Antigenemia detected by radioimmunoassay in systemic aspergillosis.

Abstract:

:Because of difficulties in antemortem diagnosis of systemic aspergillosis, a radioimmunoassay to an Aspergillus fumigatus carbohydrate was developed and evaluated in patients with mycotic or bacterial infections. Antigenemia was detected in sera obtained antemortem from four of seven patients with systemic aspergillosis and in pleural fluid from an Aspergillus empyema but not in control sera or pleural fluid from 43 patients or 27 normal donors. When characterized with reference to onset of disease, antigenemia was an early sign of infection. This study shows the usefulness of the Aspergillus antigen radioimmunoassay for early, specific immunodiagnosis of systemic aspergillosis.

journal_name

Ann Intern Med

authors

Weiner MH

doi

10.7326/0003-4819-92-6-793

subject

Has Abstract

pub_date

1980-06-01 00:00:00

pages

793-6

issue

6

eissn

0003-4819

issn

1539-3704

journal_volume

92

pub_type

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