Amantadine effect on peripheral airways abnormalities in influenza. A study in 15 students with natural influenza A infection.

Abstract:

:Amantadine HCl administration has resulted in accelerated resolution of influenza A illness. Prolonged abnormalities in pulmonary function have been described in uncomplicated influenza A. To study the effect of amantadine on these changes, we evaluated young adults with documented natural influenza A with clear chest examinations and X rays. Subjects received placebo or amantadine in random, double-blind fashion. Physiologic studies included maximal expiratory flow volume curves with air and helium-oxygen mixtures. Air flow rates were unchanged in all subjects throughout. Initially, both groups showed comparable decreases in mean helium-oxygen maximal expiratory flow rates. The amantadine group showed accelerated physiologic improvement: significant increase in helium-oxygen flow rates occurred within 7 days (P less than 0.05). The rate of improvement in the helium-oxygen flow rates in the placebo group was not statistically significant. These studies confirm peripheral airways dysfunction after uncomplicated influenza A and suggest that amantadine is associated with accelerated resolution of this dysfunction.

journal_name

Ann Intern Med

authors

Little JW,Hall WJ,Douglas RG Jr,Hyde RW,Speers DM

doi

10.7326/0003-4819-85-2-177

subject

Has Abstract

pub_date

1976-08-01 00:00:00

pages

177-82

issue

2

eissn

0003-4819

issn

1539-3704

journal_volume

85

pub_type

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