Treatment of intractable lupus nephritis with total lymphoid irradiation.

Abstract:

:Ten patients with lupus nephritis and marked proteinuria (3.9 g or more/d) that did not respond adequately to treatment with prednisone alone or prednisone in combination with azathioprine were treated with total lymphoid irradiation in an uncontrolled feasibility study. Within 6 weeks after the start of total lymphoid irradiation, the serum albumin level rose in all patients in association with a reduction in the serum level of anti-DNA antibodies, an increase in the serum complement level, or both. Improvement in these variables persisted in eight patients followed for more than 1 year, with the stabilization or reduction of the serum creatinine level. Urinary leakage of albumin was substantially reduced in all patients. Side effects associated with radiotherapy included transient constitutional complaints in ten patients, transient blood element depressions in three, localized viral and bacterial infections in four, and ovarian failure in one. The results suggest that total lymphoid irradiation may provide an alternative to cytotoxic drugs in the treatment of lupus nephritis.

journal_name

Ann Intern Med

authors

Strober S,Field E,Hoppe RT,Kotzin BL,Shemesh O,Engleman E,Ross JC,Myers BD

doi

10.7326/0003-4819-102-4-450

subject

Has Abstract

pub_date

1985-04-01 00:00:00

pages

450-8

issue

4

eissn

0003-4819

issn

1539-3704

journal_volume

102

pub_type

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