Comparative effectiveness of new oral anticoagulants and standard thromboprophylaxis in patients having total hip or knee replacement: a systematic review.

Abstract:

BACKGROUND:Pharmacologic thromboprophylaxis reduces the risk for venous thromboembolism after total hip replacement (THR) or total knee replacement (TKR). New oral anticoagulants (NOACs), including direct thrombin inhibitors and factor Xa inhibitors, are emerging options for thromboprophylaxis after these procedures. PURPOSE:To compare the benefits and risks of NOACs versus standard thromboprophylaxis for adults having THR or TKR. DATA SOURCES:MEDLINE, EMBASE, and the Cochrane Database of Systematic Reviews from January 2009 through March 2013. STUDY SELECTION:English-language systematic reviews. DATA EXTRACTION:Two independent reviewers abstracted data and rated study quality and strength of evidence. DATA SYNTHESIS:Six good-quality systematic reviews compared NOACs with low-molecular-weight heparin (LMWH) for thromboprophylaxis after THR or TKR. Risk for symptomatic deep venous thrombosis, but not risk for death or nonfatal pulmonary embolism, was reduced with factor Xa inhibitors compared with LMWH (4 fewer events per 1000 patients). Conversely, the risk for major bleeding increased (2 more events per 1000 patients). Outcomes of dabigatran did not significantly differ from those of LMWH. Indirect evaluation of NOACs by common comparison with LMWH showed nonsignificantly reduced risks for venous thromboembolism with rivaroxaban compared with dabigatran (risk ratio [RR], 0.68 [95% CI, 0.21 to 2.23]) and apixaban (RR, 0.59 [CI, 0.26 to 1.33]) but increased major bleeding. New oral anticoagulants have not been compared with warfarin, aspirin, or unfractionated heparin. LIMITATIONS:Head-to-head comparisons among NOACs were not available. Efficacy is uncertain in routine clinical practice. CONCLUSION:New oral anticoagulants are effective for thromboprophylaxis after THR and TKR. Their clinical benefits over LMWH are marginal and offset by increased risk for major bleeding. PRIMARY FUNDING SOURCE:U.S. Department of Veterans Affairs.

journal_name

Ann Intern Med

authors

Adam SS,McDuffie JR,Lachiewicz PF,Ortel TL,Williams JW Jr

doi

10.7326/0003-4819-159-4-201308200-00008

subject

Has Abstract

pub_date

2013-08-20 00:00:00

pages

275-84

issue

4

eissn

0003-4819

issn

1539-3704

pii

1726824

journal_volume

159

pub_type

杂志文章,评审
  • Hairy cell leukemia: a clinical review based on 71 cases.

    abstract::We studied the clinical and laboratory characteristics of 71 patients with hairy cell leukemia to ascertain whether prognostic factors important for the therapy of the disease existed. Granulocytopenia of less than 500/mu 1 was associated with the occurrence of a serious infection in 46% of the patients, compared to 1...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-89-5-677

    authors: Golomb HM,Catovsky D,Golde DW

    更新日期:1978-11-01 00:00:00

  • Lymphomatoid papulosis: a T-cell dyscrasia with a propensity to transform into malignant lymphoma.

    abstract:OBJECTIVE:To describe the diagnostic difficulties, response to therapy, and clinical features of lymphomatoid papulosis and the cumulative frequency of transformation to lymphoma. DESIGN:Case series. SETTING:University hospitals. METHODS:The records of 21 patients with lymphomatoid papulosis who were seen from 1986 ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-122-3-199502010-00009

    authors: Cabanillas F,Armitage J,Pugh WC,Weisenburger D,Duvic M

    更新日期:1995-02-01 00:00:00

  • Pathologic blood flow in pulmonary vascular disease as shown by gated magnetic resonance imaging.

    abstract::Axial, dual spin-echo magnetic resonance (MR) images, taken at the level of the pulmonary arteries and gated to the cardiac cycle, were qualitatively and quantitatively evaluated in nine patients with primary pulmonary arterial hypertension and six controls. In controls and patients, intravascular signal intensity was...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-103-3-317

    authors: von Schulthess GK,Fisher MR,Higgins CB

    更新日期:1985-09-01 00:00:00

  • Recombinant leukocyte A interferon in advanced breast cancer. Results of a phase II efficacy trial.

