In COVID-19, adding lopinavir-ritonavir to usual care did not shorten time to clinical improvement.

abstract：:A retrospective analysis of the course of systemic lupus erythematosus in pregnant patients hospitalized at UCLA during a 15-year period provided important prognostic information. Women with systemic lupus erythematosus became pregnant if renal function was reasonably well preserved. Pregnancy infrequently posed a ser...

journal_title：Annals of internal medicine

authors：

更新日期：1981-05-01 00:00:00

abstract：OBJECTIVE:To assess the effectiveness of housestaff physician reporting as a method for identifying adverse events on a medical service and to compare the physician reporting mechanism with a retrospective record review mechanism. SETTING:Medical service of an urban, university-affiliated teaching hospital. DESIGN:Co...

journal_title：Annals of internal medicine

authors： O'Neil AC,Petersen LA,Cook EF,Bates DW,Lee TH,Brennan TA

更新日期：1993-09-01 00:00:00

abstract：OBJECTIVE:To review the incidence of reversible renal insufficiency in patients with hypertensive nephrosclerosis undergoing antihypertensive therapy. DESIGN:Retrospective analysis of 73 patients in a long-term blood pressure control study that compared the effects of an angiotensin converting enzyme (ACE) inhibitor p...

journal_title：Annals of internal medicine

authors： Toto RD,Mitchell HC,Lee HC,Milam C,Pettinger WA

更新日期：1991-10-01 00:00:00

abstract：OBJECTIVE:To examine, from the perspective of primary care physicians, the value of mental status findings and ancillary tests in diagnosing dementia or its causes. DATA SOURCES:Studies identified using MEDLINE and bibliographies of pertinent articles. STUDY SELECTION:Selection based on availability of information on...

journal_title：Annals of internal medicine

authors： Siu AL

更新日期：1991-07-15 00:00:00

abstract：:The observations that have provided the foundation of the sodium hypothesis of human hypertension are reviewed. Clinical observations made over 125 years ago initiated an investigative effort that has encompassed epidemiologic data, development of salt-related experimental models, and elucidation of theoretical mechan...

journal_title：Annals of internal medicine

authors： Porter GA

更新日期：1983-05-01 00:00:00

abstract：BACKGROUND:Although weight loss improves risk factors for cardiovascular and metabolic disease, it is unclear whether intentional weight loss reduces mortality rates. OBJECTIVE:To examine the relationships among intention to lose weight, weight loss, and all-cause mortality. DESIGN:Prospective cohort study using a pr...

journal_title：Annals of internal medicine

authors： Gregg EW,Gerzoff RB,Thompson TJ,Williamson DF

更新日期：2003-03-04 00:00:00

abstract：:Between 20 July and 15 Octoboer 1975, five cases of human infection with Babesia microti were diagnosed on Nantucket Island, Massachusetts. The illness was characterized by fever, drenching sweats, shaking chills, myalgia, arthralgia, extreme fatigue, and a mild-to-moderate hemolytic anemia. None of the patients had a...

journal_title：Annals of internal medicine

authors： Reubush TK 2nd,Cassaday PB,Marsh HJ,Lisker SA,Voorhees DB,Mahoney EB,Healy GR

更新日期：1977-01-01 00:00:00

abstract：:A controlled clinical trial compared three-drug and four-drug combination chemotherapy in 109 patients with advanced small-cell anaplastic carcinoma of the lung. The combination of vincristine, 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), cyclophosphamide, and methotrexate was significantly superior to the com...

journal_title：Annals of internal medicine

authors： Hansen HH,Dombernowsky P,Hansen M,Hirsch F

更新日期：1978-08-01 00:00:00

abstract：Background:The benefits of pay-for-performance (P4P) programs are uncertain. Purpose:To update and expand a prior review examining the effects of P4P programs targeted at the physician, group, managerial, or institutional level on process-of-care and patient outcomes in ambulatory and inpatient settings. Data Sources...

journal_title：Annals of internal medicine

authors： Mendelson A,Kondo K,Damberg C,Low A,Motúapuaka M,Freeman M,O'Neil M,Relevo R,Kansagara D

更新日期：2017-03-07 00:00:00

abstract：BACKGROUND:Retail clinics are an increasingly popular source for medical care. Concerns have been raised about the effect of these clinics on the cost, quality, and delivery of preventive care. OBJECTIVE:To compare the care received at retail clinics for 3 acute conditions with that received at other care settings. D...

