In the clinic. Sickle cell disease.

Abstract:

:This issue provides a clinical overview of sickle cell disease focusing on prevention, diagnosis, treatment, practice improvement, and patient information. Readers can complete the accompanying CME quiz for 1.5 credits. Only ACP members and individual subscribers can access the electronic features of In the Clinic. Non-subscribers who wish to access this issue of In the Clinic can elect "Pay for View." Subscribers can receive 1.5 category 1 CME credits by completing the CME quiz that accompanies this issue of In the Clinic. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including PIER (Physicians' Information and Education Resource) and MKSAP (Medical Knowledge and Self Assessment Program). Annals of Internal Medicine editors develop In the Clinic from these primary sources in collaboration with the ACP's Medical Education and Publishing division and with assistance of science writers and physician writers. Editorial consultants from PIER and MKSAP provide expert review of the content. Readers who are interested in these primary resources for more detail can consult www.acponline.org, http://pier.acponline.org, and other resources referenced within each issue of In the Clinic.

journal_name

Ann Intern Med

authors

Steinberg MH

doi

10.7326/0003-4819-155-5-201109060-01003

subject

Has Abstract

pub_date

2011-09-06 00:00:00

pages

ITC31-15; quiz ITC316

issue

5

eissn

0003-4819

issn

1539-3704

pii

155/5/ITC3-1

journal_volume

155

pub_type

杂志文章,评审
  • Right-sided endocarditis in intravenous drug users. Prognostic features in 102 episodes.

    abstract:OBJECTIVE:To describe the clinical, laboratory, and echocardiographic findings in a large group of patients with right-sided endocarditis and to determine whether any of these findings is predictive of prognosis. DESIGN:Retrospective survey of medical records to evaluate the course of hospitalization with follow-up on...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-117-7-560

    authors: Hecht SR,Berger M

    更新日期:1992-10-01 00:00:00

  • Lymphadenopathy-associated virus: from molecular biology to pathogenicity.

    abstract::Recent data indicate that the lymphadenopathy-associated virus (LAV) is morphologically similar to animal lentiviruses, such as equine infectious anemia and visna viruses. This finding, together with the cross-reactivity of the core proteins of LAV with those of the equine infectious anemia virus and a similarity in g...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-103-5-689

    authors: Montagnier L

    更新日期:1985-11-01 00:00:00

  • Aspirin-induced ultrastructural changes in human gastric mucosa: correlation with potential difference.

    abstract::Aspirin breaks the gastric mucosal barrier. We studied the effect of aspirin on this barrier, correlating changes in potential difference and ultrastructure. Mean control potential difference for seven subjects was -48 +/- 1.0 mV. Oral aspirin, 600 mg in 100 ml of saline, reduced potential difference to -39 +/- 1.4 mV...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-85-3-299

    authors: Baskin WN,Ivey KJ,Krause WJ,Jeffrey GE,Gemmell RT

    更新日期:1976-09-01 00:00:00

  • Effects of nurse-managed protocols in the outpatient management of adults with chronic conditions: a systematic review and meta-analysis.

    abstract:BACKGROUND:Changes in federal health policy are providing more access to medical care for persons with chronic disease. Providing quality care may require a team approach, which the American College of Physicians calls the "medical home." One new model may involve nurse-managed protocols. PURPOSE:To determine whether ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,meta分析

    doi:10.7326/M13-2567

    authors: Shaw RJ,McDuffie JR,Hendrix CC,Edie A,Lindsey-Davis L,Nagi A,Kosinski AS,Williams JW Jr

    更新日期:2014-07-15 00:00:00

  • Aspirin hepatotoxicity and disseminated intravascular coagulation.

    abstract::A 17-year-old girl with a clinical diagnosis of adult-type juvenile rheumatoid arthritis developed a severe hepatotoxic reaction to 3.6 g of aspirin per day. This was associated with a microangiopathic anemia and transient congestive cardiac failure. She responded well to steroids, and when all laboratory test finding...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-86-2-183

    authors: Sbarbaro JA,Bennett RM

    更新日期:1977-02-01 00:00:00

  • Formulating questions and locating primary studies for inclusion in systematic reviews.

    abstract::Much time and effort are spent on designing primary research studies. Similar care must be given to planning systematic reviews. The review should be based on an important, well-focused question that is relevant to patient care. By formulating the question properly, the criteria that primary studies must meet to be in...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-127-5-199709010-00008

    authors: Counsell C

    更新日期:1997-09-01 00:00:00

  • NIH conference. Insulin-like growth factors in health and disease.

