Blood-group-A-like substance in a preparation of pneumococcal vaccine.

Abstract:

:A platelet transfusion from a blood group O donor, immunized 1 month before with Pneumovax, caused a hemolytic reaction in a blood group A recipient. Forty-five of 59 group O donors (76%) and all of nine group B donors immunized with Pneumovax had a fourfold or higher anti-A response. Half of the anti-A antibody in high titered donors was in the IgG fraction. Pneumovax contained approximately 30 micrograms of an A-like substance per dose; polyvalent pneumococcal vaccines prepared by two other manufactures contained very low and probably subimmunogenic concentrations. Several culture media prepared from animal tissues contained as antigen of similar physical, immunologic, and chemical properties, and were the most likely source of the contaminant. Manufacturing procedures have since been revised to eliminate A-like substances.

journal_name

Ann Intern Med

authors

Siber GR,Ambrosino DM,Gorgone BC

doi

10.7326/0003-4819-96-5-580

subject

Has Abstract

pub_date

1982-05-01 00:00:00

pages

580-6

issue

5

eissn

0003-4819

issn

1539-3704

journal_volume

96

pub_type

杂志文章
  • Association of fibrinogen with glycemic control and albumin excretion rate in patients with non-insulin-dependent diabetes mellitus.

    abstract:BACKGROUND:The high prevalence of classic cardiac risk factors in patients with non-insulin-dependent diabetes mellitus does not explain the increased cardiovascular-related morbidity and mortality in these patients. Fibrinogen may have a role in this excess risk. OBJECTIVE:To evaluate the following in patients with n...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-125-8-199610150-00005

    authors: Bruno G,Cavallo-Perin P,Bargero G,Borra M,D'Errico N,Pagano G

    更新日期:1996-10-15 00:00:00

  • Occupational exposures to body fluids among medical students. A seven-year longitudinal study.

    abstract:BACKGROUND:Medical students may be at high risk for occupational exposures to blood. OBJECTIVE:To measure the frequency of medical students' exposure to infectious body substances, to identify factors that affect the probability of such exposure, and to suggest targets for the prevention of such exposure. DESIGN:Revi...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-130-1-199901050-00009

    authors: Osborn EH,Papadakis MA,Gerberding JL

    更新日期:1999-01-05 00:00:00

  • Guidelines for the care of patients hospitalized with viral hepatitis.

    abstract::For years patients hospitalized with viral hepatitis have been placed in two categories of isolation--enteric precautions and blood precautions. This strategy was based on the inability to differentiate between hepatitis A and B and on the assumption that feces and blood from patients with either type might be infecti...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-91-6-872

    authors: Favero MS,Maynard JE,Leger RT,Graham DR,Dixon RE

    更新日期:1979-12-01 00:00:00

  • Biliary excretion of aluminum in aluminum osteodystrophy with liver disease.

    abstract::Two patients with chronic liver disease developed elevated serum aluminum concentrations and biopsy-proven osteodystrophy. Neither patient had chronic renal failure but both had received aluminum-containing antacids for long periods. We measured biliary and urinary aluminum excretion during antacid loading in patients...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-104-6-782

    authors: Williams JW,Vera SR,Peters TG,Luther RW,Bhattacharya S,Spears H,Graham A,Pitcock JA,Crawford AJ,Palmieri GM

    更新日期:1986-06-01 00:00:00

  • Preventing Firearm-Related Death and Injury.

    abstract::Deaths and injuries from firearms are significant public health problems, and clinicians are in a unique position to identify risk among their patients and discuss the importance of safe firearm practices. Although clinicians may be ill-prepared to engage in such discussions, an adequate body of evidence is available ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/AITC201906040

    authors: Pallin R,Spitzer SA,Ranney ML,Betz ME,Wintemute GJ

    更新日期:2019-06-04 00:00:00

  • Variability in Pathologists' Interpretations of Individual Breast Biopsy Slides: A Population Perspective.

    abstract:BACKGROUND:The effect of physician diagnostic variability on accuracy at a population level depends on the prevalence of diagnoses. OBJECTIVE:To estimate how diagnostic variability affects accuracy from the perspective of a U.S. woman aged 50 to 59 years having a breast biopsy. DESIGN:Applied probability using Bayes'...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/M15-0964

    authors: Elmore JG,Nelson HD,Pepe MS,Longton GM,Tosteson AN,Geller B,Onega T,Carney PA,Jackson SL,Allison KH,Weaver DL

    更新日期:2016-05-17 00:00:00

  • A randomized trial of diagnostic strategies after normal proximal vein ultrasonography for suspected deep venous thrombosis: D-dimer testing compared with repeated ultrasonography.