journal_title：Annals of internal medicine

authors： Mehrotra A,Liu H,Adams JL,Wang MC,Lave JR,Thygeson NM,Solberg LI,McGlynn EA

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Radiation therapy is one of many treatment options for patients with prostate cancer. PURPOSE:To update findings on the clinical and biochemical outcomes of radiation therapies for localized prostate cancer. DATA SOURCES:MEDLINE (2007 through March 2011) and the Cochrane Central Register of Controlled Tria...

journal_title：Annals of internal medicine

authors： Bannuru RR,Dvorak T,Obadan N,Yu WW,Patel K,Chung M,Ip S

更新日期：2011-08-02 00:00:00

abstract：:Imaging under loading stress is hypothesized to improve the diagnostic value of magnetic resonancel imaging (MRI) for musculoskeletal conditions. This article reviews 57 studies about MRI under physiologic loading stress performed in an upright or sitting position or under axial loading by using a compression device. ...

journal_title：Annals of internal medicine

authors： Dahabreh IJ,Hadar N,Chung M

更新日期：2011-11-01 00:00:00

abstract：:Access to information about clinical trials is important to researchers, health care professionals, and patients. Many have argued for the establishment of clinical trials registries, citing their substantial benefits. Although some registries do exist, it has been difficult to create comprehensive, easily accessible ...

journal_title：Annals of internal medicine

authors： McCray AT

更新日期：2000-10-17 00:00:00

abstract：:Clinical features of 99 patients with staphylococcal infection were reviewed, and sera were tested by solid-phase radioimmunoassay and gel diffusion for staphylococcal antibodies to ascertain whether these variables predict the extent of infection and the need for prolonged therapy. Clinical features, including the pr...

journal_title：Annals of internal medicine

authors： Wheat LJ,Kohler RB,White A

更新日期：1978-10-01 00:00:00

abstract：:Visual loss from the complications of advanced diabetic retinopathy now can be managed more effectively by surgical vitrectomy with a significant reduction in operative and postoperative ocular morbidity. Ocular structures are now maintained in a more normal physiologic state, leaving the patient's lens in place, help...

journal_title：Annals of internal medicine

authors： Aaberg TM

更新日期：1983-10-01 00:00:00

abstract：OBJECTIVE:To determine the toxicity and efficacy of low-dose interferon-alpha therapy in inducing remissions and prolonging survival in patients with chronic myeloid leukemia. DESIGN:Phase II evaluation and comparison with historical control patients and other series in which the investigators used higher interferon-a...

journal_title：Annals of internal medicine

authors： Schofield JR,Robinson WA,Murphy JR,Rovira DK

更新日期：1994-11-15 00:00:00

abstract：:Five of 70 patients with systemic lupus erythematosus seen over a 5-year period had peripheral blood films suggestive of hyposplenism. Technetium-99m-sulfur colloid scans showed no splenic activity in three patients. One of these three patients, who had a spontaneous remission of persistent thrombocytopenia concurrent...

journal_title：Annals of internal medicine

authors： Dillon AM,Stein HB,English RA

更新日期：1982-01-01 00:00:00

abstract：:The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including PIER (Physicians' Information and Education Resource) and MKSAP (Medical Knowledge and Self Assessment Program). Annals of Internal Medicine editors develop In the Clinic f...

journal_title：Annals of internal medicine

authors： McDermott MT

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:U.S. HIV treatment guidelines recommend branded once-daily, 1-pill efavirenz-emtricitabine-tenofovir as first-line antiretroviral therapy (ART). With the anticipated approval of generic efavirenz in the United States, a once-daily, 3-pill alternative (generic efavirenz, generic lamivudine, and tenofovir) wil...

journal_title：Annals of internal medicine

authors： Walensky RP,Sax PE,Nakamura YM,Weinstein MC,Pei PP,Freedberg KA,Paltiel AD,Schackman BR

更新日期：2013-01-15 00:00:00

abstract：:We report a case of combined idiopathic immune neutropenia and immune thrombocytopenia (thromboneutropenia). Therapy with prednisone was ineffective. Treatment with vincristine raised the patient's platelet count but did not increase the neutrophil count. Splenectomy led to a prompt complete remission. Using radioimmu...

journal_title：Annals of internal medicine

authors： Linker CA,Newcom SR,Nilsson CM,Wolf JL,Shuman MA

更新日期：1980-11-01 00:00:00

abstract：OBJECTIVE:To describe the prevalence of cognitive impairment among elderly primary care patients and to compare diagnostic evaluations and use of health services among patients with and those without cognitive impairment. DESIGN:Prospective cohort study. SETTING:Academic primary care group practice. PATIENTS:3954 pa...

