Vericiguat reduced a composite of CV death or HF hospitalization in patients with HF and reduced LVEF.

abstract：:The availability of vidarabine for the therapy of suspected herpes simplex encephalitis presents a difficult decision for a physician as to whether to do brain biopsy, to treat blindly, or to withhold specific therapy in a patient. The choice is made more difficult because the physician must weigh four likelihoods sim...

journal_title：Annals of internal medicine

authors： Barza M,Pauker SG

更新日期：1980-05-01 00:00:00

abstract：OBJECTIVE:To evaluate the incidence and symptoms of and risk factors for biliary sludge and gallstones during pregnancy and to assess the natural history of these conditions in the first year after delivery. DESIGN:Cohort study. PATIENTS:A total of 272 pregnant women recruited in the first trimester. MEASUREMENTS:Bi...

journal_title：Annals of internal medicine

authors： Maringhini A,Ciambra M,Baccelliere P,Raimondo M,Orlando A,Tinè F,Grasso R,Randazzo MA,Barresi L,Gullo D,Musico M,Pagliaro L

更新日期：1993-07-15 00:00:00

abstract：:Infection with human immunodeficiency virus (HIV) may cause viral antigenemia, detected primarily as p24 viral core protein. Among 16 patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex studied serially, 12 had or developed antigenemia ranging from 16 to 3006 pg/mL in plasma. The level ...

journal_title：Annals of internal medicine

authors： Jackson GG,Paul DA,Falk LA,Rubenis M,Despotes JC,Mack D,Knigge M,Emeson EE

更新日期：1988-02-01 00:00:00

abstract：BACKGROUND:Lateral epicondylitis is a common condition for which botulinum toxin has been reported to have a therapeutic role in uncontrolled studies. OBJECTIVE:To determine if an injection of botulinum toxin is more effective than placebo for reducing pain in adults with lateral epicondylitis. DESIGN:Randomized, dou...

journal_title：Annals of internal medicine

authors： Wong SM,Hui AC,Tong PY,Poon DW,Yu E,Wong LK

更新日期：2005-12-06 00:00:00

abstract：OBJECTIVE:To determine whether the detection of tuberculostearic acid (TBSA) in bronchial aspirate and bronchoalveolar lavage specimens is useful for the rapid diagnosis of active pulmonary tuberculosis in patients suspected of having the disease. SETTING:A pulmonary clinic in a teaching hospital. PATIENTS:Forty pati...

journal_title：Annals of internal medicine

authors： Pang JA,Chan HS,Chan CY,Cheung SW,French GL

更新日期：1989-10-15 00:00:00

abstract：:Hyperamylasemia, which has been reported in patients with the eating disorders anorexia nervosa and bulimia, generally has been thought to result from pancreatitis. To evaluate the mechanisms of hyperamylasemia, we measured amylase, lipase, and isoamylase activity in 17 consecutive patients admitted to the eating diso...

journal_title：Annals of internal medicine

authors： Humphries LL,Adams LJ,Eckfeldt JH,Levitt MD,McClain CJ

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:ClinicalTrials.gov requires reporting of result summaries for many drug and device trials. PURPOSE:To evaluate the consistency of reporting of trials that are registered in the ClinicalTrials.gov results database and published in the literature. DATA SOURCES:ClinicalTrials.gov results database and matched ...

journal_title：Annals of internal medicine

authors： Hartung DM,Zarin DA,Guise JM,McDonagh M,Paynter R,Helfand M

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Thymectomy is standard therapy fornonthymomatousmyasthenia gravis despite the absence of randomized clinical trials (1). Myasthenia gravis is uncommonly reported in monozygous twins; disease concordance occurs in approximately one third of such identical twin pairs; and treatment for myasthenia gravis, when ...

journal_title：Annals of internal medicine

authors： Riggs KR,Gutmann L,Riggs JE

更新日期：2011-10-04 00:00:00

abstract：:Dietary deficiency of vitamin B-12 has been reported, yet most people ingesting vitamin-B12-deficient diets even for many years appear to achieve a balance that does not lead to overt signs and symptoms of deficiency. I present the case of a vegan of 25 years' duration who developed severe neurologic abnormalities due...

journal_title：Annals of internal medicine

authors： Carmel R

更新日期：1978-05-01 00:00:00

abstract：:Two patients with chronic liver disease developed elevated serum aluminum concentrations and biopsy-proven osteodystrophy. Neither patient had chronic renal failure but both had received aluminum-containing antacids for long periods. We measured biliary and urinary aluminum excretion during antacid loading in patients...

journal_title：Annals of internal medicine

authors： Williams JW,Vera SR,Peters TG,Luther RW,Bhattacharya S,Spears H,Graham A,Pitcock JA,Crawford AJ,Palmieri GM

更新日期：1986-06-01 00:00:00

abstract：BACKGROUND:HIV-1 genotypic and phenotypic susceptibility testing (GPT) optimizes antiretroviral selection, but its effect on survival is unknown. OBJECTIVE:To evaluate the association between GPT and survival. DESIGN:Cohort study. SETTING:10 U.S. HIV clinics. PATIENTS:2699 HIV-infected patients eligible for GPT (pl...

journal_title：Annals of internal medicine

authors： Palella FJ Jr,Armon C,Buchacz K,Cole SR,Chmiel JS,Novak RM,Wood K,Moorman AC,Brooks JT,HOPS (HIV Outpatient Study) Investigators.

