Asymptomatic glomerulonephritis after nonstreptococcal upper respiratory infections.

Abstract:

:Two hundred forty previously healthy military personnel with nonstreptococcal upper respiratory infections were prospectively studied to define the incidence and clinicopathologic characteristics of possible virus-associated glomerulonephritis. Nine patients without preceding streptococcal infection had erythrocyte casts on urinalysis and glomerulonephritis on biopsy. Of these nine, four had a reduction in total hemolytic complement and five had serologic evidence of infection with adenovirus, influenza A, or influenza B. Initial renal biopsy showed either focal or diffuse mesangial proliferation in all nine, with mesangial C3 deposits in six specimens. Repeat biopsy in three showed histologic improvement or loss of immunofluorescent staining, or both. Sequential creatinine clearances were reduced to 74 to 90 mL/min.1.73 m2 in five patients for the duration of follow-up. We conclude that nonstreptococcal upper respiratory infection is frequently associated with glomerulonephritis and that abnormal glomerular structure and decreased creatinine clearances may persist for at least 2 to 8 months.

journal_name

Ann Intern Med

authors

Smith MC,Cooke JH,Zimmerman DM,Bird JJ,Feaster BL,Morrison RE,Reimann BE

doi

10.7326/0003-4819-91-5-697

subject

Has Abstract

pub_date

1979-11-01 00:00:00

pages

697-702

issue

5

eissn

0003-4819

issn

1539-3704

journal_volume

91

pub_type

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