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A randomized clinical trial of acupuncture compared with sham acupuncture in fibromyalgia.

Abstract：

BACKGROUND:Fibromyalgia is a common chronic pain condition for which patients frequently use acupuncture. OBJECTIVE:To determine whether acupuncture relieves pain in fibromyalgia. DESIGN:Randomized, sham-controlled trial in which participants, data collection staff, and data analysts were blinded to treatment group. SETTING:Private acupuncture offices in the greater Seattle, Washington, metropolitan area. PATIENTS:100 adults with fibromyalgia. INTERVENTION:Twice-weekly treatment for 12 weeks with an acupuncture program that was specifically designed to treat fibromyalgia, or 1 of 3 sham acupuncture treatments: acupuncture for an unrelated condition, needle insertion at nonacupoint locations, or noninsertive simulated acupuncture. MEASUREMENTS:The primary outcome was subjective pain as measured by a 10-cm visual analogue scale ranging from 0 (no pain) to 10 (worst pain ever). Measurements were obtained at baseline; 1, 4, 8, and 12 weeks of treatment; and 3 and 6 months after completion of treatment. Participant blinding and adverse effects were ascertained by self-report. The primary outcomes were evaluated by pooling the 3 sham-control groups and comparing them with the group that received acupuncture to treat fibromyalgia. RESULTS:The mean subjective pain rating among patients who received acupuncture for fibromyalgia did not differ from that in the pooled sham acupuncture group (mean between-group difference, 0.5 cm [95% CI, -0.3 cm to 1.2 cm]). Participant blinding was adequate throughout the trial, and no serious adverse effects were noted. LIMITATIONS:A prescription of acupuncture at fixed points may differ from acupuncture administered in clinical settings, in which therapy is individualized and often combined with herbal supplementation and other adjunctive measures. A usual-care comparison group was not studied. CONCLUSION:Acupuncture was no better than sham acupuncture at relieving pain in fibromyalgia.

journal_name

Ann Intern Med

journal_title

Annals of internal medicine

authors

Assefi NP,Sherman KJ,Jacobsen C,Goldberg J,Smith WR,Buchwald D

doi

10.7326/0003-4819-143-1-200507050-00005

subject

Has Abstract

pub_date

2005-07-05 00:00:00

pages

10-9

issue

eissn

0003-4819

issn

1539-3704

pii

143/1/10

journal_volume

143

pub_type

临床试验,杂志文章,多中心研究,随机对照试验

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A randomized clinical trial of acupuncture compared with sham acupuncture in fibromyalgia.