Acute renal infection in women: treatment with trimethoprim-sulfamethoxazole or ampicillin for two or six weeks. A randomized trial.

Abstract:

:We compared the efficacy of orally administered ampicillin, 2 g/d, with that of trimethoprim-sulfamethoxazole, 320 mg/d-1600 mg/d, given for 2 or 6 weeks for outpatient management of acute uncomplicated renal infection in women. Of 98 women participating in the trial, 60 had renal infections with susceptible strains, complied with drug therapy, and completed 6 weeks of follow-up. Before treatment, 39 women had symptoms and signs of acute pyelonephritis; 21 had symptoms of cystitis but positive tests for antibody-coated bacteria. All 60 women had alleviation of symptoms and resolution of bacteriuria after 7 days of therapy. Subsequent recurrences occurred in 12 of 27 women given ampicillin, compared with 4 of 33 given trimethoprim-sulfamethoxazole (p = 0.008). Serotyping showed that most recurrences were reinfections with ampicillin-resistant strains. With each drug, a 2-week regimen of therapy proved as efficacious as a 6-week regimen, but the longer regimen was less well tolerated. We conclude that a 2-week treatment regimen is sufficient to manage acute pyelonephritis in outpatients and that trimethoprim-sulfamethoxazole is preferable to ampicillin therapy.

journal_name

Ann Intern Med

authors

Stamm WE,McKevitt M,Counts GW

doi

10.7326/0003-4819-106-3-341

subject

Has Abstract

pub_date

1987-03-01 00:00:00

pages

341-5

issue

3

eissn

0003-4819

issn

1539-3704

journal_volume

106

pub_type

临床试验,杂志文章,随机对照试验
  • Diagnostic utility of ultrasonography of leg veins in patients suspected of having pulmonary embolism.

    abstract:BACKGROUND:The standard diagnostic approach in patients suspected of having pulmonary embolism starts with perfusion-ventilation lung scanning. If the resulting scan is not diagnostic, pulmonary angiography should be done. The use of tests for deep venous thrombosis has been advocated as an adjunct to establishing the ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-126-10-199705150-00005

    authors: Turkstra F,Kuijer PM,van Beek EJ,Brandjes DP,ten Cate JW,Büller HR

    更新日期:1997-05-15 00:00:00

  • An inherited disorder of lymphocyte apoptosis: the autoimmune lymphoproliferative syndrome.

    abstract::The autoimmune lymphoproliferative syndrome (ALPS) affords novel insights into the mechanisms that regulate lymphocyte homeostasis and underlie the development of autoimmunity. This syndrome arises early in childhood in persons who inherit mutations in genes that mediate apoptosis, or programmed cell death. The timely...

    journal_title:Annals of internal medicine

    pub_type: 共识发展会议,杂志文章,评审

    doi:10.7326/0003-4819-130-7-199904060-00020

    authors: Straus SE,Sneller M,Lenardo MJ,Puck JM,Strober W

    更新日期:1999-04-06 00:00:00

  • Cholesterol reduction and life expectancy. A model incorporating multiple risk factors.

    abstract::In deciding whether to undertake a dietary program to reduce serum cholesterol levels, a person must consider how much benefit to expect. We developed a model that assumes cholesterol reduction is effective and safe in reducing the risk for death from ischemic heart disease. In the model, we considered asymptomatic ad...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-106-4-605

    authors: Taylor WC,Pass TM,Shepard DS,Komaroff AL

    更新日期:1987-04-01 00:00:00

  • Perspectives in the treatment of breast cancer: 1976.

    abstract::Breast cancer is the major cancer killer of women in the United States. Recent advances in therapy promise more effective control of this illness. The development of hormone receptor analysis permits us to better understand the mechanisms of action of steroid and peptide hormones and increases the likelihood of using ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-86-6-784

    authors:

    更新日期:1977-06-01 00:00:00

  • Institutional Variation in Quality of Cardiovascular Implantable Electronic Device Implantation: A Cohort Study.

