Ventricular arrhythmias in ischemic heart disease.

Abstract:

:Ventricular arrhythmias remain the leading cause of death from coronary artery disease. This review summarizes current thinking in several areas relating to the pathophysiology, prognosis, and therapy of ventricular arrhythmias associated with acute and chronic coronary artery disease syndromes. The experimental basis of arrhythmias in the setting of acute myocardial ischemia and chronic myocardial infarction is described, stressing the important pathophysiologic differences between these two conditions. The effects of the autonomic nervous system as a key modulator of ischemic arrhythmogenesis are discussed. Insights, derived from endocardial mapping studies, into the nature of ventricular tachycardia in humans with chronic myocardial infarction are described, including implications for risk stratification and therapy to prevent arrhythmia recurrence. Current therapeutic principles are discussed in the management of ventricular arrhythmias associated with coronary artery disease, including pharmacologic approaches, surgical and catheter ablation, and automatic implantable cardioverting and defibrillating devices.

journal_name

Ann Intern Med

authors

Weiss JN,Nademanee K,Stevenson WG,Singh B

doi

10.7326/0003-4819-114-9-784

subject

Has Abstract

pub_date

1991-05-01 00:00:00

pages

784-97

issue

9

eissn

0003-4819

issn

1539-3704

journal_volume

114

pub_type

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