    abstract:BACKGROUND:With suspected deep venous thrombosis and normal results on proximal vein ultrasonography, a negative d-dimer result may exclude thrombosis and a positive D-dimer result may be an indication for venography. OBJECTIVE:To evaluate and compare the safety of 2 diagnostic strategies for deep venous thrombosis. ...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.7326/0003-4819-142-7-200504050-00007

    authors: Kearon C,Ginsberg JS,Douketis J,Crowther MA,Turpie AG,Bates SM,Lee A,Brill-Edwards P,Finch T,Gent M

    更新日期:2005-04-05 00:00:00

  • Screening for testicular cancer: U.S. Preventive Services Task Force reaffirmation recommendation statement.

    abstract:DESCRIPTION:Reaffirmation of the 2004 U.S. Preventive Services Task Force (USPSTF) recommendation statement on screening for testicular cancer. METHODS:The USPSTF performed a targeted literature search for benefits and harms of screening for testicular cancer in asymptomatic males and found no new studies. RECOMMENDA...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,实务指引

    doi:10.7326/0003-4819-154-7-201104050-00006

    authors: U.S. Preventive Services Task Force.

    更新日期:2011-04-05 00:00:00

  • Hospital ventilation and risk for tuberculous infection in canadian health care workers. Canadian Collaborative Group in Nosocomial Transmission of TB.

    abstract:BACKGROUND:The risk for and determinants of transmission of tuberculosis in hospitals caring for moderate numbers of patients with tuberculosis remain uncertain. OBJECTIVE:To study the association of tuberculin conversion among health care workers with ventilation of patient care areas. DESIGN:Cross-sectional observa...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-133-10-200011210-00010

    authors: Menzies D,Fanning A,Yuan L,FitzGerald JM

    更新日期:2000-11-21 00:00:00

  • Multivitamin use, folate, and colon cancer in women in the Nurses' Health Study.

    abstract:BACKGROUND:High intake of folate may reduce risk for colon cancer, but the dosage and duration relations and the impact of dietary compared with supplementary sources are not well understood. OBJECTIVE:To evaluate the relation between folate intake and incidence of colon cancer. DESIGN:Prospective cohort study. SETT...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-129-7-199810010-00002

    authors: Giovannucci E,Stampfer MJ,Colditz GA,Hunter DJ,Fuchs C,Rosner BA,Speizer FE,Willett WC

    更新日期:1998-10-01 00:00:00

  • Reactivation of chronic hepatitis B virus infection by cancer chemotherapy.

    abstract::Two patients referred for cancer chemotherapy were found to be chronic, asymptomatic hepatitis B surface antigen (HBsAg) carriers. They had normal serum aminotransferase levels, but their sera were positive for HGsAg and antibody to hepatitis B e antigen. Both patients developed acute, icteric hepatitis within 3 month...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-96-4-447

    authors: Hoofnagle JH,Dusheiko GM,Schafer DF,Jones EA,Micetich KC,Young RC,Costa J

    更新日期:1982-04-01 00:00:00

  • Prevalence of neutropenia in the U.S. population: age, sex, smoking status, and ethnic differences.

    abstract:BACKGROUND:Benign reductions in neutrophil counts may be more common at certain ages and in certain ethnic groups and may be affected by sex and smoking status. OBJECTIVE:To determine differences in neutrophil counts in the U.S. population according to ethnicity, age, sex, and smoking status. DESIGN:Population-based,...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-146-7-200704030-00004

    authors: Hsieh MM,Everhart JE,Byrd-Holt DD,Tisdale JF,Rodgers GP

    更新日期:2007-04-03 00:00:00

  • Death and taxes.

    abstract::Tax incentives can provide a large financial impetus to change behavior. Current U.S. law establishes a substantial discontinuity in the amount of estate tax that many patients will have to pay in 2010: During this year only, the tax rate drops to zero. This article discusses concerns regarding the sharp change in tax...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-149-11-200812020-00010

    authors: Mendenhall GS

    更新日期:2008-12-02 00:00:00

  • Is antimicrobial prophylaxis of urinary tract infections cost effective?

    abstract::Antimicrobial prophylaxis prevents recurrent urinary tract infections in susceptible women, but its cost effectiveness has not been studied. In a recent placebo-controlled trial of urinary prophylaxis, we also assessed cost effectiveness using a decision analysis model. In our hospital the direct cost of 1 patient yea...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.7326/0003-4819-94-2-251

    authors: Stamm WE,McKevitt M,Counts GW,Wagner KF,Turck M,Holmes KK

    更新日期:1981-02-01 00:00:00

  • Asthma in respiratory therapists.