    abstract:Background:Cardiovascular implantable electronic devices (CIEDs) are associated with procedure-related complications, yet little is known about variation in complication rates among institutions that may suggest disparities in care quality. Objective:To assess institutional variation in risk-standardized complication ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/M18-2810

    authors: Ranasinghe I,Labrosciano C,Horton D,Ganesan A,Curtis JP,Krumholz HM,McGavigan A,Hossain S,Air T,Hariharaputhiran S

    更新日期:2019-09-03 00:00:00

  • Thromboenbolism, oral contraceptives, and cigarettes.

    abstract::The relationship between oral contraceptives and death from thromboembolism shown by studies of vital statistics, and the contribution of cigarette smoking to these deaths are reviewed. In 1968 a British study showed that a slight increase in deaths from thromboembolism had occurred in young women, proportional to th...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:

    authors: Masi AT

    更新日期:1970-09-01 00:00:00

  • Effects of diet and sodium intake on blood pressure: subgroup analysis of the DASH-sodium trial.

    abstract:BACKGROUND:Initial findings from the Dietary Approaches to Stop Hypertension (DASH)-Sodium Trial demonstrated that reduction of sodium intake in two different diets decreased blood pressure in participants with and without hypertension. OBJECTIVE:To determine effects on blood pressure of reduced sodium intake and the ...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.7326/0003-4819-135-12-200112180-00005

    authors: Vollmer WM,Sacks FM,Ard J,Appel LJ,Bray GA,Simons-Morton DG,Conlin PR,Svetkey LP,Erlinger TP,Moore TJ,Karanja N,DASH-Sodium Trial Collaborative Research Group.

    更新日期:2001-12-18 00:00:00

  • Critical perfusion pressure for renal function in patients with bilateral atherosclerotic renal vascular disease.

    abstract::We studied renal plasma flow and glomerular filtration rate during graded blood pressure reduction induced with sodium nitroprusside infusion in 16 hypertensive patients with atherosclerotic renovascular disease. Eight patients with unilateral disease tolerated pressure reduction from 205 +/- 9 (SE)/103 +/- 2 mm Hg to...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-102-3-308

    authors: Textor SC,Novick AC,Tarazi RC,Klimas V,Vidt DG,Pohl M

    更新日期:1985-03-01 00:00:00

  • A high molecular weight antigen in Legionnaires' disease bacterium: isolation and partial characterization.

    abstract::We isolated a high molecular weight antigen of the Legionnaires' disease (LD) bacterium by column chromatography. The antigen was composed of 35% carbohydrate, 2.6% protein, 1.8% phospholipid, and 1% 2-keto-3-deoxyoctonate and was important in the host's antibody response because it inhibited the indirect immunofluore...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-90-4-638

    authors: Johnson W,Elliott JA,Helms CM,Renner ED

    更新日期:1979-04-01 00:00:00

  • Critical pathways as a strategy for improving care: problems and potential.

    abstract::In an era of increasing competition in medical care, critical pathway guidelines have emerged as one of the most popular new initiatives intended to reduce costs while maintaining or even improving the quality of care. Developed primarily for high-volume hospital diagnoses, critical pathways display goals for patients...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-123-12-199512150-00008

    authors: Pearson SD,Goulart-Fisher D,Lee TH

    更新日期:1995-12-15 00:00:00

  • Good enough: a primer on the analysis and interpretation of noninferiority trials.

    abstract::Active-control noninferiority trials are being performed with increasing frequency when standard placebo-controlled trials are considered unethical. Three attributes are optimally required to establish noninferiority: 1) The treatment under consideration exhibits therapeutic noninferiority to the active control; 2) th...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-145-1-200607040-00011

    authors: Kaul S,Diamond GA

    更新日期:2006-07-04 00:00:00

  • Poststreptococcal acute glomerulonephritis: fact and controversy.

