Abstract:
BACKGROUND:Although few retrospective studies of high altitude have reported that obesity might be associated with the development of acute mountain sickness (AMS), this association has not been studied prospectively. OBJECTIVE:To determine whether obesity is associated with the development of AMS. DESIGN:Obese and nonobese men were compared at a simulated altitude of 3658 m (12 000 ft). SETTING:24 hours in a hypobaric environmental chamber. PARTICIPANTS:9 obese and 10 nonobese men. MEASUREMENTS:Percentage body fat (by hydrostatic weighing), Lake Louise AMS score, and Sao2 level (by pulse oximetry) were measured. RESULTS:Average AMS scores increased more rapidly with time spent at simulated high altitudes for obese men than for nonobese men (P < 0.001). The response of Sao2 with exposure differed between nonobese and obese men. After 24 hours in the altitude chamber, seven obese men (78%) and four nonobese men (40%) had AMS scores of 4 or more. CONCLUSION:Obesity seems to be associated with the development of AMS, which may be partly related to greater nocturnal desaturation with altitude exposure.
journal_name
Ann Intern Medjournal_title
Annals of internal medicineauthors
Ri-Li G,Chase PJ,Witkowski S,Wyrick BL,Stone JA,Levine BD,Babb TGdoi
10.7326/0003-4819-139-4-200308190-00007subject
Has Abstractpub_date
2003-08-19 00:00:00pages
253-7issue
4eissn
0003-4819issn
1539-3704pii
139/4/253journal_volume
139pub_type
杂志文章abstract:BACKGROUND:The high prevalence of classic cardiac risk factors in patients with non-insulin-dependent diabetes mellitus does not explain the increased cardiovascular-related morbidity and mortality in these patients. Fibrinogen may have a role in this excess risk. OBJECTIVE:To evaluate the following in patients with n...
journal_title:Annals of internal medicine
pub_type: 杂志文章
doi:10.7326/0003-4819-125-8-199610150-00005
更新日期:1996-10-15 00:00:00
abstract::The expression of ischemic heart disease was studied in a large kindred with familial hypercholesterolemia. Tendon xanthomas, multiple generation transmission, and the appearance of bimodality in the distributions of total and low-density lipoprotein cholesterol were found. The segregation ratio was 0.9 in females and...
journal_title:Annals of internal medicine
pub_type: 杂志文章
doi:10.7326/0003-4819-89-6-871
更新日期:1978-12-01 00:00:00
abstract:BACKGROUND:Many dispensing errors made in hospital pharmacies can harm patients. Some hospitals are investing in bar code technology to reduce these errors, but data about its efficacy are limited. OBJECTIVE:To evaluate whether implementation of bar code technology reduced dispensing errors and potential adverse drug ...
journal_title:Annals of internal medicine
pub_type: 杂志文章
doi:10.7326/0003-4819-145-6-200609190-00006
更新日期:2006-09-19 00:00:00
abstract::Hypophosphatemic osteomalacia that remits after resection of a coexisting tumor has been described in 35 patients. Because the associated neoplasms have been of mesenchymal origin, it has been inferred that this tumor-induced osteomalacia syndrome is uniquely related to tumours of this derivation. However, in the pres...
journal_title:Annals of internal medicine
pub_type: 杂志文章
doi:10.7326/0003-4819-93-2-275
更新日期:1980-08-01 00:00:00
abstract::Recently acquired knowledge about vitamin D metabolism has improved our understanding in different varieties of osteomalacia. Many new causes of osteomalacia continue to be found. Radiologic and biochemical changes are not always characteristic and may occasionally be misleading. Bone biopsy after a double tetracyclin...
journal_title:Annals of internal medicine
pub_type: 杂志文章,评审
doi:10.7326/0003-4819-89-6-966
更新日期:1978-12-01 00:00:00
abstract:PURPOSE:To review the status of emergency, urgent, routine, and selective angiography after intravenous thrombolytic therapy. DATA SOURCES:Relevant English-language articles published from January 1985 to July 1990 were identified through MEDLINE. STUDY SELECTION:For emergency angiography, four major randomized studi...
journal_title:Annals of internal medicine
pub_type: 杂志文章,评审
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更新日期:1991-05-15 00:00:00
abstract::The past 2 decades have seen a revolution in legal access to cannabis, driven largely by activists and business interests. As a result, the population of cannabis users nationwide-especially daily users-has grown significantly. An estimated 4.5-7 million persons in the United States now meet criteria for cannabis use ...
journal_title:Annals of internal medicine
pub_type: 杂志文章,评审
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更新日期:2020-11-03 00:00:00
abstract:BACKGROUND:Pharmaceutical companies and other trial sponsors must submit certain trial results to ClinicalTrials.gov. The validity of these results is unclear. PURPOSE:To validate results posted on ClinicalTrials.gov against publicly available U.S. Food and Drug Administration (FDA) reviews on Drugs@FDA. DATA SOURCES...
journal_title:Annals of internal medicine
pub_type: 杂志文章
doi:10.7326/M15-2658
更新日期:2016-09-20 00:00:00
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journal_title:Annals of internal medicine
pub_type: 杂志文章,多中心研究
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更新日期:2020-12-15 00:00:00
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journal_title:Annals of internal medicine
pub_type: 杂志文章
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更新日期:2001-02-06 00:00:00
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journal_title:Annals of internal medicine
pub_type: 杂志文章
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journal_title:Annals of internal medicine
pub_type: 杂志文章
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更新日期:2003-01-21 00:00:00
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journal_title:Annals of internal medicine
pub_type: 杂志文章
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更新日期:1975-09-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2017-01-17 00:00:00
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journal_title:Annals of internal medicine
pub_type: 杂志文章,多中心研究
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更新日期:1997-01-15 00:00:00
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更新日期:2001-05-01 00:00:00
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journal_title:Annals of internal medicine
pub_type: 评论,杂志文章,评审
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更新日期:1996-03-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Annals of internal medicine
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2001-10-02 00:00:00
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更新日期:1983-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-01-03 00:00:00
abstract:BACKGROUND:Many nonpharmacologic therapies are available for treatment of low back pain. PURPOSE:To assess benefits and harms of acupuncture, back schools, psychological therapies, exercise therapy, functional restoration, interdisciplinary therapy, massage, physical therapies (interferential therapy, low-level laser ...
journal_title:Annals of internal medicine
pub_type: 杂志文章,meta分析,评审
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更新日期:2007-10-02 00:00:00
abstract:BACKGROUND:Despite advances in prevention and treatment, sexually transmitted infections (STIs) remain an important cause of morbidity and mortality in the United States. PURPOSE:To systematically review the evidence for behavioral counseling interventions to prevent STIs in adolescents and adults (nonpregnant and pre...
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pub_type: 杂志文章,评审
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更新日期:2008-10-07 00:00:00
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更新日期:2010-10-19 00:00:00
abstract::This paper is part 1 of a 2-part series on interpretation of 12-lead resting electrocardiograms (ECGs). Part 1 is a position paper that presents recommendations for initial competency, competency assessment, and maintenance of competency on ECG interpretation, as well as recommendations for the role of computer-assist...
journal_title:Annals of internal medicine
pub_type: 指南,杂志文章,实务指引
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更新日期:2003-05-06 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2003-09-02 00:00:00