Obesity: associations with acute mountain sickness.

Abstract:

BACKGROUND:Although few retrospective studies of high altitude have reported that obesity might be associated with the development of acute mountain sickness (AMS), this association has not been studied prospectively. OBJECTIVE:To determine whether obesity is associated with the development of AMS. DESIGN:Obese and nonobese men were compared at a simulated altitude of 3658 m (12 000 ft). SETTING:24 hours in a hypobaric environmental chamber. PARTICIPANTS:9 obese and 10 nonobese men. MEASUREMENTS:Percentage body fat (by hydrostatic weighing), Lake Louise AMS score, and Sao2 level (by pulse oximetry) were measured. RESULTS:Average AMS scores increased more rapidly with time spent at simulated high altitudes for obese men than for nonobese men (P < 0.001). The response of Sao2 with exposure differed between nonobese and obese men. After 24 hours in the altitude chamber, seven obese men (78%) and four nonobese men (40%) had AMS scores of 4 or more. CONCLUSION:Obesity seems to be associated with the development of AMS, which may be partly related to greater nocturnal desaturation with altitude exposure.

journal_name

Ann Intern Med

authors

Ri-Li G,Chase PJ,Witkowski S,Wyrick BL,Stone JA,Levine BD,Babb TG

doi

10.7326/0003-4819-139-4-200308190-00007

subject

Has Abstract

pub_date

2003-08-19 00:00:00

pages

253-7

issue

4

eissn

0003-4819

issn

1539-3704

pii

139/4/253

journal_volume

139

pub_type

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