    abstract::Poststreptococcal acute glomerulonephritis is prototypic of the immunologic glomerulonephritides. It most commonly follows streptococcal infection of the pharynx or skin. The diagnosis is usually not difficult when a nephritic clinical presentation (with such manifestations as hematuria, edema, and hypertension) is as...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-91-1-76

    authors: Nissenson AR,Baraff LJ,Fine RN,Knutson DW

    更新日期:1979-07-01 00:00:00

  • Relation between plasma leptin levels and measures of body fat in identical twins discordant for obesity.

    abstract:BACKGROUND:Plasma levels of leptin, the recently discovered satiety hormone, are associated with adiposity in humans. OBJECTIVE:To determine whether genetic factors or body fat distribution affect the association between leptin levels and obesity. PARTICIPANTS:23 healthy identical twin pairs (9 male pairs and 14 fema...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-126-1-199701010-00004

    authors: Rönnemaa T,Karonen SL,Rissanen A,Koskenvuo M,Koivisto VA

    更新日期:1997-01-01 00:00:00

  • The role of medical necessity and cost-effectiveness in making medical decisions.

    abstract::The term "medical necessity" is used ubiquitously in health care, but its meaning and implementation vary substantially among providers, payers, and patients. This ambiguity has led some to suggest that cost-effectiveness be used as a basis for decision rules. This paper presents an analytical framework that is famili...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-126-2-199701150-00011

    authors: Glassman PA,Model KE,Kahan JP,Jacobson PD,Peabody JW

    更新日期:1997-01-15 00:00:00

  • Patient-physician connectedness and quality of primary care.

    abstract:BACKGROUND:Valid measurement of physician performance requires accurate identification of patients for whom a physician is responsible. Among all patients seen by a physician, some will be more strongly connected to their physician than others, but the effect of connectedness on measures of physician performance is not...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,多中心研究

    doi:10.7326/0003-4819-150-5-200903030-00008

    authors: Atlas SJ,Grant RW,Ferris TG,Chang Y,Barry MJ

    更新日期:2009-03-03 00:00:00

  • The association between midlife cardiorespiratory fitness levels and later-life dementia: a cohort study.

    abstract:BACKGROUND:Primary prevention of Alzheimer disease and other types of dementia (all-cause dementia) is an important public health goal. Evidence to date is insufficient to recommend any lifestyle change to prevent or delay the onset of dementia. OBJECTIVE:To assess the association between objectively measured midlife ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-158-3-201302050-00005

    authors: Defina LF,Willis BL,Radford NB,Gao A,Leonard D,Haskell WL,Weiner MF,Berry JD

    更新日期:2013-02-05 00:00:00

  • How variability in the institutional review board review process affects minimal-risk multisite health services research.

    abstract:BACKGROUND:The Department of Health and Human Services recently called for public comment on human subjects research protections. OBJECTIVE:To assess variability in reviews across institutional review boards (IRBs) for a multisite, minimal-risk trial of financial incentives for evidence-based hypertension care and to ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,多中心研究

    doi:10.7326/0003-4819-156-10-201205150-00011

    authors: Petersen LA,Simpson K,Sorelle R,Urech T,Chitwood SS

    更新日期:2012-05-15 00:00:00

  • Successful treatment of gram-negative bacillary meningitis with moxalactam.

    abstract::Meningitis caused by enteric gram-negative bacilli is relatively uncommon but is very difficult to treat despite susceptibility in vitro to many antimicrobics. A major problem appears to be poor entry of many drugs into the central nervous system. Moxalactam is an investigational cephalosporin that attains concentrati...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-95-3-302

    authors: Olson DA,Hoeprich PD,Nolan SM,Goldstein E

    更新日期:1981-09-01 00:00:00

  • Sex differences in access to coronary revascularization after cardiac catheterization: importance of detailed clinical data.

    abstract:BACKGROUND:Although some studies suggest that access to cardiac procedures may differ by sex, others have found no evidence of gender bias in cardiac care. OBJECTIVE:To study rates of percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) surgery in men and women after cardiac catheterization....