journal_title：Annals of internal medicine

authors： Callahan CM,Hendrie HC,Tierney WM

更新日期：1995-03-15 00:00:00

abstract：:Cataract disrupts the crystalline lens, a transparent, elastic, avascular, biconvex structure composed of a capsule, lens epithelium, and lens fiber cells. Many factors contribute to the progression of lens opacity, but aging is most frequently associated with cataract. As aging-related cataract develops, many biochem...

journal_title：Annals of internal medicine

authors： Straatsma BR,Foos RY,Horwitz J,Gardner KM,Pettit TH

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Prospective data defining the clinical course in idiopathic pulmonary fibrosis (IPF) are sparse. OBJECTIVE:To analyze the clinical course of patients with mild to moderate IPF. DESIGN:Analysis of data from the placebo group of a randomized, controlled trial evaluating interferon-gamma1b. SETTING:Academic ...

journal_title：Annals of internal medicine

authors： Martinez FJ,Safrin S,Weycker D,Starko KM,Bradford WZ,King TE Jr,Flaherty KR,Schwartz DA,Noble PW,Raghu G,Brown KK,IPF Study Group.

更新日期：2005-06-21 00:00:00

abstract：:Medicine has long sought to match diagnostic and treatment approaches to the particular needs and risks of individual patients. The decreasing cost and increasing ease of genetic sequencing have propelled the rise of precision medicine. Precision medicine aims to use genetic and other information to provide care tailo...

journal_title：Annals of internal medicine

authors： Kiryluk K,Goldstein DB,Rowe JW,Gharavi AG,Wapner R,Chung WK

更新日期：2019-05-07 00:00:00

abstract：OBJECTIVE:To evaluate whether a brief course of treatment with gallium nitrate can reduce biochemical parameters of accelerated bone turnover in patients with advanced Paget disease. DESIGN:Unblinded trial, decreasing dose schedules of gallium nitrate. SETTING:University hospital with primary orthopedic and metabolic...

journal_title：Annals of internal medicine

authors： Warrell RP Jr,Bosco B,Weinerman S,Levine B,Lane J,Bockman RS

更新日期：1990-12-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the effect of massive cocaine intoxication on lung water and ascites accumulation and the effect of beta- and alpha-adrenergic blockade on survival in massive cocaine intoxication in the mouse. DESIGN:The effect of massive cocaine intoxication on lung water, ascitic fluid accumulation, and...

journal_title：Annals of internal medicine

authors： Robin ED,Wong RJ,Ptashne KA

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND:Previous meta-analyses demonstrated that high-dose glucocorticoids were not beneficial in sepsis. Recently, lower-dose glucocorticoids have been studied. PURPOSE:To compare recent trials of glucocorticoids for sepsis with previous glucocorticoid trials. DATA SOURCES:Systematic MEDLINE search for studies pu...

journal_title：Annals of internal medicine

authors： Minneci PC,Deans KJ,Banks SM,Eichacker PQ,Natanson C

更新日期：2004-07-06 00:00:00

abstract：BACKGROUND:Recently, liver transplantation has been used to treat patients with familial amyloid polyneuropathy (FAP). OBJECTIVE:To describe the clinical course of patients with FAP who received partial-liver transplantation from living donors. DESIGN:Case series. SETTING:University hospital in Matsumoto, Japan. PA...

journal_title：Annals of internal medicine

authors： Takei Y,Ikeda S,Hashikura Y,Ikegami T,Kawasaki S

更新日期：1999-10-19 00:00:00

abstract：DESCRIPTION:Updated U.S. Preventive Services Task Force (USPSTF) recommendation about screening for type 2 diabetes mellitus in adults. METHODS:To estimate the balance of benefits and harms of screening, the USPSTF updated its 2003 evidence review, adding evidence from new trials as well as updates on earlier studies....

journal_title：Annals of internal medicine

authors： U.S. Preventive Services Task Force.

更新日期：2008-06-03 00:00:00

abstract：:Sudden cardiac death remains a leading cause of death in the United States, accounting for more than 350,000 deaths each year, and the survival rate of victims remains low. Most survivors face a significant risk for recurrence. The typical substrate is chronic--abnormal myocardium with fibrosis (often from previous my...

journal_title：Annals of internal medicine

authors： Akhtar M,Garan H,Lehmann MH,Troup PJ

更新日期：1991-03-15 00:00:00