An additional basic science for clinical medicine: I. The constraining fundamental paradigms.

abstract：:In deciding whether to undertake a dietary program to reduce serum cholesterol levels, a person must consider how much benefit to expect. We developed a model that assumes cholesterol reduction is effective and safe in reducing the risk for death from ischemic heart disease. In the model, we considered asymptomatic ad...

journal_title：Annals of internal medicine

authors： Taylor WC,Pass TM,Shepard DS,Komaroff AL

更新日期：1987-04-01 00:00:00

abstract：:The approximately 1.2 million inmates in U.S. correctional institutions have a high prevalence of communicable diseases, such as human immunodeficiency virus (HIV) infection, tuberculosis, hepatitis B virus infection, and gonorrhea. Before their incarceration, most inmates had limited access to health care, which, tog...

journal_title：Annals of internal medicine

authors： Glaser JB,Greifinger RB

更新日期：1993-01-15 00:00:00

abstract：BACKGROUND:Risk for transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to close contacts of infected persons has not been well estimated. OBJECTIVE:To evaluate the risk for transmission of SARS-CoV-2 to close contacts in different settings. DESIGN:Prospective cohort study. SETTING:Close con...

journal_title：Annals of internal medicine

authors： Luo L,Liu D,Liao X,Wu X,Jing Q,Zheng J,Liu F,Yang S,Bi H,Li Z,Liu J,Song W,Zhu W,Wang Z,Zhang X,Huang Q,Chen P,Liu H,Cheng X,Cai M,Yang P,Yang X,Han Z,Tang J,Ma Y,Mao C

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Valid measurement of physician performance requires accurate identification of patients for whom a physician is responsible. Among all patients seen by a physician, some will be more strongly connected to their physician than others, but the effect of connectedness on measures of physician performance is not...

journal_title：Annals of internal medicine

authors： Atlas SJ,Grant RW,Ferris TG,Chang Y,Barry MJ

更新日期：2009-03-03 00:00:00

abstract：OBJECTIVE:To describe the course of rheumatoid arthritis over 5 years in adults and to evaluate the effect of parenterally administered gold salts on that course. DESIGN:A prospective observational study of adults with rheumatoid arthritis. Data derived from annual interviews with patients from 1983 to 1988 and from p...

journal_title：Annals of internal medicine

authors： Epstein WV,Henke CJ,Yelin EH,Katz PP

更新日期：1991-03-15 00:00:00

abstract：BACKGROUND:Variants in genes involved in warfarin metabolism and sensitivity affect individual warfarin requirements and the risk for bleeding. Testing for these variant alleles might allow more personalized dosing of warfarin during the induction phase. In 2007, the U.S. Food and Drug Administration changed the labeli...

journal_title：Annals of internal medicine

authors： Eckman MH,Rosand J,Greenberg SM,Gage BF

更新日期：2009-01-20 00:00:00

abstract：:Protein S activity may be compromised in patients with the nephrotic syndrome and contribute to a thrombotic diathesis. Protein S is found in two forms in plasma as free and functionally active protein S, and complexed to C4b-binding protein. When compared with controls, patients with nephrotic syndrome had reduced fu...

journal_title：Annals of internal medicine

authors： Vigano-D'Angelo S,D'Angelo A,Kaufman CE Jr,Sholer C,Esmon CT,Comp PC

更新日期：1987-07-01 00:00:00

abstract：:This statement summarizes the U.S. Preventive Services Task Force (USPSTF) recommendations on screening for family and intimate partner violence, based on the USPSTF's examination of evidence specific to family and intimate partner violence, and updates the 1996 recommendations on this topic. In 1996, the USPSTF found...

journal_title：Annals of internal medicine

authors： U. S. Preventive Services Task Force.

更新日期：2004-03-02 00:00:00

abstract：:Population screening for hemochromatosis done by using the transferrin saturation test has been advocated by experts to permit the initiation of therapeutic phlebotomy before the onset of clinical disease. The discovery of a gene associated with hemochromatosis has made DNA testing another option for screening and dia...

journal_title：Annals of internal medicine

authors： Cogswell ME,McDonnell SM,Khoury MJ,Franks AL,Burke W,Brittenham G

更新日期：1998-12-01 00:00:00

abstract：:The scope of recent literature on the concept of "vulnerable plaque" was reviewed by examining 463 abstracts of primary and review articles identified through MEDLINE (2003 to April 2010). Proposed definition criteria of vulnerable plaque included active inflammation, a thin cap with a large lipid core, endothelial de...

