Using serum creatinine to estimate glomerular filtration rate: accuracy in good health and in chronic kidney disease.

Abstract:

BACKGROUND:The National Kidney Foundation has advocated the use of the abbreviated Modification of Diet in Renal Disease (MDRD) equation to estimate glomerular filtration rate (GFR) from serum creatinine measurements in clinical laboratories. However, healthy persons were not included in the development of the MDRD equation. OBJECTIVES:To assess the accuracy of the MDRD equation in patients with chronic kidney disease compared with healthy persons and to develop a new equation that uses both patients with chronic kidney disease and healthy persons. DESIGN:Cross-sectional study. SETTING:The Mayo Clinic, a tertiary-care medical center. PARTICIPANTS:Consecutive patients (n = 320) who had an iothalamate clearance test specifically for chronic kidney disease evaluation and consecutive healthy persons (n = 580) who had an iothalamate clearance test specifically for kidney donor evaluation. MEASUREMENTS:Serum creatinine levels, GFR, demographic characteristics, and clinical characteristics were abstracted from the medical record. RESULTS:The MDRD equation underestimated GFR by 6.2% in patients with chronic kidney disease and by 29% in healthy persons. Re-estimated coefficients for serum creatinine and sex were similar to the original MDRD equation in the chronic kidney disease series but not in the healthy series. At the same serum creatinine level, age, and sex, GFR was on average 26% higher in healthy persons than in patients with chronic kidney disease (P < 0.001). A quadratic GFR equation was developed to estimate logarithmic GFR from the following covariates: 1/SCr, 1/SCr2, age, and sex (where SCr = serum creatinine). LIMITATIONS:The new equation was not developed in a general population sample. Elderly and African-American persons were underrepresented. CONCLUSION:The MDRD equation systematically underestimates GFR in healthy persons. A new equation developed with patients who have chronic kidney disease and healthy persons may be a step toward accurately estimating GFR when the diagnosis of chronic kidney disease is unknown.

journal_name

Ann Intern Med

authors

Rule AD,Larson TS,Bergstralh EJ,Slezak JM,Jacobsen SJ,Cosio FG

doi

10.7326/0003-4819-141-12-200412210-00009

subject

Has Abstract

pub_date

2004-12-21 00:00:00

pages

929-37

issue

12

eissn

0003-4819

issn

1539-3704

pii

141/12/929

journal_volume

141

pub_type

杂志文章
  • Pleural effusions in hospitalized patients with AIDS.

    abstract:OBJECTIVE:To determine the incidence, cause, and characteristics of pleural effusions in hospitalized patients with the acquired immunodeficiency syndrome (AIDS). DESIGN:Retrospective. PARTICIPANTS:A total of 222 patients with AIDS hospitalized between January 1986 and January 1992 at the Medical University of South ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-118-11-199306010-00005

    authors: Joseph J,Strange C,Sahn SA

    更新日期:1993-06-01 00:00:00

  • 9-(1,3-Dihydroxy-2-propoxymethyl)guanine (ganciclovir) in the treatment of cytomegalovirus gastrointestinal disease with the acquired immunodeficiency syndrome.

    abstract::9-(1,3-dihydroxy-2-propoxymethyl) guanine (ganciclovir) was used to treat 41 patients (median age, 37 years) with the acquired immunodeficiency syndrome and cytomegalovirus gastrointestinal infection. Sites of infection were the colon in 31, the esophagus in 5, the rectum in 4, and the small bowel in 1. Patients recei...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-107-2-133

    authors: Chachoua A,Dieterich D,Krasinski K,Greene J,Laubenstein L,Wernz J,Buhles W,Koretz S

    更新日期:1987-08-01 00:00:00

  • Concepts of time in clinical research.

