Salicylate-induced pulmonary edema. Clinical features and prognosis.

Abstract:

:To assess the course and prognosis of salicylate-induced pulmonary edema, we reviewed the records of 36 consecutive patients admitted with serum salicylate levels greater than 30 mg/dL. Pulmonary edema developed in eight patients, and pulmonary infiltrates were never seen in 28 patients. Several features distinguished the two patient groups. Persons with pulmonary edema were older, ingested salicylates chronically, and had a history of smoking. They also were more likely to present with neurologic abnormalities. proteinuria, and serum salicylate levels greater than 40 mg/dL. The severity of pulmonary edema ranged from moderate (no assisted ventilation) to severe (characteristics of adult respiratory distress syndrome requiring assisted ventilation with positive end-expiratory pressure). Pulmonary edema resolved concomitant with a decline in serum salicylate levels. We conclude that certain patients are at increased risk for salicylate pulmonary edema, which responds to measures that lower serum salicylate levels.

journal_name

Ann Intern Med

authors

Heffner JE,Sahn SA

doi

10.7326/0003-4819-95-4-405

subject

Has Abstract

pub_date

1981-10-01 00:00:00

pages

405-9

issue

4

eissn

0003-4819

issn

1539-3704

journal_volume

95

pub_type

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