The internist as gatekeeper. Preparing the general internist for a new role.

abstract：Background:Probiotics, prebiotics, and synbiotics are used increasingly, although the safety and potential harms of these interventions are poorly understood. Purpose:To examine how harms-related information is reported in publications of randomized controlled trials (RCTs) of probiotics, prebiotics, and synbiotics. ...

journal_title：Annals of internal medicine

authors： Bafeta A,Koh M,Riveros C,Ravaud P

更新日期：2018-08-21 00:00:00

abstract：:Hypophosphatemic osteomalacia that remits after resection of a coexisting tumor has been described in 35 patients. Because the associated neoplasms have been of mesenchymal origin, it has been inferred that this tumor-induced osteomalacia syndrome is uniquely related to tumours of this derivation. However, in the pres...

journal_title：Annals of internal medicine

authors： Lyles KW,Berry WR,Haussler M,Harrelson JM,Drezner MK

更新日期：1980-08-01 00:00:00

abstract：BACKGROUND:Depressive disorders are persistent, recurring illnesses that cause great suffering for patients and their families. PURPOSE:To evaluate the benefits and adverse effects of newer pharmacotherapies and herbal treatments for depressive disorders in adults and adolescents. DATA SOURCES:English-language and no...

journal_title：Annals of internal medicine

authors： Williams JW Jr,Mulrow CD,Chiquette E,Noël PH,Aguilar C,Cornell J

更新日期：2000-05-02 00:00:00

abstract：:Hepatitis is a significant complication of the treatment of hemophilia A with factor VIII concentrates. Chronic liver disease in these patients is infrequently documented in the literature. The results of percutaneous liver biopsy, under the coverage of glycine-precipitated factor VIII, in six patients with hemophilia...

journal_title：Annals of internal medicine

authors： Lesesne HR,Morgan JE,Blatt PM,Webster WP,Roberts HR

更新日期：1977-06-01 00:00:00

abstract：:Young adults with cystic fibrosis have lower blood pressures than control subjects of similar age and sex. The low blood pressure may be related to the excessive loss of salt in the sweat of these patients. A beneficial effect of the cystic fibrosis gene may be protection against developing hypertension in both the ho...

journal_title：Annals of internal medicine

authors： Lieberman J,Rodbard S

更新日期：1975-06-01 00:00:00

abstract：:The Advisory Committee on Immunization Practices (ACIP) consists of 15 experts in immunization and related fields, selected by the Secretary of the U.S. Department of Health and Human Services, to provide advice and guidance on control of vaccine-preventable diseases. In its role as a federal advisory committee, the A...

journal_title：Annals of internal medicine

authors： Smith JC,Snider DE,Pickering LK,Advisory Committee on Immunization Practices.

更新日期：2009-01-06 00:00:00

abstract：OBJECTIVE:To assess the safety and efficacy of intravenous adenosine in terminating acute episodes of paroxysmal supraventricular tachycardia. DESIGN:Two prospective, double-blind, randomized, placebo-controlled trials to evaluate dose response in patients receiving adenosine and to compare the effects of adenosine wi...

journal_title：Annals of internal medicine

authors： DiMarco JP,Miles W,Akhtar M,Milstein S,Sharma AD,Platia E,McGovern B,Scheinman MM,Govier WC

更新日期：1990-07-15 00:00:00

abstract：:Twenty-three patients with hyperparathyroidism from six families with the multiple endocrine adenomatosis (MEA) I-syndrome were tested by secretin provocation. In nine cases this led to increases in serum gastrin ranging from 298 to 13 300 pg/ml, whereas the maximum rise in gastrin in the other 14 patients was 32 pg/m...

journal_title：Annals of internal medicine

authors： Lamers CB,Buis JT,van Tongeren J

更新日期：1977-06-01 00:00:00

abstract：:Two patients had recurrent facial edema and peripheral blood eosinophilia. One patient showed a marked increase in the serum level of the eosinophil granule major basic protein. In both patients, skin biopsy samples showed nonspecific mononuclear cell inflammation with few eosinophils. However, immunofluorescence stai...

journal_title：Annals of internal medicine

authors： Songsiridej V,Peters MS,Dor PJ,Ackerman SJ,Gleich GJ,Busse WW

更新日期：1985-10-01 00:00:00

abstract：:In deciding whether to undertake a dietary program to reduce serum cholesterol levels, a person must consider how much benefit to expect. We developed a model that assumes cholesterol reduction is effective and safe in reducing the risk for death from ischemic heart disease. In the model, we considered asymptomatic ad...

journal_title：Annals of internal medicine

authors： Taylor WC,Pass TM,Shepard DS,Komaroff AL

更新日期：1987-04-01 00:00:00

abstract：PURPOSE:It is currently unknown whether intensive insulin treatment of diabetes decreases the risk for cardiovascular complications by lowering glucose levels or increases the risk by postulated direct atherogenic effects. This article reviews published data from two long-term, randomized clinical trials that compared ...