    abstract:STUDY OBJECTIVE:To test the hypothesis that work as a respiratory therapist is associated with an increased risk of developing asthma. DESIGN:Cross-sectional questionnaire study comparing respiratory therapists with controls (physical therapists and radiologic technologists). Subsequent validation of reported asthma w...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-110-10-767

    authors: Kern DG,Frumkin H

    更新日期:1989-05-15 00:00:00

  • Pyelonephritis associated with Legionella pneumophila, serogroup 4.

    abstract::A patient with bladder carcinoma metastatic to lung and brain died of pneumonia. Autopsy examination showed a confluent bronchopneumonia with several small abscesses and acute pyelonephritis with abscess formation. Legionella pneumophila, serogroup 4, was isolated in pure culture from lung tissue postmortem and was al...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-93-6-835

    authors: Dorman SA,Hardin NJ,Winn WC Jr

    更新日期:1980-12-01 00:00:00

  • Coccidioidomycosis of the thyroid.

    abstract::In two patients with thyroiditis caused by Coccidioides immitis, presented thyroid symptoms and findings were characteristic of subacute thyroiditis. Fine needle aspiration biopsy of the thyroid proved useful in establishing the diagnosis of coccidioidomycosis. This is the first report of coccidioidomycosis presenting...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-91-3-409

    authors: Loeb JM,Livermore BM,Wofsy D

    更新日期:1979-09-01 00:00:00

  • Care of the aged: the barriers of traditions.

    abstract::The growing population of older persons in our society will require increased attention. It is contended that the current pattern of third-party reimbursement for hospitalization and technical procedures focuses upon acute care and cure. The philosophy underlying medical education and practice is a barrier to the prov...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-94-2-256

    authors: Eisdorfer C

    更新日期:1981-02-01 00:00:00

  • Spondyloarthropathy associated with hidradenitis suppurative and acne conglobata.

    abstract::We evaluated 10 patients with hidradenitis suppurative or acne conglobata who developed arthritis. In contrast to patients with acne fulminans and arthritis, all our subjects were adults over 22 years of age; nine were black; and four were women. Nine patients had episodic inflammatory oligoarthritis affecting mainly ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-97-4-520

    authors: Rosner IA,Richter DE,Huettner TL,Kuffner GH,Wisnieski JJ,Burg CG

    更新日期:1982-10-01 00:00:00

  • Care of the Patient Using Cannabis.

    abstract::The past 2 decades have seen a revolution in legal access to cannabis, driven largely by activists and business interests. As a result, the population of cannabis users nationwide-especially daily users-has grown significantly. An estimated 4.5-7 million persons in the United States now meet criteria for cannabis use ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/AITC202011030

    authors: Williams AR,Hill KP

    更新日期:2020-11-03 00:00:00

  • Absence of echocardiographic abnormalities of the anterior mitral valve leaflet in rheumatoid arthritis.

    abstract::Thirty-five consecutives patients with classic or definite rheumatoid arthritis underwent echocardiography to evaluate the motion of the anterior mitral valve leaflet. Adequate echocardiograms were obtained in 31 patients. All 31 patients showed normal valve motion and a normal EF slope. If meticulous technique was no...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-83-4-500

    authors: Davia JE,Cheitlin MD,de Castro CM,Lawless O,Niemi L

    更新日期:1975-10-01 00:00:00

  • Oral zinc therapy for Wilson's disease.

    abstract::Wilson's disease is an inherited disorder of copper accumulation that is fatal if untreated. Because penicillamine, the established treatment, is toxic in a substantial number of patients, we studied the efficacy of zinc treatment. We induced a negative or neutral copper balance in five out of five patients with Wilso...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-99-3-314

    authors: Brewer GJ,Hill GM,Prasad AS,Cossack ZT,Rabbani P

    更新日期:1983-09-01 00:00:00

  • General internal medicine at the crossroads of prosperity and despair: caring for patients with chronic diseases in an aging society.

    abstract::During the past quarter century, general internal medicine has emerged as a vital discipline. In the realm of patient care, it is the integrating discipline par excellence. Ironically, as general internists face the challenge of integrating advances of dizzying speed and complexity, and as their clinical practice beco...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-134-10-200105150-00013

    authors: Larson EB

    更新日期:2001-05-15 00:00:00

  • Extracranial Carotid Disease and Effect of Intra-arterial Treatment in Patients With Proximal Anterior Circulation Stroke in MR CLEAN.

