Fecal Immunochemical Test Program Performance Over 4 Rounds of Annual Screening: A Retrospective Cohort Study.

Abstract:

BACKGROUND:The fecal immunochemical test (FIT) is a common method for colorectal cancer (CRC) screening, yet its acceptability and performance over several rounds of annual testing are largely unknown. OBJECTIVE:To assess FIT performance characteristics over 4 rounds of annual screening. DESIGN:Retrospective cohort study. SETTING:Kaiser Permanente Northern and Southern California. PATIENTS:323 349 health plan members aged 50 to 70 years on their FIT mailing date in 2007 or 2008 who completed the first round of FIT and were followed for up to 4 screening rounds. MEASUREMENTS:Screening participation, FIT positivity (≥20 µg of hemoglobin/g), positive predictive values for adenoma and CRC, and FIT sensitivity for detecting CRC obtained from Kaiser Permanente electronic databases and cancer registries. RESULTS:Of the patients invited for screening, 48.2% participated in round 1. Of those who remained eligible, 75.3% to 86.1% participated in subsequent rounds. Median follow-up was 4.0 years, and 32% of round 1 participants crossed over to endoscopy over 4 screening rounds-7.0% due to a positive FIT result. The FIT positivity rate (5.0%) and positive predictive values (adenoma, 51.5%; CRC, 3.4%) were highest in round 1. Overall, programmatic FIT screening detected 80.4% of patients with CRC diagnosed within 1 year of testing, including 84.5% in round 1 and 73.4% to 78.0% in subsequent rounds. LIMITATION:Screening detection, rather than long-term cancer prevention, was evaluated. CONCLUSION:Annual FIT screening was associated with high sensitivity for CRC, with high adherence to annual follow-up screening among initial participants. The findings indicate that annual programmatic FIT screening is feasible and effective for population-level CRC screening. PRIMARY FUNDING SOURCE:National Institutes of Health.

journal_name

Ann Intern Med

authors

Jensen CD,Corley DA,Quinn VP,Doubeni CA,Zauber AG,Lee JK,Zhao WK,Marks AR,Schottinger JE,Ghai NR,Lee AT,Contreras R,Klabunde CN,Quesenberry CP,Levin TR,Mysliwiec PA

doi

10.7326/M15-0983

subject

Has Abstract

pub_date

2016-04-05 00:00:00

pages

456-63

issue

7

eissn

0003-4819

issn

1539-3704

pii

2484289

journal_volume

164

pub_type

杂志文章
  • Guidelines for the care of patients hospitalized with viral hepatitis.

    abstract::For years patients hospitalized with viral hepatitis have been placed in two categories of isolation--enteric precautions and blood precautions. This strategy was based on the inability to differentiate between hepatitis A and B and on the assumption that feces and blood from patients with either type might be infecti...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-91-6-872

    authors: Favero MS,Maynard JE,Leger RT,Graham DR,Dixon RE

    更新日期:1979-12-01 00:00:00

  • Oral acyclovir to suppress frequently recurrent herpes labialis. A double-blind, placebo-controlled trial.

    abstract:OBJECTIVE:To determine whether oral acyclovir reduces the incidence of recurrent herpes labialis in otherwise healthy patients with proven frequently recurrent disease. DESIGN:Randomized, double-blind, placebo-controlled, crossover trial. SETTING:Outpatient facility of the Clinical Center, National Institutes of Heal...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.7326/0003-4819-118-4-199302150-00004

    authors: Rooney JF,Straus SE,Mannix ML,Wohlenberg CR,Alling DW,Dumois JA,Notkins AL

    更新日期:1993-02-15 00:00:00

  • Management strategies for Helicobacter pylori-seropositive patients with dyspepsia: clinical and economic consequences.