journal_title：Annals of internal medicine

authors： Genuth S

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the influence of a human immunodeficiency virus (HIV) vaccine given to uninfected volunteers on the interpretation of serodiagnostic HIV test results. DESIGN:Retrospective cohort study. SETTING:5 AIDS Vaccine Evaluation Units funded by the National Institute of Allergy and Infectious Diseases. ...

journal_title：Annals of internal medicine

authors： Belshe RB,Clements ML,Keefer MC,Graham BS,Corey L,Sposto R,Wescott S,Lawrence D

更新日期：1994-10-15 00:00:00

abstract：STUDY OBJECTIVE:To determine whether obesity preceded knee osteoarthritis and was thus a possible cause. DESIGN:Cohort study with weight and other important variables measured in 1948 to 1951 (mean age of subjects, 37 years) and knee arthritis evaluated in 1983 to 1985 (mean age of subjects, 73 years). SETTING:Popula...

journal_title：Annals of internal medicine

authors： Felson DT,Anderson JJ,Naimark A,Walker AM,Meenan RF

更新日期：1988-07-01 00:00:00

abstract：:After decades of silence, the German Society for Internal Medicine (DGIM) has made considerable efforts to come to terms with its role and actions during the Nazi era (1933 to 1945). This is particularly important because, with more than 27 000 members, the DGIM is the largest medical society in present-day Germany. S...

journal_title：Annals of internal medicine

authors： Hofer HG,Forsbach R,Fölsch UR

更新日期：2020-09-01 00:00:00

abstract：:Treatment selection markers, sometimes called predictive markers, are factors that help clinicians select therapies that maximize good outcomes and minimize adverse outcomes for patients. Existing statistical methods for evaluating a treatment selection marker include assessing its prognostic value, evaluating treatme...

journal_title：Annals of internal medicine

authors： Janes H,Pepe MS,Bossuyt PM,Barlow WE

更新日期：2011-02-15 00:00:00

abstract：:Early defibrillation is the most important determinant of survival for victims of cardiac arrest due to ventricular fibrillation. The automated external defibrillator (AED) was developed as the result of the American Heart Association's Public Access Defibrillation initiative. The goal of this initiative is to place A...

journal_title：Annals of internal medicine

authors： Takata TS,Page RL,Joglar JA

更新日期：2001-12-04 00:00:00

abstract：OBJECTIVE:To determine whether self-assessment of purified protein derivative of tuberculin (PPD) skin test reactions, done using a simple two-choice approach, is an effective screening method for tuberculosis. DESIGN:Double-blind comparison between self-assessments and trained professional readings of PPD skin test r...

journal_title：Annals of internal medicine

authors： Prezant DJ,Kelly KJ,Karwa ML,Kavanagh K

更新日期：1996-08-15 00:00:00

abstract：BACKGROUND:Vertebral fractures are a hallmark of postmenopausal osteoporosis and an important end point in trials of osteoporosis treatment, but the clinical significance of these fractures remains uncertain. OBJECTIVE:To determine the association of new vertebral fractures with back pain and back-related functional l...

journal_title：Annals of internal medicine

authors： Nevitt MC,Ettinger B,Black DM,Stone K,Jamal SA,Ensrud K,Segal M,Genant HK,Cummings SR

更新日期：1998-05-15 00:00:00

abstract：BACKGROUND:Travelers' diarrhea causes substantial morbidity and postinfectious irritable bowel syndrome. OBJECTIVE:To evaluate nonabsorbable rifaximin for prevention of travelers' diarrhea. DESIGN:Randomized, double-blind, placebo-controlled clinical trial. SETTING:Guadalajara, Mexico. PARTICIPANTS:U.S. students. ...

journal_title：Annals of internal medicine

authors： DuPont HL,Jiang ZD,Okhuysen PC,Ericsson CD,de la Cabada FJ,Ke S,DuPont MW,Martinez-Sandoval F

更新日期：2005-05-17 00:00:00

abstract：BACKGROUND:The fecal immunochemical test (FIT) is a common method for colorectal cancer (CRC) screening, yet its acceptability and performance over several rounds of annual testing are largely unknown. OBJECTIVE:To assess FIT performance characteristics over 4 rounds of annual screening. DESIGN:Retrospective cohort s...

journal_title：Annals of internal medicine

authors： Jensen CD,Corley DA,Quinn VP,Doubeni CA,Zauber AG,Lee JK,Zhao WK,Marks AR,Schottinger JE,Ghai NR,Lee AT,Contreras R,Klabunde CN,Quesenberry CP,Levin TR,Mysliwiec PA