journal_title：Annals of internal medicine

authors： Alsheikh-Ali AA,Kitsios GD,Balk EM,Lau J,Ip S

更新日期：2010-09-21 00:00:00

abstract：:Disseminated candidiasis has become an important infection, particularly in immunocompromised and postoperative patients. Although serologic tests may, in some settings, facilitate a premortem diagnosis, the disease is usually diagnosed by comprehensive clinical evaluation. Detection of the relatively newly recognized...

journal_title：Annals of internal medicine

authors： Edwards JE Jr,Lehrer RI,Stiehm ER,Fischer TJ,Young LS

更新日期：1978-07-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the usefulness of the continuous intravenous dexamethasone suppression test in the differential diagnosis of patients with the Cushing syndrome. DESIGN:Comparison of the results of this test with those of other tests in the study population and with data from the literature. SETTING:Refer...

journal_title：Annals of internal medicine

authors： Biemond P,de Jong FH,Lamberts SW

更新日期：1990-05-15 00:00:00

abstract：:The Residency Program in Social Medicine at Montefiore Medical Center is a collaborative, integrated training program for primary care pediatricians, internists, and family physicians within one interdisciplinary organization. Since 1970 we have trained more than 200 physicians, prepared them for board certification i...

journal_title：Annals of internal medicine

authors： Strelnick AH,Bateman WB,Jones C,Shepherd SD,Massad RJ,Townsend JM,Grossman R,Korin E,Schorow M

更新日期：1988-08-15 00:00:00

abstract：:Because the cholesterol-rich very low density (VLD) lipoproteins of subjects with type III hyperlipoproteinemia are distinctively enriched in apolipoprotein E, a radial immunodiffusion assay for apolipoprotein E in whole plasma was developed. Its diagnostic usefulness was tested in randomly selected (n = 174) and hype...

journal_title：Annals of internal medicine

authors： Kushwaha RS,Hazzard WR,Wahl PW,Hoover JJ

更新日期：1977-11-01 00:00:00

abstract：:Conventional interpretation of clinical trials relies heavily on the classic p value. The p value, however, represents only a false-positive rate, and does not tell the probability that the investigator's hypothesis is correct, given his observations. This more relevant posterior probability can be quantified by an ex...

journal_title：Annals of internal medicine

authors： Diamond GA,Forrester JS

更新日期：1983-03-01 00:00:00

abstract：:Reversible cerebral vasoconstriction syndromes (RCVS) comprise a group of diverse conditions, all characterized by reversible multifocal narrowing of the cerebral arteries heralded by sudden (thunderclap), severe headaches with or without associated neurologic deficits. Reversible cerebral vasoconstriction syndromes a...

journal_title：Annals of internal medicine

authors： Calabrese LH,Dodick DW,Schwedt TJ,Singhal AB

更新日期：2007-01-02 00:00:00

abstract：:In April 1976 the attack rate of chills and fever with or without falls in blood pressure increased in association with cardiac catheterizations. Fevers were associated with coronary angiography and right and left heart catheterizations. Blood cultures were negative, and reactions did not correlate with amounts of con...

journal_title：Annals of internal medicine

authors： Reyes MP,Ganguly S,Fowler M,Brown WJ,Gatmaitan BG,Friedman C,Lerner AM

更新日期：1980-07-01 00:00:00

abstract：:Brain death has been discussed extensively for the last 25 years. Most investigators now believe that requiring death of the entire brain as the criterion for brain death in the Uniform Determination of Death Act and the standard clinical tests of brain death outlined in the Report of the Medical Consultants to the Pr...

journal_title：Annals of internal medicine

authors： Halevy A,Brody B

更新日期：1993-09-15 00:00:00

abstract：:To describe more explicitly the components of competence required of the internist, The American Board of Internal Medicine has analyzed the medical encounter and defined the major variables involved: the abilities required of the internist, the tasks that must be performed to solve a medical problem, the medical illn...

journal_title：Annals of internal medicine

authors：

更新日期：1979-03-01 00:00:00

abstract：:Recent reviews have suggested a higher frequency of the lupus anticoagulant or related antiphospholipid antibodies in patients with systemic lupus erythematosus (21% to 65%) than was found in earlier studies (6% to 18%). In our study of 60 consecutive patients, we found the frequency of the lupus anticoagulant by Russ...

journal_title：Annals of internal medicine

authors： Petri M,Rheinschmidt M,Whiting-O'Keefe Q,Hellmann D,Corash L

更新日期：1987-04-01 00:00:00

abstract：Background:A 2007 American College of Physicians guideline addressed pharmacologic options for low back pain. New evidence and medications have now become available. Purpose:To review the current evidence on systemic pharmacologic therapies for acute or chronic nonradicular or radicular low back pain. Data Sources:Ov...