    abstract::The insulin-like growth factor (IGF) family of peptides, binding proteins, and receptors are ubiquitous and important for normal human growth and development. Modern techniques including specific radioimmunoassays, radioreceptor assays and recombinant DNA technology have improved our understanding of the role of IGFs ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-116-10-854

    authors: LeRoith D,Clemmons D,Nissley P,Rechler MM

    更新日期:1992-05-15 00:00:00

  • Prevalence of Human Papillomavirus and Estimation of Human Papillomavirus Vaccine Effectiveness in Thimphu, Bhutan, in 2011-2012 and 2018 : A Cross-sectional Study.

    abstract:BACKGROUND:Bhutan implemented a national program for human papillomavirus (HPV) vaccination in 2010 involving girls aged 12 to 18 years and achieving nearly 90% coverage. OBJECTIVE:To estimate HPV vaccine effectiveness in a city in Bhutan. DESIGN:2 cross-sectional surveys, 2011-2012 and 2018. SETTING:2 hospitals in ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/M20-2849

    authors: Baussano I,Tshomo U,Tenet V,Heideman DAM,Wangden T,Franceschi S,Clifford GM

    更新日期:2020-12-01 00:00:00

  • Asymptomatic glomerulonephritis after nonstreptococcal upper respiratory infections.

    abstract::Two hundred forty previously healthy military personnel with nonstreptococcal upper respiratory infections were prospectively studied to define the incidence and clinicopathologic characteristics of possible virus-associated glomerulonephritis. Nine patients without preceding streptococcal infection had erythrocyte ca...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-91-5-697

    authors: Smith MC,Cooke JH,Zimmerman DM,Bird JJ,Feaster BL,Morrison RE,Reimann BE

    更新日期:1979-11-01 00:00:00

  • Hypernatremia in elderly patients. A heterogeneous, morbid, and iatrogenic entity.

    abstract::The causes, therapy for, and consequences of hypernatremia in elderly patients are not well understood. We found that in 15,187 consecutive hospital admissions, 162 (1.1%) patients who were at least 60 years of age had serum sodium levels that measured greater than 148 meq/L. Of that 162, 57% had become hypernatremic ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-107-2-309

    authors: Snyder NA,Feigal DW,Arieff AI

    更新日期:1987-09-01 00:00:00

  • Transitional care interventions to prevent readmissions for persons with heart failure: a systematic review and meta-analysis.

    abstract:BACKGROUND:Nearly 25% of patients hospitalized with heart failure (HF) are readmitted within 30 days. PURPOSE:To assess the efficacy, comparative effectiveness, and harms of transitional care interventions to reduce readmission and mortality rates for adults hospitalized with HF. DATA SOURCES:MEDLINE, Cochrane Librar...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.7326/M14-0083

    authors: Feltner C,Jones CD,Cené CW,Zheng ZJ,Sueta CA,Coker-Schwimmer EJ,Arvanitis M,Lohr KN,Middleton JC,Jonas DE

    更新日期:2014-06-03 00:00:00

  • Advanced seminoma: the role of chemotherapy and adjunctive surgery.

    abstract:STUDY OBJECTIVE:To determine the effectiveness of chemotherapy and adjunctive surgery in managing patients with advanced seminoma. DESIGN:Nonrandomized prospective clinical trial of chemotherapy in a cohort of patients with advanced seminoma. SETTING:Referral cancer hospital. PATIENTS:Consecutive sample of 62 patien...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-108-4-513

    authors: Motzer RJ,Bosl GJ,Geller NL,Penenberg D,Yagoda A,Golbey R,Whitmore WF Jr,Fair WR,Sogani P,Herr H

    更新日期:1988-04-01 00:00:00

  • Noninvasive positive pressure ventilation to treat respiratory failure.

    abstract:PURPOSE:To review the clinical use of noninvasive positive pressure ventilation, including its efficacy with acute and chronic forms of respiratory failure, its mechanism of action, and its implementation. DATA SOURCES:Studies were identified through a MEDLINE search using the key words respiratory failure and mechani...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-120-9-199405010-00008

    authors: Meyer TJ,Hill NS

    更新日期:1994-05-01 00:00:00

  • Hearing loss in the Sjögren syndrome.

    abstract:BACKGROUND:Ear involvement is not unusual in autoimmune diseases, but few data on this problem in the Sjögren syndrome are available. OBJECTIVES:To determine whether the incidence of hearing loss is increased in patients with the Sjögren syndrome and to determine what factors might be involved in the pathogenesis of S...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-126-6-199703150-00005

    authors: Tumiati B,Casoli P,Parmeggiani A

    更新日期:1997-03-15 00:00:00

  • Sleep and sleep disorders in pregnancy.