    abstract:BACKGROUND:Noninvasive testing for Helicobacter pylori is widely available and has been considered as an initial management strategy for uninvestigated dyspepsia. However, data to guide clinicians in the management of patients with dyspepsia who are seropositive for H. pylori are lacking. OBJECTIVE:To examine the econ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-126-4-199702150-00004

    authors: Ofman JJ,Etchason J,Fullerton S,Kahn KL,Soll AH

    更新日期:1997-02-15 00:00:00

  • Complementary value of two-dimensional exercise echocardiography to routine treadmill exercise testing.

    abstract::Two-dimensional echocardiograms were done during rest and after exercise in 95 patients who subsequently had coronary arteriography. Prior myocardial infarction was present in 36 patients, 35 of whom had wall motion abnormalities. There was no evidence of prior infarction in 59 patients, 44 of whom had coronary diseas...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-105-6-829

    authors: Armstrong WF,O'Donnell J,Dillon JC,McHenry PL,Morris SN,Feigenbaum H

    更新日期:1986-12-01 00:00:00

  • Effectiveness and cost-effectiveness of expanded antiviral prophylaxis and adjuvanted vaccination strategies for an influenza A (H5N1) pandemic.

    abstract:BACKGROUND:The pandemic potential of influenza A (H5N1) virus is a prominent public health concern of the 21st century. OBJECTIVE:To estimate the effectiveness and cost-effectiveness of alternative pandemic (H5N1) mitigation and response strategies. DESIGN:Compartmental epidemic model in conjunction with a Markov mod...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-151-12-200912150-00156

    authors: Khazeni N,Hutton DW,Garber AM,Owens DK

    更新日期:2009-12-15 00:00:00

  • Acute severe aortic regurgitation. Pathophysiology, clinical recognition, and management.

    abstract::Acute severe aortic regurgitation is a relatively unfamiliar, though life-threatening, disease. We review its diverse causes, anatomic faults, and hemodynamic sequelae and set the stage for an understanding of the clinical manifestations in light of their physiologic mechanisms. Clinical information includes the natur...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-87-2-223

    authors: Morganroth J,Perloff JK,Zeldis SM,Dunkman WB

    更新日期:1977-08-01 00:00:00

  • Current diagnosis of venous thromboembolism in primary care: a clinical practice guideline from the American Academy of Family Physicians and the American College of Physicians.

    abstract::This guideline summarizes the current approaches for the diagnosis of venous thromboembolism. The importance of early diagnosis to prevent mortality and morbidity associated with venous thromboembolism cannot be overstressed. This field is highly dynamic, however, and new evidence is emerging periodically that may cha...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-146-6-200703200-00013

    authors: Qaseem A,Snow V,Barry P,Hornbake ER,Rodnick JE,Tobolic T,Ireland B,Segal JB,Bass EB,Weiss KB,Green L,Owens DK,Joint American Academy of Family Physicians\/American College of Physicians Panel on Deep Venous Thrombosis\/Pulmonary

    更新日期:2007-03-20 00:00:00

  • Have we treated AIDS too well? Rationing and the future of AIDS exceptionalism.

    abstract::During the past decade, medical therapy for AIDS has become more effective but also prohibitively expensive. A medical tragedy has been transformed into a financial crisis, and society has responded by establishing special programs and sources of funding for AIDS. These maneuvers parallel earlier approaches to HIV tes...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-128-9-199805010-00009

    authors: Casarett DJ,Lantos JD

    更新日期:1998-05-01 00:00:00

  • Digitoxin elimination reduced during quinidine therapy.

    abstract::Elevated serum digoxin concentrations and clinical toxicity have been reported in patients receiving quinidine. The present study was undertaken to ascertain whether a similar interaction occurs between quinidine and another cardiac glycoside, digitoxin, and if so to evaluate the pharmacokinetic basis in five healthy ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-94-1-35

    authors: Garty M,Sood P,Rollins DE

    更新日期:1981-01-01 00:00:00

  • Association of fibrinogen with glycemic control and albumin excretion rate in patients with non-insulin-dependent diabetes mellitus.