    abstract:Background:The presence of extracranial carotid disease (ECD) is associated with less favorable clinical outcomes in patients with acute ischemic stroke caused by intracranial proximal occlusion. Acute intra-arterial treatment (IAT) in the setting of extracranial and intracranial lesions is considered challenging, and ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.7326/M16-1536

    authors: Berkhemer OA,Borst J,Kappelhof M,Yoo AJ,van den Berg LA,Fransen PSS,Beumer D,Schonewille WJ,Nederkoorn PJ,Wermer MJH,Marquering HA,Lingsma HF,Roos YBWEM,van Oostenbrugge RJ,Dippel DWJ,van Zwam WH,Majoie CBLM,Emmer BJ,

    更新日期:2017-06-20 00:00:00

  • Reversible renal insufficiency due to angiotensin converting enzyme inhibitors in hypertensive nephrosclerosis.

    abstract:OBJECTIVE:To review the incidence of reversible renal insufficiency in patients with hypertensive nephrosclerosis undergoing antihypertensive therapy. DESIGN:Retrospective analysis of 73 patients in a long-term blood pressure control study that compared the effects of an angiotensin converting enzyme (ACE) inhibitor p...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.7326/0003-4819-115-7-513

    authors: Toto RD,Mitchell HC,Lee HC,Milam C,Pettinger WA

    更新日期:1991-10-01 00:00:00

  • Selective venous sampling for ACTH in Cushing's syndrome: differentiation between Cushing disease and the ectopic ACTH syndrome.

    abstract::We performed selective venous catheterization and sampling for ACTH in six patients with ACTH-secreting pituitary adenomas (Cushing's disease) and four patients with occult ectopic ACTH-secreting neoplasms. In five patients with Cushing's disease in whom the inferior petrosal sinus could be catheterized, ACTH levels w...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-94-5-647

    authors: Findling JW,Aron DC,Tyrrell JB,Shinsako JH,Fitzgerald PA,Norman D,Wilson CB,Forsham PH

    更新日期:1981-05-01 00:00:00

  • Screening for abdominal aortic aneurysm: U.S. Preventive Services Task Force recommendation statement.

    abstract:DESCRIPTION:Update of the 2005 U.S. Preventive Services Task Force (USPSTF) recommendation on screening for abdominal aortic aneurysm (AAA). METHODS:The USPSTF commissioned a systematic review that assessed the evidence on the benefits and harms of screening for AAA and strategies for managing small (3.0 to 5.4 cm) sc...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,实务指引

    doi:10.7326/M14-1204

    authors: LeFevre ML,U.S. Preventive Services Task Force.

    更新日期:2014-08-19 00:00:00

  • New federal initiatives to enhance the medical treatment of opioid dependence.

    abstract::Opioid dependence is a chronic relapsing medical condition with substantial health and societal complications. Recent federal initiatives are designed to enhance the medical treatment of patients with opioid dependence and will expand the role of internists in the care of these patients. These initiatives include a pr...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-137-8-200210150-00014

    authors: Fiellin DA,O'Connor PG

    更新日期:2002-10-15 00:00:00

  • Extended-duration venous thromboembolism prophylaxis in acutely ill medical patients with recently reduced mobility: a randomized trial.

    abstract:BACKGROUND:Extended-duration low-molecular-weight heparin has been shown to prevent venous thromboembolism (VTE) in high-risk surgical patients. OBJECTIVE:To evaluate the efficacy and safety of extended-duration enoxaparin thromboprophylaxis in acutely ill medical patients. DESIGN:Randomized, parallel, placebo-contro...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.7326/0003-4819-153-1-201007060-00004

    authors: Hull RD,Schellong SM,Tapson VF,Monreal M,Samama MM,Nicol P,Vicaut E,Turpie AG,Yusen RD,EXCLAIM (Extended Prophylaxis for Venous ThromboEmbolism in Acutely Ill Medical Patients With Prolonged Immobilization) study.

    更新日期:2010-07-06 00:00:00

  • Meta-analysis: the effect of dietary counseling for weight loss.

    abstract:BACKGROUND:Dietary and lifestyle modification efforts are the primary treatments for people who are obese or overweight. The effect of dietary counseling on long-term weight change is unclear. PURPOSE:To perform a meta-analysis of the effect of dietary counseling compared with usual care on body mass index (BMI) over ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.7326/0003-4819-147-1-200707030-00007

    authors: Dansinger ML,Tatsioni A,Wong JB,Chung M,Balk EM

    更新日期:2007-07-03 00:00:00