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Prevalence of neutropenia in the U.S. population: age, sex, smoking status, and ethnic differences.

Abstract：

BACKGROUND:Benign reductions in neutrophil counts may be more common at certain ages and in certain ethnic groups and may be affected by sex and smoking status. OBJECTIVE:To determine differences in neutrophil counts in the U.S. population according to ethnicity, age, sex, and smoking status. DESIGN:Population-based, cross-sectional study. SETTING:Various locations in the United States. PARTICIPANTS:25,222 participants in the 1999 to 2004 National Health and Nutrition Examination Survey who were 1 year of age or older. MEASUREMENTS:Complete blood counts and comparison of means and the proportion of participants with neutropenia. RESULTS:Relative to white participants, black participants had lower leukocyte counts (mean difference, 0.89 x 10(9) cells/L; P < 0.001), lower neutrophil counts (0.83 x 10(9) cells/L; P < 0.001), and similar lymphocyte counts (0.022 x 10(9) cells/L; P = 0.36), whereas Mexican-American participants had slightly higher mean leukocyte counts (0.16 x 10(9) cells/L; P = 0.014), higher neutrophil counts (0.11 x 10(9) cells/L; P = 0.026), and higher lymphocyte counts (0.095 x 10(9) cells/L; P < 0.001). The prevalence of neutropenia (neutrophil count <1.5 x 10(9) cells/L) was 4.5% among black participants, 0.79% among white participants, and 0.38% among Mexican-American participants. The prevalence of neutropenia was higher among males and children younger than 5 years of age. Neutrophil counts less than 1.0 x 10(9) cells/L were observed in fewer than 1% of the overall sample (0.57% in black participants, 0.11% in white participants, and 0.08% in Mexican-American participants). Smoking was associated with higher leukocyte and neutrophil counts but had a smaller effect among black and Mexican-American participants than among white participants. LIMITATION:Because estimates are based on single measures, fluctuations over time could not be determined. CONCLUSIONS:In the United States, neutrophil counts are lower in black persons than in white persons and neutropenia is more prevalent in black persons. Neutrophil counts are slightly higher in Mexican-American persons than in white persons, and neutropenia is uncommon in both groups. The clinical implications of these findings are unclear, but they suggest that when determining the need for a diagnostic evaluation for neutropenia, clinicians should consider the patient's age, sex, ethnicity, and smoking status.

journal_name

Ann Intern Med

journal_title

Annals of internal medicine

authors

Hsieh MM,Everhart JE,Byrd-Holt DD,Tisdale JF,Rodgers GP

doi

10.7326/0003-4819-146-7-200704030-00004

subject

Has Abstract

pub_date

2007-04-03 00:00:00

pages

486-92

issue

eissn

0003-4819

issn

1539-3704

pii

146/7/486

journal_volume

146

pub_type

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Prevalence of neutropenia in the U.S. population: age, sex, smoking status, and ethnic differences.