Anatomic substages of stage III-A Hodgkin's disease. A collaborative study.

Abstract:

:The clinical significance of anatomic substage was assessed in 130 patients with Hodgkin's disease in pathologic stage III-A: stage III1-A includes involvement of spleen, or splenic, celiac, or portal nodes, or any combination of these; stage III2-A includes involvement of para-aortic, iliac, or mesenteric nodes, with or without upper abdominal involvement. Median follow-up was 58 months. Both 5-year disease-free survival, 74% versus 46%, and 5-year survival, 94% versus 65%, were better (P less than 0.001) in stage III1-A than in stage III2-A. In stage III1-A, 5-year disease-free survival was better in patients receiving radiotherapy and chemotherapy than in patients receiving radiotherapy alone as initial treatment, 96% versus 63%, P less than 0.003; however, 5-year survival rates in P = 0.22. For stage III2-A, both 5-year disease-free survival, 76% versus 32%, P less than 0.001, and 5-year survival, 84% versus 56%, P less than 0.03, were superior with radiotherapy-chemotherapy. Consideration of anatomic substage may aid therapeutic planning for stage III Hodgkin's disease.

journal_name

Ann Intern Med

authors

Stein RS,Golomb HM,Diggs CH,Mauch P,Hellman S,Wiernik PH,Ultmann JE,Rosenthal DS

doi

10.7326/0003-4819-92-2-159

subject

Has Abstract

pub_date

1980-02-01 00:00:00

pages

159-65

issue

2 Pt 1

eissn

0003-4819

issn

1539-3704

journal_volume

92

pub_type

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