    abstract::The study of events in time is fundamental to biomedical research and public health surveillance. Clinicians have an intuitive appreciation for the relevance of time to health and disease, and patients invariably ask questions relating to time for which clinicians need answers. An appreciation of the picture of health...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-132-1-200001040-00007

    authors: Samet JM

    更新日期:2000-01-04 00:00:00

  • A systematic review of newer pharmacotherapies for depression in adults: evidence report summary.

    abstract:BACKGROUND:Depressive disorders are persistent, recurring illnesses that cause great suffering for patients and their families. PURPOSE:To evaluate the benefits and adverse effects of newer pharmacotherapies and herbal treatments for depressive disorders in adults and adolescents. DATA SOURCES:English-language and no...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-132-9-200005020-00011

    authors: Williams JW Jr,Mulrow CD,Chiquette E,Noël PH,Aguilar C,Cornell J

    更新日期:2000-05-02 00:00:00

  • Marrow transplantation for the treatment of chronic myelogenous leukemia.

    abstract::One hundred ninety-eight patients with chronic myelogenous leukemia received marrow transplants after intensive chemotherapy and total body irradiation. Multivariate analysis showed disease status at time of transplantation to be the most powerful predictor of survival. The probability of long-term survival for alloge...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-104-2-155

    authors: Thomas ED,Clift RA,Fefer A,Appelbaum FR,Beatty P,Bensinger WI,Buckner CD,Cheever MA,Deeg HJ,Doney K

    更新日期:1986-02-01 00:00:00

  • Is there a role for maintaining sinus rhythm in patients with atrial fibrillation?

    abstract::Recent studies have indicated that outcomes in patients with atrial fibrillation who are managed with rate control and anticoagulation are similar to those in patients who have maintenance of sinus rhythm. These studies did not include important groups of patients with atrial fibrillation in whom antiarrhythmic therap...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-141-9-200411020-00015

    authors: Zimetbaum P,Josephson ME

    更新日期:2004-11-02 00:00:00

  • Discrepancy between consensus recommendations and actual community use of adjuvant chemotherapy in women with breast cancer.

    abstract:BACKGROUND:Although the efficacy of adjuvant chemotherapy in prolonging survival for women with breast cancer has been well documented, limited population-based information is available on the actual use of chemotherapy. OBJECTIVE:To examine the relationship between age and chemotherapy use. DESIGN:Cohort study. SET...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-138-2-200301210-00009

    authors: Du XL,Key CR,Osborne C,Mahnken JD,Goodwin JS

    更新日期:2003-01-21 00:00:00

  • Hydroxychloroquine in Nonhospitalized Adults With Early COVID-19 : A Randomized Trial.

    abstract:BACKGROUND:No effective oral therapy exists for early coronavirus disease 2019 (COVID-19). OBJECTIVE:To investigate whether hydroxychloroquine could reduce COVID-19 severity in adult outpatients. DESIGN:Randomized, double-blind, placebo-controlled trial conducted from 22 March through 20 May 2020. (ClinicalTrials.gov...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.7326/M20-4207

    authors: Skipper CP,Pastick KA,Engen NW,Bangdiwala AS,Abassi M,Lofgren SM,Williams DA,Okafor EC,Pullen MF,Nicol MR,Nascene AA,Hullsiek KH,Cheng MP,Luke D,Lother SA,MacKenzie LJ,Drobot G,Kelly LE,Schwartz IS,Zarychanski R,M

    更新日期:2020-10-20 00:00:00

  • Extraintestinal manifestations in patients with diverticulitis.

    abstract::Three patients had diverticulitis and extraintestinal manifestations of arthritis and pyoderma gangrenosum. In each, a mistaken diagnosis of idiopathic inflammatory bowel disease was first made because of extraintestinal complaints associated with the gastrointestinal symptoms of diverticular disease. The joint and sk...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-108-5-700

    authors: Klein S,Mayer L,Present DH,Youner KD,Cerulli MA,Sachar DB

    更新日期:1988-05-01 00:00:00

  • Trends in the incidence of venous thromboembolism during pregnancy or postpartum: a 30-year population-based study.