    abstract::Nineteen patients with advanced refractory metastatic breast cancer no longer responsive to chemotherapy were treated in the first phase II efficacy trial of recombinant leukocyte A interferon (IFL-rA), a highly purified single molecular species of alpha interferon prepared by recombinant DNA methods. Patients receive...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章

    doi:10.7326/0003-4819-98-5-598

    authors: Sherwin SA,Mayer D,Ochs JJ,Abrams PG,Knost JA,Foon KA,Fein S,Oldham RK

    更新日期:1983-05-01 00:00:00

  • Remdesivir for Adults With COVID-19 : A Living Systematic Review for an American College of Physicians Practice Points.

    abstract:BACKGROUND:Few treatments exist for coronavirus disease 2019 (COVID-19). PURPOSE:To evaluate the effectiveness and harms of remdesivir for COVID-19. DATA SOURCES:Several databases, tables of contents of journals, and U.S. Food and Drug Administration and company websites were searched from 1 January through 31 August...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/M20-5752

    authors: Wilt TJ,Kaka AS,MacDonald R,Greer N,Obley A,Duan-Porter W

    更新日期:2020-10-05 00:00:00

  • Arizona hinshawii infections. New cases, antimicrobial sensitivities, and literature review.

    abstract::Although disease caused by Arizona hinshawii is known to resemble the spectrum of clinical syndromes seen with Salmonella infections, little is known of their sensitivity to antimicrobials. We present three cases that are illustrative of Arizona sepsis, localized infection, or both; review the literature; and report s...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-85-5-587

    authors: Johnson RH,Lutwick LI,Huntley GA,Vosti KL

    更新日期:1976-11-01 00:00:00

  • Screening for chronic kidney disease: U.S. Preventive Services Task Force recommendation statement.

    abstract:DESCRIPTION:New U.S. Preventive Services Task Force (USPSTF) recommendation statement on screening for chronic kidney disease (CKD). METHODS:The USPSTF reviewed evidence on screening for CKD, including evidence on screening, accuracy of screening, early treatment, and harms of screening and early treatment. POPULATIO...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,实务指引

    doi:10.7326/0003-4819-157-8-201210160-00533

    authors: Moyer VA,U.S. Preventive Services Task Force.

    更新日期:2012-10-16 00:00:00

  • Interferon-gamma, the activated macrophage, and host defense against microbial challenge.

    abstract::Recent research on human macrophage activation has reemphasized the critical role of the lymphokine-secreting T cell in converting quiescent macrophages to efficient microbicidal phagocytes. Interferon-gamma, a key lymphokine secreted by antigen-triggered T4+ helper cells, is capable of inducing the macrophage to act ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-108-4-595

    authors: Murray HW

    更新日期:1988-04-01 00:00:00

  • Human babesiosis on Nantucket Island. Clinical features.

    abstract::Between 20 July and 15 Octoboer 1975, five cases of human infection with Babesia microti were diagnosed on Nantucket Island, Massachusetts. The illness was characterized by fever, drenching sweats, shaking chills, myalgia, arthralgia, extreme fatigue, and a mild-to-moderate hemolytic anemia. None of the patients had a...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-86-1-6

    authors: Reubush TK 2nd,Cassaday PB,Marsh HJ,Lisker SA,Voorhees DB,Mahoney EB,Healy GR

    更新日期:1977-01-01 00:00:00

  • Short-term hormone therapy suspension and mammography recall: a randomized trial.

    abstract:BACKGROUND:Without population-based evidence, some clinicians recommend short-term suspension of hormone therapy to improve the performance of mammography. Hormone therapy increases breast density, and abnormal screening mammograms are more common among women with denser breasts and among women using hormone therapy. ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.7326/0003-4819-150-11-200906020-00003

    authors: Buist DS,Anderson ML,Reed SD,Aiello Bowles EJ,Fitzgibbons ED,Gandara JC,Seger D,Newton KM