    abstract:BACKGROUND:The high prevalence of classic cardiac risk factors in patients with non-insulin-dependent diabetes mellitus does not explain the increased cardiovascular-related morbidity and mortality in these patients. Fibrinogen may have a role in this excess risk. OBJECTIVE:To evaluate the following in patients with n...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-125-8-199610150-00005

    authors: Bruno G,Cavallo-Perin P,Bargero G,Borra M,D'Errico N,Pagano G

    更新日期:1996-10-15 00:00:00

  • Effects of an intervention to increase bed alarm use to prevent falls in hospitalized patients: a cluster randomized trial.

    abstract:BACKGROUND:Bed alarm systems intended to prevent hospital falls have not been formally evaluated. OBJECTIVE:To investigate whether an intervention aimed at increasing bed alarm use decreases hospital falls and related events. DESIGN:Pair-matched, cluster randomized trial over 18 months. Nursing units were allocated b...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.7326/0003-4819-157-10-201211200-00005

    authors: Shorr RI,Chandler AM,Mion LC,Waters TM,Liu M,Daniels MJ,Kessler LA,Miller ST

    更新日期:2012-11-20 00:00:00

  • New federal initiatives to enhance the medical treatment of opioid dependence.

    abstract::Opioid dependence is a chronic relapsing medical condition with substantial health and societal complications. Recent federal initiatives are designed to enhance the medical treatment of patients with opioid dependence and will expand the role of internists in the care of these patients. These initiatives include a pr...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-137-8-200210150-00014

    authors: Fiellin DA,O'Connor PG

    更新日期:2002-10-15 00:00:00

  • Intravascular coagulation with use of human prothrombin complex concentrates.

    abstract::Prothrombin complex concentrates are used in the treatment of the congenital bleeding disorders associated with Factors II, VII, IX, and X deficiencies. They have also been extensively used to treat acquired coagulation abnormalities secondary to vitamin K deficiency, warfarin ingestion, and various types of liver dis...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-84-6-683

    authors: Cederbaum AI,Blatt PM,Roberts HR

    更新日期:1976-06-01 00:00:00

  • A professional response to demands for accountability: practical recommendations regarding ethical aspects of patient care. Working Group on Accountability.

    abstract::Forceful new demands for accountability in medicine are arising from many interested parties. To maintain professional standards, physicians need to establish which demands are desirable and which are not. We adopt a model of stratified accountability that includes three major components: the accountable parties, the ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-124-2-199601150-00008

    authors: Emanuel LL

    更新日期:1996-01-15 00:00:00

  • Atenolol compared with nifedipine: effect on cognitive function and mood in elderly hypertensive patients.

    abstract:OBJECTIVE:To compare the effects of atenolol and nifedipine on mood and cognitive function in elderly hypertensive patients. DESIGN:Randomized, double-blind, crossover trial. PATIENTS:Thirty-one elderly volunteers (7 women and 4 men) 60 to 81 years of age with mild to moderate hypertension were recruited from the gen...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.7326/0003-4819-116-8-615

    authors: Skinner MH,Futterman A,Morrissette D,Thompson LW,Hoffman BB,Blaschke TF

    更新日期:1992-04-15 00:00:00

  • Sulfasalazine. Pharmacology, clinical use, toxicity, and related new drug development.

    abstract::Sulfasalazine is metabolized by intestinal bacteria, resulting in the release of sulfapyridine and 5-aminosalicylate. The drug is useful in the treatment of active ulcerative colitis as well as in preventing relapses of the disease in remission. Although effective in active Crohn's disease as well, sulfasalazine appea...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,评审

    doi:10.7326/0003-4819-101-3-377

    authors: Peppercorn MA

    更新日期:1984-09-01 00:00:00

  • Aging-related cataract: laboratory investigation and clinical management.