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-136-10-200205210-00007

    authors: Ghali WA,Faris PD,Galbraith PD,Norris CM,Curtis MJ,Saunders LD,Dzavik V,Mitchell LB,Knudtson ML,Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease (APPROACH) Investigators.

    更新日期:2002-05-21 00:00:00

  • Combination therapy with telaprevir for chronic hepatitis C virus genotype 1 infection in patients with HIV: a randomized trial.

    abstract:BACKGROUND:Telaprevir (TVR) plus peginterferon-α2a (PEG-IFN-α2a) and ribavirin substantially increases treatment efficacy for genotype 1 chronic hepatitis C virus (HCV) infection versus PEG-IFN-α2a-ribavirin alone. Its safety and efficacy in patients with HCV and HIV-1 are unknown. OBJECTIVE:To assess the safety and e...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.7326/0003-4819-159-2-201307160-00654

    authors: Sulkowski MS,Sherman KE,Dieterich DT,Bsharat M,Mahnke L,Rockstroh JK,Gharakhanian S,McCallister S,Henshaw J,Girard PM,Adiwijaya B,Garg V,Rubin RA,Adda N,Soriano V

    更新日期:2013-07-16 00:00:00

  • Brief communication: tolerability of meropenem in patients with IgE-mediated hypersensitivity to penicillins.

    abstract:BACKGROUND:Although clinicians avoid giving meropenem to patients with penicillin allergy because of potential cross-reactivity, the rate of cross-reactivity between penicillins and meropenem has not been prospectively determined. OBJECTIVE:To assess the tolerability of meropenem in patients with documented penicillin...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.7326/0003-4819-146-4-200702200-00005

    authors: Romano A,Viola M,Guéant-Rodriguez RM,Gaeta F,Valluzzi R,Guéant JL

    更新日期:2007-02-20 00:00:00

  • Cognitive Behavioral Therapy for Chronic Insomnia: A Systematic Review and Meta-analysis.

    abstract:BACKGROUND:Because psychological approaches are likely to produce sustained benefits without the risk for tolerance or adverse effects associated with pharmacologic approaches, cognitive behavioral therapy for insomnia (CBT-i) is now commonly recommended as first-line treatment for chronic insomnia. PURPOSE:To determi...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.7326/M14-2841

    authors: Trauer JM,Qian MY,Doyle JS,Rajaratnam SM,Cunnington D

    更新日期:2015-08-04 00:00:00

  • Addition of sildenafil to long-term intravenous epoprostenol therapy in patients with pulmonary arterial hypertension: a randomized trial.

    abstract:BACKGROUND:Oral sildenafil and intravenous epoprostenol have independently been shown to be effective in patients with pulmonary arterial hypertension. OBJECTIVE:To investigate the effect of adding oral sildenafil to long-term intravenous epoprostenol in patients with pulmonary arterial hypertension. DESIGN:A 16-week...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.7326/0003-4819-149-8-200810210-00004

    authors: Simonneau G,Rubin LJ,Galiè N,Barst RJ,Fleming TR,Frost AE,Engel PJ,Kramer MR,Burgess G,Collings L,Cossons N,Sitbon O,Badesch DB,PACES Study Group.

    更新日期:2008-10-21 00:00:00

  • Perceptions by family members of the dying experience of older and seriously ill patients. SUPPORT Investigators. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments.

    abstract:BACKGROUND:Alleviating the problems faced by dying persons and their families has drawn substantial public attention, but little is known about the experience of dying. OBJECTIVE:To characterize the experience of dying from the perspective of surrogate decision makers, usually close family members (89%). DESIGN:Prosp...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,多中心研究

    doi:10.7326/0003-4819-126-2-199701150-00001

    authors: Lynn J,Teno JM,Phillips RS,Wu AW,Desbiens N,Harrold J,Claessens MT,Wenger N,Kreling B,Connors AF Jr