    abstract::Sleep problems are common in pregnant women. This review examines sleep in normal pregnancy; discusses the physiologic bases for alterations in sleep, including hormonal and mechanical factors; and correlates these factors with changes in sleep of pregnant women, as determined subjectively by surveys and objectively b...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-134-5-200103060-00012

    authors: Santiago JR,Nolledo MS,Kinzler W,Santiago TV

    更新日期:2001-03-06 00:00:00

  • Absence of echocardiographic abnormalities of the anterior mitral valve leaflet in rheumatoid arthritis.

    abstract::Thirty-five consecutives patients with classic or definite rheumatoid arthritis underwent echocardiography to evaluate the motion of the anterior mitral valve leaflet. Adequate echocardiograms were obtained in 31 patients. All 31 patients showed normal valve motion and a normal EF slope. If meticulous technique was no...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-83-4-500

    authors: Davia JE,Cheitlin MD,de Castro CM,Lawless O,Niemi L

    更新日期:1975-10-01 00:00:00

  • Cardiovascular hospitalizations and mortality among recipients of hematopoietic stem cell transplantation.

    abstract:BACKGROUND:Hematopoietic stem cell transplantation (HSCT) is increasingly used to treat multiple malignant and nonmalignant conditions. The risk for cardiovascular disease after the procedure has not been well-described. OBJECTIVE:To compare rates and hazards of cardiovascular-related hospitalization and death among p...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-155-1-201107050-00004

    authors: Chow EJ,Mueller BA,Baker KS,Cushing-Haugen KL,Flowers ME,Martin PJ,Friedman DL,Lee SJ

    更新日期:2011-07-05 00:00:00

  • Bone disease in alcohol abuse.

    abstract::We evaluated bone disease in eight white men between the ages of 49 and 61 years who had been abusing alcohol for at least 10 years. The mean density of vertebral cancellous bone was 58% of normal, whereas the mean density of appendicular cortical bone was 90% of normal. Marked reduction in active bone resorption and ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-103-1-42

    authors: Bikle DD,Genant HK,Cann C,Recker RR,Halloran BP,Strewler GJ

    更新日期:1985-07-01 00:00:00

  • Concierge medicine: a "regular" physician's perspective.

    abstract::Concierge medical practices, which advertise expanded access to care and individualized attention, collect charges both from insurance companies and directly from their patients. Some bill hundreds of dollars for one-time "executive" physicals, whereas others have patients pay annual retainer fees. Yet, virtually no d...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-152-6-201003160-00009

    authors: Stillman M

    更新日期:2010-03-16 00:00:00

  • Medical complications and medical management of bulimia.

    abstract::The syndrome of bulimia is a common disorder and can be associated with serious psychological and physical morbidity. Unfortunately, many patients are reluctant to discuss their symptoms with their physicians and few clues can be found on physical examination to aid in the diagnosis. Possible physical signs include ul...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-107-1-71

    authors: Mitchell JE,Seim HC,Colon E,Pomeroy C

    更新日期:1987-07-01 00:00:00

  • Implantable cardioverter-defibrillators: implications for the nonelectrophysiologist.

    abstract:PURPOSE:To review clinical scenarios in which nonelectrophysiologist physicians may interact with patients who have implantable defibrillators. DATA SOURCES:Peer-reviewed original articles and reviews addressing aspects of implantable defibrillator therapy that are relevant to the clinician. DATA SYNTHESIS:The capaci...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-122-10-199505150-00007

    authors: Pinski SL,Trohman RG

    更新日期:1995-05-15 00:00:00

  • Ethionamide-induced goitrous hypothyroidism.

    abstract::A 42-year-old woman developed goitrous hypothyroidism while receiving ethionamide for treatment of an atypical mycobacterial infection. Five weeks after discontinuation of ethionamide therapy, thyroid function had returned to normal. The goitrogenic effect was studied in vitro by incubating ethionamide in various conc...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-100-6-837

    authors: Drucker D,Eggo MC,Salit IE,Burrow GN

    更新日期:1984-06-01 00:00:00

  • Transition from systemic lupus erythematosus to common variable hypogammaglobulinemia.