    abstract:BACKGROUND:The risk for venous thromboembolism during pregnancy or postpartum is uncertain. OBJECTIVES:To estimate the relative and absolute risk for deep venous thrombosis and pulmonary embolism during pregnancy and postpartum and to describe trends in incidence. DESIGN:Population-based inception cohort study using ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-143-10-200511150-00006

    authors: Heit JA,Kobbervig CE,James AH,Petterson TM,Bailey KR,Melton LJ 3rd

    更新日期:2005-11-15 00:00:00

  • Preclinical carotid atherosclerosis in patients with rheumatoid arthritis.

    abstract:BACKGROUND:Rheumatoid arthritis is associated with increased morbidity and mortality because of cardiovascular disease, independent of traditional risk factors. OBJECTIVE:To determine the prevalence of preclinical atherosclerosis in patients with rheumatoid arthritis and to identify clinical and biological markers for...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-144-4-200602210-00006

    authors: Roman MJ,Moeller E,Davis A,Paget SA,Crow MK,Lockshin MD,Sammaritano L,Devereux RB,Schwartz JE,Levine DM,Salmon JE

    更新日期:2006-02-21 00:00:00

  • Current diagnosis of venous thromboembolism in primary care: a clinical practice guideline from the American Academy of Family Physicians and the American College of Physicians.

    abstract::This guideline summarizes the current approaches for the diagnosis of venous thromboembolism. The importance of early diagnosis to prevent mortality and morbidity associated with venous thromboembolism cannot be overstressed. This field is highly dynamic, however, and new evidence is emerging periodically that may cha...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-146-6-200703200-00013

    authors: Qaseem A,Snow V,Barry P,Hornbake ER,Rodnick JE,Tobolic T,Ireland B,Segal JB,Bass EB,Weiss KB,Green L,Owens DK,Joint American Academy of Family Physicians\/American College of Physicians Panel on Deep Venous Thrombosis\/Pulmonary

    更新日期:2007-03-20 00:00:00

  • Effect of nasogastric tube size on gastroesophageal reflux and microaspiration in intubated patients.

    abstract:BACKGROUND:Little evidence exists to support the theory that small-bore nasogastric tubes prevent gastroesophageal reflux and microaspiration in intubated patients. OBJECTIVE:To determine whether gastroesophageal reflux and microaspiration in intubated patients can be reduced by the use of a small-bore nasogastric tub...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.7326/0003-4819-130-12-199906150-00007

    authors: Ferrer M,Bauer TT,Torres A,Hernández C,Piera C

    更新日期:1999-06-15 00:00:00

  • Breast cancer in black women.

    abstract:PURPOSE:To review the current knowledge about breast cancer in black women--including epidemiology, risk factors, screening practices, pathology, clinical manifestations, treatment, and outcome--with emphasis on issues that might explain why the survival rate in this population of women is lower than that in white wome...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-124-10-199605150-00007

    authors: Moormeier J

    更新日期:1996-05-15 00:00:00

  • 12-month outcomes of community engagement versus technical assistance to implement depression collaborative care: a partnered, cluster, randomized, comparative effectiveness trial.

    abstract:BACKGROUND:Depression collaborative care implementation using community engagement and planning (CEP) across programs improves 6-month client outcomes in minority communities, compared with technical assistance to individual programs (resources for services [RS]). However, 12-month outcomes are unknown. OBJECTIVE:To c...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.7326/M13-3011

    authors: Chung B,Ong M,Ettner SL,Jones F,Gilmore J,McCreary M,Sherbourne C,Ngo V,Koegel P,Tang L,Dixon E,Miranda J,Belin TR,Wells KB

    更新日期:2014-11-18 00:00:00

  • Causes of persistent dizziness. A prospective study of 100 patients in ambulatory care.