更新日期：2009-07-21 00:00:00

abstract：:We surveyed the faculty, fellows, and residents of a department of medicine to determine the relative importance of each of eight personal characteristics evaluated during the interview of house staff candidates. A booklet containing all possible pairings of the eight characteristics was distributed to 219 participant...

journal_title：Annals of internal medicine

authors： Greganti MA,McGaghie WC,Finn WF

更新日期：1982-07-01 00:00:00

abstract：BACKGROUND:Pretreatment antimicrobial resistance has an important impact on the efficacy of many Helicobacter pylori treatment regimens. OBJECTIVE:To estimate the prevalence of H. pylori resistance to antimicrobials in the United States, to characterize risk factors associated with H. pylori antimicrobial resistance, ...

journal_title：Annals of internal medicine

authors： Meyer JM,Silliman NP,Wang W,Siepman NY,Sugg JE,Morris D,Zhang J,Bhattacharyya H,King EC,Hopkins RJ

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:An outbreak of seven cases (in six patients and one health care worker, all of whom had AIDS) of multidrug-resistant tuberculosis occurred in a hospital in Chicago. The hospital had a respirator-fit testing program but no acid-fast bacilli isolation rooms. OBJECTIVE:To identify risk factors for transmission...

journal_title：Annals of internal medicine

authors： Kenyon TA,Ridzon R,Luskin-Hawk R,Schultz C,Paul WS,Valway SE,Onorato IM,Castro K

更新日期：1997-07-01 00:00:00

abstract：:Quality improvement (QI) activities can improve health care but must be conducted ethically. The Hastings Center convened leaders and scholars to address ethical requirements for QI and their relationship to regulations protecting human subjects of research. The group defined QI as systematic, data-guided activities d...

journal_title：Annals of internal medicine

authors： Lynn J,Baily MA,Bottrell M,Jennings B,Levine RJ,Davidoff F,Casarett D,Corrigan J,Fox E,Wynia MK,Agich GJ,O'Kane M,Speroff T,Schyve P,Batalden P,Tunis S,Berlinger N,Cronenwett L,Fitzmaurice JM,Dubler NN,James B

更新日期：2007-05-01 00:00:00

abstract：:Electrophysiologic studies were done in 32 patients with aortic stenosis. In 24 patients with intact A-V conduction, A-H intervals ranged from 55 to 145 msec and were prolonged in two. Two had split His bundle potentials. The H-V intervals ranged from 25 to 94 msec and were prolonged in 12. The mean H-V interval was 6...

journal_title：Annals of internal medicine

authors： Dhingra RC,Amat-y-Leon F,Pietras RJ,Wyndham C,Deedwania PC,Wu D,Denes P,Rosen KM

更新日期：1977-09-01 00:00:00

abstract：BACKGROUND:Tumor necrosis factor-alpha is present in arteries in giant cell arteritis. OBJECTIVE:To evaluate the efficacy of infliximab, an anti-tumor necrosis factor-alpha agent, in giant cell arteritis. DESIGN:Randomized, controlled trial. SETTING:22 sites in the United States, the United Kingdom, Belgium, Italy, ...

journal_title：Annals of internal medicine

authors： Hoffman GS,Cid MC,Rendt-Zagar KE,Merkel PA,Weyand CM,Stone JH,Salvarani C,Xu W,Visvanathan S,Rahman MU,Infliximab-GCA Study Group.

更新日期：2007-05-01 00:00:00

abstract：:For over 200 years digitalis compounds have been used to treat atrial fibrillation. The rapid ventricular response to atrial fibrillation is frequently treated with digoxin to produce a controlled heart rate. Digoxin has also been proposed as a treatment for terminating recent-onset atrial fibrillation, for maintainin...

journal_title：Annals of internal medicine

authors： Falk RH,Leavitt JI

更新日期：1991-04-01 00:00:00

abstract：:The Hospital Readmissions Reduction Program (HRRP) has penalized hospitals with higher 30-day readmission rates more than $3 billion to date. Clinicians and policy experts have raised concerns that the 30-day readmission measure used in this program provides an incomplete picture of performance because it does not cap...

journal_title：Annals of internal medicine

authors： Wadhera RK,Joynt Maddox KE,Desai NR,Landon BE,Md MV,Gilstrap LG,Shen C,Yeh RW