    abstract::A 34-year-old man had polar extremes of B cell dysfunction: systemic lupus erythematosus evolving into common variable hypogammaglobulinemia. He presented in 1974 with seizures and six other criteria for systemic lupus erythematosus; his antinuclear antibody titer was 1:1024 and IgG level, 2870 mg/dL. After 5 months o...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-99-1-32

    authors: Sussman GL,Rivera VJ,Kohler PF

    更新日期:1983-07-01 00:00:00

  • Bilateral massive adrenal hemorrhage: early recognition and treatment.

    abstract:PURPOSE:To develop a clinical perspective on bilateral massive adrenal hemorrhage and an algorithm for its diagnosis and treatment. DATA IDENTIFICATION:Case reports were identified through a computer search using MEDLIN (1976 to 1987), and from bibliographies in review articles (up to 1978). STUDY SELECTION:Twelve re...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-110-3-227

    authors: Rao RH,Vagnucci AH,Amico JA

    更新日期:1989-02-01 00:00:00

  • Association between medications that relax the lower esophageal sphincter and risk for esophageal adenocarcinoma.

    abstract:BACKGROUND:The incidence of esophageal adenocarcinoma is increasing rapidly. Gastroesophageal reflux is a strong risk factor for this disease. The increase in incidence of esophageal adenocarcinoma coincided with the introduction of medications that promote reflux by relaxing the lower esophageal sphincter (LES), such ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-133-3-200008010-00007

    authors: Lagergren J,Bergström R,Adami HO,Nyrén O

    更新日期:2000-08-01 00:00:00

  • Community-based interventions to promote blood pressure control in a developing country: a cluster randomized trial.

    abstract:BACKGROUND:Despite convincing evidence that lowering blood pressure decreases cardiovascular morbidity and mortality, the hypertension burden remains high and control rates are poor in developing countries. OBJECTIVE:To assess the effectiveness of 2 community-based interventions on blood pressure in hypertensive adult...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.7326/0003-4819-151-9-200911030-00004

    authors: Jafar TH,Hatcher J,Poulter N,Islam M,Hashmi S,Qadri Z,Bux R,Khan A,Jafary FH,Hameed A,Khan A,Badruddin SH,Chaturvedi N,Hypertension Research Group.

    更新日期:2009-11-03 00:00:00

  • A leap of faith. What can we do to curtail intrainstitutional transmission of tuberculosis?

    abstract::Large-scale, epidemic transmission of tuberculosis to patients, nonprofessional staff, nurses, and physicians has been documented recently in hospitals, clinics, acquired immunodeficiency syndrome (AIDS) residencies, and correctional facilities. Prominent factors in these outbreaks have included human immunodeficiency...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-117-3-251

    authors: Iseman MD

    更新日期:1992-08-01 00:00:00

  • Asymptomatic coronary artery disease: angiography in diabetic patients before renal transplantation. Relation of findings to postoperative survival.

    abstract::Twenty-one juvenile-onset diabetic patients with azotemic nephropathy underwent coronary angiography and left ventriculography before renal transplantation or chronic hemodialysis. Two-year survival of 12 patients with no coronary artery disease (group A) was 88% compared to 22% for nine patients with coronary artery ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-88-3-346

    authors: Weinrauch LA,D'elia JA,Healy RW,Gleason RE,Takacs FJ,Libertino JA,Leland OS

    更新日期:1978-03-01 00:00:00

  • Selective venous sampling for ACTH in Cushing's syndrome: differentiation between Cushing disease and the ectopic ACTH syndrome.

    abstract::We performed selective venous catheterization and sampling for ACTH in six patients with ACTH-secreting pituitary adenomas (Cushing's disease) and four patients with occult ectopic ACTH-secreting neoplasms. In five patients with Cushing's disease in whom the inferior petrosal sinus could be catheterized, ACTH levels w...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-94-5-647

    authors: Findling JW,Aron DC,Tyrrell JB,Shinsako JH,Fitzgerald PA,Norman D,Wilson CB,Forsham PH

    更新日期:1981-05-01 00:00:00

  • Changes in plasma HIV RNA levels and CD4+ lymphocyte counts predict both response to antiretroviral therapy and therapeutic failure. VA Cooperative Study Group on AIDS.

    abstract:BACKGROUND:Markers are needed for assessing response to antiretroviral therapy over time. The CD4+ lymphocyte count is one such surrogate, but it is relatively weak. OBJECTIVE:To assess the association of changes in plasma human immunodeficiency virus (HIV) RNA level and CD4+ lymphocyte count with progression to the a...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.7326/0003-4819-126-12-199706150-00002

    authors: O'Brien WA,Hartigan PM,Daar ES,Simberkoff MS,Hamilton JD

    更新日期:1997-06-15 00:00:00