    abstract:OBJECTIVE:To determine the causes of persistent dizziness in outpatients. DESIGN:Consecutive adult outpatients presenting with a chief complaint of dizziness. SETTING:Four clinics (internal medicine, walk-in, emergency room, and neurology) in a teaching hospital. PATIENTS:Of 185 patients presenting during the 10-mon...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-117-11-898

    authors: Kroenke K,Lucas CA,Rosenberg ML,Scherokman B,Herbers JE Jr,Wehrle PA,Boggi JO

    更新日期:1992-12-01 00:00:00

  • Effect of parenterally administered gold therapy on the course of adult rheumatoid arthritis.

    abstract:OBJECTIVE:To describe the course of rheumatoid arthritis over 5 years in adults and to evaluate the effect of parenterally administered gold salts on that course. DESIGN:A prospective observational study of adults with rheumatoid arthritis. Data derived from annual interviews with patients from 1983 to 1988 and from p...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-114-6-437

    authors: Epstein WV,Henke CJ,Yelin EH,Katz PP

    更新日期:1991-03-15 00:00:00

  • Screening for lung cancer.

    abstract::Lung cancer is the commonest cause of death from cancer in both men and women, with approximately 152,000 new cases and 139,000 deaths in 1988. The incidence and mortality rates are increasing rapidly in women. Two main tests have been used to screen for lung cancer: chest roentgenography and sputum cytology. Four rec...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-111-3-232

    authors: Eddy DM

    更新日期:1989-08-01 00:00:00

  • Hepatitis-associated lipid storage myopathy.

    abstract::We report the case of a 23-year-old woman who developed severe myalgias in association with mild hepatitis B surface antigen-positive hepatitis. Muscle biopsy showed myriads of microvacuoles filled with neutral lipid. Prednisone therapy was associated with complete clearing of all clinical and laboratory abnormalities...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-87-4-417

    authors: Patten BM,Shabot JM,Alperin J,Dodson RF

    更新日期:1977-10-01 00:00:00

  • An appraisal of tests for native DNA antibodies in connective tissue diseases. Clinical usefulness of Crithidia luciliae assay.

    abstract::Antibody to native DNA was measured by five techniques: the Crithidia luciliae immunofluorescence (CL-IF) test; filter radioimmunoassays using either untreated human KB DNA, endonuclease-treated KB DNA, or a synthetic polynucleotide (poly dAT); and the Farr immunoprecipitation assay using KB DNA. The specificity and s...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-89-2-186

    authors: Chubick A,Sontheimer RD,Gilliam JN,Ziff M

    更新日期:1978-08-01 00:00:00

  • The clinical course of patients with idiopathic pulmonary fibrosis.

    abstract:BACKGROUND:Prospective data defining the clinical course in idiopathic pulmonary fibrosis (IPF) are sparse. OBJECTIVE:To analyze the clinical course of patients with mild to moderate IPF. DESIGN:Analysis of data from the placebo group of a randomized, controlled trial evaluating interferon-gamma1b. SETTING:Academic ...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.7326/0003-4819-142-12_part_1-200506210-00005

    authors: Martinez FJ,Safrin S,Weycker D,Starko KM,Bradford WZ,King TE Jr,Flaherty KR,Schwartz DA,Noble PW,Raghu G,Brown KK,IPF Study Group.

    更新日期:2005-06-21 00:00:00

  • Preventing Firearm-Related Death and Injury.

    abstract::Deaths and injuries from firearms are significant public health problems, and clinicians are in a unique position to identify risk among their patients and discuss the importance of safe firearm practices. Although clinicians may be ill-prepared to engage in such discussions, an adequate body of evidence is available ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/AITC201906040

    authors: Pallin R,Spitzer SA,Ranney ML,Betz ME,Wintemute GJ

    更新日期:2019-06-04 00:00:00

  • Meta-analysis: efficacy and safety of inhaled insulin therapy in adults with diabetes mellitus.