    更新日期:2009-06-02 00:00:00

  • Type III hyperlipoproteinemia: diagnosis in whole plasma by apolipoprotein-E immunoassay.

    abstract::Because the cholesterol-rich very low density (VLD) lipoproteins of subjects with type III hyperlipoproteinemia are distinctively enriched in apolipoprotein E, a radial immunodiffusion assay for apolipoprotein E in whole plasma was developed. Its diagnostic usefulness was tested in randomly selected (n = 174) and hype...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-87-5-509

    authors: Kushwaha RS,Hazzard WR,Wahl PW,Hoover JJ

    更新日期:1977-11-01 00:00:00

  • In the clinic. Clostridium difficile Infection.

    abstract::This issue provides a clinical overview of Clostridium difficile infection focusing on prevention, diagnosis, treatment, practice improvement, and patient information. Readers can complete the accompanying CME quiz for 1.5 credits. Only ACP members and individual subscribers can access the electronic features of In th...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-153-7-201010050-01004

    authors: Hessen MT

    更新日期:2010-10-05 00:00:00

  • Hypophosphatemic osteomalacia: association with prostatic carcinoma.

    abstract::Hypophosphatemic osteomalacia that remits after resection of a coexisting tumor has been described in 35 patients. Because the associated neoplasms have been of mesenchymal origin, it has been inferred that this tumor-induced osteomalacia syndrome is uniquely related to tumours of this derivation. However, in the pres...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-93-2-275

    authors: Lyles KW,Berry WR,Haussler M,Harrelson JM,Drezner MK

    更新日期:1980-08-01 00:00:00

  • Physical performance in peripheral arterial disease: a slower rate of decline in patients who walk more.

    abstract:BACKGROUND:Exercise rehabilitation programs increase treadmill walking performance in patients with peripheral arterial disease (PAD) and intermittent claudication. However, it is unknown whether patients with PAD who walk for exercise regularly have less functional decline than those with less walking activity. OBJEC...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-144-1-200601030-00005

    authors: McDermott MM,Liu K,Ferrucci L,Criqui MH,Greenland P,Guralnik JM,Tian L,Schneider JR,Pearce WH,Tan J,Martin GJ

    更新日期:2006-01-03 00:00:00

  • Low-dose aspirin for prevention of morbidity and mortality from preeclampsia: a systematic evidence review for the U.S. Preventive Services Task Force.

    abstract:BACKGROUND:Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality. PURPOSE:To systematically review benefits and harms of low-dose aspirin for preventing morbidity and mortality from preeclampsia. DATA SOURCES:MEDLINE, Database of Abstracts of Reviews of Effects, PubMed, and Cochrane Centra...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/M13-2844

    authors: Henderson JT,Whitlock EP,O'Connor E,Senger CA,Thompson JH,Rowland MG

    更新日期:2014-05-20 00:00:00

  • Lipophilic Statins and Risk for Hepatocellular Carcinoma and Death in Patients With Chronic Viral Hepatitis: Results From a Nationwide Swedish Population.

    abstract:Background:Whether statin type influences hepatocellular carcinoma (HCC) incidence or mortality in chronic hepatitis B or C virus infection is unknown. Objective:To assess the relationship between lipophilic or hydrophilic statin use and HCC incidence and mortality in a nationwide population with viral hepatitis. Des...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/M18-2753

    authors: Simon TG,Duberg AS,Aleman S,Hagstrom H,Nguyen LH,Khalili H,Chung RT,Ludvigsson JF

    更新日期:2019-09-03 00:00:00

  • Myocardial ischemia during cocaine withdrawal.

    abstract:STUDY OBJECTIVE:To determine the prevalence of myocardial ischemia in patients with cocaine addiction. DESIGN:Myocardial ischemia in chronic cocaine users was detected by serial 24-hour electrocardiographic ambulatory (Holter) monitoring and exercise treadmill testing in chronic cocaine users. The Holter tapes were co...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-111-11-876

    authors: Nademanee K,Gorelick DA,Josephson MA,Ryan MA,Wilkins JN,Robertson HA,Mody FV,Intarachot V

