Recovery from rabies in man.

Abstract:

:A 45-year-old woman from Mendoza, Argentina, was severely bitten by a dog that died 4 days later. Before death, the dog was nervous, aggressive, and had occasional seizures. Ten days after the woman had been bitten, rabies vaccine treatment was begun: 14 daily doses of suckling mouse brain vaccine followed by 2 booster doses. Twenty-one days after the biting episode, she developed a cerebellar striatal syndrome, which persisted throughout several months, and severe encephalitic symptoms, which persisted for 75 days. After 13 months, recovery was nearly complete. The patient's serum and cerebrospinal fluid contained rabies-neutralizing antibodies reaching maximum titers of 1:640 000 and 1:160 000, respectively. Titers of this magnitude have never been previusly recorded after suckling mouse brain vaccine treatment. This phenomenon, together with the epidemiologic, clinical, and laboratory data presented, supports the conclusion of a nonfatal case of rabies in man.

journal_name

Ann Intern Med

authors

Porras C,Barboza JJ,Fuenzalida E,Adaros HL,Oviedo AM,Furst J

doi

10.7326/0003-4819-85-1-44

subject

Has Abstract

pub_date

1976-07-01 00:00:00

pages

44-8

issue

1

eissn

0003-4819

issn

1539-3704

journal_volume

85

pub_type

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