Bone disease in alcohol abuse.

Abstract:

:We evaluated bone disease in eight white men between the ages of 49 and 61 years who had been abusing alcohol for at least 10 years. The mean density of vertebral cancellous bone was 58% of normal, whereas the mean density of appendicular cortical bone was 90% of normal. Marked reduction in active bone resorption and bone formation was seen without evidence of osteomalacia. Serum levels of calcium and magnesium were in the lower range of normal; serum levels of phosphorus, calcifediol, and calcitriol were normal; and serum levels of parathyroid hormone and nephrogenous cyclic adenosine monophosphate were in the higher range of normal. These data suggest that bone disease in these subjects is not due to inhibition of parathyroid hormone secretion or function, or abnormal vitamin D metabolism, but to an inhibition of bone remodeling by a mechanism independent of the calciotropic hormones.

journal_name

Ann Intern Med

authors

Bikle DD,Genant HK,Cann C,Recker RR,Halloran BP,Strewler GJ

doi

10.7326/0003-4819-103-1-42

subject

Has Abstract

pub_date

1985-07-01 00:00:00

pages

42-8

issue

1

eissn

0003-4819

issn

1539-3704

journal_volume

103

pub_type

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