-ras mutations in pure pancreatic juice collected during endoscopic retrograde pancreatography. DESIGN:Prospective study with masked comparison. The standard criteria for the diagnosis of pancreatic cancer were pancreat...

journal_title：Annals of internal medicine

authors： Berthélemy P,Bouisson M,Escourrou J,Vaysse N,Rumeau JL,Pradayrol L

更新日期：1995-08-01 00:00:00