更新日期：2016-04-05 00:00:00

abstract：BACKGROUND:Staphylococcus aureus is a common cause of serious infection in patients infected with HIV. OBJECTIVES:To evaluate risk factors for and quantitative effect of S. aureus infection in HIV-infected patients, with special attention to nasal carriage. DESIGN:Prospective, multihospital cohort study. SETTING:Thr...

journal_title：Annals of internal medicine

authors： Nguyen MH,Kauffman CA,Goodman RP,Squier C,Arbeit RD,Singh N,Wagener MM,Yu VL

更新日期：1999-02-02 00:00:00

abstract：:Despite some impressive recent gains, improving the glaring deficiencies in health care quality is proving to be very hard. Improvement is local, rather than system-wide, and is sustained with difficulty, rather than becoming an intrinsic feature of care. My right knee will probably need to be replaced soon. This has ...

journal_title：Annals of internal medicine

authors： Berwick DM

更新日期：2005-01-18 00:00:00

abstract：:We performed selective venous catheterization and sampling for ACTH in six patients with ACTH-secreting pituitary adenomas (Cushing's disease) and four patients with occult ectopic ACTH-secreting neoplasms. In five patients with Cushing's disease in whom the inferior petrosal sinus could be catheterized, ACTH levels w...

journal_title：Annals of internal medicine

authors： Findling JW,Aron DC,Tyrrell JB,Shinsako JH,Fitzgerald PA,Norman D,Wilson CB,Forsham PH

更新日期：1981-05-01 00:00:00

abstract：:Research participants require ongoing protection of the kind already established in law and regulation. However, "special scrutiny" for certain types of research is also needed. Three criteria for special scrutiny are 1) research that involves initial experiences of translating new scientific advances into humans, esp...

journal_title：Annals of internal medicine

authors： Levine C,Faden R,Grady C,Hammerschmidt D,Eckenwiler L,Sugarman J,Consortium to Examine Clinical Research Ethics.

更新日期：2004-02-03 00:00:00

abstract：BACKGROUND:Recent postmarketing trials produced conflicting results about the risk for hospitalized heart failure (hHF) associated with dipeptidyl peptidase-4 (DPP-4) inhibitors, creating uncertainty about the safety of these antihyperglycemic agents. OBJECTIVE:To examine the associations of hHF with saxagliptin and s...

journal_title：Annals of internal medicine

authors： Toh S,Hampp C,Reichman ME,Graham DJ,Balakrishnan S,Pucino F,Hamilton J,Lendle S,Iyer A,Rucker M,Pimentel M,Nathwani N,Griffin MR,Brown NJ,Fireman BH

更新日期：2016-06-07 00:00:00

abstract：OBJECTIVE:To determine whether oral acyclovir reduces the incidence of recurrent herpes labialis in otherwise healthy patients with proven frequently recurrent disease. DESIGN:Randomized, double-blind, placebo-controlled, crossover trial. SETTING:Outpatient facility of the Clinical Center, National Institutes of Heal...

journal_title：Annals of internal medicine

authors： Rooney JF,Straus SE,Mannix ML,Wohlenberg CR,Alling DW,Dumois JA,Notkins AL

更新日期：1993-02-15 00:00:00

abstract：:A severe shortage of organs greatly limits the ability to deliver the miracle of transplantation to people suffering from end-stage organ disease. Contributing to this shortage is a high rate of refusal among families who are asked for permission to remove organs from a recently deceased relative. Mandated choice offe...

journal_title：Annals of internal medicine

authors： Spital A

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:The current standard initial therapies for deep venous thrombosis are low-molecular-weight heparin and unfractionated heparin. In a dose-ranging study of patients with symptomatic deep venous thrombosis, fondaparinux had efficacy and a safety profile similar to those of low-molecular-weight heparin (daltepar...

journal_title：Annals of internal medicine

authors： Büller HR,Davidson BL,Decousus H,Gallus A,Gent M,Piovella F,Prins MH,Raskob G,Segers AE,Cariou R,Leeuwenkamp O,Lensing AW,Matisse Investigators.

更新日期：2004-06-01 00:00:00

abstract：:The youthful habits and family attitudes of medical students who later developed or died from one of five disease states were different from those of healthy classmate controls to begin with. In medical school, the total disorder group had significantly more nervous tension, anxiety, and anger under stress, had more i...

journal_title：Annals of internal medicine

authors： Thomas CB

更新日期：1976-11-01 00:00:00

abstract：STUDY OBJECTIVE:To assess respiratory muscle fatigue in acute respiratory failure in patients with chronic obstructive pulmonary disease and evaluate its influence on weaning patients from mechanical ventilation. DESIGN AND PATIENTS:We studied the time course of tracheal occlusion pressure (P0.1) and high-to-low ratio...

journal_title：Annals of internal medicine

authors： Murciano D,Boczkowski J,Lecocguic Y,Emili JM,Pariente R,Aubier M

更新日期：1988-06-01 00:00:00