    更新日期:1989-12-01 00:00:00

  • Systematic review: comparative effectiveness of treatments to prevent fractures in men and women with low bone density or osteoporosis.

    abstract:BACKGROUND:Although several agents are available to treat osteoporosis, the relative efficacy and toxicity of these agents when used to prevent fractures has not been well described. PURPOSE:To compare the benefits in fracture reduction and the harms from adverse events of various therapies for osteoporosis. DATA SOU...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,meta分析

    doi:10.7326/0003-4819-148-3-200802050-00198

    authors: MacLean C,Newberry S,Maglione M,McMahon M,Ranganath V,Suttorp M,Mojica W,Timmer M,Alexander A,McNamara M,Desai SB,Zhou A,Chen S,Carter J,Tringale C,Valentine D,Johnsen B,Grossman J

    更新日期:2008-02-05 00:00:00

  • In the clinic. Sickle cell disease.

    abstract::This issue provides a clinical overview of sickle cell disease focusing on prevention, diagnosis, treatment, practice improvement, and patient information. Readers can complete the accompanying CME quiz for 1.5 credits. Only ACP members and individual subscribers can access the electronic features of In the Clinic. No...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-155-5-201109060-01003

    authors: Steinberg MH

    更新日期:2011-09-06 00:00:00

  • Using serum creatinine to estimate glomerular filtration rate: accuracy in good health and in chronic kidney disease.

    abstract:BACKGROUND:The National Kidney Foundation has advocated the use of the abbreviated Modification of Diet in Renal Disease (MDRD) equation to estimate glomerular filtration rate (GFR) from serum creatinine measurements in clinical laboratories. However, healthy persons were not included in the development of the MDRD equ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-141-12-200412210-00009

    authors: Rule AD,Larson TS,Bergstralh EJ,Slezak JM,Jacobsen SJ,Cosio FG

    更新日期:2004-12-21 00:00:00

  • Chemoprevention of breast cancer: a summary of the evidence for the U.S. Preventive Services Task Force.

    abstract:PURPOSE:Chemoprevention offers promise as a strategy for reducing morbidity and mortality from breast cancer in women. This review examined the evidence for the effectiveness of chemoprevention in women without a history of breast cancer. DATA SOURCES:MEDLINE (1966 to December 2001). STUDY SELECTION:English-language,...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-137-1-200207020-00017

    authors: Kinsinger LS,Harris R,Woolf SH,Sox HC,Lohr KN

    更新日期:2002-07-02 00:00:00

  • Cases in Precision Medicine: A Personalized Approach to Stroke and Cardiovascular Risk Assessment in Women.

    abstract::Cardiovascular disease is the leading cause of death among women in the United States, and stroke is third. This article uses a case scenario to examine female sex-specific cardiovascular risk factors across the lifespan and describes a precision medicine-based approach to risk factor modification and primary preventi...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/M19-1601

    authors: Bello NA,Miller EC,Cleary KL,Wapner R

    更新日期:2019-12-03 00:00:00

  • A tuberculostearic acid assay in the diagnosis of sputum smear-negative pulmonary tuberculosis. A prospective study of bronchoscopic aspirate and lavage specimens.

    abstract:OBJECTIVE:To determine whether the detection of tuberculostearic acid (TBSA) in bronchial aspirate and bronchoalveolar lavage specimens is useful for the rapid diagnosis of active pulmonary tuberculosis in patients suspected of having the disease. SETTING:A pulmonary clinic in a teaching hospital. PATIENTS:Forty pati...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-111-8-650

    authors: Pang JA,Chan HS,Chan CY,Cheung SW,French GL

    更新日期:1989-10-15 00:00:00

  • Management of chronic stable angina: medical therapy, percutaneous transluminal coronary angioplasty, and coronary artery bypass graft surgery. Lessons from the randomized trials.