    更新日期:1997-01-15 00:00:00

  • The safety of treadmill exercise stress testing in patients with abdominal aortic aneurysms.

    abstract:BACKGROUND:Exercise stress testing in patients with abdominal aortic aneurysms may cause enlargement or rupture of aneurysms. OBJECTIVE:To evaluate the safety of treadmill exercise stress testing in patients with abdominal aortic aneurysms. DESIGN:Retrospective descriptive study. SETTING:Tertiary care center. PATIE...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-129-8-199810150-00008

    authors: Best PJ,Tajik AJ,Gibbons RJ,Pellikka PA

    更新日期:1998-10-15 00:00:00

  • Low-molecular-weight heparin for women with unexplained recurrent pregnancy loss: a multicenter trial with a minimization randomization scheme.

    abstract:BACKGROUND:A daily injection of low-molecular-weight heparin (LMWH) is often prescribed to women with unexplained recurrent pregnancy loss (RPL), although evidence suggesting a benefit is questionable. OBJECTIVE:To determine whether LMWH increases ongoing pregnancy and live-birth rates in women with unexplained RPL. ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.7326/M14-2062

    authors: Schleussner E,Kamin G,Seliger G,Rogenhofer N,Ebner S,Toth B,Schenk M,Henes M,Bohlmann MK,Fischer T,Brosteanu O,Bauersachs R,Petroff D,ETHIG II group.

    更新日期:2015-05-05 00:00:00

  • The common hyperlipoproteinemias: an understanding of disease mechanisms and their control.

    abstract::Our review focuses on low density lipoprotein (LD lipoprotein) and very low density lipoprotein (VLD lipoprotein) in their roles as transporters of cholesterol and triglyceride and as factors contributing to premature arteriovascular disease. We describe the clinical manifestations of the common, primary hyperlipoprot...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-85-4-497

    authors: Fisher WR,Truitt DH

    更新日期:1976-10-01 00:00:00

  • Pulmonary function and gastroesophageal reflux in systemic sclerosis.

    abstract:OBJECTIVE:To determine the relations among esophageal dysfunction, gastroesophageal reflux, and lung involvement in patients with systemic sclerosis. DESIGN:Retrospective review of esophageal motility, esophageal pH, and pulmonary function data. SETTING:University hospital outpatient clinic and community. PATIENTS:3...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-121-1-199407010-00002

    authors: Troshinsky MB,Kane GC,Varga J,Cater JR,Fish JE,Jimenez SA,Castell DO

    更新日期:1994-07-01 00:00:00

  • Motor Vehicle Crash Fatalities in States With Primary Versus Secondary Seat Belt Laws: A Time-Series Analysis.

    abstract:BACKGROUND:Motor vehicle crashes (MVCs) remain a leading cause of injury-related deaths in the United States. Primary seat belt laws allow vehicle occupants to be ticketed solely for not wearing seat belts, and secondary laws allow ticketing only for failure to wear seat belts in the setting of other violations. OBJEC...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/M14-2368

    authors: Lee LK,Monuteaux MC,Burghardt LC,Fleegler EW,Nigrovic LE,Meehan WP,Schutzman SA,Mannix R

    更新日期:2015-08-04 00:00:00

  • Unrelated donor bone marrow transplantation for chronic myelogenous leukemia: a decision analysis.

    abstract:BACKGROUND:Chronic myelogenous leukemia (CML) is an indolent but ultimately fatal disease. Because the natural history of CML varies and quality of life with CML may be excellent until shortly before death, deciding whether and when to pursue unrelated donor bone marrow transplantation is often difficult. OBJECTIVE:To...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-127-12-199712150-00005

    authors: Lee SJ,Kuntz KM,Horowitz MM,McGlave PB,Goldman JM,Sobocinski KA,Hegland J,Kollman C,Parsons SK,Weinstein MC,Weeks JC,Antin JH

    更新日期:1997-12-15 00:00:00