    abstract::Cataract disrupts the crystalline lens, a transparent, elastic, avascular, biconvex structure composed of a capsule, lens epithelium, and lens fiber cells. Many factors contribute to the progression of lens opacity, but aging is most frequently associated with cataract. As aging-related cataract develops, many biochem...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-102-1-82

    authors: Straatsma BR,Foos RY,Horwitz J,Gardner KM,Pettit TH

    更新日期:1985-01-01 00:00:00

  • A high molecular weight antigen in Legionnaires' disease bacterium: isolation and partial characterization.

    abstract::We isolated a high molecular weight antigen of the Legionnaires' disease (LD) bacterium by column chromatography. The antigen was composed of 35% carbohydrate, 2.6% protein, 1.8% phospholipid, and 1% 2-keto-3-deoxyoctonate and was important in the host's antibody response because it inhibited the indirect immunofluore...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-90-4-638

    authors: Johnson W,Elliott JA,Helms CM,Renner ED

    更新日期:1979-04-01 00:00:00

  • Familial hyperparathyroidism. Description of a large kindred with physiologic observations and a review of the literature.

    abstract::Sixty-nine out of a kindred of 100 members covering five generations were examined and studied, and 34 were hypercalcemic. Sixteen subjects were believed, on the basis of laboratory and clinical observations, to have primary hyperparathyroidism. Eight patients were subjected to exhaustive study to identify polyendocri...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-84-1-36

    authors: Goldsmith RE,Sizemore GW,Chen IW,Zalme E,Altemeier WA

    更新日期:1976-01-01 00:00:00

  • Narrative review: reversible cerebral vasoconstriction syndromes.

    abstract::Reversible cerebral vasoconstriction syndromes (RCVS) comprise a group of diverse conditions, all characterized by reversible multifocal narrowing of the cerebral arteries heralded by sudden (thunderclap), severe headaches with or without associated neurologic deficits. Reversible cerebral vasoconstriction syndromes a...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/0003-4819-146-1-200701020-00007

    authors: Calabrese LH,Dodick DW,Schwedt TJ,Singhal AB

    更新日期:2007-01-02 00:00:00

  • The Effects of Pay-for-Performance Programs on Health, Health Care Use, and Processes of Care: A Systematic Review.

    abstract:Background:The benefits of pay-for-performance (P4P) programs are uncertain. Purpose:To update and expand a prior review examining the effects of P4P programs targeted at the physician, group, managerial, or institutional level on process-of-care and patient outcomes in ambulatory and inpatient settings. Data Sources...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,评审

    doi:10.7326/M16-1881

    authors: Mendelson A,Kondo K,Damberg C,Low A,Motúapuaka M,Freeman M,O'Neil M,Relevo R,Kansagara D

    更新日期:2017-03-07 00:00:00

  • Biliary tract obstruction in the acquired immunodeficiency syndrome.

    abstract::Three patients with the acquired immunodeficiency syndrome had biliary obstruction resulting from benign strictures of the biliary tract. Stenosis of the distal common bile duct with differing degrees of irregularity of the smaller intrahepatic and extrahepatic ducts was seen in association with either cryptosporidial...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-105-2-207

    authors: Margulis SJ,Honig CL,Soave R,Govoni AF,Mouradian JA,Jacobson IM

    更新日期:1986-08-01 00:00:00

  • The case for treating tobacco dependence as a chronic disease.

    abstract::Smoking remains the leading cause of preventable death in the United States, yet it is still regarded by many as merely a bad habit. Most smokers want to quit but find it difficult. Behavioral counseling and pharmacotherapies are available, safe, and effective in the treatment of tobacco dependence. Nicotine replaceme...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-148-7-200804010-00012

    authors: Steinberg MB,Schmelzer AC,Richardson DL,Foulds J

    更新日期:2008-04-01 00:00:00

  • Undiagnosed sleep apnea in patients with essential hypertension.