    abstract:BACKGROUND:Injection insulin therapy is not readily accepted by patients and many health care providers; therefore, less invasive options for insulin therapy are desirable. PURPOSE:To examine the efficacy, safety, and patient acceptability of inhaled insulin therapy in nonpregnant adults with diabetes mellitus. DATA ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,meta分析

    doi:10.7326/0003-4819-145-9-200611070-00009

    authors: Ceglia L,Lau J,Pittas AG

    更新日期:2006-11-07 00:00:00

  • Thyrotoxic bone disease in women: a potentially reversible disorder.

    abstract:OBJECTIVE:To measure changes in spinal and femoral neck bone mineral densities in patients treated for Graves thyrotoxicosis. DESIGN:Cohort study. SETTING:Tertiary care center. PATIENTS:Fifteen women with active Graves thyrotoxicosis. Six patients were premenopausal and nine were postmenopausal. All patients had evi...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-120-1-199401010-00002

    authors: Diamond T,Vine J,Smart R,Butler P

    更新日期:1994-01-01 00:00:00

  • "Comparably massive" penicillin G therapy in renal failure.

    abstract::Impairment of penicillin G excretion in renal failure may result in life-threatening, dose-related toxicity. We report a method for achieving a desired mean serum penicillin G concentration in patients with renal failure, with minimal risk of both undertreatment and drug toxicity. The method is based on the linear rel...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-82-2-189

    authors: Bryan CS,Stone WJ

    更新日期:1975-02-01 00:00:00

  • Hypercalcemia in active pulmonary tuberculosis.

    abstract::We ascertained the incidence of hypercalcemia in 79 consecutive patients with active pulmonary tuberculosis and a control group of 79 patients with chronic obstructive pulmonary disease. Twenty-two patients developed hypercalcemia (serum calcium greater than 10.5 mg/dl) within 4 to 16 weeks after initiation of chemoth...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-90-3-324

    authors: Abbasi AA,Chemplavil JK,Farah S,Muller BF,Arnstein AR

    更新日期:1979-03-01 00:00:00

  • Prevention of intravascular catheter-related infections.

    abstract:PURPOSE:To review the literature on prevention of intravascular catheter-related infections. DATA SOURCES:The MEDLINE database, conference proceedings, and bibliographies of review articles and book chapters were searched for relevant articles. Primary authors were contacted directly if data were incomplete. STUDY SE...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,meta分析

    doi:10.7326/0003-4819-132-5-200003070-00009

    authors: Mermel LA

    更新日期:2000-03-07 00:00:00

  • Drugs five years later: acyclovir.

    abstract::In the 5 years since its release for clinical use, acyclovir (9-[2-hydroxyethoxymethyl]guanine) has proved to be a safe and effective agent for therapy of herpes simplex and varicella-zoster infections. The drug's availability in topical, oral, and intravenous preparations has allowed its use in a range of clinical si...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-107-6-859

    authors: Dorsky DI,Crumpacker CS

    更新日期:1987-12-01 00:00:00

  • Dementia in elderly outpatients: a prospective study.

    abstract::We prospectively studied the evaluation of dementia in 107 unselected outpatients; 83 had so-called "irreversible" dementias, including 74 who had an Alzheimer-type dementia. Fifteen patients had potentially reversible dementias, of which hypothyroidism and drug toxicity were the commonest causes. Distinguishing featu...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-100-3-417

    authors: Larson EB,Reifler BV,Featherstone HJ,English DR

    更新日期:1984-03-01 00:00:00

  • Pathologic blood flow in pulmonary vascular disease as shown by gated magnetic resonance imaging.

    abstract::Axial, dual spin-echo magnetic resonance (MR) images, taken at the level of the pulmonary arteries and gated to the cardiac cycle, were qualitatively and quantitatively evaluated in nine patients with primary pulmonary arterial hypertension and six controls. In controls and patients, intravascular signal intensity was...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-103-3-317

    authors: von Schulthess GK,Fisher MR,Higgins CB

    更新日期:1985-09-01 00:00:00