更新日期：2021-01-01 00:00:00

abstract：:Restrictive cardiomyopathy produced by primary cardiac amyloidosis may have a clinical syndrome identical to noncalcific constrictive pericarditis. We report two patients with amyloidosis and restrictive physiology who had enlarged papillary muscles shown on left ventricular angiocardiogram. Rapid volume expansion wit...

journal_title：Annals of internal medicine

authors： Maule WF,Martin RH

更新日期：1983-02-01 00:00:00

abstract：BACKGROUND:High intake of folate may reduce risk for colon cancer, but the dosage and duration relations and the impact of dietary compared with supplementary sources are not well understood. OBJECTIVE:To evaluate the relation between folate intake and incidence of colon cancer. DESIGN:Prospective cohort study. SETT...

journal_title：Annals of internal medicine

authors： Giovannucci E,Stampfer MJ,Colditz GA,Hunter DJ,Fuchs C,Rosner BA,Speizer FE,Willett WC

更新日期：1998-10-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the sensitivity of herpes simplex virus isolates to acyclovir and the importance of resistant isolates in hospitalized patients. DESIGN:Retrospective incidence cohort study. SETTING:All herpes simplex virus isolates cultured over 1 year from patients followed at a tertiary care center. P...

journal_title：Annals of internal medicine

authors： Englund JA,Zimmerman ME,Swierkosz EM,Goodman JL,Scholl DR,Balfour HH Jr

更新日期：1990-03-15 00:00:00

abstract：:Four hemodialysis patients receiving deferoxamine for metal overload had fatal rhinocerebral rhizopus infections. Serious fungal infections are not commonly seen in patients on dialysis, and none of these patients had the usual risk factors for rhizopus infection. Deferoxamine is being used with increased frequency in...

journal_title：Annals of internal medicine

authors： Windus DW,Stokes TJ,Julian BA,Fenves AZ

更新日期：1987-11-01 00:00:00

abstract：:We have seen two patients whose hepatitis was due to the administration of aprindine, a new antiarrhythmic agent. In both patients evidence of hepatitis appeared within 3 weeks of initiating aprindine therapy and resolved rapidly when the drug was withdrawn. The reintroduction of aprindine in one patient was associate...

journal_title：Annals of internal medicine

authors： Herlong HF,Reid PR,Boitnott JK,Maddrey WC

更新日期：1978-09-01 00:00:00

abstract：:Myocardial infarction was diagnosed in 431 (30%) of 1460 patients with acute chest pain who had serial enzyme testing after admission to intensive or intermediate care units at three teaching and three community hospitals. The diagnosis was made within 12 hours of admission in 331 (77%) patients and within 24 hours in...

journal_title：Annals of internal medicine

authors： Lee TH,Rouan GW,Weisberg MC,Brand DA,Cook EF,Acampora D,Goldman L

更新日期：1987-02-01 00:00:00

abstract：:Population screening for hemochromatosis done by using the transferrin saturation test has been advocated by experts to permit the initiation of therapeutic phlebotomy before the onset of clinical disease. The discovery of a gene associated with hemochromatosis has made DNA testing another option for screening and dia...

journal_title：Annals of internal medicine

authors： Cogswell ME,McDonnell SM,Khoury MJ,Franks AL,Burke W,Brittenham G

更新日期：1998-12-01 00:00:00

abstract：:The presence of a low anion gap in patients with multiple myeloma has recently been emphasized. This has been related to the retention of chloride and bicarbonate anions to offset the cationic charge of the monoclonal immunoglobulins. We now report the presence of a low anion gap in 50 patients with asymptomatic plasm...

journal_title：Annals of internal medicine

authors： Schnur MJ,Appel GB,Karp G,Osserman EP

更新日期：1977-03-01 00:00:00

abstract：:Opioid dependence is a chronic relapsing medical condition with substantial health and societal complications. Recent federal initiatives are designed to enhance the medical treatment of patients with opioid dependence and will expand the role of internists in the care of these patients. These initiatives include a pr...

journal_title：Annals of internal medicine

authors： Fiellin DA,O'Connor PG

更新日期：2002-10-15 00:00:00

abstract：BACKGROUND:Because clinical diagnosis is inaccurate, objective testing is usually considered necessary when patients present with suspected deep venous thrombosis (DVT). OBJECTIVE:To determine whether a negative result on a quantitative latex D dimer assay eliminates the need for further investigation in patients with...

journal_title：Annals of internal medicine

authors： Bates SM,Kearon C,Crowther M,Linkins L,O'Donnell M,Douketis J,Lee AY,Weitz JI,Johnston M,Ginsberg JS

更新日期：2003-05-20 00:00:00

abstract：:Recent research on human macrophage activation has reemphasized the critical role of the lymphokine-secreting T cell in converting quiescent macrophages to efficient microbicidal phagocytes. Interferon-gamma, a key lymphokine secreted by antigen-triggered T4+ helper cells, is capable of inducing the macrophage to act ...

journal_title：Annals of internal medicine

authors： Murray HW

更新日期：1988-04-01 00:00:00