Abstract:
BACKGROUND:Castleman disease, an unusual condition of unknown cause consisting of a massive proliferation of lymphoid tissue, remains a clinicopathologic diagnosis. Three histologic variants (hyaline vascular, plasma-cell, and mixed) and two clinical types (localized and multicentric) of Castleman disease have been described. OBJECTIVE:To analyze the clinical features, management, and outcome of patients with Castleman disease. DESIGN:Case series. SETTING:University referral hospitals. PATIENTS:All patients with Castleman disease who were seen at Texas Medical Center, Houston, Texas, between 1977 and 1995. INTERVENTIONS:Surgical excision for localized disease; surgery, combination chemotherapy, or prednisone for multicentric disease. MEASUREMENTS:Patients were identified according to initial presentation as having localized or multicentric Castleman disease. Patients within each group were further subdivided according to whether they had hyaline vascular, plasma-cell, or mixed disease. RESULTS:Data from 15 patients were analyzed. All 7 patients with localized disease underwent surgical excision and remain free of disease. The 8 patients with multicentric disease were further subdivided according to initial treatment: Three patients who received combination chemotherapy are currently alive and free of disease; 2 patients treated with prednisone are alive but have needed intermittent maintenance therapy for disease reactivations; and 2 patients treated with surgery only have died, 1 of infectious complications and 1 of non-Hodgkin lymphoma. CONCLUSIONS:Localized and multicentric Castleman disease are different clinical disorders with overlapping histologic features. Localized disease can be cured with surgery, but complete remissions in patients with multicentric disease have been achieved only with chemotherapy or prednisone given at the time of diagnosis.
journal_name
Ann Intern Medjournal_title
Annals of internal medicineauthors
Herrada J,Cabanillas F,Rice L,Manning J,Pugh Wdoi
10.7326/0003-4819-128-8-199804150-00010subject
Has Abstractpub_date
1998-04-15 00:00:00pages
657-62issue
8eissn
0003-4819issn
1539-3704journal_volume
128pub_type
杂志文章abstract::Patients with serious psychiatric disorders are frequently treated by primary care physicians, who may have difficulty keeping up with recent advances in psychiatry. This paper presents an updated synopsis for three major psychiatric illnesses: major depression, bipolar disorder, and schizophrenia. Current definitions...
journal_title:Annals of internal medicine
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abstract:BACKGROUND:Despite extensive literature, the diagnostic role of d-dimer for deep venous thrombosis (DVT) or pulmonary embolism (PE) remains unclear, reflecting multiple d-dimer assays and concerns about differing sensitivities and variability. PURPOSE:To systematically review trials that assessed sensitivity, specific...
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journal_title:Annals of internal medicine
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2009-04-07 00:00:00
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journal_title:Annals of internal medicine
pub_type: 临床试验,杂志文章,评审
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journal_title:Annals of internal medicine
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更新日期:2003-03-18 00:00:00
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更新日期:1988-11-15 00:00:00
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更新日期:2006-04-04 00:00:00
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更新日期:2015-02-03 00:00:00
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更新日期:1993-11-01 00:00:00
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更新日期:2001-07-03 00:00:00
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更新日期:1995-03-15 00:00:00
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更新日期:1998-11-01 00:00:00
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更新日期:1995-12-15 00:00:00
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更新日期:1980-02-01 00:00:00
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更新日期:1984-02-01 00:00:00