journal_title：Annals of internal medicine

authors： Chou R,Deyo R,Friedly J,Skelly A,Weimer M,Fu R,Dana T,Kraegel P,Griffin J,Grusing S

更新日期：2017-04-04 00:00:00

abstract：BACKGROUND:Benign reductions in neutrophil counts may be more common at certain ages and in certain ethnic groups and may be affected by sex and smoking status. OBJECTIVE:To determine differences in neutrophil counts in the U.S. population according to ethnicity, age, sex, and smoking status. DESIGN:Population-based,...

journal_title：Annals of internal medicine

authors： Hsieh MM,Everhart JE,Byrd-Holt DD,Tisdale JF,Rodgers GP

更新日期：2007-04-03 00:00:00

abstract：:We performed selective venous catheterization and sampling for ACTH in six patients with ACTH-secreting pituitary adenomas (Cushing's disease) and four patients with occult ectopic ACTH-secreting neoplasms. In five patients with Cushing's disease in whom the inferior petrosal sinus could be catheterized, ACTH levels w...

journal_title：Annals of internal medicine

authors： Findling JW,Aron DC,Tyrrell JB,Shinsako JH,Fitzgerald PA,Norman D,Wilson CB,Forsham PH

更新日期：1981-05-01 00:00:00

abstract：OBJECTIVE:To identify the cause of a hypersensitivity pneumonitis and to determine its pathogenesis. DESIGN:Case study. SETTING:Intensive care unit of a referral hospital. PATIENT:A 51-year-old man with chronic bronchitis who developed a hypersensitivity pneumonitis within 1 month after exposure to minocycline, amox...

journal_title：Annals of internal medicine

authors： Guillon JM,Joly P,Autran B,Denis M,Akoun G,Debré P,Mayaud C

更新日期：1992-09-15 00:00:00

abstract：:A patient with a retained bullet developed lead poisoning in association with thyrotoxicosis. The clinical and laboratory data suggest that lead was mobilized from an increased mobile bone pool during the hypermetabolic period with resultant poisoning. The findings give factual support to earlier concepts that lead po...

journal_title：Annals of internal medicine

authors： Cagin CR,Diloy-Puray M,Westerman MP

更新日期：1978-10-01 00:00:00

abstract：:Type 2 diabetes mellitus is a chronic metabolic disorder that results from defects in both insulin secretion and insulin action. An elevated rate of basal hepatic glucose production in the presence of hyperinsulinemia is the primary cause of fasting hyperglycemia; after a meal, impaired suppression of hepatic glucose ...

journal_title：Annals of internal medicine

authors： DeFronzo RA

更新日期：1999-08-17 00:00:00

abstract：BACKGROUND:Urine tests for Chlamydia trachomatis permit expansion of screening beyond traditional clinic environments. Prevention of infection in teenagers is a high priority. OBJECTIVE:To define the prevalence of C. trachomatis among teenagers by using the ligase chain reaction assay on urine specimens and to evaluat...

journal_title：Annals of internal medicine

authors： Marrazzo JM,White CL,Krekeler B,Celum CL,Lafferty WE,Stamm WE,Handsfield HH

更新日期：1997-11-01 00:00:00

abstract：:Therapy of pulmonary hypertension is limited by the low potency and adverse effects of current pulmonary vasodilators. The hemodynamic effects of nitroglycerin in human pulmonary hypertension are not known. We administered nitroglycerin to nine patients with chronic pulmonary hypertension. Nitroglycerin increased card...

journal_title：Annals of internal medicine

authors： Pearl RG,Rosenthal MH,Schroeder JS,Ashton JP

更新日期：1983-07-01 00:00:00

abstract：OBJECTIVE:To develop an early diagnostic test for pancreatic cancer based on the identification of K-ras mutations in pure pancreatic juice collected during endoscopic retrograde pancreatography. DESIGN:Prospective study with masked comparison. The standard criteria for the diagnosis of pancreatic cancer were pancreat...

journal_title：Annals of internal medicine

authors： Berthélemy P,Bouisson M,Escourrou J,Vaysse N,Rumeau JL,Pradayrol L

更新日期：1995-08-01 00:00:00

abstract：:Antibiotic-associated diarrhea and colitis were well established soon after antibiotics became available. Early work implicated Staphylococcus aureus, but in 1978 Clostridium difficile became the established pathogen in the vast majority of cases. In the first 5 years (1978 through 1983), the most common cause was cli...

journal_title：Annals of internal medicine

authors： Bartlett JG

更新日期：2006-11-21 00:00:00