    abstract:PURPOSE:To review the available data on the treatment of chronic stable angina and formulate a rational approach to the use of pharmacologic therapy, percutaneous transluminal coronary angioplasty (PTCA), and coronary artery bypass graft surgery (CABG). DATA SOURCES:A MEDLINE search of English-language literature publ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-128-3-199802010-00008

    authors: Solomon AJ,Gersh BJ

    更新日期:1998-02-01 00:00:00

  • Judging the Past: How History Should Inform Bioethics.

    abstract::Bioethics has become a common course of study in medical schools, other health professional schools, and graduate and undergraduate programs. An analysis of past ethical scandals, as well as the bioethics apparatus that emerged in response to them, is often central to the discussion of bioethical questions. This histo...

    journal_title:Annals of internal medicine

    pub_type: 历史文章,杂志文章

    doi:10.7326/M15-2642

    authors: Lerner BH,Caplan AL

    更新日期:2016-04-19 00:00:00

  • Cost-effectiveness of using pharmacogenetic information in warfarin dosing for patients with nonvalvular atrial fibrillation.

    abstract:BACKGROUND:Variants in genes involved in warfarin metabolism and sensitivity affect individual warfarin requirements and the risk for bleeding. Testing for these variant alleles might allow more personalized dosing of warfarin during the induction phase. In 2007, the U.S. Food and Drug Administration changed the labeli...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-150-2-200901200-00005

    authors: Eckman MH,Rosand J,Greenberg SM,Gage BF

    更新日期:2009-01-20 00:00:00

  • Extended-duration venous thromboembolism prophylaxis in acutely ill medical patients with recently reduced mobility: a randomized trial.

    abstract:BACKGROUND:Extended-duration low-molecular-weight heparin has been shown to prevent venous thromboembolism (VTE) in high-risk surgical patients. OBJECTIVE:To evaluate the efficacy and safety of extended-duration enoxaparin thromboprophylaxis in acutely ill medical patients. DESIGN:Randomized, parallel, placebo-contro...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.7326/0003-4819-153-1-201007060-00004

    authors: Hull RD,Schellong SM,Tapson VF,Monreal M,Samama MM,Nicol P,Vicaut E,Turpie AG,Yusen RD,EXCLAIM (Extended Prophylaxis for Venous ThromboEmbolism in Acutely Ill Medical Patients With Prolonged Immobilization) study.

    更新日期:2010-07-06 00:00:00

  • Unrelated donor bone marrow transplantation for chronic myelogenous leukemia: a decision analysis.

    abstract:BACKGROUND:Chronic myelogenous leukemia (CML) is an indolent but ultimately fatal disease. Because the natural history of CML varies and quality of life with CML may be excellent until shortly before death, deciding whether and when to pursue unrelated donor bone marrow transplantation is often difficult. OBJECTIVE:To...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-127-12-199712150-00005

    authors: Lee SJ,Kuntz KM,Horowitz MM,McGlave PB,Goldman JM,Sobocinski KA,Hegland J,Kollman C,Parsons SK,Weinstein MC,Weeks JC,Antin JH

    更新日期:1997-12-15 00:00:00

  • Nodular cutaneous microsporidiosis in a patient with AIDS and successful treatment with long-term oral clindamycin therapy.

    abstract:BACKGROUND:In AIDS, nodular skin disease can result from various causes. OBJECTIVE:To report a new manifestation of microsporidial infection presenting as nodular skin disease with underlying osteomyelitis. DESIGN:Case report. SETTING:Tertiary-care military medical center in Washington, D.C. PATIENT:A 36-year-old w...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-128-11-199806010-00009

    authors: Kester KE,Turiansky GW,McEvoy PL

    更新日期:1998-06-01 00:00:00

  • Hypercalcemia in active pulmonary tuberculosis.

    abstract::We ascertained the incidence of hypercalcemia in 79 consecutive patients with active pulmonary tuberculosis and a control group of 79 patients with chronic obstructive pulmonary disease. Twenty-two patients developed hypercalcemia (serum calcium greater than 10.5 mg/dl) within 4 to 16 weeks after initiation of chemoth...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-90-3-324

    authors: Abbasi AA,Chemplavil JK,Farah S,Muller BF,Arnstein AR

    更新日期:1979-03-01 00:00:00