e Antigen in hepatitis B virus infected dialysis patients: assessment of its prognostic value.

Abstract:

:Many investigations consider the presence of e antigen (HBeAg) valuable in predicting which patients with acute hepatitis B are at risk of remaining infected and developing chronic liver disease. We tested this hypothesis in a retrospective study of serial samples from patients undergoing long-term hemodialysis. We found HBeAg in the early phase of all hepatitis B virus (HBV) infections. There was no significant difference between transiently and persistently hepatitis B surface antigen (HBsAg)-positive persons with regard to the frequency of HBeAg during the first 3 months of HBs antigenemia. Thus during the early period of viral activity, the presence of HBeAg is of no prognostic values in determining chronicity of HBV infection. We believe the disagreement on the prognostic value of HBeAg is a reflection of variations in time and frequency of sampling. The HBeAg remains, however, a useful indicator of potential infectivity of HBsAg(+)persons.

journal_name

Ann Intern Med

authors

Werner BG,Blumberg BS

doi

10.7326/0003-4819-89-3-310

subject

Has Abstract

pub_date

1978-09-01 00:00:00

pages

310-4

issue

3

eissn

0003-4819

issn

1539-3704

journal_volume

89

pub_type

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