Newly acquired left bundle-branch block: the Framingham study.

Abstract:

:The clinical implications of newly acquired left bundle-branch block (LBBB) were examined prospectively in the Framingham Study population. During 18 years of observation 55 people developed LBBB. The mean age at the onset of LBBB was 62; LBBB occurred largely in people with antecedent hypertension, cardiac enlargement, coronary heart disease, or a combination of these. Coincident with or subsequent to the onset of LBBB, 48% developed clinical coronary disease or congestive failure for the first time. Throughout the entire period of observation only 11% remained free of clinically apparent cardiovascular abnormalities. Within 10 years of the onset of LBBB, 50% had died from cardiovascular diseases. In men, the appearance of LBBB contributed independently to an increased risk of cardiovascular disease mortality. Comparison with age- and sex-matched control subjects free from LBBB confirmed that in the general adult population, newly acquired LBBB is most often a hallmark of advanced hypertensive or ischemic heart disease, or both.

journal_name

Ann Intern Med

authors

Schneider JF,Thomas HE Jr,Kreger BE,McNamara PM,Kannel WB

doi

10.7326/0003-4819-90-3-303

subject

Has Abstract

pub_date

1979-03-01 00:00:00

pages

303-10

issue

3

eissn

0003-4819

issn

1539-3704

journal_volume

90

pub_type

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