    abstract::The prevalence of sleep apnea was studied in 46 middle- and older-aged men with "essential hypertension." Thirty-four age- and weight-similar normotensive men were also studied. Fourteen hypertensive men and three controls had sleep apnea syndrome, as defined as greater than ten apneas per hour of sleep. Hypertensive ...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-103-2-190

    authors: Fletcher EC,DeBehnke RD,Lovoi MS,Gorin AB

    更新日期:1985-08-01 00:00:00

  • Facial edema and eosinophilia. Evidence for eosinophil degranulation.

    abstract::Two patients had recurrent facial edema and peripheral blood eosinophilia. One patient showed a marked increase in the serum level of the eosinophil granule major basic protein. In both patients, skin biopsy samples showed nonspecific mononuclear cell inflammation with few eosinophils. However, immunofluorescence stai...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-103-4-503

    authors: Songsiridej V,Peters MS,Dor PJ,Ackerman SJ,Gleich GJ,Busse WW

    更新日期:1985-10-01 00:00:00

  • Arizona hinshawii infections. New cases, antimicrobial sensitivities, and literature review.

    abstract::Although disease caused by Arizona hinshawii is known to resemble the spectrum of clinical syndromes seen with Salmonella infections, little is known of their sensitivity to antimicrobials. We present three cases that are illustrative of Arizona sepsis, localized infection, or both; review the literature; and report s...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-85-5-587

    authors: Johnson RH,Lutwick LI,Huntley GA,Vosti KL

    更新日期:1976-11-01 00:00:00

  • Effect of treatment of Helicobacter pylori infection on the long-term recurrence of gastric or duodenal ulcer. A randomized, controlled study.

    abstract:OBJECTIVE:To determine the effect of treating Helicobacter pylori infection on the recurrence of gastric and duodenal ulcer disease. DESIGN:Follow-up of up to 2 years in patients with healed ulcers who had participated in randomized, controlled trials. SETTING:A Veterans Affairs hospital. PARTICIPANTS:A total of 109...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.7326/0003-4819-116-9-705

    authors: Graham DY,Lew GM,Klein PD,Evans DG,Evans DJ Jr,Saeed ZA,Malaty HM

    更新日期:1992-05-01 00:00:00

  • The myocarditis of systemic lupus erythematosus: association with myositis.

    abstract::Five patients with clinically overt myocarditis in the setting of systemic lupus erythematosus were analyzed in terms of associated clinical and serologic features. Myositis and antibodies to nuclear ribonucleoprotein (RNP) were present in all. A retrospective review in 140 consecutive patients with systemic lupus ery...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章

    doi:10.7326/0003-4819-89-5-619

    authors: Borenstein DG,Fye WB,Arnett FC,Stevens MB

    更新日期:1978-11-01 00:00:00

  • Durable treatment-free remission after high-dose cyclophosphamide therapy for previously untreated severe aplastic anemia.

    abstract:BACKGROUND:Severe aplastic anemia is a life-threatening bone marrow failure disorder. High-dose cyclophosphamide therapy followed by allogeneic bone marrow transplantation cures the disease. However, it requires a suitable donor and carries the risk for graft-versus-host disease. A small pilot study demonstrated that h...

    journal_title:Annals of internal medicine

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.7326/0003-4819-135-7-200110020-00006

    authors: Brodsky RA,Sensenbrenner LL,Smith BD,Dorr D,Seaman PJ,Lee SM,Karp JE,Brodsky I,Jones RJ

    更新日期:2001-10-02 00:00:00

  • Short-course therapy of catheter-related Staphylococcus aureus bacteremia: a meta-analysis.

    abstract:OBJECTIVE:To determine, through structured methodologic review of published articles, the effectiveness of short-course (< or = 2 weeks) antibiotic therapy for catheter-related Staphylococcus aureus bacteremia. DATA SOURCES:English-language publications on catheter-related S. aureus bacteremia identified using MEDLINE...

    journal_title:Annals of internal medicine

    pub_type: 杂志文章,meta分析

    doi:10.7326/0003-4819-119-4-199308150-00010

    authors: Jernigan JA,Farr BM

    更新日期:1993-08-15 00:00:00