Hairy cell leukemia: a clinical review based on 71 cases.

Abstract:

:We studied the clinical and laboratory characteristics of 71 patients with hairy cell leukemia to ascertain whether prognostic factors important for the therapy of the disease existed. Granulocytopenia of less than 500/mu 1 was associated with the occurrence of a serious infection in 46% of the patients, compared to 19% of patients whose absolute granulocyte count was greater than 500/mu 1 (P less than 0.05). In most patients with symptoms of thrombocytopenia or leukopenia, splenectomy led to improved blood counts. Patients treated with splenectomy only had a significantly longer survival than those treated with steroids only (P less than 0.05). A group of patients who were slightly older and had minimal splenomegaly and few hairy cells in the peripheral blood did well without therapeutic intervention. Twenty-four patients have died, 16 of an infectious process. The actuarial survival for the group is 51% at 4 years, and there has been no change subsequently.

journal_name

Ann Intern Med

authors

Golomb HM,Catovsky D,Golde DW

doi

10.7326/0003-4819-89-5-677

subject

Has Abstract

pub_date

1978-11-01 00:00:00

pages

677-83

issue

5 Pt 1

eissn

0003-4819

issn

1539-3704

journal_volume

89

pub_type

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